Annals of African Medicine Vol. 14, No. 1; 2015
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Case Report
Website: www.annalsafrmed.org DOI: 10.4103/1596-3519.148746 PMID: ******
Acanthomatous ameloblastoma of mandible crossing the midline: A rare case report Neha Bansal, Soheyl Sheikh1, Richa Bansal2, Robin Sabharwal3, Aanchal Gupta4, Ankit Goyal4, Nitika Kainth5 Departments of Oral Medicine and Radiology, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, 1MM College of Dental Sciences and Research, Mullana, Ambala, Haryana, 2Departments of Oral Pathology and Microbiology, Seema Dental College and Research Institute, Rishikesh, Uttarakhand, 3Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, 4Department of Oral Medicine and Radiology, Kalka Dental College and Hospital, Meerut, 5Private Practitioner, Max Hospital, Noida, Uttar Pradesh, India
Correspondence to: Dr. Robin Sabharwal, Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India. E‑mail: [email protected]
Abstract Ameloblastoma is the most common aggressive benign odontogenic tumor of the jaws. Ameloblastoma is a benign epithelial odontogenic tumor that typically arises in the mandible or maxilla or, rarely, in the immediate adjacent soft tissues. A clinical, radiographic and histopathological report is presented of a case of acanthomatous ameloblastoma in relation to molar in the left mandible of a 30-year-old healthy male. The histopathological examination of the removed specimen revealed the histopathological pattern of an acanthomatous ameloblastoma. The radiographic appearance of the lesion showed the presence of multilocular radiolucencies, which were crossing the midline, which is rarely found in ameloblastoma. Due to its rarity and lack of data, we take this opportunity to present a world first case of acanthomatous ameloblastoma which was crossing the midline. Keywords: Acanthomatous, ameloblastoma, computed tomography‑scan, multilocular radioluceny, odontogenic tumor
Résumé Ameloblastoma est la plus commune tumeur agressive odontogènes bénigne des mâchoires. Ameloblastoma est une tumeur bénigne odontogènes épithéliales qui se présentent généralement dans la mandibule ou maxillaire ou, plus rarement, dans les tissus mous adjacents immédiats.Rapport clinique, radiographique et histopathologique de A est présenté d'un cas d'acanthomatous ameloblastoma en ce qui concerne la molaire dans la mandibule gauche d'un homme âgé de 30 ans en bonne santé. L'examen histopathologique de l'échantillon enlevé a révélé le patron histopathologique d'une ameloblastoma acanthomatous.L'aspect radiographique de la lésion ont révélé la présence de radiolucencies multiloculaires, qui traversaient la ligne médiane, que l'on trouve rarement dans les ameloblastoma. En raison de sa rareté et de l'absence de données, nous saisissons cette occasion pour présenter un premier cas de monde de acanthomatous ameloblastoma, qui franchissait la ligne médiane. Mots clés: Acanthomatous,ameloblastoma, calculé tomographie-scan, multiloculaire radioluceny, odontogènes tumeur
Introduction Ameloblastoma is a benign epithelial odontogenic tumor that typically arises in the mandible or maxilla or, rarely, in the immediate adjacent soft tissues.[1] Annals of African Medicine
It arises from dental embryonic remnants possibly from the epithelial lining of an odontogenic cyst; dental lamina or enamel organ; stratified squamous epithelium of the oral cavity; or displaced epithelial remnants.[2] Ameloblastoma is reported to constitute Vol. 14, January-March, 2015
Page | 65
Bansal, et al.: Acanthomatous ameloblastoma of mandible
Page | 66
about 1-3% of tumors and cysts of the jaws.[1] The peak incidence occurs in the third and fourth decades of life, they are uncommon in the second decade and exceedingly rare in children under the age of 10.[3] The vast majority of ameloblastomas occur in the posterior mandible (80-85%) with the remainder of tumors presenting in the maxilla. Histologically, ameloblastoma is of six types‑follicular, plexiform, granular, basal, desmoplastic and acanthomatous.[4] Ameloblastoma is a locally destructive tumor with a propensity for recurrence if not entirely excised. We report a rare case of acanthomatous ameloblastoma occurring in the left posterior mandible and crossing the midline involving the right side of jaw. It is of concern that this acanthomatous ameloblastoma crossing the midline, which is rarest entity and never found as a lesion in human but it was seen in the case report of dogs as a canine acanthomatous ameloblastoma.
