mycoses
Diagnosis,Therapy and Prophylaxis of Fungal Diseases
Scientific Programme Thursday 15 May 2014 17:15 – 18:00
Keynote 1
ICCC Opening lecture Tom Harrison (UK) – Cryptococcal meningitis – the ongoing challenge
09:00
S1.1
Benjamin Park (USA) – Update on global burden of cryptococcosis
09:20
S1.2
Nelesh Govender (South Africa) – Reducing the burden and mortality of cryptococcosis in Africa
09:40
S1.3
Anuradha Chowdary (India) – Cryptococcosis in Asia
10:00
S1.4
Marcia Lazera (Brazil) – Cryptococcosis in South America. An ongoing challenge
10:20
S1.5
Volker Rickerts (Germany) – Cryptococcosis due to Cryptococcus gattii in Germany between 2004 and 2013
Friday 16 May 2014 09:00 – 10:30
Session 1. Public Health Aspects of Cryptococcosis
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 2. Treatment and Resistance
11:00
S2.1
Bob Larsen (USA) – High dose fluconazole therapy for cryptococcal meningitis
11:20
S2.2
Peter Pappas (USA) – Liposomal amphotericin
11:40
S2.3
Angela Loyse (UK) – Access to essential antifungals for cryptococcal meningitis in low and middle-income countries
12:00
S2.4
Eddy Sionov (USA) – Mechanisms of resistance and heteroresistance in C. neoformans
12:20
S2.5
Ji-Qin Wu (China) – Identification of amphotericin B as a P-glycoprotein substrate at the blood-brain barrier: in vitro and in vivo evidence
12:30 – 14:00
Lunch break
13:00 – 13:45
Clinical session CS1
John Perfect (USA) – 2010 IDSA cryptococcal guidelines: a dynamic document; does it need updating?
CS2
Jeremy Day (UK) – Open access clinical trials in cryptococcal meningitis
14:00 – 15:30
Session 3. Pathogenesis
14:00
S3.1
Liping Zhu (China) – Human susceptibility to Cryptococcus neoformans
14:20
S3.2
Liise-ann Pirofski (USA) – The role of B cells in immunity to cryptococcosis
14:40
S3.3
Marcio Rodrigues (Brazil) – Secretory regulators and cryptococcal pathogenesis
15:00
S3.4
Kirsten Nielsen (USA) – Role of titan cells during infection
15:20
S3.5
Greetje Vande Velde (Belgium) – The course of mouse pulmonary cryptococcosis visualized by multimodal imaging in live animals
15:30 – 16:00
16:00 – 16:45 17:00 – 18:30
Tea break
Keynote 2
Keynote Françoise Dromer (France) – Cryptococcosis, what matters, the bug, the host or ... ? Poster session I
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
1
Scientific Programme
Saturday 17 May 2014 08:00 – 08:45
ISHAM working group [Breakfast session]
08:00
ISHAM1
Wieland Meyer (Australia) – The global MLST network
08:15
ISHAM2
Ferry Hagen (The Netherlands) – The global population structure of Cryptococcus neoformans as determined by multi-locus microsatellite typing
08:30
ISHAM3
Massimo Cogliati (Italy) – Environmental survey of Cryptococccus neoformans and C. gattii in European and Mediterranean area
09:00 – 10:30
Session 4. Genetics & molecular biology I
09:00
S4.1
Andrew Alspaugh (USA) – Rim pathway-mediated adaptation to the host environment
09:20
S4.2
Julie Djordjevic (Australia) – A novel branch of phospholipase C1-mediated signalling via inositol polyphosphate kinases, is essential for fungal virulence
09:40
S4.3
Damian Krysan (USA) – Identification, activity, and mechanism of action of novel anti-cryptococcal small molecules
10:00
S4.4
