Scientific Program Schedule 61st Annual Scientific Meeting

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Thursday, March 27, 2014 - Plenary 9:00 AM-10:00 AM

Plenary

Presidential New Investigator Plenary Session Auditorium Serdar Bulun and Kelle Moley 9:00 Effect of Maternal BMI on O-001 5-Hydroxymethylcytosine, a Novel Epigenetic Modification and Resultant Gene Expression in the Placenta. Ashley N Parker, Leslie Myatt, and Mitsuyah Kohzoh. San Antonio, TX, USA. 9:15 Sexually Dimorphic Regulation of KLF11 O-002 Epigenetically Alters the Fibrotic Response and Progression of Endometriosis. Zaraq Khan, Ye Zheng, and Gaurang S Daftary. Rochester, MN, USA. 9:30 O-003

Androgens Action and Androgen Receptor (AR) Expression in Myometrial Smooth Muscle Cells (MSMCs) at Term Pregnancy. Sofia Makieva, Philippa TK Saunders, and Jane E Norman. Edinburgh, United Kingdom.

9:45 Loss of MiR-148 Enhances Ovarian Cancer O-004 Growth and Metastasis by Promoting MTMR9 Expression. Triparna Ghosh-Choudhury, Ying-Wooi Wan, Zhandong Liu, and Matthew Anderson. Houston, TX, USA.

3A

4A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Concurrent Session I 1:30 PM-3:30 PM

Concurrent Session

1:30 PM-3:30 PM

Concurrent Session

Maternal Obesity & Perinatology

Developmental Programming

Fourth Floor

Ground Floor

Mark Johnson and Mark Phillippe

Juanita Jellyman and Genevieve Neal-Perry

1:30 Omental Adipokine Secretion Impairs O-005 Maternal Artery Function. Christina E Hayward, Elizabeth J Cowley, Tracey A Mills, Colin P Sibley, and Mark Wareing. United Kingdom. 1:45 Maternal Adiponectin Inhibits Placental O-006 Insulin-Signaling by PPARγ-Mediated Ceramide Synthesis and Prevents Fetal Overgrowth Associated with Maternal Obesity. I Aye, F Rosario, X Gao, S Weintraub, T Powell, and T Jansson. San Antonio, TX, USA. 2:00 Obesity Alters Timing and Completion of O-007 Oocyte Maturation. Kate O’Neill, Tami Stuart, Becky Simmons, Kelle Moley, and Monica Mainigi. Philadelphia, PA, USA and St. Louis, MO, USA. 2:15 Venous and Autonomic Function in O-008 Formerly Preeclamptic Women and BMIMatched Controls. Wieteke M Heidema, Ralph R Scholten, Fred K Lotgering, and Marc EA Spaanderman. Nijmegen, Netherlands and Maastricht, Netherlands. 2:30 A Randomized Prospective Study: O-009 Intravenous Oxytocin Compared to Vaginal Dinoprostone for Labor Induction in Patients Non Responders to a First Dose of Dinoprostone. Patrizio Antonazzo, Arianna Laoreti, Carlo Personeni, Elena Grossi, Anna Martinelli, and Irene Cetin. Italy. 2:45 Validation of a Point-of-Care Lactate Testing O-010 (POCT) Device for Fetal Scalp Blood Sampling during Labor: Clinical Considerations, Practicalities and Realities. Philipp Reif, Ioanna Lakovschek, Carmen Tappauf, Josef Haas, Uwe Lang, and Wolfgang Schoell. Graz, Austria. 3:00 O-011

3:15 O-012

Chorioamnionitis Prevents Protective Effect of Magnesium Sulfate in the Preterm Infant. Manijeh Kamyar, Erin AS Clark, Michael W Varner, and Tracy A Manuck. Salt Lake City, UT, USA.

Efficacy of Arabin Cervical Pessary to Prevent Preterm Birth in Twin Pregnancies. Mariarosaria Di Tommaso, Silvana Arduino, Viola Seravalli, Carlotta Bossotti, Giovanni Sisti, Francesca L Vellucci, and Tullia Todros. Florence, Italy and Turin, Italy.

1:30 O-013

Melanocortin 4 Receptor in the Paraventricular Nucleus Plays an Essential Role in Appetite and Blood Pressure Regulation in Neonatal Experimental Hyperleptinaemia. Anne-Maj Samuelsson, Nina Balthasar, Sarah Wylie, Joaquim Pombo, Lucilla Poston, and Paul Taylor. London, United Kingdom and Bristol, United Kingdom.

1:45 O-014

Multigenerational Metabolic Programming of Daughters (F1) and Granddaughters (F2) in an Ovine Model of Maternal Overnutrition/Obesity (OB). Stephen P Ford, Desiree R Shasa, Nathan M Long, Tursanjan Nurmamat, John F Odhiambo, and Peter W Nathanielsz. Laramie, WY, USA and San Antonio, TX, USA.

2:00 Maternal Vitamin D3 Deficiency Programs O-015 Transgenerational Subfertility in Females. Thomas Fisher, Cari Nicholas, Jun Sun, and Genevieve Neal-Perry. Bronx, NY, USA. 2:15 Reduced Developmental Growth (RDG) O-016 Produces Fetal Cardiac Histological and MiRNA Changes Indicating Fibrosis by Term Followed by MRI Evidence of Cardiac Stiffness at Five Years of Age. Geoff Clarke, Alina Maloyan, Sribalasubashini Muralimanoharan, Cun Li, Leslie Myatt, Peter Nathanielsz, and Peter W Nathanielsz. San Antonio, TX, USA. 2:30 DNA Methylation (DNAm) Evidence Links O-017 Maternal Smoking with Pre- and Post-Natal Growth. J Ng, C Relton, and D Olson. Canada and United Kingdom. 2:45 O-018

Antioxidants as Therapeutic Targets to Prevent Cognitive Impairment and Alterations in Cerebral Structure at Adulthood Following Chronic Fetal Hypoxia. EJ Camm, CM Cross, AD Kane, and DA Giussani. United Kingdom.

3:00 Voluntary Exercise (Ex) by Male Offspring O-019 of Obese Rats Prevents Adverse Lipid Changes. Claudia J Bautista, Carlos A Ibanez-Chavez, Consuelo Lomas-Soria, Peter Nathanielsz, and Elena Zambrano. Mexico City, DF, Mexico and San Antonio, TX, USA. 3:15 O-020

Epigenetic Histone Modifications in Adipocytes of Intrauterine Growth Restricted Newborns: Mechanism for Early Induction of Adipocyte Differentiation and Programmed Obesity. Mina Desai, Juanita K Jellyman, Guang Han, and Michael G Ross. USA.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

5A

Thursday, March 27, 2014 - Concurrent Session I 1:30 PM-3:30 PM

Concurrent Session

Global Health and Epidemiology

Auditorium

Adua I

Janna Morrison and Charles Wood

George Macones and Robert Goldenberg

Quantitative Evaluation of Umbilical Venous Blood Flow through the Ductus Venosus and Its Distribution to Fetal Organs during Labor. Giulia C Tiso, Maria Bellotti, Chiara Garo, and Anna Maria Marconi. Milano, Italy.

2:00 Congenic Amniotic Fluid Stem Cells O-023 Show Stable Long-Term Engraftment in the Haematopoietic System after In Utero Transplantation. Panicos Shangaris, Stavros P Loukogeorgakis, Michael P Blundell, Eleni Petra, Durrgah Ramachandra, Panagiotis Maghsoudlou, Luca Urbani, Enrica Bertin, Adrian Thrasher, Paolo De Coppi, and Anna L David. London, United Kingdom and Padua, Italy. 2:15 Offspring of Mice from Sildenafil Citrate O-024 Treated Pregnancies Demonstrate Raised Blood Pressure in Adulthood. Lewis J Renshall, Mark R Dilworth, Elizabeth C Cottrell, Ainslie J Garrod, Susan L Greenwood, and Mark Wareing. Manchester, United Kingdom. 2:30 Increased Adrenergic Signaling Is O-025 Responsible or Decreased GlucoseStimulated Insulin Secretion in the Chronically Hyperinsulinemic Ovine Fetus. Sasha Andrews, Laura Brown, Stephanie Thorn, Melissa Davis, Sean Limesand, and William Hay Jr., Aurora, CO, USA and Tucson, AZ, USA. 2:45 O-026

Concurrent Session

Fetus I

1:30 Impaired Cardiac and Vasomotor Baroreflex O-021 Responses to Hypotension in the Chronically Hypoxic Fetus. BJ Allison, KL Brain, Y Niu, N Itani, KL Skeffington, TJ Ashmore, A J Brew, and DA Giussani. United Kingdom. 1:45 O-022

1:30 PM-3:30 PM

Maternal Dendrimer-Based N-Acetyl-LCysteine Therapy Improves Offspring Outcomes in a Model of Intrauterine Inflammation. Jason M Rosenzweig, Manoj Mishra, Ahmad Almalki, Rudhab Bahabry, Talaibek Borbiev, Kannan Rangaramanujam, and Irina Burd. USA.

3:00 Analysis of Fetal ECG in Fetal Growth O-027 Restriction. T Stampalija, D Casati, V Maggi, M Rivolta, S Lupini, K Rizas, R Sassi, A Bauer, and E Ferrazzi. Italy and Germany. 3:15 In Vivo Evaluation of Acceleration and O-028 Deceleration Capacity of Fetal Heart Rate in Worsening Hypoxic Acidemia. M Rivolta, R Sassi, D Casati, T Stampalija, M Frasch, B Richardson, MG Ross, K Rizas, A Bauer, and E Ferrazzi. Italy; Canada; Germany and USA.

1:30 Sensitive Windows of Vulnerability to O-030 Phthalate Exposure for the Risk of Preterm Birth. Kelly K Ferguson, Thomas F McElrath, Yi-An Ko, Bhramar Mukherjee, and John D Meeker. Ann Arbor, MI, USA and Boston, MA, USA. 1:45 Genetic Susceptibility Loci for Breast O-031 Cancer (BC) in Women Delivering Large for Gestational Age Infants. Radek Bukowski, William L Lowe, and Rowan Chlebowski. USA. 2:00 O-032

Metabolic Profiling Identifies Biomarkers of FGR in Maternal Hair. K Sulek, TL Han, SG Villas-Boas, K Kwek, YS Chong, DS S Wishart, LC Kenny, and PN Baker. New Zealand; Singapore; Canada and Ireland.

2:15 O-033

Angiogenic and Inflammatory Biomarkers Predict Preterm Birth in a Prospective Cohort of Tanzanian Women. Andrea L Conroy, Chloe R McDonald, Anne Marie Darling, Kyla Hayford, Nimerta Rajwans, Said Aboud, Willy Urassa, Wafaie Fawzi, and Kevin C Kain. Toronto, ON, Canada; Boston, MA, USA and United Republic of Tanzania.

2:30 Long-Term Cardiovascular Disease Risk O-034 Elevated after Hysterectomy with Ovarian Conservation. Shannon K Laughlin-Tommaso, Zaraq Khan, Amy H Weaver, Cathy D Schleck, Walter A Rocca, and Elizabeth A Stewart. USA. 2:45 Quality of Life and Psychosocial Impact of O-035 Infertility in Uganda. Rashmi Kudesia, Mark Muyingo, Meera Shah, David Aderu, Josaphat ByaMugisha, and Peter C Klatsky. Bronx, NY, USA; Kampala, Uganda and San Francisco, CA, USA. 3:00 O-036

Maternal Cardiovascular Complications in Pregnancy in an Extreme Advanced Maternal Age Cohort. Sima Parmar, Yen Troung, Guibo Xing, and Cheryl Walker. Sacramento, CA, USA.

3:15 Weight Loss in Obese Pregnant Women O-029 and Risk for Adverse Perinatal Outcomes: An Epidemiological Study. Annick Bogaerts, Lieveke Ameye, Evelyne Martens, and Roland Devlieger. Hasselt, Belgium; Belgium; Leuven, Belgium and Brussels, Belgium.

