Abstracts of the 19th Annual Meeting of The Perinatal Society of Australia and New Zealand


Abstracts of the 19th Annual PSANZ Congress

CONCURRENT SESSION 1: MONDAY 20 APRIL MORNING Neurodevelopment & neuroprotection A001

FETAL GROWTH RESTRICTION AND PRETERM BIRTH MAY LEAD TO DISTURBED SLEEP IN CHILDHOOD Yiallourou SR1,2, Hollis S1, Odoi A1, Weichert A1, Wallace EM1,2,3, Horne RSC1,2 1 The Ritchie Centre, MIMR-PHI Institute of Medical Research, 2 Department of Paediatrics, Monash University, Clayton, Australia, 3 Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia Email: [email protected] Background: Fetal growth restriction (FGR) is associated with increased risk of prematurity and neurodevelopmental impairment. FGR also alters sleep state distribution in utero and delays circadian rhythm maturation in infancy. Currently, limited data on the long-term effects of FGR on childhood sleep exist. Given that sleep is important for neurodevelopment and that poor sleep can lead to impairments in neurocognition, we assessed the effect of FGR on sleep in children aged between 5 and 12 years. Method: 11 children born preterm and FGR (gestation at birth: 30 ± 1 wks, birthweight: 1117 ± 125 g), 6 children born preterm but appropriately grown (AGA) (gestation at birth: 30 ± 1 wks, birthweight: 1627 ± 331 g) and 10 term-born, appropriately grown children (controls) were studied using overnight polysomnography. Non-rapid eye movement (NREM) and rapid-eye movement sleep (REM) were scored in the following stages NREM1, NREM2 (N2), NREM3 (N3) and REM sleep. There were no differences in age or weight at the time of testing between the three groups. Results: Compared to term and preterm AGA children, FGR children had a higher amount of N2 (p < 0.05) and a lower amount of N3 (p < 0.05). Preterm AGA children had reduced sleep efficiency compared to IUGR and term children (p < 0.05). Conclusions: Prematurity and FGR have long-lasting effects on childhood sleep. N3 sleep is important for brain maturation and memory consolidation. Sleep disturbance and its impact on neurodevelopment in FGR and preterm children warrants further investigation as a means of mitigating neurodevelopmental impairment in preterm children, whether born FGR or not. A002

REDUCED CONNECTIVITY IN 7-YEAR-OLD PRETERM BRAIN NETWORKS RELATES TO ADVERSE PERINATAL EVENTS, COGNITIVE AND MOTOR IMPAIRMENT Thompson DK1,2,3, Chen J1, Beare R1, Adamson C1, Ahmadzai ZM1, Kelly CE1, Inder TE4, Doyle LW1,5, Seal M1, Anderson PJ1,3 1 Murdoch Childrens Research Institute, Melbourne, Australia, 2Florey Institute of Neuroscience & Mental Health, Melbourne, Australia, 3 Paediatrics, University of Melbourne, Australia, 4Brigham & Women’s Hospital, Boston, United States, 5Royal Women’s Hospital, Melbourne, Australia Email: [email protected]

reduced connectivity in a frontal network (p = 0.054). Major brain abnormality at term related to reduced connectivity in the occipital and parietal lobes, thalamus and putamen (p = 0.013). Impaired IQ was associated with reduced connectivity in a diffuse network (p = 0.051). VP children with motor impairment had reduced connectivity in the right parietal and temporal lobes (p = 0.052). Conclusions: Adverse perinatal events have a lasting negative impact on white matter connectivity. Structural connectivity reveals brain networks underlying impairments in VP children. A003

POSITIVE PARENTING BEHAVIOUR AT 2 YEARS PREDICTS CHILD SCHOOL-AGE PERFORMANCE AT 7 YEARS IN VERY PRETERM CHILDREN Treyvaud K1,2, Doyle LW1,2,3, Ure A1, Lee KJ1,2, Inder TE4, Anderson PJ1,2 1 Murdoch Childrens Research Institute, Melbourne, Australia, 2The University of Melbourne, Melbourne, Australia, 3The Royal Women’s Hospital, Melbourne, Australia, 4Brigham and Women’s Hospital, Boston, United States Email: [email protected] Background: Parenting influences child development, but it is uncertain whether early parenting can predict school age outcomes in very preterm (VPT) children, and whether parenting influences all “at-risk” children equally (differential susceptibility model). This was examined in the current study. Method: Participants were 147 children born

Abstracts of the 19th Annual Meeting of The Perinatal Society of Australia and New Zealand (PSANZ), 19-22 April 2015, Crown Promenade, Melbourne, Australia.

Abstracts of the 19th Annual Meeting of The Perinatal Society of Australia and New Zealand (PSANZ), 19-22 April 2015, Crown Promenade, Melbourne, Australia. - PDF Download Free
1MB Sizes 42 Downloads 60 Views