Case Report The present case report is about a 30‑year‑old male patient, a shop keeper by profession presented to the Department of Oral Medicine and Radiology with a chief complaint of painless, gradually progressive swelling in the left posterior side of mandible for 6 months. The present history revealed that the swelling was slowly growing over a period of 6 months and was not associated with pain, tenderness or discharge. The swelling was associated with numbness of lower lip.
history and medical history were unremarkable and nonsignificant. On radiographic investigations, intraoral periapical radiograph revealed multilocular radiolucencies in region of 35, 36, 37 [Figure 2]. A series of intraoral periapical radiographs with respect to 31, 32, 33, 34, 35, 36, 37, 38, 41, 42, 43 were made and that revealed multilocular radiolucencies extending and crossing the midline [Figure 3]. Significant root resorption was seen in relation to 31, 32, 33 and 34. Further investigations were carried out, which included panoramic radiography and noncontrast computed tomography (CT). Panoramic radiograph revealed multilocular radiolucencies extending from the region of 37 to 42. However, the lower border of mandible was spared [Figure 4]. Occlusal radiograph revealed typical soap bubble appearance along with buccal and lingual plate expansion. CT scan revealed lobulated, predominantly lytic, expansile, multiloculated lesion involving the mandibular alveolus on the left side in relation to lower left incisors, canine and premolar reaching up to symphysis and causing widening of mandibular alveolus with thinning and erosion of both buccal and lingual surfaces. The lesion was seen extending up to adjacent soft tissue on buccal surface [Figures 5 and 6].
Intraoral examination showed a well‑circumscribed swelling on both buccal and lingual aspect, extending from lower mesial of second premolar to distal second molar, obliterating both labial and lingual sulcus [Figure 1]. On palpation, the swelling was bony hard, nonpulsatile, noncompressible and nontender in nature. No lymphadenopathy or fistulae were present. Past
On aspiration, straw colored fluid was extracted which was inconclusive of diagnosis. Hence the patient was sent for incisional biopsy since the growth was of larger size. The histopathological examination revealed numerous follicles of tumor cells in connective tissue stroma. At the periphery, follicle was lined by single layer of tall columnar ameloblast like cells with reverse polarity. In center island showed loosely arranged polygonal or angular cells resembling stellate reticulum. Many follicles showed squamous metaplasia. Some
Figure 1: Intraoral swelling in the left posterior side of mandible on buccal vestibule
Figure 2: Introral periapical radiograph revealed multilocular radiolucencies in region of 35, 36, 37
Vol. 14, January-March, 2015
Annals of African Medicine
Bansal, et al.: Acanthomatous ameloblastoma of mandible
follicle showed cystic degeneration of central stellate reticulum like cells. Thus, on clinical, radiographical and histopathological findings, final diagnosis was given of acanthomatous ameloblastoma and the patient was sent to Department of Oral and Maxillofacial Surgery for complete excision. An informed and written consent about anesthesia and surgical procedure was obtained. Patient was operated general anesthesia and hemimandibulactomy was carried out leaving
sufficient margins [Figure 6]. All involved teeth were removed along with the lesion[Figure 7]. Post operative OPG was done [Figure 8]
Discussion Ameloblastoma is a benign epithelial odontogenic tumor but is often aggressive and destructive, with the capacity to attain great size, erode bone and invade adjacent structures. Although the term ameloblastoma was coined by Churchill in 1933,