6A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Concurrent Session I 1:30 PM-3:30 PM

1:30 O-037

Concurrent Session

Concurrent Session

Gynecology

Placenta I

Verde Hall

Basement

Amber Cooper and Erica Marsh

Nadia Alfaidy and Theresa Powell

Mass Spectrometry Analysis of the Human Endometrial Stromal Cell Secretome Identifies Stanniocalcin-1 as a Long-Acting Progesterone Contraceptive- Associated Biomarker That Increases Human Endometrial Endothelial Cell Proliferation. J Shapiro, O Guzeloglu-Kayisli, M Basar, A Suarez, G Ozer, J Huang, F Schatz, and CJ Lockwood. USA.

1:45 Depot Medroxyprogesterone Acetate O-038 (DMPA) and the Levonorgestrel Intrauterine System (LNG-IUS) Alter Expression of Genes Regulating Immune Activation and Cell Death in the Upper Female Reproductive Tract (FRT). Gabriel A Goldfien, Fatima Barragan, Joseph C Chen, Jane Pannell, Jean Perry, Juan C Irwin, Karen K Smith-McCune, Barbara Shacklett, Ruth M Greenblatt, Warner C Greene, and Linda C Giudice. USA. 2:00 O-039

1:30 PM-3:30 PM

Menopausal Hot Flash Suppression with a Kappa Opioid Receptor Agonist. Susan D Reed, Donald Clifton, Charles Chavkin, and Robert A Steiner. USA.

2:15 Decreased Serum AMH Levels in Girls with O-040 Newly Diagnosed Cancer. Wendy van Dorp, Marry van den Heuvel-Eibrink, Andrica de Vries, Saskia Pluijm, Jenny Visser, Rob Pieters, and Joop Laven. Netherlands. 2:30 Trans-Ethnic GWAS of Pelvic Organ O-041 Prolapse among African American and Hispanic Women of the Women’s Health Initiative. Digna R Velez Edwards, Renee M Ward, Ayush Giri, Katherine E Hartmann, Amy J Parks, Christy L Avery, Robert Wallace, Gihan Bareh, Lihong Qi, Mary Jo O’Sullivan, Alex Reiner, Todd L Edwards, and Jennifer M Wu. USA. 2:45 HOXA11 Regulates Expression of Oxytocin O-042 Receptor in Uterosacral Ligaments. Ritsuko Iwanaga, Yi Chen, Jameson Arnett, David J Orlicky, Marsha K Guess, Rachael Crnich, K Joseph Hurt, and Kathleen A Connell. Aurora, CO, USA and New Haven, CT, USA. 3:00 The Med12 Gene Is Functionally Associated O-043 with Growth of Human Uterine Fibroid Cells. Sunil K Halder, Chakradhari Sharan, Kevin G Osteen, and Ayman Al-Hendy. Nashville, TN, USA. 3:15 Rapid Validation of Novel Medical Therapies O-044 for Fibroids: Use of Human 3-Dimensional in Vitro Fibroid Models to Test Liarozole Treatment. William H Catherino, Joy Britten, Gary Levy, Minnie Malik, and Amrita Patel. Bethesda, MD, USA.

1:30 O-045

Deficient Hypoxia Inducible Factor 1-Beta (HIF1β) Impairs Fetoplacental Endothelial Cell Angiogenesis in Severe Fetal Growth Restriction with Abnormal Umbilical Artery Doppler Velocimetry. Emily J Su, Hong Xin, Serdar Bulun, and Linda Ernst. USA.

1:45 The Potential Role of Calcium Channels O-046 P2X4 and TRPV4 as Shear Stress Sensors in the Fetoplacental Endothelium. K Lattey, H Bischof, C Hayward, P Brownbill, and S Jones. Manchester, United Kingdom and Brighton, East Sussex, United Kingdom. 2:00 Development of Targeted Nanocarriers to O-047 Treat Impaired Placental Function. Anna E King, Nicola Tirelli, Francesco Cellesi, John D Aplin, and Lynda K Harris. Manchester, United Kingdom and Milan, Italy. 2:15 O-048

Pro-Inflammatory Cytokines Raise the Level of HIF-1 (Hypoxia-Inducible Factor-1) in Trophoblast Cells. Joseph Panza, Stacy Zamudio, Abdulla AlKhan, and Nicholas P Illsley. Livingston, NJ, USA and Hackensack, NJ, USA.

2:30 Reproductive Tract Targets of Listeria O-049 Monocytogenes (LM) in Early Pregnancy Loss. T Golos, G Bondarenko, M Garthwaite, L DeGregorio, M Durning, N Faith, K Jacobs, K Organ, A Ragoschke, JD Sauer, and C Czuprynski. Madison, WI, USA. 2:45 Placental Inflammation and Repetitive O-050 Umbilical Cord Occlusions with Severe Acidemia in the Ovine Fetus. Alex Xu, Brad Matushewski, Mingju Cao, Rob Hammond, Martin Frasch, and Bryan S Richardson. ON, Canada; QC, Canada and Canada. 3:00 Placental Epigenetic Variation in O-051 Intrahepatic Cholestasis of Pregnancy. Katherine S Kohari, Luca Lambertini, Yula Ma, and Joanne Stone. New York, NY, USA. 3:15 Decidual Natural Killer Cell Conditioned O-052 Medium Stimulates, While TNF-ɑ Inhibits Angiogenin Production by Extravillous Trophoblast. Genevieve Eastabrook, Yuxiang Hu, Rusung Tan, Jan Dutz, John Boyd, and Peter von Dadelszen. London, ON, Canada and Vancouver, BC, Canada.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

7A

Friday, March 28, 2014 - Concurrent Session II 10:15 AM-11:45 AM

Concurrent Session

Concurrent Session

Cancer Biology

Parturition I

Adua I

Auditorium

J Julie Kim and Claire Mach

Sarah England and Rachel Tribe

10:15 Novel Targeted Therapies for Granulosa O-053 Cell Tumors Using High-Throughput Drug Screen of Primary Tumor Cells. Ulla-Maija Haltia, Noora Andersson, Bhaqwan Yadav, Evgeny Kulesskiy, Petteri Hintsanen, Anniina Farkkila, Annika Riska, Leila Unkila-Kallio, Krister Wennerberg, Tero Aittokallio, and Mikko Anttonen. Helsinki, Finland. 10:30 The Receptor Tyrosine Kinase, AXL, O-054 Regulates c-MET in Epithelial Ovarian Cancer. Katherine C Fuh, Erinn B Rankin, Teri Longacre, Mihalis Kariolis, Jennifer Cochran, and Amato Giaccia. St. Louis, MO, USA and Stanford, CA, USA. 10:45 The Histone Demethylase KDM4B O-055 Contributes to Ovarian Cancer Progression by Regulating Metastatic Behavior. Lei Qiu, Cailin Wilson, Yan Hong, Guirguiss Tadros, Jacob New, Sacha Krieg, Ossama Tawfik, Katherine Roby, and Adam J Krieg. USA. 11:00 HER2 Over-Expressing High Grade O-056 Endometrial Cancer Expresses High Levels of p95HER2 Variant. Whitfield B Growdon, Virginia Byron, Celeste DiGloria, Darrell R Borger, Rosemary Foster, John Winslow, Ahmed Chenna, Jeffrey Sperinde, and Bo R Rueda. Boston, MA, USA and South San Francisco, CA, USA. 11:15 Profiling the Endocannabinoid System in O-057 Endometrial Carcinoma. Thangesweran Ayakannu, Anthony Taylor, Jonathon Willets, and Justin Konje. United Kingdom. 11:30 O-058

10:15 AM-11:45 AM

HGF/c-Met Axis Drives Cancer Aggressiveness in the Neo-Adjuvant Setting of Ovarian Cancer. Marisa Mariani, Mark McHugh, Marco Petrillo, Steven Sieber, Shiquan He, Mirko Andreoli, Zheyang Wu, Paul Fiedler, Giovanni Scambia, Shohreh Shahabi, and Cristiano Ferlini. Danbury, CT, USA; Rome, Italy and Worcester, MA, USA.

10:15 O-059

Uterine Gene Expression Profile of Preterm and Term Birth. R Bukowski, H Zhang, J Biggio, M Varner, S Parry, M Esplin, W Andrews, G Saade, Y Sadovsky, J Ilekis, U Reddy, and D Baldwin. USA.

10:30 O-060

Acute Uterine Stretch Induces an Inflammatory “Pulse” in Amniotic Fluid and Maternal Plasma Followed by Preterm Labor in Nonhuman Primates. K Adams Waldorf, S Sooranna, M Gravett, L Paolella, L Ngo, J Tsai, T Bammler, J MacDonald, F Farin, L Rajagopal, and M Johnson. USA and United Kingdom.

10:45 Hydrogen Sulfide Is a Potassium ChannelO-061 Independent Uterine tocolytic. Brian Wakefield, Kelsey Breen, and K Joseph Hurt. USA. 11:00 O-062

Progesterone Governs the Ratio of Alternate Splice Variants of Uterine ERɑ in Pregnancy. Rebecca S Moreci, Karen Florio, and Pancharatnam Jeyasuria. USA.

11:15 O-063

Alterations to DNA Methylome Identified in Myometrium with Idiopathic Preterm Labor. Kohzoh Mitsuya, Natasha Singh, Suren R Sooranna, Lu Liu, Jianhua Ruan, Mark R Johnson, and Leslie Myatt. USA and London, United Kingdom.

11:30 Impact of Maternal Ageing on Murine O-064 Myometrium Function. Rima Patel, Poston Lucilla, and Tribe M Rachel. London, United Kingdom.

8A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Friday, March 28, 2014 - Concurrent Session II 10:15 AM-11:45 AM

Concurrent Session

Preeclampsia I

Basement

Ground Floor

Vicki Clifton and Lynda Harris

Errol Norwitz and Joanna Stanley

Gender and Disease Specific Transcripts in the Placenta. Justyna Dopierala, Gordon C Smith, and Stephen D Charnock-Jones. Cambridge, United Kingdom.

10:45 New Insights into the Mechanism of O-067 Control of Trophoblast Invasion by PPARɣ: Evidences for EG-VEGF Involvement. Vanessa Garnier, Thierry Fournier, Pascale Hoffmann, Aude Salomon, Frederic Sergent, Jean-Jacques Feige, and Nadia Alfaidy. France. 11:00 Vitamin D Attenuates Sphingosine-1O-068 Phosphate (S1P)-Mediated Inhibition of Extravillous Trophoblast Migration. Melissa Westwood, Khiria Al-Saghir, Naa Ado, Daman Adlam, and Edward D Johnstone. Manchester, United Kingdom. 11:15 O-069

Concurrent Session

Placenta II

10:15 Placental Dysfunction Resulting from O-065 Placenta-Specific Loss of Autophagy. Alina Maloyan, Sribalasubashini Muralimanoharan, and Leslie Myatt. San Antonio, TX, USA. 10:30 O-066

10:15 AM-11:45 AM

Folate Sensing by mTOR Is a Novel Mechanism by Which Folate Regulates Trophoblast Cell Function. F Rosario, I Aye, Powell TL, and Jansson T. San Antonio, USA.

11:30 Melatonin Increases Fetal Weight in the O-070 Endothelial Nitric Oxide Synthase Knockout Mouse. Hymke Moens, Elizabeth C Cottrell, Lewis J Renshall, Philip N Baker, Mark Wareing, Colin P Sibley, Susan L Greenwood, and Mark R Dilworth. United Kingdom and New Zealand.

