J Int Med Äej (1977) 5, 68
An Investigation into the Effect on Cigarette Smolcing of a New Anti-Smoking Chewing Gum Abraham Rosenberg, M D , The Tobacco Clinic, Copenhagen,
Denmark
A preparation* claimed to help patients to break the habit of smoking has recently been introduced. Material released in the mouth from a chewing gum causes an unpleasant taste when tobacco smoke Is inhaled. This claim has been investigated in a double-blind trial on sixty subjects, thirty of whom took the active chewing gum and thirty the placebo chewing gum. The subjects each used one piece of chewing gum four times a day over a period of two weeks. This investigation clearly indicates that the active chewing gum is effective as an anti-smoking preparation, when used over a period of two weeks and the effect is still demonstrable one month later, although to a lesser extent.
Introduction The purpose of this investigation was to assess the effectiveness of Tabmint®, an antismoking chewing gum, on the smoking pattern of cigarette smokers when ad ministered over a period of two weeks. This investigation forms a part of our research with anti-smoking preparations. An investiga tion of the effect of Respaton® has been published previously (Rosenberg 1974). Materials and Method The active preparation (Tabmint) is a chewing gum containing silver acetate 6 mg, ammonium chloride 10 mg and co-carboxylase 0-025 mg as the active ingredients. The control chewing gums matched the active chewing gums in all respects except for the active ingredients. *Tabmint® Anti-Smoking Chewing Gum
Sixty subjects, all habitual cigarette smokers, took part in a double-blind trial. The daily consumption of cigarettes ranged from a minimum of 10 to a maximum of 35, with an average of 18 cigarettes a day. The triallists joined the experiment wishing to reduce their daily consumption of cigarettes (85%) or desirous of stopping the habit of smoking entirely (15%). The triallists were divided into two groups, each being compar able to the other regarding age (mean: 37 and 35 years), daily consumption of cigarettes (mean: 17 and 19) and sex (males: 4 5 % and 55%). The triallists were instructed to use one piece of Tabmint chewing gum four times a day over a period of two weeks, to make a record of the daily consumption of cigarettes during the period of the investigation and finally again one month after the conclusion of the trial.
Downloaded from imr.sagepub.com at Australian National University on March 13, 2015
A
Rosenberg
69
Results The results are presented in Tables 1 and 2. A difference in the daily consumption of cigarettes was present from the beginning of the period of investigation, the group receiving the active chewing gum having a lower intake. This effect was maximum in the final few days of the two week period. Twenty-two out of thirty persons in the Tabmint-group had either stopped entirely or reduced the consumption of cigarettes to one third of their daily intake prior to the trial. The corresponding figures in the placebogroup were five out of thirty, the difference being significant at the ρ < 0 · 0 0 2 level (Fisher Exact Probability Test) (Table 1). One m o n t h later a difference between the two groups was still present (Table 2). Fourteen out of the twenty-two persons in
Table 1 Effect of Tabmint on the daily consumption of cigarettes after two weeks Stopped/reduced
No effect
i
to of the consumption prior to the trial Tabmint group Placebo group
22 5
8 25
p < 0 002
Table 2 Effect of Tabmint on the daily consumption of cigarettes one month after completion of the trial Reduced to ^ of the consumption prior to the trial Tabmint group Placebo group p
An Investigation into the Effect on Cigarette Smolcing of a New Anti-Smoking Chewing Gum Abraham Rosenberg, M D , The Tobacco Clinic, Copenhagen,
Denmark
A preparation* claimed to help patients to break the habit of smoking has recently been introduced. Material released in the mouth from a chewing gum causes an unpleasant taste when tobacco smoke Is inhaled. This claim has been investigated in a double-blind trial on sixty subjects, thirty of whom took the active chewing gum and thirty the placebo chewing gum. The subjects each used one piece of chewing gum four times a day over a period of two weeks. This investigation clearly indicates that the active chewing gum is effective as an anti-smoking preparation, when used over a period of two weeks and the effect is still demonstrable one month later, although to a lesser extent.
Introduction The purpose of this investigation was to assess the effectiveness of Tabmint®, an antismoking chewing gum, on the smoking pattern of cigarette smokers when ad ministered over a period of two weeks. This investigation forms a part of our research with anti-smoking preparations. An investiga tion of the effect of Respaton® has been published previously (Rosenberg 1974). Materials and Method The active preparation (Tabmint) is a chewing gum containing silver acetate 6 mg, ammonium chloride 10 mg and co-carboxylase 0-025 mg as the active ingredients. The control chewing gums matched the active chewing gums in all respects except for the active ingredients. *Tabmint® Anti-Smoking Chewing Gum
Sixty subjects, all habitual cigarette smokers, took part in a double-blind trial. The daily consumption of cigarettes ranged from a minimum of 10 to a maximum of 35, with an average of 18 cigarettes a day. The triallists joined the experiment wishing to reduce their daily consumption of cigarettes (85%) or desirous of stopping the habit of smoking entirely (15%). The triallists were divided into two groups, each being compar able to the other regarding age (mean: 37 and 35 years), daily consumption of cigarettes (mean: 17 and 19) and sex (males: 4 5 % and 55%). The triallists were instructed to use one piece of Tabmint chewing gum four times a day over a period of two weeks, to make a record of the daily consumption of cigarettes during the period of the investigation and finally again one month after the conclusion of the trial.
Downloaded from imr.sagepub.com at Australian National University on March 13, 2015
A
Rosenberg
69
Results The results are presented in Tables 1 and 2. A difference in the daily consumption of cigarettes was present from the beginning of the period of investigation, the group receiving the active chewing gum having a lower intake. This effect was maximum in the final few days of the two week period. Twenty-two out of thirty persons in the Tabmint-group had either stopped entirely or reduced the consumption of cigarettes to one third of their daily intake prior to the trial. The corresponding figures in the placebogroup were five out of thirty, the difference being significant at the ρ < 0 · 0 0 2 level (Fisher Exact Probability Test) (Table 1). One m o n t h later a difference between the two groups was still present (Table 2). Fourteen out of the twenty-two persons in
Table 1 Effect of Tabmint on the daily consumption of cigarettes after two weeks Stopped/reduced
No effect
i
to of the consumption prior to the trial Tabmint group Placebo group
22 5
8 25
p < 0 002
Table 2 Effect of Tabmint on the daily consumption of cigarettes one month after completion of the trial Reduced to ^ of the consumption prior to the trial Tabmint group Placebo group p
