Accepted Manuscript Advanced Lung Cancer Inflammation Index (ALI), a New Prognostic Score, Predicts Outcomes in Patients with Small-cell Lung Cancer Xiaobo He, Ting Zhou, Yunpeng Yang, Shaodong Hong, Jianhua Zhan, Zhihuang Hu, Wenfeng Fang, Tao Qin, Yuxiang Ma, Yuanyuan Zhao, Zhibin Cheng, Yan Huang, Hongyun Zhao, Guangwei Yang, Li Zhang PII:

S1525-7304(15)00078-9

DOI:

10.1016/j.cllc.2015.03.005

Reference:

CLLC 366

To appear in:

Clinical Lung Cancer

Received Date: 6 February 2015 Revised Date:

16 March 2015

Accepted Date: 19 March 2015

Please cite this article as: He X, Zhou T, Yang Y, Hong S, Zhan J, Hu Z, Fang W, Qin T, Ma Y, Zhao Y, Cheng Z, Huang Y, Zhao H, Yang G, Zhang L, Advanced Lung Cancer Inflammation Index (ALI), a New Prognostic Score, Predicts Outcomes in Patients with Small-cell Lung Cancer, Clinical Lung Cancer (2015), doi: 10.1016/j.cllc.2015.03.005. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT

Advanced Lung Cancer Inflammation Index (ALI), a New

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Prognostic Score, Predicts Outcomes in Patients with Small-cell

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Lung Cancer

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Xiaobo He1,2,3*,Ting Zhou1,2,3*, Yunpeng Yang1,2,3*, Shaodong Hong1,2,3, Jianhua

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Zhan1,2,3, Zhihuang Hu1,2,3, Wenfeng Fang1,2,3, Tao Qin1,2,3, Yuxiang Ma1,2,3,

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Yuanyuan Zhao1,2,3, Zhibin Cheng4, Yan Huang1,2,3, Hongyun Zhao1,2,3, Guangwei

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Yang4, Li Zhang1,2,3,†

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Department of Medical Oncology, Sun Yat-Sen University Cancer Center,

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Guangzhou, China, 2State Key Laboratory of Oncology in South China, Guangzhou,

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China, 3Collaborative innovation Center for Cancer Medicine, Guangzhou, China,

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Department of Oncological Radiotherapy, the Fifth Affiliated Hospital of Sun

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Yat-Sen University, Zhuhai, Guangdong, China.

*These authors contributed equally to this work and share the first authorship.

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†Corresponding authors:

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Li Zhang, Tel: +862087343458; Fax: +862087343392; Email: [email protected]

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u.edu.cn; Department of Medical Oncology, Sun Yat-Sen University Cancer Ce nter, 651# Dongfeng East Road, Guangzhou, China, 510060

ACCEPTED MANUSCRIPT

This article is the first to utilize the value of advanced lung cancer

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inflammation index to predict the overall survival in patients with

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small-cell lung cancer. We enrolled 365 patients were eligible for analysis

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and found that lower ALI significantly associated with worse overall

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survival in small-cell lung cancer patients. The result provided the

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evaluation of ALI could authenticate the patients with poor prognosis

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and be a useful prognostic marker in clinical practice.

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ACCEPTED MANUSCRIPT

Background: A recent study indicated that advanced lung cancer

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inflammation index (ALI) could predict the overall survival (OS) in

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patients with non-small cell lung cancer (NSCLC). However, the

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prognostic value in small-cell lung cancer (SCLC) has not been studied yet.

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Therefore, the aim of this study is to explore the relationship between

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ALI and the prognosis of SCLC.

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Patients and methods: we screened 460 patients who were

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diagnosed as SCLC from June 2006 to December 2011 in Sun Yat-Sen

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University Cancer Center. Data acquisition was though patients’ medical

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information, blood results recorded at diagnosis. ALI was calculated as

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the formula: BMI (body mass index) × Alb (serum albumin)/NLR

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(neutrophil-lymphocyte ratio).

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Result: Totally, 365 patients were enrolled in this study. Patients were

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allocated to two groups: ALI

Advanced Lung Cancer Inflammation Index, a New Prognostic Score, Predicts Outcome in Patients With Small-Cell Lung Cancer.

This report is the first to use the value of the Advanced Lung Cancer Inflammation Index (ALI) to predict the overall survival in patients with small-...
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