10:15 O-071

Abstract Withdrawn

10:30 Interleukin-10 Deficiency Causes O-072 Dysregulation of the Regulatory T Cell Response to Pregnancy in Mice. Jelmer R Prins, Leigh R Guerin, Bihong Zhang, John E Schjenken, Simon C Barry, and Sarah A Robertson. Adelaide, SA, Australia and Groningen, Netherlands. 10:45 Decreased Seizure Threshold during O-073 Pregnancy and Experimental Preeclampsia: Roles for GABAA Receptors and Microglial Activation. Abbie C Johnson, Sarah M Tremble, and Marilyn J Cipolla. Burlington, VT, USA. 11:00 Stem Villous Arteries of IUGR Placentas O-074 Undergo Remodelling Due to Smooth Muscle Cell Dedifferentiation, Leading to Increased Vascular Resistance. T Cindrova-Davies, L Lu, J Kingdom, and GJ Burton. United Kingdom and Canada. 11:15 Identification of Proteins Directly O-075 Interacting with the HELLP-Syndrome Associated LincRNA Using ChIRP. Marie van Dijk, Allerdien Visser, Ruud Zaremba, and Cees Oudejans. Amsterdam, Netherlands. 11:30 Toll-Like Receptor 9 Activation Potentiates O-076 Uterine Artery Responsiveness to Thromboxane A2 Via CyclooxygenaseDependent Mechanisms in Pregnant Rats. Styliani Goulopoulou, Takayuki Matsumoto, Camilla F Wenceslau, Cameron G McCarthy, Kathryn Spitler, and R Clinton Webb. Augusta, GA, USA and Tokyo, Japan.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

9A

Friday, March 28, 2014 - Concurrent Session II 10:15 AM-11:45 AM

Concurrent Session

Concurrent Session

Reproductive Biology I

Stem Cells I

Fourth Floor

Verde Hall

Kuniaki Ota and Danny Schust

Caroline Gargett and Chiara Novielli

10:15 Dendritic Cells Partake in Regulation of O-077 Ovarian Physiology. Adva Cohen-Fredarow, Ari Tadmor, Tal Raz, Naama Meterani, Nava Nevo, Michal Neeman, Gil Mor, and Nava Dekel. Rehovot, Israel and New Haven, Connecticut, USA. 10:30 O-078

10:15 AM-11:45 AM

Anti-Müllerian Hormone and Ovarian Function after Hysterectomy. Emanuel C Trabuco, Patricia G Moorman, Amy L Weaver, and Cliby A William. Rochester, MN, USA and Durham, NC, USA.

10:45 Regulation of Implantation by Interaction O-079 between the Type-1 IGF Receptor (IGF1R) and MiR-145. Karen Forbes, Miranda Lees, Youn-Jung Kang, Laura C Matthews, and John D Aplin. Manchester, Greater Manchester, United Kingdom. 11:00 The MiR-200 Family and Its Targets in O-080 Implantation and Decidualization. Patricia T Jimenez, and Carole R Mendelson. Dallas, TX, USA. 11:15 The Potential Significance of PostO-081 Translational Regulation of Glycoprotein Dystroglycan in the Human Endometrium for Embryo Implantation. Sophea Heng, Ying Li, Sarah Paule, Lois Salamonsent, Luk Rombauts, Beverley Vollenhoven, and Guiying Nie. Melbourne, Australia and Australia. 11:30 Insulin Regulates Glycogen Synthesis in O-082 Endometrial Epithelial Cells through a Novel Mechanism Unique to the Reproductive Tract. Clare Flannery, Gina Choe, Farrah Saleh, and Hugh Taylor. New Haven, CT, USA.

10:15 Characterization of the Putative Surface O-083 Epitope of DDX4 in Rhesus Ovarian Cells. Nima Vahidi, Richard Weitzel, George Patounakis, John Tisdale, and Erin Wolff. USA. 10:30 Retrospective Analysis of Gene Expression O-084 in Stem Cells. Ruben Boers, Joost Gribnau, and Joop Laven. Netherlands. 10:45 Transient Exposure to Hypoxia Impairs the O-085 Function of Fetal Endothelial Colony Forming Cells (ECFC). Peter Sipos, Stephane Bourque, Phil Baker, Sandra Davidge, and Ian Crocker. United Kingdom; Canada and New Zealand. 11:00 Human Amnion Epithelial Cells Exert O-086 Reparative Effects in Acute Lung Injury Via Modulation of Macrophage and Treg Function. Rebecca Lim, Jean Tan, and Euan M Wallace. Clayton, Victoria, Australia. 11:15 Trophoblast Stem Cell Derivation from O-087 Human Embryonic Stem Cells. Katsuyuki Adachi, Ying Yang, Toshihiko Ezashi, Laura C Shultz, Danny J Schust, and RM Roberts. Columbia, MO, USA. 11:30 Derivation of Cardiac Endothelium from O-088 Human Embryonic Stem Cells (hESCs) Via Dual Transgenic Labeling. David Reichman, Kenny Chou, Michael Poulos, Zev Rosenwaks, and Daylon James. NY, NY, USA.

10A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Friday, March 28, 2014 - Concurrent Session III 5:15 PM-6:45 PM

Concurrent Session

5:15 PM-6:45 PM

Concurrent Session

Endometriosis / Adenomyosis

Fetus II

Fourth Floor

Auditorium

Erkut Attar and Hugh Taylor

Beth Allison and Anna David

5:15 SOX9 Is Up-Regulated in the Secretory O-089 Phase Endometrium of Women with Endometriosis and Is Regulated by Ovarian Hormones; Implication in the Pathogenesis of Endometriosis. Hannah Draper, Adam Earp, Nicola Tempest, Anthony Valentijn, Jo Drury, and Dharani Hapangama. United Kingdom.

5:15 Do Adverse Conditions during Pregnancy O-095 Trigger a Fetal Origin of Heart Disease or Do They Programme Cardiac Disease in Later Life by Altering Adaptive Responses to Later Challenges? Y Niu, BJ Allison, KL Brain, A D Kane, EA Herrera, and DA Giussani. United Kingdom and Chile.

5:30 Gefitinib Restores Decidualization Marker O-090 Expression in Women with Endometriosis. David W Erikson, Joseph C Chen, Terhi T Piltonen, Marco Conti, Juan C Irwin, and Linda C Giudice. USA and Finland.

5:30 The Role of Infection and the TNF Family of O-096 Cytokines in Neonatal Hypoxic-Ischemic Brain Injury. Eridan Rocha-Ferreira, Erika FranceschDomenech, Laura Thei, Ahad Rahim, Sigrun Lange, Donald Peebles, Mariya Hristova, and Gennadij Raivich. United Kingdom.

5:45 Iron Overload in the Peritoneal Cavity O-091 Leads to Upregulation of MMP3 and VEGF Transcripts in Ectopic Endometrium of Mice with Endometriosis. Ana M Sanchez, Paola Vigano, Massimo Candiani, and Paola Panina-Bordignon. Milan, Italy. 6:00 Meta-Analysis of GWAS Signals for O-092 Endometriosis to Date: Consistency and Heterogeneity across Eight Datasets Totaling More Than 11,000 Cases and 32,000 Controls. Nilufer Rahmioglu, Stacey A Missmer, Grant W Montgomery, and Krina T Zondervan. Oxford, United Kingdom; Boston, USA and Brisbane, Australia. 6:15 Receptor Switching in Endometriosis May O-093 Convert Anti-Inflammatory Signaling into Pro-Inflammatory Signaling. Steven L Young, Tolga B Mesen, Geraldine O Canny, Langenheim John, and Bruce A Lessey. Chapel Hill, NC, USA; SC, USA and Versoix, Switzerland. 6:30 MicroRNA Mir142-3p as a Potential O-094 Diagnostic Marker and Modulator of Inflammation and Cytoskeletal Function in Endometriosis. Christin Kastingschafer, Johanna Bockenholt, Denise Ludwig, Ludwig Kiesel, Andreas N Schuring, and Martin Gotte. Münster, Germany.

5:45 O-097

Combination of Interleukin-1 Receptor Antagonist (IL-1Ra) and Clavulinic Acid (CLAV) to Prevent Fetal Inflammatory Brain Injury. Valeria Dell’Ovo,1 Nune Darbinian,1 Nana Merabova, Irina Burd, and Laura Goetzl. Philadelphia, PA, USA and Baltimore, MD, USA

6:00 Single Nucleotide Polymorphism Analysis O-098 of Trophoblast Cells Isolated from the Endocervical Canal of Ongoing Pregnancies. Rani Fritz, Brian A Kilburn, Jay M Bolnick, Alan Bolnick, Michael P Diamond, and D Randall Armant. Detroit, MI, USA; Augusta, GA, USA and Bethesda, MD, USA. 6:15 Ductus Venosus Morphology Is Not Related O-099 to Increased Nuchal Translucency, Cardiac Defects or Aberrant Lymphatic Development. Nicole B Burger, Monique C Haak, Christianne J De Groot, James F Martin, Weinian Shou, Peter J Scambler, Vincent M Christoffels, and Mireille N Bekker. Amsterdam, Netherlands; Leiden, Netherlands; Houston, USA; Indianapolis, USA; London, United Kingdom and Nijmegen, Netherlands. 6:30 O-100

Astrocyte-Derived Factors Increase Multidrug Resistance Via P-Glycoprotein at the Developing Blood-Brain Barrier. Stephanie Baello, Majid Iqbal, William Gibb, and Stephen G Matthews. Canada.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

11A

Friday, March 28, 2014 - Concurrent Session III 5:15 PM-6:45 PM

Concurrent Session

5:15 PM-6:45 PM

Concurrent Session

Parturition II

Preeclampsia II

Basement

Ground Floor

Indira Mysorekar and John Newnham

Arie Franx and Augustine Rajakumar

5:15 Chemokine Receptor Antagonism Inhibits O-101 Transendothelial Migration by Activated Leukocytes: A Potential Novel Approach for Preterm Birth Prevention. Yu-Hui Lee, Oksana Shynlova, and Stephen Lye. ON, Canada and Toronto, ON, Canada.

5:15 Plasma Gelsolin as an Endogenous O-107 Inhibitor of Syncytiotrophoblast Microparticle Shedding in Pregnancy. Neil Nadkarni, Augustine Rajakumar, Rama Krishnan, Thomas Stossel, and S Ananth Karumanchi. Boston, MA, USA and Chevy Chase, MD, USA.

5:30 The Androgen Receptor Is an Apoptosis O-102 Regulator of Myometrial Cells. Haolong Li, Ning Xie, Liangliang Liu, Stephen Lye, and Xuesen Dong. Vanocuver, BC, Canada and Toronto, ON, Canada. 5:45 Oxytocin Receptor Antagonist, Atosiban, O-103 Drives Proinflammatory Effects in Human Amnion Via Gai Signaling. Sung Hye Kim, Andrew Blanks, Steve Thornton, Phillip R Bennett, and Vasso Terzidou. United Kingdom. 6:00 O-104

Enhancement of Anti-Inflammatory Effect by the Combination of Progesterone and cAMP on IL-1β-Stimulated Human Myometrial Cells. Angela Yulia, Extoras X Georgiou, Ananya Das, Kaiyu Lei, Suren R Sooranna, Vasso Terzidou, and Mark R Johnson. London, United Kingdom.

6:15 Microbes in the Maternal Basal Plate: New O-105 Etiologies for Preterm Birth. Bin Cao, Molly J Stout, and Indira U Mysorekar. St. Louis, MO, USA. 6:30 Detection of Bacterial DNA in Amniotic O-106 Fluid. Is There an Association with Elevated Cytokine Levels and Pregnancy Outcome? Matthew S Payne, Shaofu Li, Dorota Doherty, Jeffrey A Keelan, and John P Newnham. Crawley, Western Australia, Australia.

5:30 Decidualization Defect in Patients That O-108 Suffered Severe Preeclampsia Is Mediated through ANXA2 Deficiency. Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quinonero, Pablo Padilla Iserte, Alfredo Perales Marin, and Carlos Simon. Valencia, Spain. 5:45 ET-1, ADMA and SDMA in Pregnancies O-109 with Systemic Lupus Erythematodes and Antiphospholipid Syndrome. Karoline Mayer-Pickel, Vassiliki KolovetsiouKreiner, Christina Stern, Daniela Ulrich, Josef Haas, Manfred Mortl, Dietmar Schlembach, Uwe Lang, and Mila CervarZivkovic. Graz, Austria. 6:00 The Preeclampsia-Like Phenotype in an O-110 Obese Mouse Model Is Associated with Increased LOX-1 Expression. Joanna L Stanley, Anita Quon, Colin P Sibley, Sandra T Davidge, and Philip N Baker. New Zealand; Canada and United Kingdom. 6:15 The Uterine Natural Killer Cell O-111 Transcriptome Is Differentially Regulated over the Course of Human Pregnancy: Role for Type I Interferons? Emiel D Post Uiterweer, Niels Eijkelkamp, Marian J Groot Koerkamp, Louis L Peeters, Frank C Holstege, Cobi J Heijnen, and Arie Franx. Netherlands and USA. 6:30 Effect of Hypoxia-Reoxygenation on the O-112 Renin Angiotensin System (RAS) in Human Placental Explants In Vitro. Lesia Kurlak, Hiten Mistry, Yosef Mansour, Tereza Cindrova-Davies, Graham Burton, and Fiona Broughton Pipkin. United Kingdom.