Figure 4: Orthopantamogram revealed multilocular radiolucencies extending from the region of 37 to 42 Figure 3: Introral periapical radiograph revealed multilocular radiolucencies extending and crossing the midline
Figures 5: Computed tomography scan revealed lobulated predominantly lytic, expansile, multiloculated lesions and erosion of both buccal and lingual surfaces
Figure 7: Biopsy specimen
Annals of African Medicine
Figure 6: Revealed that hemimandibulactomy was carried out leaving sufficient margins
Figure 8: Posttreatment orthopantamogram
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Bansal, et al.: Acanthomatous ameloblastoma of mandible
Page | 68
the first detailed description of this lesion was by Falkson in 1879.[5,6] It is the most common odontogenic tumor although it represents only about 1% of tumors and cysts of the jaws and 11% of the odontogenic tumors. In the mandible (80% of ameloblastomas), 70% are located in the area of the molars or the ascending ramus, 20% in the premolar region and 10% in the anterior region.[7‑10] On an average 10-15% of ameloblastomas are associated with a nonerupted tooth. The study by Adebiyi et al. reported that most of the solid lesions belonged to the follicular type (70.4%), plexiform (14.1%) and acanthomatous (4.2%).[11] In this case, acanthomatous type of ameloblastoma found in the molar region of the mandible and it was not associated with a nonerupted tooth. Ameloblastoma appears equal frequency between sexes, although a higher frequency in females than in males has been described.[5,6] Acanthomatous ameloblastoma mostly occurs in older patients rather than younger ones. The mean age of occurrence (±standard deviation) was 61.3 ± 1.2 range 60-62 years with a peak incidence in the 7th decade of life. [8] However, in our case, the patient was male and was in third decade of his life.[11] The acanthomatous ameloblastoma exhibits varying degrees of squamous metaplasia and even keratinization of the stellate reticulum portion of the tumor islands; however, peripheral palisading is maintained and no cytologic features of malignancy are found. The so‑called kerato‑ameloblastoma is a rare variant of ameloblastoma that contains prominent keratinizing cysts that may cause some alarm and distract the pathologist from the otherwise ameloblastomatous feature.[2] “Radiographically, ameloblastoma shows a typical soap bubble” appearance when the radiolucent loculations are large and as being “honeycombed” when the lobulations area small. In our case study, the radiographic appearance of the lesion was consistent with that of an ameloblastoma except for the presence of multilocular radiolucencies extending and spreading widely crossing the midline, which is rarely found in ameloblastoma. Clinically, ameloblastomic carcinomas are more aggressive than most typical ameloblastomas. Perforation of the cortical plate, extension into surrounding soft tissue, numerous recurrent lesions and metastasis, usually to cervical lymph nodes, can
Vol. 14, January-March, 2015
be associated with ameloblastic carcinomas and hence it should be considered as the differential diagnosis.[12]
Conclusion The present case has some interesting findings distinguished it from other reported cases of ameloblastoma. First, this is a case of acanthomatous ameloblastoma which is an extremely rare variant. Second, radiographically seen the lesion is crossing the midline which is never been in literature. Third, the size of the lesion is extremely small. Finally, it is usually found in the age of old age years, but in this case, the age was only 30 years.
References 1.
