Adjunctive Medical Therapy with α-Blocker after Extracorporeal Shock Wave Lithotripsy of Renal and Ureteral Stones: A MetaAnalysis Mingchao Li1, Zhengyun Wang2, Jun Yang1, Xiaolin Guo1*, Tao Wang1, Shaogang Wang1, Chunping Yin3*, Jihong Liu1, Zhangqun Ye1 1 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, P. R. China, 2 Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China, 3 Department of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China * [email protected]
(XLG); [email protected]
Abstract Background OPEN ACCESS Citation: Li M, Wang Z, Yang J, Guo X, Wang T, Wang S, et al. (2015) Adjunctive Medical Therapy with α-Blocker after Extracorporeal Shock Wave Lithotripsy of Renal and Ureteral Stones: A MetaAnalysis. PLoS ONE 10(4): e0122497. doi:10.1371/ journal.pone.0122497 Academic Editor: Xin Gao, Sun Yat-sen University, CHINA
Although some trials assessed the efficacy and safety of the α-blocker in facilitating renal and ureteral stones expulsion after extracorporeal shock wave lithotripsy (ESWL), the role of the α-blocker in facilitating upper urinary calculi expulsion after ESWL remain controversial.
Aims To determine the efficacy and safety of the α-blocker in facilitating renal and ureteral stones expulsion after ESWL.
Received: July 14, 2014 Accepted: February 22, 2015
Published: April 10, 2015
A literature search was carried out using the PubMed database, EMBASE and the Cochrane Library database to identify relevant studies. Two reviewers independently extracted data and assessed methodological quality. Pooled effect estimates were obtained using a fixed- and random-effects meta-analysis.
Copyright: © 2015 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.
Results The meta-analysis included 23 RCTs, α-blocker significantly enhanced expulsion rate of upper urinary tract calculi after ESWL (P25%) the data was analyzed using the random-effects model, otherwise a fixed-effect was used. For all studies analyzed, a P-value of less than 0.05 was considered statistically significant. Publication bias was explored via a funnel-plot analysis. The Begg rank correlation and Egger weighted regression test methods were also used to statistically assess publication bias by Stata 12.0 (P