12A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Friday, March 28, 2014 - Concurrent Session III 5:15 PM-6:45 PM

Concurrent Session

5:15 PM-6:45 PM

Reproductive Biology II

Concurrent Session

Reproductive Endocrinology, Infertility I

Verde Hall

Adua I

Clare Flannery and Ertug Kovanci 5:15 Identification of Corpus Luteum MicroRNAs O-113 Regulated by Weight Gain in the Vervet Monkey. Andrew Bradford, Kenneth Jones, Justin Chosich, Margaret May, Katerina Kechris, Susan Appt, and Alex Polotsky. Aurora, CO, USA and Winston-Salem, NC, USA. 5:30 Telomere Lengths Are Reduced in Women O-114 with Primary Ovarian Insufficiency Due to Fragile X Premutation Compared to Age Matched Controls. Shvetha M Zarek, Lawrence M Nelson, James H Segars, Alan H DeCherney, Neal S Young, Muharrem Yunce, Bogdan Dumitriu, and Erin F Wolff. Bethesda, MD, USA. 5:45 γ-Amino Butyric Acid (GABA) Levels and O-115 GABA-Ergic Gene Expression in Ovarian Follicular Fluid (FF) during Controlled Ovarian Stimulation. Li Hou, Yimin Shu, Erika B JohnstonMacAnanny, and Tamer M Yalcinkaya. Winston-Salem, NC, USA. 6:00 Structural Maintenance of Chromosome O-116 1β(SMC1-β) Expression in Aging Human Oocytes. Sahadat K Nurudeen, Maryam Shirazi, Robert Prosser, Dorothy Warburton, Mark V Sauer, and Vaidehi Jobanputra. NY, NY, USA. 6:15 Haplotype Identification of HLA-G Gene: O-117 Implications for Spontaneous Abortion. Valeria S Vanni, Alessandra Mugione, Enrico Papaleo, Paola Vigano, Massimo Candiani, Giada Amodio, Silvia Gregori, and Paola Panina-Bordignon. Milan, MI, Italy. 6:03 O-118

MiR-146a Regulates Antiphospholipid Antibody-Induced IL-8 Secretion by Human Trophoblast Cells. Stefan M Gysler, Larry W Chamley, Jan J Brosens, and Vikki M Abrahams. New Haven, CT, USA; New Zealand and United Kingdom.

Monica Mainigi and Alex Polotsky 5:15 O-119

Sex-Specific Methionine Cycle Changes in Cystathionine Gamma Lyase Null Mice Suggest Cytoprotection by Cystathionine. K Joseph Hurt, H Jiang, K Breen, DJ Orlicky, SP Stabler, and KN Maclean. Aurora, CO, USA and USA.

5:30 miR-210 Induces Angiogenesis and O-120 Endothelin-2 Expression in Human Granulosa Cells under Normoxic and Hypoxic Conditions. Tal Imbar, Esther Oyesiji Adepeju, Iris Eisenberg-Loebl, Caryn Greenfield, Debra Goldman-Wohl, Ronit Haimov-Kochman, Arye Hurwitz, Simcha Yagel, and Rina Meidan. Jerusalem, Israel and Rehovot, Israel. 5:45 Targeted Next Generation DNA Sequencing O-121 Identifies New Candidate Genes in Kallmann Syndrome and Hypogonadotropic Hypogonadism. ME Bosley, LV Lee, MP Jett, SD Quaynor, IN Falk, LP Chorich, HG Kim, RS Cameron, JH Choi, and LC Layman. GA, USA; USA and Augusta, GA, USA. 6:00 Reversal of the Metabolic Phenotype of an O-122 Obesogenic Diet Does Not Reverse the Altered Reproductive Phenotype in a Mouse Model. Kasey A Reynolds, Anna L Boudoures, and Kelle H Moley. St. Louis, MO, USA. 6:15 Growth Hormone Up-Regulates BMP15 and O-123 GDF9 in Follicular Fluid from Patients with Diminished Ovarian Reserve Undergoing IVF-ET. Tannaz Toloubeydokhti, Alejandra Salazar, Arlene Garcia-Soto, Salatnay Herniquez, Sylvie Roberge, and George R Attia. Miami, FL, USA. 6:30 Depicting the Dynamics of Ovarian Graft O-124 Reperfusion by Long Term Follow Up Using In-Vivo DCE MRI. Yoni Cohen, Hagit Dafni, Reut Avni, Liat Fellus, Joseph B Lessing, and Michal Neeman. Rehovot, Israel and Tel Aviv, Israel.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

13A

Saturday, March 29, 2014 - Concurrent Session IV 11:30 AM-1:15 PM

Concurrent Session

1:15 PM-2:45 PM

Concurrent Session

Hot Topics/RSDP Forum

Cancer

Basement

Adua I

Anil Sood

Adam Krieg and Alessandro Santin

11:30 Nanoparticle-Mediated Trophoblast-Specific O-125 Gene Therapy Rescues Birthweight in a Murine Model of Placental Insufficiency. Kathryn Owens, Weston Troja, Chuck Klanke, and Helen Jones. USA. 12:00 Oogonial Stem Cells Generate Mature O-126 Oocytes in an Autologous Rhesus Macaque Transplantation Model. Erin F Wolff, Lauren L Libfraind, R Patrick Weitzel, Dori Woods, Yanling Feng, Jonathan Tilly, Alan H DeCherney, and John F Tisdale. Bethesda, MD, USA and Boston, MA, USA.

1:15 Adoptive Transfer of CD3/CD28 CoO-127 Stimulated T Cells Improves Clinical Outcome in Patient with Recurrent Ovarian Cancer. Janos Tanyi, Emese Zsiros, Drew Torigan, Lana E Kandalaft, and George Coukos. Philadelphia, PA, USA. 1:30 Efficacy of Subcutaneous Bremelanotide O-128 Self-Administered at Home by Premenopausal Women with Female Sexual Dysfunction: A Placebo-Controlled DoseRanging Study. David Portman, Anita Clayton, Robert Jordan, Jeffrey Edelson, Sally Greenberg, Leonard DeRogatis, Sheryl Kingsberg, Raymond Rosen, Stanley Althof, and Michael Krychman. USA and Cleveland, OH, USA. 1:45 Weekly Ixabepilone±Bevacizumab in the O-129 Treatment of Platinum/Taxane-Resistant Endometrial & Ovarian Cancers. Dana M Roque, Carlton L Schwab, Diana P English, Elena S Ratner, Dan-Arin Silasi, Masoud Azodi, Thomas Rutherford, Peter E Schwartz, and Alessandro D Santin. USA. 2:00 Serum Anti-Müllerian Hormone Is a O-130 Sensitive and Specific Marker in the Follow-Up of Ovarian Granulosa Cell Tumor Patients – A Comparative Study with Inhibin-B. Anniina Farkkila, Sanna Koskela, Saara Bryk, Henrik Alfthan, Ralf Butzow, Arto Leminen, Ulla Puistola, Juha Tapanainen, Markku Heikinheimo, Mikko Anttonen, and Leila Unkila-Kallio. Helsinki, Finland; Finland and St Louis, MO, USA. 2:15 ECT2: A Molecular Target for the Treatment O-131 of Uterine Papillary Serous Carcinoma (UPSC). Claire M Mach, Thomas J Magliaro, Jr., and Matthew L Anderson. Houston, TX, USA. 2:30 Targeting c-Jun N-Terminal Kinase (JNK) O-132 Pathway in Granulosa Cell Tumor of the Ovary: Translating the Findings from Reproductive Biology into Cancer Biology. Filiz Senbabaoglu, Nathan Lack, Yilmaz Guzel, Gizem Nur Sahin, Bulent Urman, and Ozgur Oktem. Istanbul, Turkey.

14A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Saturday, March 29, 2014 - Concurrent Session IV 1:15 PM-2:45 PM

Concurrent Session

Concurrent Session

Maternal Health

Parturition III

Basement

Auditorium

David Lissauer and Ronald Magness

Matthew Kemp and Sam Mesiano

1:15 Prenatal Stress in the Second Generation: O-133 Evidence of Effects on the Duration of Pregnancy and Neonatal Weight. Amy-Eunice Furcron, Derek StLouis, Roberto Romero, Sonia Hassan, and Nardhy Gomez-Lopez. Detroit, MI, USA. 1:30 Maternal Exercise (MEx) in Obese Rats O-134 Decreases Lipogenesis and Fat Accumulation in the Liver of Male Offspring (OFF). Consuelo Lomas-Soria, Claudia J Bautista, Luis A Reyes-Castro, Fernando Larrea, Peter W Nathanielsz, and Elena Zambrano. Mexico City, DF, Mexico and San Antonio, TX, USA. 1:45 Fas/FasL Interactions Regulate Maternal O-135 Immunity in Pregnancy. Sharon A McCracken, Anthony W Ashton, and Jonathan M Morris. St Leonards, NSW, Australia. 2:00 O-136

Preeclampsia Relates to Heart Failure within 7 Years after Pregnancy. Chahinda Ghossein-Doha, Brechtje Wissink, and Marc EA Spaanderman. Maastricht, Netherlands.

2:15 O-137

A Biomarker Profile Characterizing “Healthy” vs. “Unhealthy” Overweight and Obese Women Postpartum. Calvin Hobel, Christine Dunkel Schetter, Susan Jackman, Donnabeth Young, James Mirocha, and Loretta Jones. LA, CA, USA and Los Angeles, CA, USA.

2:30 O-138

1:15 PM-2:45 PM

Pre-Eclampsia Is Associated with Early Postpartum Endothelial Dysfunction as Measured by Laser Doppler Flowmetry and Iontophoresis. Malia SQ Murphy, and Graeme N Smith. Canada.

1:15 O-139

PLCL1, a Potent Suppressor of AgonistMediated IP3 Signaling in Human Myometrium, Is Down-Regulated at the Onset of Labor. Paul J Brighton, Sefan Russo, Nehal Bejaj, and Andrew M Blanks. Coventry, United Kingdom.

1:30 EP2 Receptor Activates Dual G Protein O-140 Signalling Pathways That Mediate Contrasting Pro- and Anti-Labor Responses in Term Pregnant Human Myometrium. Shirin Khanjani, Mandeep K Kandola, Yun S Lee, Lynne Sykes, Mark R Johnson, Phillip R Bennett, and Aylin C Hanyaloglu. London, United Kingdom. 1:45 O-141

Aza-Amino Acyl Peptide Analogs (CAR 10 Analogs) Have Dichotomous Roles as Prostaglandin (PG)F2a Receptor (PTGFR) Allosteric Modulators That Inhibit mRNA Expression of PTGFR and OTR in Human Myometrial Smooth Muscle Cells (HMSMC). Kelycia B Leimert, Xin Fang, William Lubell, Sylvain Chemtob, and David M Olson. Edmonton, AB, Canada and Montreal, QC, Canada.

2:00 The Uterine Endoplasmic Reticulum Stress O-142 Response Regulates Myometrial Connexin 43 Levels. Chandrashekara N Kyathanahalli, Jeyasuria Pancharatnam, and Jennifer C Condon. Pittsburgh, PA, USA. 2:15 O-143

Alpha-2-Macroglobulin: A Novel ImmunoModulator of MaxiK Activity in Human Myometrial Smooth Muscle Cells. Monali Prabagaran, Chinwendu Amazu, Susan J Stamnes, Michael E Wright, Ramon A Lorca, Kris Hyrc, and Sarah K England. St. Louis, MO, USA; Baltimore, MD, USA and Iowa City, IA, USA.