Al‑Khateeb T, Ababneh KT. Ameloblastoma in young Jordanians: A review of the clinicopathologic features and treatment of 10 cases. J Oral Maxillofac Surg 2003;61:13‑8. 2. Avon SL, McComb J, Clokie C. Ameloblastic carcinoma: Case report and literature review. J Can Dent Assoc 2003;69:573‑6. 3. Wlodawsky, Abubaker AO, Strauss RA. Ameloblastoma: A pathologic review and discussion of four case reports. Rehabil Oncol 2004;22:10‑5. 4. Bansal M, Chaturvedi TP, Bansal R, Kumar M. Acanthomatous ameloblastoma of anterior maxilla. J Indian Soc Pedod Prev Dent 2010;28:209‑11. 5. Iordanidis S, Makos C, Dimitrakopoulos J, Kariki H. Ameloblastoma of the maxilla. Case report. Aust Dent J 1999;44:51‑5. 6. Varkhede A, Tupkari JV, Mandale MS, Sarda M. Plexiform ameloblastoma of mandible: Case report. J Clin Exp Dent 2010;2:e146‑8. 7. Vohra FA, Hussain M, Mudassir MS. Ameloblastomas and their management: A review. J Surg Pak (Int) 2009;14:136‑42. 8. Small IA, Waldron CA. Ameloblastomas of the jaws. Oral Surg Oral Med Oral Pathol 1955;8:281‑97. 9. Ajagbe HA, Daramola JO. Ameloblastoma: A survey of 199 cases in the University of College Hospital, Ibadan, Nigeria. J Natl Med Assoc 1987;79:324‑7. 10. Fulco GM, Nonaka CF, Souza LB, Miguel MC, Pinto LP. Solid ameloblastomas – Retrospective clinical and histopathologic study of 54 cases. Braz J Otorhinolaryngol 2010;76:172‑7. 11. Adebiyi KE, Ugboko VI, Omoniyi‑Esan GO, Ndukwe KC, Oginni FO. Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med 2006;2:42. 12. Mubeen K, Shakya HK, Jigna VR. Ameoblastic carcinoma of mandible – A rare case report with review of literature. J Clin Exp Dent 2010;2:e100‑4. Cite this article as: Bansal N, Sheikh S, Bansal R, Sabharwal R, Gupta A, Goyal A, et al. Acanthomatous ameloblastoma of mandible crossing the midline: A rare case report. Ann Afr Med 2015;14:65-8. Source of support: Nil, Conflicts of interest: None declared
Annals of African Medicine
Copyright of Annals of African Medicine is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Access this article online Quick Response Code:
Case Report
Website: www.annalsafrmed.org DOI: 10.4103/1596-3519.148746 PMID: ******
Acanthomatous ameloblastoma of mandible crossing the midline: A rare case report Neha Bansal, Soheyl Sheikh1, Richa Bansal2, Robin Sabharwal3, Aanchal Gupta4, Ankit Goyal4, Nitika Kainth5 Departments of Oral Medicine and Radiology, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, 1MM College of Dental Sciences and Research, Mullana, Ambala, Haryana, 2Departments of Oral Pathology and Microbiology, Seema Dental College and Research Institute, Rishikesh, Uttarakhand, 3Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, 4Department of Oral Medicine and Radiology, Kalka Dental College and Hospital, Meerut, 5Private Practitioner, Max Hospital, Noida, Uttar Pradesh, India
Correspondence to: Dr. Robin Sabharwal, Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India. E‑mail: [email protected]
Abstract Ameloblastoma is the most common aggressive benign odontogenic tumor of the jaws. Ameloblastoma is a benign epithelial odontogenic tumor that typically arises in the mandible or maxilla or, rarely, in the immediate adjacent soft tissues. A clinical, radiographic and histopathological report is presented of a case of acanthomatous ameloblastoma in relation to molar in the left mandible of a 30-year-old healthy male. The histopathological examination of the removed specimen revealed the histopathological pattern of an acanthomatous ameloblastoma. The radiographic appearance of the lesion showed the presence of multilocular radiolucencies, which were crossing the midline, which is rarely found in ameloblastoma. Due to its rarity and lack of data, we take this opportunity to present a world first case of acanthomatous ameloblastoma which was crossing the midline. Keywords: Acanthomatous, ameloblastoma, computed tomography‑scan, multilocular radioluceny, odontogenic tumor