Maurizio Del Poeta (USA) – Role of sphingolipids in virulence
10:20
S4.5
Sara Gonzalez-Hilarion (France) – Nonsense-mediated mRNA decay (NMD) in Cryptococcus neoformans
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 5. Host-pathogen interaction I
11:00
S5.1
June Kwon-Chung (USA) – Differences in the host’s response to Cryptococcus gattii and C. neoformans are more pronounced than previously thought
11:20
S5.2
Bettina Fries (USA) – Replicative aging of C. neoformans and its relevance for the pathogenesis of chronic cryptococcosis
11:40
S5.3
Alex Idnurm (USA) – DNA mutation and its impact on Cryptococcus neoformans pathogenicity
12:00
S5.4
Oscar Zaragoza (Spain) – Phenotypic variation during cryptococcosis
12:20
S5.5
Mitra Shourian (Canada) – The Cnes2 locus on mouse chromosome 17 regulates host resistance to progressive cryptococcal infection through pleiotropic effects on host immunity
12:30 – 14:00
Lunch break
14:00 – 15:30 S6.1
Joe Heitman (USA) – Evolutionary genomics of the Cryptococcus species complex
14:20
S6.2
Matthew Fischer (UK) – Fungal whole genome sequence typing – it’s not just for bacteria
14:40
S6.3
Christina Cuomo (USA) – Population genomic analysis of the human pathogenic fungus Cryptococcus neoformans
15:00
S6.4
Maureen Donlin (USA) – Cross talk between the cell wall integrity and cAMP/protein kinase A pathways in C. neoformans
15:10
S6.5
Candy Ramirez Zavaleta (USA) – Characterization of two drug transporters during late stages of sexual development in Cryptococcus neoformans
15:20
S6.6
Kyla Selvig (USA) – The basics of the Cryptococcus neoformans alkaline response pathway: adapting to a bitter host
15:30 – 16:00
Tea break
16:00 – 17:00
Best recent literature
16:00
John Perfect (USA) – Basic Cryptococcal Research
16:20
Vishnu Chaturvedi (USA) – Laboratory science and diagnostics
16:40
2
Session 6. The species complex
14:00
BRL
Peter R. Williamson (USA) – A new disease to learn: pulmonary alveolar proteinosis in C. gattii infections
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
Scientific Programme
17:00 – 17:45
Keynote 3
Keynote Ambrose Jong (USA) – Hitch hiking through the blood-brain barrier
Sunday 18 May 2014 09:00 – 10:30
Session 7. Immunology I
09:00
S7.1
Guangxun Meng (China) – Function of the inflammasome in the host defense against Cryptococcus neoformans infection
09:20
S7.2
Theo Geijtenbeek (The Netherlands) – C-type lectin receptors in defense against fungi
09:40
S7.3
Kazu Kawakami (Japan) – Defect of type I interferon signaling leads to promoted Th1 response, IL-4dependent mucin production and clearance of Cryptococcus neoformans
10:00
S7.4
Karen Wozniak (USA) – Protection Against C. neoformans Pulmonary Infection in the Absence of Adaptive Immunity
10:10
S7.5
Daniel Piehler (Germany) – Characterization of T1/ST2-expressing T helper 2 cells and innate lymphoid cells type 2 in pulmonary cryptococcosis
10:20
S7.6
Darin Wiesner (USA) – Specialized regulatory T cells suppress pathologic type-2 helper T cell inflammation during pulmonary cryptococcosis
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 8. Immunology II
11:00
S8.1
Michael Olszewski (USA) – Interactions with macrophages: the bug, the cell, or inflammatory microenvironment?
