Accepted Manuscript Altered synchrony and loss of consciousness during frontal lobe seizures Francesca Bonini, Isabelle Lambert, Fabrice Wendling, Aileen McGonigal, Fabrice Bartolomei PII: DOI: Reference:

S1388-2457(15)00286-2 http://dx.doi.org/10.1016/j.clinph.2015.04.050 CLINPH 2007447

To appear in:

Clinical Neurophysiology

Accepted Date:

4 April 2015

Please cite this article as: Bonini, F., Lambert, I., Wendling, F., McGonigal, A., Bartolomei, F., Altered synchrony and loss of consciousness during frontal lobe seizures, Clinical Neurophysiology (2015), doi: http://dx.doi.org/ 10.1016/j.clinph.2015.04.050

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1

Altered synchrony and loss of consciousness during frontal lobe seizures

Francesca Bonini1,3, Isabelle Lambert1, Fabrice Wendling2, Aileen McGonigal1,3, Fabrice Bartolomei1,3,4,*

1

CHU Timone, Service de Neurophysiologie Clinique, Assistance Publique des Hôpitaux de Marseille,

Marseille, 13005, France 2

INSERM, U642, Université Rennes 1, Rennes, France

3

“Institut de Neurosciences des Systèmes, INSERM UMR 1106“, France

4

Hôpital Henri Gastaut/Centre Saint-Paul ; CINAPSE, 300 Bd Sainte-Marguerite, 13009 Marseille,

France

* Corresponding Author Pr Fabrice Bartolomei Service de Neurophysiologie Clinique CHU Timone-264 Rue st Pierre. 13005-Marseille, France E-mail: [email protected]

2 Abstract Objective Loss of consciousness (LOC) in frontal lobe epilepsy (FLE) has been rarely specifically studied until now. In this study we evaluated the LOC in a population of patients with FLE and studied the relationship between changes in synchrony and degree of LOC Methods 24 patients undergoing stereoelectroencephalography (SEEG) during pre-surgical evaluation of FLE were studied. The LOC intensity was scored using the Consciousness Seizure Scale (CSS). For each studied seizure (n=52), interdependencies between signals recorded from 5 brain regions were estimated as a function of time by using non-linear regression analysis (h² coefficient). Results Seizures were divided into 3 groups according to the CSS scale: group A (no LOC) with a score ≤2, group B (intermediate or partial LOC) with a score ranging from 3 to 5, and group C (maximal LOC) with a score ≥ 6. The majority of seizures in FLE patients disclosed significant LOC, particularly for patients with prefrontal lobe seizures. Mean correlation values were significantly different between groups A and C (p

Altered synchrony and loss of consciousness during frontal lobe seizures.

Loss of consciousness (LOC) in frontal lobe epilepsy (FLE) has been rarely specifically studied until now. In this study we evaluated the LOC in a pop...
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