2:30 O-144

Macrophages Are Required for In Vitro Human Myometrial Cells Activation in Response to Inflammatory Stimuli. M Wendremaire, T Hadi, M Barrichon, M Bardou, P Sagot, C Garrido, and F Lirussi. France.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

15A

Saturday, March 29, 2014 - Concurrent Session IV 1:15 PM-2:45 PM

Concurrent Session

1:15 PM-2:45 PM

Reproductive Endocrinology, Infertility II

Concurrent Session

Stem Cells II Verde Hall

Fourth Floor

Emiel Post Uiterweer and Erin Wolff Amanda Kallen and Joop Laven 1:15 O-145

Constitutive Wnt/B-Catenin Signaling in Mice in the Absence of Müllerian Inhibiting Substance/AntiMulleiran Hormone Signaling Leads to the Development of a Polycystic Ovary Phenotype. Pradeep S Tanwar, Tomoko Kaneko-Tarui, and Jose M Teixeira. Boston, MA, USA and Grand Rapids, MI, USA.

1:30 Preconception Predictors of Gestational O-146 Diabetes: A Prospective Cohort Study on the Predominant Complication of Pregnancy in PCOS. Marlieke A de Wilde, Susanne M VeltmanVerhulst, Angelique J Goverde, Cornelis B Lambalk, Joop S Laven, Arie Franx, Maria P Koster, Marinus J Eijkemans, and Bart C Fauser. Utrecht, Netherlands; Amsterdam, Noord-Holland, Netherlands and Rotterdam, Zuid-Holland, Netherlands. 1:45 Impact of Aerobic Exercise on O-147 Mitochondrial Function and Insulin Sensitivity in Women with Polycystic Ovary Syndrome – A Randomized Controlled Trial. Albert Asante, Adam R Konopka, Elizabeth A Stewart, Charles C Coddington, and Sreekumaran K Nair. Rochester, MN, USA. 2:00 O-148

Cream Ingestion Promotes the Expression of Toll-Like Receptor-4 (TLR-4) and Suppressor of Cytokine Signaling-3 (SOCS-3) in Polycystic Ovary Syndrome. Ola A Abdelhadi, Robert V Considine, Anthony J Acton, Marguerite K Shepard, and Frank Gonzalez. Indianapolis, IN, USA.

2:15 The Impact of Medication Used for AcidO-149 Related Gastrointestinal Symptoms on Semen Quality in Subfertile Couples. Nicole A Huijgen, Hedwig J Goijen, John M Twigt, Annemarie M Mulders, Jan Lindemans, Gert R Dohle, Joop S Laven, and Regine P Steegers-Theunissen. Netherlands. 2:30 O-150

Apolipoprotein-E Induction in Syrian Hamster Testis Following Tributyltin Exposure: A Potential Mechanism of Male Infertility. V Kanimozhi, K Palanivel1, B Kadalmani, G Krikun, and HS Taylor. Tiruchirapalli, Tamil Nadu, India and New Haven, CT, USA.

1:15 Endometrial Stem Cell Transplantation O-151 Provides Therapeutic Benefits in a Parkinson’s Non-Human Primate Model: A Pilot Study. Levent Mutlu, Erin F Wolff, John D Elsworth, Eugene Redmond, and Hugh S Taylor. USA. 1:30 The Human X-Inactivation Centre Can Be O-152 Divided in a Cis-Acting and a Trans-Acting Part. Bas de Hoon, Joop Laven, and Joost Gribnau. Rotterdam, Netherlands and Netherlands. 1:45 Telomerase Reverse Transcriptase O-153 Expression Marks Endometrial Progenitors with Epithelial Differentiation Potential. James A Deane, David T Breault, and Caroline E Gargett. Melbourne, Victoria, Australia and Boston, MA, USA. 2:00 Development of an Orthotopic O-154 Transplantation Model for Assessing Endometrial Stem Cell Functions In Vivo. James K Pru, Amanda L Patterson, and Cindy A Pru. Pullman, WA, USA. 2:15 O-155

Molecular Signatures of Fibroid Stem Cells: A Step toward New Therapeutic Targets. Molly B Moravek, Ping Yin, Masanori Ono, Gilbert Feng, and Serdar E Bulun. Chicago, IL, USA.

2:30 O-156

Molecular Evidence of Endometrial Mesenchymal Stem Cell Differentiation to Stromal Fibroblasts In Vitro Reveals Altered Molecular Phenotype in Endometriosis. Juan Irwin, Fatima Barragan, Terhi Piltonen, Ttrimble Spitzer, David Erikson, and Linda Giudice. San Francisco, CA, USA and Oulu, Finland.

16A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Poster Session I - Affari 10:00 AM-11:30 AM

Poster Session

Basic Parturition, Prematurity T-001 Long Term Outcomes after pPROM < 24 wks: Case Control Study. Federica Accordino, Agnese Pizzardi, Sara Consonni, Tiziana Fedeli, and Anna Locatelli. Monza, Italy.

T-008 Is a Single Episode of Preterm Contractions Subsequently Resulting in a Term Delivery Associated with Reduced Fetal Growth? Limor Besser, Lena Novack, Moshe Mazor, Lubna Zoabi, Adi Weintraub, Ruthy BeerWeisel, Tal Rafaeli, Batel Hamou, Orna Staretz -Chacham, Salvatore A Mastrolia, and Offer Erez. Beer Sheba, Israel and Bari, Italy.

T-002 Endotoxin Expands the Pool of Regulatory T Cells in Pregnancy but Not in the NonPregnant State. Marcia Arenas-Hernandez, Derek StLouis, Roberto Romero, Sonia Hassan, and Nardhy Gomez-Lopez. USA.

T-009

T-003 Deciphering Molecular Mechanisms of Group B Streptococcal Chorioamnionitis. Lisa Rogers, Pallavi Singh, Robert Parker, Erica Boldenow, Elizabeth Salzman, Katie Mason, Mark Chames, Rita Loch-Caruso, Shannon Manning, and David Aronoff. USA.

T-010 In-Vitro Evaluation of Induction and Inhibition of CYP1A2, CYP2A6 and CYP2B6 by Hydroxyprogesterone Caproate (HPC, Makena®, 17P). Lining Cai, Kan He, Jennifer Gudeman, Michael Jozwiakowski, and Robert Birch. Monmouth Junction, NJ, USA and Chesterfield, MO, USA.

T-004 Oxytocin Reduces the Tocolytic Effect of Magnesium Sulphate in Human Myometrium. Sarah Arrowsmith, James Neilson, and Susan Wray. Liverpool, United Kingdom. T-005 Normal- and Obese-Related Leptin Doses Induce Myometrial Cell Proliferation through Distinct ERK1/2 and STAT3 Signaling. M Barrichon, T Hadi, M Wendremaire, G Mace, M Bardou, M Dumas, P Sagot, and F Lirussi. Dijon, France. T-006

Protective Role of E. Coli Nissle 1917-Based Probiotic Against Uropathogenic E. Coli (UPEC) Strain-Mediated Inhibition of Progesterone Receptor Expression and Cell Survival in Decidual Cells. M Basar, S Justice, O Guzeloglu-Kayisli, F Schatz, CJ Lockwood, and UA Kayisli. Columbus, OH, USA.

T-007 Indicated Late Preterm Birth, How Much Is Too Many? Limor Besser, Moshe Mazor, Liat SabagShaviv, Maayan Yitzhak-Sade, Daniella Landau, Ruthy Beer-Weisel, Vered Klaitman, Lena Novack, Neta Ben Shalom Tirosh, and Offer Erez. Beer Sheba, Israel.

Metabolism of Hydroxyprogesterone Caproate (HPC, Makena®, 17P) in Mammals. James M Mathews, Anita H Lewin, Michael J Jozwiakowski, John L Chollet, and Robert Birch. Research Triangle Park, NC, USA and Chesterfield, MO, USA.

T-011 Group B Streptococcus Stimulated IL-1β in Choriodecidual Tissue Increases Human Beta Defensin-2 in Amnion Epithelial Cells. Erica J Boldenow, Kelly Hogan, Mark C Chames, David M Aronoff, Chuanwu Xi, and Rita Loch-Caruso. USA. T-012

Proteomic Discovery of Serum Biomarkers Predictive of Preterm Birth. J Boniface, T Fleischer, C Bradford, J Flick, A Gassman, I Ichetovkin, T Pugmire, R Severinsen, A Fox, S Rust, A Lueth, A Polpitiya, G Critchfield, and D Hickok. Salt Lake City, UT, USA.

T-013 Social Conditions in Pregnancy and Fetal Development. Greg Miller, Sameen Qadir, and Ann Borders. Evanston, IL, USA. T-014 Omega-3 Polyunsaturated Fatty Acids (ω-3PUFA) Induce Oxidative Stress in a Mouse Model of Preterm Delivery. T Stewart Boulis, Burton Rochelson, Olivia Novick, Xiangying Xue, Prodyot Chatterjee, Madhu Gupta, Malvika Solanki, Meredith Akerman, and Christine Metz. USA. T-015 The Effect of a Maternal Diet Enriched in ω3-Polyunsaturated Fatty Acids (ω-3PUFA) on Maternal and Fetal Inflammation Using a Mouse Model of Preterm Labor. T Stewart Boulis, Burton Rochelson, Xiangying Xue, Prodyot Chatterjee, Madhu Gupta, Malvika Solanki, and Christine Metz. USA.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

17A

Thursday, March 27, 2014 - Poster Session I - Affari T-016 The Relationship between Maternal Puerperal Infection and Offspring Neurodevelopment in Term Infants. Sara G Brubaker, Noelia Zork, Caroline Pessel, Cynthia Gyamfi-Bannerman, and Cande V Ananth. New York, NY, USA. T-017 Differential Expression of Integrins, ECM Molecules, and Signaling Proteins in the Term and Preterm Human Myometrium. Heather Burkin, and Iain Buxton. USA. T-018 Is Decreased Secretion of Alpha1Antitrypsin by Amniotic Epithelial Cells a Possible Pathogenetic Factor of Premature Rupture of Membranes? Federica Campolo, Gabriele Lanzo, Giulia Chiarle, Elisa Bellis, Alessandro Suragna, Raffaella Benvenuto, Marisa Ribotta, and Chiara Benedetto. Torino, Italy. T-019 Effect of Curcuma Comosa on Pregnant Human Myometrial Contraction. Jirapol Kumpalum, Apilada Ocharoen, Areepan Sophonsritsuk, and Boonsri Chanrachakul. Bangkok, Thailand. T-020 Inhibition of Uterine Activity by Individual Isoforms of PKC Are Related to Suppression of Synthesis Mono or Diphospho-RLC. Mei Chi, Maily Mongin, Baily Sorochan, Barbara Zielnik, and Bryan F Mitchell. Edmonton, AB, Canada. T-021 Inhibition of Rho A-Associated Kinase (ROK) Induces Relaxation in Rat Myometrial and Vascular Smooth Muscle. Mei Chi, Barbara Zielnik, Sandra Davidge, Bryan Mitchell, and Bryan Mitchell. Edmonton, AB, Canada. T-022 Regulation of Antimicrobial Peptides in Human Endocervical Epithelial Cells by IL1β, Endotoxin and Vitamin D. Evonne C Chin-Smith, and Rachel M Tribe. London, United Kingdom. T-023 Effect of Cyclic Tensile Strain on the Biochemical and Mechanical Properties of the Human Amniotic Membrane. Bipasha Chowdhury, Anna L David, Dan L Bader, Christopher Thrasivoulou, David L Becker, and Tina T Chowdhury. London, United Kingdom. T-024 Weight Gain and Leptin Impact the Gut Microbiome in Pregnancy. KL Connor, C Chehoud, L Chan, P DiStefano, T DeSantis, and SJ Lye. Canada and USA.

T-025

Maternal Diet Shapes the Gut Microbiome, Impacting Immune Status in Pregnancy. KL Connor, C Chehoud, L Chan, P DiStefano, T DeSantis, and SJ Lye. Toronto, Canada and San Francisco, USA.

T-026

Identification of Differentially Expressed MicroRNAs in Labouring and NonLabouring Human Myometrium at Term. JR Cook, DA MacIntyre, E Samara, N Singh, PR Bennett, and V Terzidou. United Kingdom.