11:20
S8.2
Floyd Wormley (USA) – Role of Th17 cells in cryptococcosis
11:40
S8.3
Anna Vecchiarelli (Italy) – Microbial capsular polysaccharide Galactoxylomannan affects T cells function of rheumatoid arthritis subjects
12:00
S8.4
Robin May (UK) – Fatal outbreak strains of Cryptococcus gattii use a novel ‘cooperative virulence’ strategy to parasitise host phagocytes
12:20
S8.5
Zachary Hadd (USA) – T-cell restricted Notch signaling promotes immune protection against C. neoformans in the infected mice
12:30 – 14:00
Lunch break
13:00 – 13:45
Debate session DEB1
Tihana Bicanic (UK) – Is early fungicidal activity a good surrogate marker for outcome in AIDS patients with cryptococcal meningitis
DEB2
Peter R. Williamson (USA) – Prognostic indicators vs. treatment surrogates: Implications for clinical studies in cryptococcosis
14:00
S9.1
James Kronstad (Canada) – Iron metabolism and virulence
14:20
S9.2
Simon Johnston (UK) – A zebrafish model of cryptococcosis to study host pathogen interactions in vivo
14:40
S9.3
Hiten Madhani (USA) – A peptide-based quorum sensing system required for fungal virulence
15:00
S9.4
Xiaorong Lin (USA) – Morphogenesis and matrix-initiated signaling in Cryptococcus
15:20
S9.5
Wilber Sabiiti (UK) – Efficient phagocytosis and laccase activity are associated with adverse clinical outcome of HIV – associated cryptococcal meningitis
14:00 – 15:30
15:30 – 16:00
Session 9. Virulence
Tea break
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
3
Scientific Programme
16:00 – 16:45
Keynote 4
17:00 – 18:30
Keynote David Boulware (USA) – How to reduce Cryptococcosis Poster session II
Monday 19 May 2014 09:00 – 10:30
Session 10. Host-pathogen interaction II
09:00
S10.1
Joe Jarvis (UK) – HIV-associated cryptococcal meningitis: host immunity and immunotherapy
09:20
S10.2
Graeme Meintjes (South Africa) – Cryptococcal immune reconstitution inflammatory syndrome
09:40
S10.3
Gottfried Alber (Germany) – Cryptococcus neoformans–related Immune Reconstitution Inflammatory Syndrome (IRIS): Analysis of pathomechanisms in a mouse model
10:00
S10.4
Robert Evans (UK) – The study of cryptococcal phospholipase B and its role in virulence during macrophage infection
10:10
S10.5
Michael Davis (USA) – Cryptococcus neoformans-induced Iysosomal damage promotes intracellular survival and growth of the organism within macrophages
10:20
S10.6
Alexandre Alanio (France) – New tools to study the dynamics of Cryptococcus neoformans adaptation to host
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 11. Genetics & molecular biology II
11:00
S11.1
Christina Hull (USA) – Spores as Infectious particles
11:20
S11.2
Tamara Doering (USA) – Regulation of cryptococcal capsule synthesis
11:40
S11.3
Guilhem Janbon (France) – Introns in Cryptococcus neoformans
12:00
S11.4
Jennifer Lodge (USA) – Dynamics of the cell wall
12:20
S11.5
John Panepinto (USA) – Post-transcriptional mechanisms of stress adaptation in Cryptococcus neoformans
12:30 – 13:30
Four 10 min talks selected from Posters / Abstracts / Prizes
13:30
Closing ICCC9
14:15 – 16:45
Genomics workshop James Fraser (Australia) and Guilhem Janbon (France) GW1
Gavin Sherlock (USA) – A manually curated gene set and community-based gene naming protocol for Cryptococcus
GW2
Rhys Farrer (USA) – Comparative genomics of C. gattii and the evolution of its pathogenicity 6 short casus presentations
14:15 – 16:45
Clinical master class Olivier Lortholary (France) – Introduction CMC1
