S461
Asian Pac J Trop Med 2014; 7(Suppl 1): S461-S468
Contents lists available at ScienceDirect
Asian Pacific Journal of Tropical Medicine journal homepage:www.elsevier.com/locate/apjtm
Document heading
Analgesic
doi: 10.1016/S1995-7645(14)60275-3
and anti-inflammatory activities of Piper nigrum L.
1
1
2
2
3*
Farhana Tasleem , Iqbal Azhar , Syed Nawazish Ali , Shaista Perveen , Zafar Alam Mahmood Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan Department of Chemistry, University of Karachi, Karachi, Pakistan 3 Colorcon Limited, Crossways, Victory Way, Kent, Dartford, England 1 2
ARTICLE INFO
ABSTRACT
Article history: Received 4 Jul 2014 Received in revised form 14 Jul 2014 Accepted 3 Aug 2014 Available online 17 Aug 2014
Objective: To evaluate and compare the analgesic and anti-inflammatory activity of pure compound, piperine along with hexane and ethanol extracts of Piper nigrum L. fruit in mice and rats. Methods: The analgesic activity was determined by tail immersion method, analgesy-meter, hot plate and acetic acid induced writhing test. While the anti-inflammatory activity was evaluated by carrageenan-induced paw inflammation in rats. Results: Piperine at a dose of 5 mg/kg and ethanol extract at a dose of 15 mg/kg after 120 min and hexane extract at a dose of 10 mg/kg after 60 min exhibited significant (P
Asian Pac J Trop Med 2014; 7(Suppl 1): S461-S468
Contents lists available at ScienceDirect
Asian Pacific Journal of Tropical Medicine journal homepage:www.elsevier.com/locate/apjtm
Document heading
Analgesic
doi: 10.1016/S1995-7645(14)60275-3
and anti-inflammatory activities of Piper nigrum L.
1
1
2
2
3*
Farhana Tasleem , Iqbal Azhar , Syed Nawazish Ali , Shaista Perveen , Zafar Alam Mahmood Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan Department of Chemistry, University of Karachi, Karachi, Pakistan 3 Colorcon Limited, Crossways, Victory Way, Kent, Dartford, England 1 2
ARTICLE INFO
ABSTRACT
Article history: Received 4 Jul 2014 Received in revised form 14 Jul 2014 Accepted 3 Aug 2014 Available online 17 Aug 2014
Objective: To evaluate and compare the analgesic and anti-inflammatory activity of pure compound, piperine along with hexane and ethanol extracts of Piper nigrum L. fruit in mice and rats. Methods: The analgesic activity was determined by tail immersion method, analgesy-meter, hot plate and acetic acid induced writhing test. While the anti-inflammatory activity was evaluated by carrageenan-induced paw inflammation in rats. Results: Piperine at a dose of 5 mg/kg and ethanol extract at a dose of 15 mg/kg after 120 min and hexane extract at a dose of 10 mg/kg after 60 min exhibited significant (P
