DIABETES/METABOLISM RESEARCH AND REVIEWS RESEARCH ARTICLE Diabetes Metab Res Rev 2015; 31: 745–751 Published online 14 July 2015 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/dmrr.2667

Access to emergency room for hypoglycaemia in people with diabetes

Elisabetta Salutini1 Cristina Bianchi1 Massimo Santini2 Angela Dardano1 Giuseppe Daniele1 Giuseppe Penno1 Roberto Miccoli1 Stefano Del Prato1* 1

Department of Clinical and Experimental Medicine – Section of Diabetes and Metabolic Diseases, University of Pisa, Pisa, Italy

Department of Emergency – Emergency Medicine Section, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy 2

*Correspondence to: Stefano Del Prato, Department of Clinical and Experimental Medicine – Section of Metabolic Diseases and Diabetes, University of Pisa, Nuovo Ospedale Santa Chiara, Via Paradisa 2, 56124 Pisa, Italy. E-mail: [email protected]

Abstract Background Hypoglycaemia is a major burden of the pharmacological therapy of diabetes and is associated with increased morbidity, mortality and treatment costs. Methods We screened all admissions to the emergency room of the Pisa University Hospital from 1 January 2009 to 31 December 2013, selecting individuals with a discharge diagnosis of hypoglycaemia. We retrieved 500 admissions involving adult diabetic patients: age 71 ± 16 years; M/F 50.2/ 49.8%; 70.2% type 2 diabetes (T2DM). Results Among T2DM, 42.2% were on insulin, 10.8% on insulin plus oral anti-diabetes drugs and 38.2% on oral anti-diabetes drugs alone (92% sulphonylureas/glinides ± insulin-sensitizers). Glibenclamide was the most frequently used sulphonylurea (69%). Individuals treated with oral antidiabetes drugs were older than those on insulin (79 ± 11 versus 74 ± 12 years; p < 0.0001). Among patients taking sulphonylurea, 47% had estimated glomerular filtration rate

Access to emergency room for hypoglycaemia in people with diabetes.

Hypoglycaemia is a major burden of the pharmacological therapy of diabetes and is associated with increased morbidity, mortality and treatment costs...
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