Graeme Meintjes (South Africa) – Clinical masterclass case presentations
CMC2
Liping Zhu (China) – Cryptococcal meningitis in an apparently immunocompetent host
CMC3
Tania Sorrell (Australia) – Diagnosis and treatment of cryptococcosis due to C. gattii 4 Short casus presentations from Jakarta, Peru, Uganda, St. Petersburg Olivier Lortholary (France) and Annemarie Brouwer (The Netherlands) – Round table: All you wanted to know on management of cryptococcal infections
4
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
Diagnosis,Therapy and Prophylaxis of Fungal Diseases
Scientific Programme Thursday 15 May 2014 17:15 – 18:00
Keynote 1
ICCC Opening lecture Tom Harrison (UK) – Cryptococcal meningitis – the ongoing challenge
09:00
S1.1
Benjamin Park (USA) – Update on global burden of cryptococcosis
09:20
S1.2
Nelesh Govender (South Africa) – Reducing the burden and mortality of cryptococcosis in Africa
09:40
S1.3
Anuradha Chowdary (India) – Cryptococcosis in Asia
10:00
S1.4
Marcia Lazera (Brazil) – Cryptococcosis in South America. An ongoing challenge
10:20
S1.5
Volker Rickerts (Germany) – Cryptococcosis due to Cryptococcus gattii in Germany between 2004 and 2013
Friday 16 May 2014 09:00 – 10:30
Session 1. Public Health Aspects of Cryptococcosis
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 2. Treatment and Resistance
11:00
S2.1
Bob Larsen (USA) – High dose fluconazole therapy for cryptococcal meningitis
11:20
S2.2
Peter Pappas (USA) – Liposomal amphotericin
11:40
S2.3
Angela Loyse (UK) – Access to essential antifungals for cryptococcal meningitis in low and middle-income countries
12:00
S2.4
Eddy Sionov (USA) – Mechanisms of resistance and heteroresistance in C. neoformans
12:20
S2.5
Ji-Qin Wu (China) – Identification of amphotericin B as a P-glycoprotein substrate at the blood-brain barrier: in vitro and in vivo evidence
12:30 – 14:00
Lunch break
13:00 – 13:45
Clinical session CS1
John Perfect (USA) – 2010 IDSA cryptococcal guidelines: a dynamic document; does it need updating?
CS2
Jeremy Day (UK) – Open access clinical trials in cryptococcal meningitis
14:00 – 15:30
Session 3. Pathogenesis
14:00
S3.1
Liping Zhu (China) – Human susceptibility to Cryptococcus neoformans
14:20
S3.2
Liise-ann Pirofski (USA) – The role of B cells in immunity to cryptococcosis
14:40
S3.3
Marcio Rodrigues (Brazil) – Secretory regulators and cryptococcal pathogenesis
15:00
S3.4
Kirsten Nielsen (USA) – Role of titan cells during infection
15:20
S3.5
Greetje Vande Velde (Belgium) – The course of mouse pulmonary cryptococcosis visualized by multimodal imaging in live animals
15:30 – 16:00
16:00 – 16:45 17:00 – 18:30
Tea break
Keynote 2
Keynote Françoise Dromer (France) – Cryptococcosis, what matters, the bug, the host or ... ? Poster session I
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
1
Scientific Programme
Saturday 17 May 2014 08:00 – 08:45
ISHAM working group [Breakfast session]
08:00
ISHAM1
Wieland Meyer (Australia) – The global MLST network
08:15
ISHAM2
Ferry Hagen (The Netherlands) – The global population structure of Cryptococcus neoformans as determined by multi-locus microsatellite typing
08:30
ISHAM3
Massimo Cogliati (Italy) – Environmental survey of Cryptococccus neoformans and C. gattii in European and Mediterranean area
09:00 – 10:30
Session 4. Genetics & molecular biology I
09:00
S4.1
Andrew Alspaugh (USA) – Rim pathway-mediated adaptation to the host environment
09:20
S4.2