Résumé Ameloblastoma est la plus commune tumeur agressive odontogènes bénigne des mâchoires. Ameloblastoma est une tumeur bénigne odontogènes épithéliales qui se présentent généralement dans la mandibule ou maxillaire ou, plus rarement, dans les tissus mous adjacents immédiats.Rapport clinique, radiographique et histopathologique de A est présenté d'un cas d'acanthomatous ameloblastoma en ce qui concerne la molaire dans la mandibule gauche d'un homme âgé de 30 ans en bonne santé. L'examen histopathologique de l'échantillon enlevé a révélé le patron histopathologique d'une ameloblastoma acanthomatous.L'aspect radiographique de la lésion ont révélé la présence de radiolucencies multiloculaires, qui traversaient la ligne médiane, que l'on trouve rarement dans les ameloblastoma. En raison de sa rareté et de l'absence de données, nous saisissons cette occasion pour présenter un premier cas de monde de acanthomatous ameloblastoma, qui franchissait la ligne médiane. Mots clés: Acanthomatous,ameloblastoma, calculé tomographie-scan, multiloculaire radioluceny, odontogènes tumeur
Introduction Ameloblastoma is a benign epithelial odontogenic tumor that typically arises in the mandible or maxilla or, rarely, in the immediate adjacent soft tissues.[1] Annals of African Medicine
It arises from dental embryonic remnants possibly from the epithelial lining of an odontogenic cyst; dental lamina or enamel organ; stratified squamous epithelium of the oral cavity; or displaced epithelial remnants.[2] Ameloblastoma is reported to constitute Vol. 14, January-March, 2015
Page | 65
Bansal, et al.: Acanthomatous ameloblastoma of mandible
Page | 66
about 1-3% of tumors and cysts of the jaws.[1] The peak incidence occurs in the third and fourth decades of life, they are uncommon in the second decade and exceedingly rare in children under the age of 10.[3] The vast majority of ameloblastomas occur in the posterior mandible (80-85%) with the remainder of tumors presenting in the maxilla. Histologically, ameloblastoma is of six types‑follicular, plexiform, granular, basal, desmoplastic and acanthomatous.[4] Ameloblastoma is a locally destructive tumor with a propensity for recurrence if not entirely excised. We report a rare case of acanthomatous ameloblastoma occurring in the left posterior mandible and crossing the midline involving the right side of jaw. It is of concern that this acanthomatous ameloblastoma crossing the midline, which is rarest entity and never found as a lesion in human but it was seen in the case report of dogs as a canine acanthomatous ameloblastoma.
Case Report The present case report is about a 30‑year‑old male patient, a shop keeper by profession presented to the Department of Oral Medicine and Radiology with a chief complaint of painless, gradually progressive swelling in the left posterior side of mandible for 6 months. The present history revealed that the swelling was slowly growing over a period of 6 months and was not associated with pain, tenderness or discharge. The swelling was associated with numbness of lower lip.
history and medical history were unremarkable and nonsignificant. On radiographic investigations, intraoral periapical radiograph revealed multilocular radiolucencies in region of 35, 36, 37 [Figure 2]. A series of intraoral periapical radiographs with respect to 31, 32, 33, 34, 35, 36, 37, 38, 41, 42, 43 were made and that revealed multilocular radiolucencies extending and crossing the midline [Figure 3]. Significant root resorption was seen in relation to 31, 32, 33 and 34. Further investigations were carried out, which included panoramic radiography and noncontrast computed tomography (CT). Panoramic radiograph revealed multilocular radiolucencies extending from the region of 37 to 42. However, the lower border of mandible was spared [Figure 4]. Occlusal radiograph revealed typical soap bubble appearance along with buccal and lingual plate expansion. CT scan revealed lobulated, predominantly lytic, expansile, multiloculated lesion involving the mandibular alveolus on the left side in relation to lower left incisors, canine and premolar reaching up to symphysis and causing widening of mandibular alveolus with thinning and erosion of both buccal and lingual surfaces. The lesion was seen extending up to adjacent soft tissue on buccal surface [Figures 5 and 6].