T-027

Cerclage Position Predicts Risk of Preterm Delivery in Women Undergoing UltrasoundIndicated Cervical Cerclage. JR Cook, S Chatfield, M Chandiramani, L Sykes, R Simcox, D Abbott, B Jones, J Loudon, A Shennan, V Terzidou, and PR Bennett. United Kingdom.

T-028 Stretch Induced Phosphoproteomic Signaling in Pregnant Human Myometrial Cells. Christian D Copley Salem, Craig C Ulrich, David R Quilici, Karen M Schlauch, Iain LO Buxton, and Heather Burkin. USA. T-029

Pre Versus Post-Ripening Sonographic Assessment of the Cervix for Predicting Successful Induction of Labor. Marcos Cordoba, Ana Monteagudo, Ashwin Jahdav, Cara Dolin, LiJin Joo, and Ilan Timor-Tritsch. New York, NY, USA and New Brunswick, NJ, USA.

T-030

Characterization of Variants of StretchActivated 2-Pore Potassium Channel TREK1. Chad L Cowles, Yi-Ying Wu, Cindy Valverde, Michael T Lee, Heather R Burkin, and Iain LO Buxton. Reno, NV, USA.

T-031

Mechanical Stretch of Human Myometrial Cells in the Absence and Presence of Specific FAK Inhibition. Ananya Das, Kaiyu Lei, Suren R Sooranna, and Mark R Johnson. London, United Kingdom.

T-032

Placenta and Myometrium Communication: APOA4 Triggers Myometrium Contractility Involving Interferon Gamma during Spontaneous Preterm Birth. Yafeng Dong, Helen H Zhou, Lahong Zhang, Minghui Tai, Shuguang Zhu, Clifford Mason, Wei Wang, and Carl P Weiner. Kansas City, KS, USA.

18A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Poster Session I - Affari T-033

Collagen Expression in Human Preterm Cervix. Aurelija Dubicke, Emma Fransson, Birgitta Bystrom, Steven M Yellon, and Gunvor Ekman-Ordeberg. Stockholm, Sweden and Loma Linda, CA, USA.

T-034 Endocrine Gland Derived Endothelial Growth Factor (EG-VEGF) Is a New Quiescence Factor of Human Fetal Membranes during the Third Trimester of Pregnancy. Camille Dunand, Pascale Hoffmann, Aude Salomon, Vanessa Garnier, Vincent Sapin, Loic Blanchon, Mohamed Benharouga, Sally Sabra, Stephen J Lye, JeanJacques Feige, and Nadia Alfaidy. France, Metropolitan and Toronto, Canada. T-035

Systemic and Local Trafficking of Myeloid Leucocytes in Late Stage Murine Pregnancy. Lydia F Edey, Kieran P O’Dea, Masao Takata, and Mark R Johnson. London, United Kingdom.

T-036 Sequential Priming of Human Decidual Cells with a TLR-7 and TLR-9 Agonist Suppresses TNF-α and IFN-γ Enhanced Expression of IP-10, a Natural Killer Cell Recruiting Chemokine. S Faramarzi, J Shapiro, UA Kayisli, F Schatz, and CJ Lockwood. Columbus, OH, USA. T-037

Abstract Withdrawn

T-038 RU486-Induced Preterm Labour: A Shifting Paradigm? Ektoras X Georgiou, Lydia F Edey, Kaiyu Lei, Bronwen Herbert, Suren R Sooranna, and Mark R Johnson. London, United Kingdom. T-039

Beyond the Intra-Uterine Environment: A Novel Model of Maternal-Fetal Ureaplasma Infection & Neonatal Survival in the NonHuman Primate. Peta L Grigsby, Meredith A Kelleher, Kamm Prongay, Cindy E McEvoy, and Robert L Schelonka. Beaverton, OR, USA and Portland, OR, USA.

T-040 Regulation of IGFBP-1 Phosphorylation by Hypoxia Requires mTORC1 Activity. Ian Damerill, Thomas Jansson, and Madhulika B Gupta. Canada and USA.

T-041

Pro-Inflammatory Cytokines Initiate Functional Progesterone Withdrawal and Chorioamnionitis-Induced Preterm Birth by Decreasing Progesterone Receptor Expression and Increasing Prostaglandin Production in Decidual Cells. O Guzeloglu-Kayisli, M Basar, N Semerci, U Kayisli, I Buhimschi, J Huang, S Mesiano, F Schatz, and C Lockwood. Columbus, OH, USA and Cleveland, OH, USA.

T-042

Phosphodiesterase Inhibition in Combination with Progesterone Treatment Can Inhibit Inflammation-Induced Preterm Labour in Mice. Bronwen R Herbert, Angela Yulia, Suren R Sooranna, and Mark R Johnson. London, United Kingdom.

T-043 Timing of Embryo Implantation and Uterine Contractility Do Not Account for Delayed Parturition in Cycloxygenase-1 Knockout Mice. Jennifer Herington, Christine O’Brien, Naoko Brown, Bibhash C Paria, and Jeff Reese. USA.

Clinical Perinatology T-044

Quantitative PCR Highly Correlates with the Nugent Score. Adi Abramovici, Elena Lobashevsky, Susan P Cliver, John C Hauth, and Joseph R Biggio. USA.

T-045

Quantitative PCR for the Assessment of Vaginal Bacterial Load in the Setting of Antibiotic Therapy. Adi Abramovici, Elena Lobashevsky, Susan P Cliver, John C Hauth, and Joseph R Biggio. USA.

T-046

Quantitative PCR: A Tool for Preterm Birth Prediction? Adi Abramovici, Elena Lobashevsky, Susan P Cliver, John C Hauth, and Joseph R Biggio. USA.

T-047 Outcomes Associated with Maternal Tobacco Use in the Setting of Gestational Diabetes. Adi Abramovici, Luisa Wetta, Alan Tita, Joseph R Biggio, and Lorie M Harper. USA. T-048

Cerclage in Triplet Pregnancy. Eduardo J Aguin, Elizabeth S Langen, Cosmas Van De Ven, and Marjorie Treadwell. Ann Arbor, MI, USA.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

19A

Thursday, March 27, 2014 - Poster Session I - Affari T-049

Cesarean Delivery and Blood Gases after Prolonged Second Stage of Labor. Eduardo J Aguin, Sarah Wallet, Michelle Housey, Marjorie Treadwell, and Cosmas Van De Ven. Ann Arbor, MI, USA.

T-058

T-050

Association of Residency Training Experience with Instrument Choice for Operative Vaginal Delivery in Practice. Sasha Andrews, Amanda Allshouse, Gaea Moore, Meredith Alston, and Torri D Metz. Aurora, CO, USA and Denver, CO, USA.

T-059 Weight Loss in Obese Pregnant Women and Pregnancy Outcomes: A Systematic Review. Annick Bogaerts, Dorien Lanssens, and Roland Devlieger. Hasselt, Limburg, Belgium; Belgium and Leuven, Belgium.

T-051 The Use of Plasma Endocannabinoids to Predict the Time of Delivery in Asymptomatic Women at ‘High-Risk’ of Preterm Birth. Panayoti Bachkangi, Anthony H Taylor, and Justin C Konje. Leicester, Leicestershire, United Kingdom. T-052

T-060

Cesarean Delivery and Risk for Subsequent Spontaneous Abortion. Zachary S Bowman, Ken R Smith, and Robert M Silver. Salt Lake City, UT, USA.

T-061

Prevalence of Antiphospholipid Antibodies and Risk of Subsequent Adverse Obstetrical Outcomes in Women with Prior Pregnancy Loss. Zachary S Bowman, Vera Wuenshe, TF Porter, Robert M Silver, and DW W Branch. Salt Lake City, UT, USA.

Prediction of Preterm Birth Risk Using a Single Blood Test. Panayoti Bachkangi, Anthony H Taylor, and Justin C Konje. Leicester, United Kingdom.

T-053 The Effect of Electronic Medical Record Implementation on Medication Errors in Peripartum Care Areas. Joel Barkely, Linda Chambliss, and Robert Garfield. Phoenix, AZ, USA. T-054

Pregnancy Following Cerebral Metastasis from Choriocarcinoma. Joseph Tharakan, and Laxmi V Baxi. Poughkeepsie, NY, USA and New York, NY, USA.

T-055

Fetal Repair of Myelomeningocele. Kelly A Bennett, Mary A Carroll, Stephane Braun, Mary E Dabrowiak, Alicia K Crum, Ray L Paschall, Ann L Kavanaugh-McHugh, Chevis N Shannon, and Noel B Tulipan. Nashville, TN, USA.

T-056

Maternal Characteristics Combined with Early Pregnancy SHBG and HbA1c Predict Fetal Overgrowth. Erica Berggren, Jennifer Culhane, Kevin Moss, Catherine Ford, and Kim Boggess. Philadelphia, PA, USA and Chapel Hill, NC, USA.

T-057 Early Pregnancy Maternal BMI Predicts First Trimester HbA1c Values among Obese, but Not Non-Obese, Women. Erica Berggren, Kim Boggess, Leny Mathew, and Jennifer Culhane. Philadelphia, PA, USA and Chapel Hill, NC, USA.

Congenital Heart Disease and Perinatal Outcomes. Dana Henry, Jensara Clay, Juan M Gonzalez, Ian S Harris, Hannah Tilden, and Katherine Bianco. San Francisco, CA, USA.

T-062 Is 40 the New 30? Pregnancy Outcomes by Degree of Weight Gain among Obesity Subclasses. Annelee Boyle, Julia Timofeev, Torre Halscott, Sameer Desale, Rita W Driggers, and Patrick S Ramsey. USA. T-063 Does Maternal Obesity Affect Offspring Intelligence Quotient (IQ)? Sara G Brubaker, Noelia Zork, Caroline Pessel, Cynthia Gyamfi-Bannerman, and Cande V Ananth. New York, NY, USA. T-064

Placental Biometry in Male and Female Fetuses of Obese and Normal Weight Women. S Calabrese, C Mando’, M Mazzocco, GM Anelli, C Novielli, and I Cetin. Italy.

T-065

Combined Fetal Fibronectin and Saliva Progesterone Measurement for Prediction of Spontaneous Preterm Birth. Jenny Carter, Natasha L Hezelgrave, Paul T Seed, Rachel M Tribe, Anna David, Gillian Lachelin, Andrew H Shennan, and Lucilla Poston. London, United Kingdom.

T-066 Insulin Response in Early Pregnancy Is Independent of Insulin Resistance. Patrick M Catalano, Larraine P Presley, and Saeid B Amini. Cleveland, OH, USA.

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Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Poster Session I - Affari T-067 The Sky High Costs of Air Ambulance Transport of Patients in Suspected Preterm Labor. Linda R Chambliss, Miha Luconvik, and Robert Garfield. Phoenix, AZ, USA and Ljublijana, Slovenia.

T-076

Further Evidence for the Involvement of Two Functional Polymorphisms in Folate Metabolising Genes, SHMT1(1420)T and MTRR(66)A, with an Increased Risk of Early Spontaneous Preterm Birth from the PGP Consortium GWAS. N McCarthy, RJ Cunneen, W Ang, MK White, M Merialdi, M Katz, S Williams, D Olson, SJ Lye, R Menon, E Moses, and CE Pennell. Australia; Switzerland; USA and Canada.

T-077

The Relationship between Metabolic Profile, Maternal Diet and Gestational Diabetes Mellitus: A Case-Control Study. Jamie de Seymour, Cathryn Conlon, Karolina Sulek, Silas Vilas-Boas, Louise Kenny, and Philip Baker. New Zealand and Ireland.

T-078

T-071 Insulin Resistance and Gestational Weight Gain in Non-Diabetic Women. Rebecca G Clifton, . Bethesda, MD, USA.

Patients Managed in a High Risk Obstetrical Clinics with Diabetes Class A2 but Not Class B Are More Likely to Have Large Newborns. Valeria Di Stefano, Revital Faro, David Blitzer, Marlene Schwebel, and Joaquin Santolaya-Forgas. USA.