Julie Djordjevic (Australia) – A novel branch of phospholipase C1-mediated signalling via inositol polyphosphate kinases, is essential for fungal virulence
09:40
S4.3
Damian Krysan (USA) – Identification, activity, and mechanism of action of novel anti-cryptococcal small molecules
10:00
S4.4
Maurizio Del Poeta (USA) – Role of sphingolipids in virulence
10:20
S4.5
Sara Gonzalez-Hilarion (France) – Nonsense-mediated mRNA decay (NMD) in Cryptococcus neoformans
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 5. Host-pathogen interaction I
11:00
S5.1
June Kwon-Chung (USA) – Differences in the host’s response to Cryptococcus gattii and C. neoformans are more pronounced than previously thought
11:20
S5.2
Bettina Fries (USA) – Replicative aging of C. neoformans and its relevance for the pathogenesis of chronic cryptococcosis
11:40
S5.3
Alex Idnurm (USA) – DNA mutation and its impact on Cryptococcus neoformans pathogenicity
12:00
S5.4
Oscar Zaragoza (Spain) – Phenotypic variation during cryptococcosis
12:20
S5.5
Mitra Shourian (Canada) – The Cnes2 locus on mouse chromosome 17 regulates host resistance to progressive cryptococcal infection through pleiotropic effects on host immunity
12:30 – 14:00
Lunch break
14:00 – 15:30 S6.1
Joe Heitman (USA) – Evolutionary genomics of the Cryptococcus species complex
14:20
S6.2
Matthew Fischer (UK) – Fungal whole genome sequence typing – it’s not just for bacteria
14:40
S6.3
Christina Cuomo (USA) – Population genomic analysis of the human pathogenic fungus Cryptococcus neoformans
15:00
S6.4
Maureen Donlin (USA) – Cross talk between the cell wall integrity and cAMP/protein kinase A pathways in C. neoformans
15:10
S6.5
Candy Ramirez Zavaleta (USA) – Characterization of two drug transporters during late stages of sexual development in Cryptococcus neoformans
15:20
S6.6
Kyla Selvig (USA) – The basics of the Cryptococcus neoformans alkaline response pathway: adapting to a bitter host
15:30 – 16:00
Tea break
16:00 – 17:00
Best recent literature
16:00
John Perfect (USA) – Basic Cryptococcal Research
16:20
Vishnu Chaturvedi (USA) – Laboratory science and diagnostics
16:40
2
Session 6. The species complex
14:00
BRL
Peter R. Williamson (USA) – A new disease to learn: pulmonary alveolar proteinosis in C. gattii infections
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
Scientific Programme
17:00 – 17:45
Keynote 3
Keynote Ambrose Jong (USA) – Hitch hiking through the blood-brain barrier
Sunday 18 May 2014 09:00 – 10:30
Session 7. Immunology I
09:00
S7.1
Guangxun Meng (China) – Function of the inflammasome in the host defense against Cryptococcus neoformans infection
09:20
S7.2
Theo Geijtenbeek (The Netherlands) – C-type lectin receptors in defense against fungi
09:40
S7.3
Kazu Kawakami (Japan) – Defect of type I interferon signaling leads to promoted Th1 response, IL-4dependent mucin production and clearance of Cryptococcus neoformans
10:00
S7.4
Karen Wozniak (USA) – Protection Against C. neoformans Pulmonary Infection in the Absence of Adaptive Immunity
10:10
S7.5
Daniel Piehler (Germany) – Characterization of T1/ST2-expressing T helper 2 cells and innate lymphoid cells type 2 in pulmonary cryptococcosis
10:20
S7.6
Darin Wiesner (USA) – Specialized regulatory T cells suppress pathologic type-2 helper T cell inflammation during pulmonary cryptococcosis
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 8. Immunology II
11:00
S8.1
Michael Olszewski (USA) – Interactions with macrophages: the bug, the cell, or inflammatory microenvironment?