Intraoral examination showed a well‑circumscribed swelling on both buccal and lingual aspect, extending from lower mesial of second premolar to distal second molar, obliterating both labial and lingual sulcus [Figure 1]. On palpation, the swelling was bony hard, nonpulsatile, noncompressible and nontender in nature. No lymphadenopathy or fistulae were present. Past
On aspiration, straw colored fluid was extracted which was inconclusive of diagnosis. Hence the patient was sent for incisional biopsy since the growth was of larger size. The histopathological examination revealed numerous follicles of tumor cells in connective tissue stroma. At the periphery, follicle was lined by single layer of tall columnar ameloblast like cells with reverse polarity. In center island showed loosely arranged polygonal or angular cells resembling stellate reticulum. Many follicles showed squamous metaplasia. Some
Figure 1: Intraoral swelling in the left posterior side of mandible on buccal vestibule
Figure 2: Introral periapical radiograph revealed multilocular radiolucencies in region of 35, 36, 37
Vol. 14, January-March, 2015
Annals of African Medicine
Bansal, et al.: Acanthomatous ameloblastoma of mandible
follicle showed cystic degeneration of central stellate reticulum like cells. Thus, on clinical, radiographical and histopathological findings, final diagnosis was given of acanthomatous ameloblastoma and the patient was sent to Department of Oral and Maxillofacial Surgery for complete excision. An informed and written consent about anesthesia and surgical procedure was obtained. Patient was operated general anesthesia and hemimandibulactomy was carried out leaving
sufficient margins [Figure 6]. All involved teeth were removed along with the lesion[Figure 7]. Post operative OPG was done [Figure 8]
Discussion Ameloblastoma is a benign epithelial odontogenic tumor but is often aggressive and destructive, with the capacity to attain great size, erode bone and invade adjacent structures. Although the term ameloblastoma was coined by Churchill in 1933,
Figure 4: Orthopantamogram revealed multilocular radiolucencies extending from the region of 37 to 42 Figure 3: Introral periapical radiograph revealed multilocular radiolucencies extending and crossing the midline
Figures 5: Computed tomography scan revealed lobulated predominantly lytic, expansile, multiloculated lesions and erosion of both buccal and lingual surfaces
Figure 7: Biopsy specimen
Annals of African Medicine
Figure 6: Revealed that hemimandibulactomy was carried out leaving sufficient margins
Figure 8: Posttreatment orthopantamogram
Vol. 14, January-March, 2015
Page | 67
Bansal, et al.: Acanthomatous ameloblastoma of mandible
Page | 68
the first detailed description of this lesion was by Falkson in 1879.[5,6] It is the most common odontogenic tumor although it represents only about 1% of tumors and cysts of the jaws and 11% of the odontogenic tumors. In the mandible (80% of ameloblastomas), 70% are located in the area of the molars or the ascending ramus, 20% in the premolar region and 10% in the anterior region.[7‑10] On an average 10-15% of ameloblastomas are associated with a nonerupted tooth. The study by Adebiyi et al. reported that most of the solid lesions belonged to the follicular type (70.4%), plexiform (14.1%) and acanthomatous (4.2%).[11] In this case, acanthomatous type of ameloblastoma found in the molar region of the mandible and it was not associated with a nonerupted tooth. Ameloblastoma appears equal frequency between sexes, although a higher frequency in females than in males has been described.[5,6] Acanthomatous ameloblastoma mostly occurs in older patients rather than younger ones. The mean age of occurrence (±standard deviation) was 61.3 ± 1.2 range 60-62 years with a peak incidence in the 7th decade of life. [8] However, in our case, the patient was male and was in third decade of his life.