Original Research published: 23 December 2015 doi: 10.3389/fimmu.2015.00634
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Tegan Emma Kastelein1* , Rob Duffield2 and Frank E. Marino1 1 School of Human Movement Studies, Charles Sturt University, Bathurst, NSW, Australia, 2 Sport and Exercise Discipline Group, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia
Edited by: Masaaki Murakami, Hokkaido University, Japan Reviewed by: Takayuki Yoshimoto, Tokyo Medical University, Japan Daisuke Kamimura, Hokkaido University, Japan *Correspondence: Tegan Emma Kastelein [email protected] Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Received: 03 October 2015 Accepted: 03 December 2015 Published: 23 December 2015 Citation: Kastelein TE, Duffield R and Marino FE (2015) Acute ImmuneInflammatory Responses to a Single Bout of Aerobic Exercise in Smokers; The Effect of Smoking History and Status. Front. Immunol. 6:634. doi: 10.3389/fimmu.2015.00634
This study examined the acute immune and inflammatory responses to exercise in smokers compared to non-smokers, and further, the effect of smoking history on these immune-inflammatory responses. Fifty-four recreationally active males who were either smokers (SM; n = 27) or non-smokers (NS; n = 27) were allocated into either young (YSM, YNS) or middle-aged groups (MSM, MNS) based on smoking status. Participants were matched for fitness and smoking habits and following familiarization and baseline testing, undertook an exercise protocol that involved 40 min of cycle ergometry at 50% of VO2peak. Venous blood was obtained pre- and post- (0 min, 1, and 4 h) exercise to measure circulating leukocytes and inflammatory markers interleukin (IL)-6, IL-1β, IL-1ra, and monocyte chemoattractant protein-1 (MCP-1). Compared to MNS, MSM showed elevated basal concentrations of MCP-1, which were increased with a longer smoking history (P
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Tegan Emma Kastelein1* , Rob Duffield2 and Frank E. Marino1 1 School of Human Movement Studies, Charles Sturt University, Bathurst, NSW, Australia, 2 Sport and Exercise Discipline Group, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia
Edited by: Masaaki Murakami, Hokkaido University, Japan Reviewed by: Takayuki Yoshimoto, Tokyo Medical University, Japan Daisuke Kamimura, Hokkaido University, Japan *Correspondence: Tegan Emma Kastelein [email protected] Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Received: 03 October 2015 Accepted: 03 December 2015 Published: 23 December 2015 Citation: Kastelein TE, Duffield R and Marino FE (2015) Acute ImmuneInflammatory Responses to a Single Bout of Aerobic Exercise in Smokers; The Effect of Smoking History and Status. Front. Immunol. 6:634. doi: 10.3389/fimmu.2015.00634
This study examined the acute immune and inflammatory responses to exercise in smokers compared to non-smokers, and further, the effect of smoking history on these immune-inflammatory responses. Fifty-four recreationally active males who were either smokers (SM; n = 27) or non-smokers (NS; n = 27) were allocated into either young (YSM, YNS) or middle-aged groups (MSM, MNS) based on smoking status. Participants were matched for fitness and smoking habits and following familiarization and baseline testing, undertook an exercise protocol that involved 40 min of cycle ergometry at 50% of VO2peak. Venous blood was obtained pre- and post- (0 min, 1, and 4 h) exercise to measure circulating leukocytes and inflammatory markers interleukin (IL)-6, IL-1β, IL-1ra, and monocyte chemoattractant protein-1 (MCP-1). Compared to MNS, MSM showed elevated basal concentrations of MCP-1, which were increased with a longer smoking history (P