T-079

T-072 Does Prolong Preterm Premature Rupture of the Membranes Influence the Neonatal Outcome of Presenting Compared to NonPresenting Twin? Aviad Cohen, Avital Skornick-Rapaport, Michael Kupferminc, Ariel Many, Joseph B Lessing, and Eli Rimon. Tel-Aviv, Israel.

Placental Alpha-Microglobulin-1 in Vaginal Secretions as a Predictor of Preterm Birth in Women with Evidence of Preterm Labor. Robert M Ehsanipoor, Morgan Swank, Seung Chik Jwa, Deborah A Wing, Gofran Tarabulsi, and Karin J Blakemore. USA and Japan.

T-080

Association between Increased Exposure to Heavy Metals and Preterm Birth. Alex Fong, Erica Davenport, Allison Serra, Jonathan Steller, Steve Rad, Aaron Turner, Deyu Pan, and Dotun Ogunyemi. Orange, CA, USA; Los Angeles, CA, USA and USA.

T-081

How Low Is Too Low: Does the Percentile of Low PAPP-A Affect Pregnancy Outcomes? Janelle Foroutan, Dawnette Lewis, Kimberly Herrera, Lorien King, and Brinnne Bimson. New York, NY, USA.

T-068

Assessment of Fetal Fibronectin Testing to Improve Preterm Birth Management. Manju Chandiramani, Anita Das, Lauren A Bolt, Annemarie de Greeff, Judy Filmer, and Andrew Shennan. United Kingdom and USA.

T-069 Second Trimester Plasma Mannose-Binding Lectin Levels and Risk of Preterm Birth. Chie-Pein Chen, Yi-Yung Chen, Jian-Pei Huang, and Chang-Ching Liu. Taipei, Taiwan. T-070 Vigorous Neonates with Acidemia at Term. Cecily Clark-Ganheart, Julia Timofeev, Annelee Boyle, Samuel Smith, Rita Driggers, and Patrick Ramsey. Washington, DC, USA and Baltimore, MD, USA.

T-073 Which Factors Make the Difference in the Progression of Cervical Dilation in VBAC? Sara Consonni, Maddalena Incerti, Davide P Bernasconi, Cristina Plevani, Patrizia Vergani, and Anna Locatelli. Monza, Italy. T-074 Vacuum Delivery: The Impact of Good Obstetric Practice on Main Outcomes. Sara Consonni, Serena Mussi, Cristina Plevani, Armando Pintucci, Anna Locatelli, Marta Ratti, Maddalena Incerti, Virginio Meregalli, and Patrizia Vergani. Monza, Italy and Carate Brianza, Italy. T-075 Impact of Obesity on the Maternal Circadian Clock during Pregnancy. Rachael C Crew, Peter J Mark, and Brendan J Waddell. Perth, Western Australia, Australia.

T-082 Does the Timing of Ultrasound Affect the Ability to Predict Birthweight in Gestational Diabetes? Janelle Foroutan, Barak Rosenn, Kimberly Herrera, Ana Mrkaic, Brianne Bimson, and Lois Brustman. New York, NY, USA. T-083

How Can We Optimize Delivery to Avoid Shoulder Dystocia? Antonia P Francis, Michelle Chevalier, Ido Sirota, and Graham Ashmead. New York, NY, USA.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

21A

Thursday, March 27, 2014 - Poster Session I - Affari T-084 Does Epidural Analgesia Increase the Rate of Cesarean Section? Chiara Garo, and Anna Maria Marconi. Milano, Italy. T-085 The Impact of Maternal Age on Vaginal Delivery. Chiara Garo, Evita Calvi, and Cinzia Lucia Paolini. Milano, Italy. T-086 Risk for Adverse Neonatal Outcome in Patients with PPROM. Shari E Gelber, Aneesha Varrey, and Katherine J Sapra. New York, NY, USA. T-087 The Utility of Vitamin D Binding Protein to Predict Term and Preterm Labor. Harry Georgiou, Stella Liong, Michael Permezel, Gabrielle Fleming, and Megan Di Quinzio. Parkville, VIC, Australia and Heidelberg, VIC, Australia. T-088 Intrapartum Uterine Rupture of the Unscarred Uterus. Karen J Gibbins, Tiffany Weber, Calla M Holmgren, T Flint Porter, and Tracy A Manuck. Salt Lake City, UT, USA. T-089

Predictors for Perioperative Injury at Cesarean Delivery. Anna I Girsen, Alexander Butwick, Allison M Faucett, and Deirdre J Lyell. USA.

T-090

Predictors of Severe Perineal Complication among Women with Vaginal Birth after Cesarean Section. Anna I Girsen, Bat Zion Shachar, and Deirdre J Lyell. USA.

T-091 Epicardial Fat Thickness in Pregnancies Complicated by Diabetes Mellitus. Ravindu Gunatilake, Daniel Jackson, David Deschamps, Marvin Williams, and Dean Myers. Oklahoma City, OK, USA. T-092

Appropriate and Timely Betamethasone Administration: Can We Do Better? Stephanie Guseh, Jeffrey Ecker, and Anjali Kaimal. Boston, MA, USA.

Developmental Programming T-093 Dissociation between Vascular Telomere Shortening and Early Vascular Ageing in a Model of Developmental Programming of Cardiovascular Risk. BJ Allison, A D Kane, EJ Camm, C Lusby, JL Tarry-Adkins, SE Ozanne, and DA Giussani. United Kingdom.

T-094 Epigenetic Effects of Maternal Tobacco Use in Pregnancy on Placental Genomic Imprinting. Kelli D Barbour, Hitesh N Appaiah, Cindy T McEvoy, David M Haas, Men-Jean Lee, and Jill L Reiter. USA. T-095

Perinatal Iron Deficiency Increases Susceptibility to Diet-Induced Obesity: Effects of Prenatal Resveratrol Treatment. Stephane L Bourque, Alison S Care, and Sandra T Davidge. Edmonton, AB, Canada.

T-096 Intervention Against Programmed Cardiovascular Disease in High Risk Ovine Pregnancy. KL Brain, BJ Allison, Y Niu, CM Cross, N Itani, A D Kane, EA Herrera, and DA Giussani. United Kingdom and Chile. T-097

Long-Term Sex-Specific Effects of a Single Course of Antenatal Betamethasone Treatment on the Placental Cortisol Barrier. T Braun, F Braun, A Gramzow, L Ehrlich, A Husar, D Sloboda, J Challis, A Plagemann, and W Henrich. Germany and Canada.

T-098

Preconception Therapeutic Intervention with Fish Oil Prevents Paternal Transmission of the Toxicant-Related Endometriosis Phenotype to F2 Female Offspring. Kaylon L Bruner-Tran, Tianbing Ding, John A Lucas, Kallie B Yeoman, and Kevin G Osteen. Nashville, TN, USA.

T-099

Complications in Myocardial Perfusion and Glucose Metabolism as a Result of Low Birth-Weight and Adverse Postnatal Diet. Jacky Chiu, Jennifer Hadway, Ting Lee, and Timothy Regnault. London, ON, Canada.

T-100 Sexually Dimorphic Epigenomic Responses of Stem Cells to Extreme Fetal Growth. Fabien Delahaye, Ari N Wijetunga, Hye J Heo, Jessica N Tozour, Yong Mei Zhao, John M Greally, and Francine H Einstein. Bronx, NY, USA. T-101 TNFa Inhibition of Fetal Hippocampal Neural Progenitor Cell (NPC) Proliferation and Neuronal Differentiation Via bHLH Mechanism: Potential for Offspring Neurobehavioral Sequelae. Mina Desai, Juanita K Jellyman, Carolina Oses, Ray Abinader, Patrick Shelar, Guang Han, Marie H Beall, and Michael G Ross. USA.

22A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Poster Session I - Affari T-102

Antenatal Steroid Exposure Alters Transient Receptor Potential Cation Channels (TRPC) Function in Adult Sheep Arteries. Jeong-Heon Lee, Jie Zhang, Gabriele A Massmann, and Jorge P Figueroa. WinstonSalem, NC, USA and Jeonju, Jeonbuk, Korea.

T-103 Role of Transient Receptor Potential Channels (TRPC) on Vascular Reactivity Responses to Endothelin in Sheep Exposed Antenatally to Betamethasone. Jorge P Figueroa, Jie Zhang, and Angela G Massmann. Winston-Salem, NC, USA. T-104 Visceral Fat Modulates the Effects of Antenatal Glucocorticoids on Epicardial Fat Depots in Adult Sheep. Angela G Massmann, Jie Zhang, and Jorge P Figueroa. Winston-Salem, NC, USA.

T-110

Maternal Obesity (MO) Has an Adverse Impact on Offspring (OFF) Adipocyte Size (AS): Effects of Male Offspring Exercise (Ex) Intervention. Carlos A Ibanez-Chavez, Magaly Vazquez, Antonmaria Minzoni, Peter W Nathanielsz, and Elena Zambrano. Mexico City, DF, Mexico and San Antonio, TX, USA.

Fetus T-111

Abnormal Growth in Fetal Growth Restriction. Catherine M Albright, Joshua D Dahlke, Lindsay Maggio, Hector Mendez-Figueroa, Nina Ayala, Suneet P Chauhan, and Katharine Wenstrom. Providence, RI, USA and Houston, TX, USA.

T-112 Growth Normalization in Fetal Growth Restriction. Catherine M Albright, Joshua D Dahlke, Lindsay Maggio, Hector Mendez-Figueroa, Nina Ayala, Suneet P Chauhan, and Katharine Wenstrom. Providence, RI, USA and Houston, TX, USA.

T-105

Antenatal Exposure to Betamethasone Has Permanent Effects on Omental Fat Preadipocytes and on In Vitro Adipogenesis in Adult Sheep. Jie Zhang, Angela G Massmann, and Jorge P Figueroa. Winston-Salem, NC, USA.

T-106

Maternal Salt and Fat Intake Impairs Uterine Artery Vasodilation and Causes Endothelial Dysfunction in the Fetal Aorta, Weanling Resistance Vessels and Hypertension in Adult Offspring. Clint Gray, Clare M Reynolds, Claudia Harrison, and Mark H Vickers. Auckland, New Zealand.

T-113

Peripartum Outcomes in SGA and AGA Neonates with Antenatal Fetal Growth Restriction. Catherine M Albrigt, Joshua D Dahlke, Lindsay Maggio, Hector Mendez-Figueroa, Nina Ayala, Suneet P Chauhan, and Katharine Wenstrom. Providence, RI, USA and Houston, TX, USA.

T-107

Modifications in DNA Methylation Induced during Development Is Predictive of Later Transcriptional Changes. Hye J Heo, Jessica Tozour, Fabien Delahaye, Yongmei Zhao, Nivia Acosta, Nir Barzilai, and Francine H Einstein. Bronx, NY, USA.

T-114

Maternal Melatonin as an Antioxidant in Fetal Growth Restriction. Nicole O Alers, Yen Pham, Graham Jenkin, Suzanne L Miller, and Euan M Wallace. Australia.

T-108

T-109

Identification of Novel DNA Methylation Profiles Associated with Gene Regulation and Metabolic Pathways in Growth Restricted Offspring. Sara L Hillman, Sarah Finer, Melissa C Smart, Vardhman Rakyan, Graham A Hitman, and David J Williams. London, United Kingdom. Aggressive Behavioral Phenotype in IUGR Male Baboons. Hillary F Huber, Susan M Ford, Thad Q Bartlett, Susan L Jenkins, Brent J Thompson, and Peter W Nathanielsz. USA.

T-115 Using Ultrasound, What Best Predicts Pathologic Discordance in Diamniotic Dichorionic Twins? Brianne E Bimson, Lois Brustman, Elizabeth Murphy, Kimberly Herrera, Janelle Foroutan, and Barak Rosenn. New York, NY, USA. T-116 Does Ultrasound Accurately Predict Growth Discordance in Dichorionic Diamniotic Twins? Brianne E Bimson, Lois Brustman, Elizabeth Murphy, Janelle Foroutan, Kimberly Herrera, and Barak Rosenn. New York, NY, USA.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

23A

Thursday, March 27, 2014 - Poster Session I - Affari T-117 Does Twin Order Affect Ultrasound Ability to Predict Birth Weight? Brianne E Bimson, Elizabeth Murphy, Barak Rosenn, Janelle Foroutan, Kimberly Herrera, and Lois Brustman. New York, NY, USA.

