HHS Public Access Author manuscript Author Manuscript
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2017 April 15. Published in final edited form as: J Acquir Immune Defic Syndr. 2016 April 15; 71(5): 570–576. doi:10.1097/QAI.0000000000000910.
Anal Cancer Screening in Men Who Have Sex with Men in the Multicenter AIDS Cohort Study Gypsyamber D’SOUZA, PhD1, Alicia WENTZ, MA1, Dorothy WILEY, PHD2, Nisha SHAH, MA1, Francine BARRINGTON, MS1, Teresa M. DARRAGH, MD3, Nancy JOSTE, MD4,8, Michael PLANKEY, PhD5, Susheel REDDY, MS6, Elizabeth C. BREEN, PhD7, Stephen YOUNG, PhD4,8, and Ross D. CRANSTON, MD9
Author Manuscript
1Department
of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD,
USA 2School
of Nursing, University of California, Los Angeles, CA, USA
3Department
of Pathology, University of California, San Francisco, CA, USA
4Department
of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM,
USA 5Department
of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA 6Department
of Infectious Disease, Northwestern University, Chicago, IL, USA
Author Manuscript
7Cousins
Center for Psychoneuroimmunology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA
8Tricore
Reference Laboratories. Albuquerque, NM, USA
9Department
of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Abstract Objective—To evaluate the prevalence of anal cytology (ACyt) abnormalities among HIVinfected and HIV-uninfected men who have sex with men (MSM)
Author Manuscript
Design—Multicenter cohort study of 723 HIV-infected and 788 HIV-uninfected MSM with ACyt, with a second ACyt collected two years later. Referral for high-resolution anoscopy (HRA) was suggested for abnormal ACyt.
Corresponding Author: Dr. Gypsyamber DSouza, Department of Epidemiology, 615 N Wolfe St. E6132, Baltimore, MD 21205, Ph: 410-502-2583, Fax: 410-614-2632, [email protected]. Meetings at which data was presented: August, 2014 International Papillomavirus Meeting in Seattle, WA, USA. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH), Johns Hopkins ICTR, or NCATS. The MACS website is located at http://aidscohortstudy.org. Conflicts of Interests: GD, AW, NS, FB, MP, SR, NJ, EB have no conflicts of interest. DW has speaker bureau fees and research support from Merck & Co. SY is a member of the Scientific Advisory Boards for Roche Diagnostic Corporation and Quidel Corporation. TMD has received research supplies from Hologic for anal cytology. RDC has institutional research support from Merck & Co. (IISP 38548)
D’SOUZA et al.
Page 2
Author Manuscript
Methods—ACyt samples were collected using a polyester swab and liquid cytology media, and read in a central laboratory. Results—Prevalence of any abnormal ACyt was 25% in HIV-uninfected MSM, and increased to 38%, 41%, and 47% among HIV-infected MSM with current CD4+ T-cell counts ≥500, 350–499, and
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2017 April 15. Published in final edited form as: J Acquir Immune Defic Syndr. 2016 April 15; 71(5): 570–576. doi:10.1097/QAI.0000000000000910.
Anal Cancer Screening in Men Who Have Sex with Men in the Multicenter AIDS Cohort Study Gypsyamber D’SOUZA, PhD1, Alicia WENTZ, MA1, Dorothy WILEY, PHD2, Nisha SHAH, MA1, Francine BARRINGTON, MS1, Teresa M. DARRAGH, MD3, Nancy JOSTE, MD4,8, Michael PLANKEY, PhD5, Susheel REDDY, MS6, Elizabeth C. BREEN, PhD7, Stephen YOUNG, PhD4,8, and Ross D. CRANSTON, MD9
Author Manuscript
1Department
of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD,
USA 2School
of Nursing, University of California, Los Angeles, CA, USA
3Department
of Pathology, University of California, San Francisco, CA, USA
4Department
of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM,
USA 5Department
of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA 6Department
of Infectious Disease, Northwestern University, Chicago, IL, USA
Author Manuscript
7Cousins
Center for Psychoneuroimmunology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA
8Tricore
Reference Laboratories. Albuquerque, NM, USA
9Department
of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Abstract Objective—To evaluate the prevalence of anal cytology (ACyt) abnormalities among HIVinfected and HIV-uninfected men who have sex with men (MSM)
Author Manuscript
Design—Multicenter cohort study of 723 HIV-infected and 788 HIV-uninfected MSM with ACyt, with a second ACyt collected two years later. Referral for high-resolution anoscopy (HRA) was suggested for abnormal ACyt.
Corresponding Author: Dr. Gypsyamber DSouza, Department of Epidemiology, 615 N Wolfe St. E6132, Baltimore, MD 21205, Ph: 410-502-2583, Fax: 410-614-2632, [email protected]. Meetings at which data was presented: August, 2014 International Papillomavirus Meeting in Seattle, WA, USA. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH), Johns Hopkins ICTR, or NCATS. The MACS website is located at http://aidscohortstudy.org. Conflicts of Interests: GD, AW, NS, FB, MP, SR, NJ, EB have no conflicts of interest. DW has speaker bureau fees and research support from Merck & Co. SY is a member of the Scientific Advisory Boards for Roche Diagnostic Corporation and Quidel Corporation. TMD has received research supplies from Hologic for anal cytology. RDC has institutional research support from Merck & Co. (IISP 38548)
D’SOUZA et al.
Page 2
Author Manuscript
Methods—ACyt samples were collected using a polyester swab and liquid cytology media, and read in a central laboratory. Results—Prevalence of any abnormal ACyt was 25% in HIV-uninfected MSM, and increased to 38%, 41%, and 47% among HIV-infected MSM with current CD4+ T-cell counts ≥500, 350–499, and