11:20
S8.2
Floyd Wormley (USA) – Role of Th17 cells in cryptococcosis
11:40
S8.3
Anna Vecchiarelli (Italy) – Microbial capsular polysaccharide Galactoxylomannan affects T cells function of rheumatoid arthritis subjects
12:00
S8.4
Robin May (UK) – Fatal outbreak strains of Cryptococcus gattii use a novel ‘cooperative virulence’ strategy to parasitise host phagocytes
12:20
S8.5
Zachary Hadd (USA) – T-cell restricted Notch signaling promotes immune protection against C. neoformans in the infected mice
12:30 – 14:00
Lunch break
13:00 – 13:45
Debate session DEB1
Tihana Bicanic (UK) – Is early fungicidal activity a good surrogate marker for outcome in AIDS patients with cryptococcal meningitis
DEB2
Peter R. Williamson (USA) – Prognostic indicators vs. treatment surrogates: Implications for clinical studies in cryptococcosis
14:00
S9.1
James Kronstad (Canada) – Iron metabolism and virulence
14:20
S9.2
Simon Johnston (UK) – A zebrafish model of cryptococcosis to study host pathogen interactions in vivo
14:40
S9.3
Hiten Madhani (USA) – A peptide-based quorum sensing system required for fungal virulence
15:00
S9.4
Xiaorong Lin (USA) – Morphogenesis and matrix-initiated signaling in Cryptococcus
15:20
S9.5
Wilber Sabiiti (UK) – Efficient phagocytosis and laccase activity are associated with adverse clinical outcome of HIV – associated cryptococcal meningitis
14:00 – 15:30
15:30 – 16:00
Session 9. Virulence
Tea break
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
3
Scientific Programme
16:00 – 16:45
Keynote 4
17:00 – 18:30
Keynote David Boulware (USA) – How to reduce Cryptococcosis Poster session II
Monday 19 May 2014 09:00 – 10:30
Session 10. Host-pathogen interaction II
09:00
S10.1
Joe Jarvis (UK) – HIV-associated cryptococcal meningitis: host immunity and immunotherapy
09:20
S10.2
Graeme Meintjes (South Africa) – Cryptococcal immune reconstitution inflammatory syndrome
09:40
S10.3
Gottfried Alber (Germany) – Cryptococcus neoformans–related Immune Reconstitution Inflammatory Syndrome (IRIS): Analysis of pathomechanisms in a mouse model
10:00
S10.4
Robert Evans (UK) – The study of cryptococcal phospholipase B and its role in virulence during macrophage infection
10:10
S10.5
Michael Davis (USA) – Cryptococcus neoformans-induced Iysosomal damage promotes intracellular survival and growth of the organism within macrophages
10:20
S10.6
Alexandre Alanio (France) – New tools to study the dynamics of Cryptococcus neoformans adaptation to host
10:30 – 11:00
Coffee break
11:00 – 12:30
Session 11. Genetics & molecular biology II
11:00
S11.1
Christina Hull (USA) – Spores as Infectious particles
11:20
S11.2
Tamara Doering (USA) – Regulation of cryptococcal capsule synthesis
11:40
S11.3
Guilhem Janbon (France) – Introns in Cryptococcus neoformans
12:00
S11.4
Jennifer Lodge (USA) – Dynamics of the cell wall
12:20
S11.5
John Panepinto (USA) – Post-transcriptional mechanisms of stress adaptation in Cryptococcus neoformans
12:30 – 13:30
Four 10 min talks selected from Posters / Abstracts / Prizes
13:30
Closing ICCC9
14:15 – 16:45
Genomics workshop James Fraser (Australia) and Guilhem Janbon (France) GW1
Gavin Sherlock (USA) – A manually curated gene set and community-based gene naming protocol for Cryptococcus
GW2
Rhys Farrer (USA) – Comparative genomics of C. gattii and the evolution of its pathogenicity 6 short casus presentations
14:15 – 16:45
Clinical master class Olivier Lortholary (France) – Introduction CMC1
Graeme Meintjes (South Africa) – Clinical masterclass case presentations
CMC2
Liping Zhu (China) – Cryptococcal meningitis in an apparently immunocompetent host
CMC3
Tania Sorrell (Australia) – Diagnosis and treatment of cryptococcosis due to C. gattii 4 Short casus presentations from Jakarta, Peru, Uganda, St. Petersburg Olivier Lortholary (France) and Annemarie Brouwer (The Netherlands) – Round table: All you wanted to know on management of cryptococcal infections
4
© 2014 The Authors Mycoses © 2014 Blackwell Verlag GmbH, 57 (Suppl. 1), 1–4