T-124

T-118 Increased Long Chain Polyunsaturated Fatty Acids in Mid-Trimester Amniotic Fluid Are Associated with Elevated Neurotrophin Concentrations. Ann Marie Bongiovanni, Kiesha Benn, Mariana Passos, Aswathi Jayaram, Faith Esbrand, Mary Harris, Daniel Skupski, and Steven S Witkin. New York City, NY, USA; Flushing, NY, USA and Fort Collins, CO, USA.

T-125 IUGR Results in Sex- and Brain RegionSpecific Gene Responses in the Term Nonhuman Baboon. Laura A Cox, Cun Li, Thomas J McDonald, Jeremy Glenn, and Peter W Nathanielsz. USA.

T-119

Fetal Sex Specific Differences in Fetal Growth. Zoe A Brown, Sarah Schalekamp Timmermans, Albert Hofman, Vincent WV Jaddoe, and Eric Steegers. Rotterdam, Netherlands.

T-120 Gastroschisis Delivery after 37 Weeks Is Associated with Improved Neonatal Respiratory Function and Outcomes. Mary A Cain, Jean P Tanner, Jason L Salemi, Hamisu M Salihu, Valerie E Whiteman, and Russell Kirby. Tampa, FL, USA. T-121

T-122

Correlation between Average Acceleration and Deceleration Capacity of Fetal Heart Rate and Biomarkers of Acid-Base Status in a Vivo Sheep Model. M Rivolta, R Sassi, T Stampalija, D Casati, M Frasch, B Richardson, MG Ross, K Rizas, A Bauer, and E Ferrazzi. Italy; Canada and Germany. Ketamine Decreases Immune, Inflammatory, and Apoptotic Gene Expression in Ovine Fetal Hippocampus Exposed to Hypoxic Hypoxia. Eileen I Chang, Maria B Rabaglino, Elaine Richards, and Charles E Wood. Gainesville, FL, USA.

T-123 The Use of Circulating Cell Free Fetal DNA in the Maternal Blood in the Investigation of Intrauterine Fetal Demise and Miscarriage. Cecily Clark-Ganheart, Melissa Fries, Peggy Ye, Nilda Moreno, and Rita Driggers. Washington, DC, USA.

Maternal Administration of Nitrite Alters Uteroplacental Vascular Function in Mice. Elizabeth Cottrell, Ainslie Garrod, Mark Wareing, Elizabeth Cowley, Susan Greenwood, Philip Baker, and Colin Sibley. United Kingdom and New Zealand.

T-126 Effects of Maternal Alcohol Consumption and Gestational Age on Human Fetal Brain Apoptosis. Nune Darbinian, Gabriel Tatevosian, Seonhee Kim, and Laura Goetzl. Philadelphia, PA, USA. T-127

Moved to O-097

T-128

A 3-Step Algorithm for Expanded Genetic Testing: Preliminary Observations in Women at Reproductive Ages. Elena Ashkinadze, Valeria Di Stefano, Stacey Rickard, and Joaquin SantolayaForgas. New Brunswick, NJ, USA.

T-129 Development of the Fetal Primate BloodCerebrospinal Fluid (CSF) Barrier. Joakim Ek, Christine Lehner, Henrik Hagberg, Peter Nathanielsz, Carina Mallard, and Cun Li. Gothenburg, Sweden; Salzburg, Austria and San Antonio, USA. T-130

Maternal Nutrient Restriction (MNR) in Pregnant Guinea Pigs Impacts FetalPlacental Growth and Erythropoietin (EPO): Implications for Regulatory Mechanisms. Alexander A Elias, Brad Matushewski, Lin Zhao, Timothy RH Regnault, and Bryan S Richardson. London, ON, Canada.

T-131 Decoding Fetal Brain-Gut Communication during Systemic Inflammation. HL Liu, L Garzoni, LD Durosier, M Cao, C Herry, P Burns, P-Y Mulon, G Fecteau, A Desrochers, C Faure, and MG Frasch. Canada.

24A

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

Scientific Program Schedule

Thursday, March 27, 2014 - Poster Session I - Affari Placenta T-132 Gestational Diabetes Is Associated with Increased Activity of the Placental mTOR Pathway: Characterisation of Mechanisms Controlling Trophoblast Differentiation and Endocrine Function. Isma Alkawafi, Muhammad F Bari, Manu Vatish, and Dimitris Grammatopoulos. Coventry, West Midlands, United Kingdom and Oxford, United Kingdom. T-133

T-134

T-135

Mitochondrial Biogenesis Is Reduced in IUGR Placental Trophoblast Cells. Gaia Maria Anelli, Chiara Mando, Chiara Novielli, Carlo Personeni, and Irene Cetin. Milan, Italy. Effect of Folate Deficiency In Vitro on Placental Amino Acid Transport. Bernadette C Baker, Susan L Greenwood, Karen Forbes, Alexander EP Heazell, and Rebecca L Jones. Manchester, United Kingdom.

T-140 Is Short Cervix a Useful Predictor of Emergent Delivery for Hemorrhage in Placenta Previa? T Stewart Boulis, Justin Weprin, Jalpa Shah, Cristina Sison, and Natalie Meirowitz. USA. T-141

Abstract Withdrawn

T-142

Fetal Sex Specific Differences in Markers of Human Placentation. Zoe A Brown, Sarah Schalekamp Timmermans, Henning W Tiemeier, Albert Hofman, Vincent WV Jaddoe, and Eric AP Steegers. Rotterdam, Netherlands.

T-143 Study of the Effect of Docosahexaenoic Acid (DHA) on Trophoblast Cells Migration In Vitro. Jorge A Carvajal, Gloria L Valdes, and Ana M Delpiano. Santiago, Chile. T-144

Proteasome Inhibition Increases Soluble Vascular Endothelial Growth Factor (sFlt1) Secretion from Human Trophoblast. J Bartley, B Campo, L Hiebert, and KP Conrad. Gainesville, FL, USA.

T-145

Characterizing Villitis of Unknown Etiology in Stillbirth. Hayley Derricott, Rebecca Lee Jones, Gauri Batra, and Alexander EP Heazell. United Kingdom.

Abstract Withdrawn

T-136 Exploring the Mechanism of AntiInflammatory Action for Magnesium within Perinatal Medicine. Men-Jean Lee, Haruka Suzuki-Kakisaka, and Helene B Bernstein. New York, NY, USA and Cleveland, OH, USA. T-137

Mechanisms of Telomere Shortening in IUGR Placentas. Tal Biron-Shental, Rivka Sukenik Halevy, Yudith Sharon, and Aliza Amiel. Kfar Saba, Israel; Tel Aviv, Israel and Ramat Gan, Israel.

T-146

Consequences of Reduced Taurine Levels for Renewal of Human Placental Syncytiotrophoblast. Michelle Desforges, Marcus J Price, Chloe R Hirst, Colin P Sibley, and Susan L Greenwood. Manchester, United Kingdom.

T-138

Biglycan Promotes Trophoblast Motility through AKT Signaling. Alexandre U Borbely, Peter Haslinger, Katarzyna Biadasiewicz, Silvana Sandri, Karen Steponavicius-Cruz, Sergio F Oliveira, Gudrun Meinhardt, Gerlinde Otti, Valerie Fock, Christian Fiala, Jurgen Pollheimer, Martin Knofler, and Estela Bevilacqua. Brazil and Austria.

T-147

Maternal Obesity Gives Decreased Placental NO, Antioxidant Capacity, and SOD Activity. LaShauna C Evans, and Leslie Myatt. USA.

T-139 IUGR Following Maternal Magnesium (Mg) Deficiency in Mice Is Accompanied by Reduced Placental Weight and Increased Fetal Demises: Evidence for Impaired Placental Growth and Health. Madhu Gupta, Nisha Nanda, T Stewart Boulis, Malvika H Solanki, Xue Xiangying, Burton Rochelson, and Christine N Metz. NY, USA.

T-148 Low First Trimester PAPP-A Does Not Predict Adverse Pregnancy Outcome in High Risk Women. Karen Florio, Ye Peng, Janet Catov, W Tony Parks, and Kriistina Parviainen. Pittsburgh, PA, USA. T-149

First Trimester Pregnancy-Associated Plasma Protein A (PAPP-A) and Placental Size in Women with Adverse Pregnancy Outcomes. Karen Florio, W Tony Park, Ye Peng, Janet Catov, and Kriistina Parviainen. Pittsburgh, PA, USA.

Scientific Program Schedule

Reproductive Sciences Vol. 21, No. 3 (Supplement), March 2014

25A

Thursday, March 27, 2014 - Poster Session I - Affari T-150

T-151

T-152

Placental Autophagy in Early Human Pregnancy. Chiara Garo, Laura Avagliano, Eleonora Virgili, Carla Martinelli, Gaetano Bulfamante, and Anna Maria Marconi. Milano, Italy and Milan, Milano, Italy. Placental Serotonin Transporter (SERT) Is Modified by Maternal Opioid Exposure: Implications for Altered Fetal Vulnerability with Multi-Substance Use. Laura Goetzl, Nune Darbinian, C Lindsay Devane, and Sammanda Ramamoorthy. Philadelphia, PA, USA; Richmond, VA, USA and Charleston, SC, USA. Protease-Activated-Receptor-2 Affects Protease-Activated-Receptor-1 Placenta Extravillous Trophoblast Invasion. Sorina Grisaru-Grnaovsky, Mohammad Jaber, Arun Kancharla, Myriam Maoz, and Rachel Bar-Shavit. Jerusalem, Israel.

T-153 1,25(OH)2D3 Suppresses Oxidative Stress-Induced COX-2 Up-Regulation and Thromboxane Production by Placental Trophoblast Cells. Yang Gu, Jingxia Sun, Weijie Zhong, Lynn J Groome, and Yuping Wang. Shreveport, LA, USA and Harbin, Heilongjiang, China. T-154

Inflammatory Cytokine Secretion by Endothelial Cells Is Specifically Enhanced by Placental-Derived TNF-α: Implications in Preeclampsia (PE). Seth Guller, Jeff Shaw, Zhonghua Tang, Henning Schneider, and Stefan R Hansson. USA; Berne, Switzerland and Lund, Sweden.

T-155 Expression and Function of p32/gC1qR in the Human Placenta. Patricia Matos, James Horn, Frances Beards, Sylvia Lui, Michelle Desforges, and Lynda K Harris. United Kingdom. T-156 The alpha-Arrestin ARRDC3 Is Expressed by Trophoblast and Impacts Trophoblast Cell Migration. Audrey Hertenstein, Paula Marin, Victoria Gore, Josephine Ko, Melissa Sanchez, Parth Patwari, and Wendy Kuohung. Boston, MA, USA. T-157 Umbilical Artery PI/RI Fail to Detect Aberrant Placental Arterial Function in Reduced Fetal Movement Pregnancies. Lucy E Higgins, Colin P Sibley, Mark Wareing, Edward D Johnstone, and Alexander EP Heazell. United Kingdom.

T-158

Aberrant DNA Methylation in DeciduaPlacental Interface in Common Trisomies. Sahar Houshdaran, and Katherine Bianco. San Francisco, CA, USA.

T-159

Screening, Identification and Preliminary Investigation of Target Transporters in Pregnancy Pathologies. Xiao Huang, Edgar C Ontsouka, Michael P Luthi, Matthias A Hedigar, Marc U Baumann, Daniel V Surbek, Pascale Anderle, and Christiane Albrecht. Switzerland and Bern, Switzerland.

T-160 Network Biology Used to Integrate Omic Datasets, Providing Novel Targets to Understand the Effect of Hyperglycemia on the Trophoblast. Charlotte H Hulme, Melissa Westwood, Adam Stevens, Katherine Hollywood, Paul Begley, Warwick Dunn, Alexander E Heazell, and Jenny Myers. United Kingdom. T-161 The Small Placenta: Who Are the Babies with Placental Weight