Int J Clin Exp Med 2015;8(11):20675-20678 www.ijcem.com /ISSN:1940-5901/IJCEM0015599

Original Article Acute promyelocytic leukemia transformation in a patient with aplastic anemia: a case report with literature review Xiaoning Wang1, Tingting Yuan2, Wenjuan Wang1, Limei Chen1, Huaiyu Wang1, Yalin Liu1 1 Department of Hematology, The First Affiliated Hospital of Xi’an Jiaotong University, Shaan Xi, P. R. China; 2Department of Clinical Laboratory, Affiliated Hospital of Yulin, Traditional Chinese Medicine of Shaan Xi Province, P. R. China

Received September 4, 2015; Accepted November 2, 2015; Epub November 15, 2015; Published November 30, 2015 Abstract: Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation to acute promyelocytic leukemia (APL) has never been reported. Here, we reported a patient initially diagnosed with AA. while 19 years later, PML/RAR αfusion gene were detected and the patient was eventually diagnosed as APL. The diagnosis and management of this interesting case are discussed. Keywords: Aplastic anemia, acute promyelocytic leukemia, immunosuppressive therapy

Introduction Aplastic anemia (AA) is a hematological disease characterized by low bone marrow hematopoietic function and decrease of whole blood cells caused by a variety of reasons. Immunosuppressive therapy (IST) including anti-thymocyte globulin (ATG) and cyclosporine A (CSA) is indicated for patients with severe AA who are >40 years old those

Acute promyelocytic leukemia transformation in a patient with aplastic anemia: a case report with literature review.

Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with...
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