[11] The acanthomatous ameloblastoma exhibits varying degrees of squamous metaplasia and even keratinization of the stellate reticulum portion of the tumor islands; however, peripheral palisading is maintained and no cytologic features of malignancy are found. The so‑called kerato‑ameloblastoma is a rare variant of ameloblastoma that contains prominent keratinizing cysts that may cause some alarm and distract the pathologist from the otherwise ameloblastomatous feature.[2] “Radiographically, ameloblastoma shows a typical soap bubble” appearance when the radiolucent loculations are large and as being “honeycombed” when the lobulations area small. In our case study, the radiographic appearance of the lesion was consistent with that of an ameloblastoma except for the presence of multilocular radiolucencies extending and spreading widely crossing the midline, which is rarely found in ameloblastoma. Clinically, ameloblastomic carcinomas are more aggressive than most typical ameloblastomas. Perforation of the cortical plate, extension into surrounding soft tissue, numerous recurrent lesions and metastasis, usually to cervical lymph nodes, can
Vol. 14, January-March, 2015
be associated with ameloblastic carcinomas and hence it should be considered as the differential diagnosis.[12]
Conclusion The present case has some interesting findings distinguished it from other reported cases of ameloblastoma. First, this is a case of acanthomatous ameloblastoma which is an extremely rare variant. Second, radiographically seen the lesion is crossing the midline which is never been in literature. Third, the size of the lesion is extremely small. Finally, it is usually found in the age of old age years, but in this case, the age was only 30 years.
References 1.
Al‑Khateeb T, Ababneh KT. Ameloblastoma in young Jordanians: A review of the clinicopathologic features and treatment of 10 cases. J Oral Maxillofac Surg 2003;61:13‑8. 2. Avon SL, McComb J, Clokie C. Ameloblastic carcinoma: Case report and literature review. J Can Dent Assoc 2003;69:573‑6. 3. Wlodawsky, Abubaker AO, Strauss RA. Ameloblastoma: A pathologic review and discussion of four case reports. Rehabil Oncol 2004;22:10‑5. 4. Bansal M, Chaturvedi TP, Bansal R, Kumar M. Acanthomatous ameloblastoma of anterior maxilla. J Indian Soc Pedod Prev Dent 2010;28:209‑11. 5. Iordanidis S, Makos C, Dimitrakopoulos J, Kariki H. Ameloblastoma of the maxilla. Case report. Aust Dent J 1999;44:51‑5. 6. Varkhede A, Tupkari JV, Mandale MS, Sarda M. Plexiform ameloblastoma of mandible: Case report. J Clin Exp Dent 2010;2:e146‑8. 7. Vohra FA, Hussain M, Mudassir MS. Ameloblastomas and their management: A review. J Surg Pak (Int) 2009;14:136‑42. 8. Small IA, Waldron CA. Ameloblastomas of the jaws. Oral Surg Oral Med Oral Pathol 1955;8:281‑97. 9. Ajagbe HA, Daramola JO. Ameloblastoma: A survey of 199 cases in the University of College Hospital, Ibadan, Nigeria. J Natl Med Assoc 1987;79:324‑7. 10. Fulco GM, Nonaka CF, Souza LB, Miguel MC, Pinto LP. Solid ameloblastomas – Retrospective clinical and histopathologic study of 54 cases. Braz J Otorhinolaryngol 2010;76:172‑7. 11. Adebiyi KE, Ugboko VI, Omoniyi‑Esan GO, Ndukwe KC, Oginni FO. Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med 2006;2:42. 12. Mubeen K, Shakya HK, Jigna VR. Ameoblastic carcinoma of mandible – A rare case report with review of literature. J Clin Exp Dent 2010;2:e100‑4. Cite this article as: Bansal N, Sheikh S, Bansal R, Sabharwal R, Gupta A, Goyal A, et al. Acanthomatous ameloblastoma of mandible crossing the midline: A rare case report. Ann Afr Med 2015;14:65-8. Source of support: Nil, Conflicts of interest: None declared
Annals of African Medicine
Copyright of Annals of African Medicine is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
