This article was downloaded by: [New York University] On: 01 July 2015, At: 06:53 Publisher: Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Human Vaccines & Immunotherapeutics Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/khvi20
Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination a
a
b
c
b
Heba Elrashidy , Gamal El-Didamony , Ashraf Elbahrawy , Alaa Hashim , Ahmed Alashker , d
b
b
Mohamed Hanafy Morsy , Ahmed Elwassief , Amr Elmestikawy , Abdallah Mahmoud b
b
e
f
Abdallah , Abdel-Gawad Saeid Mohammad , Mohamed Mostafa , Nilly M George & Hafez b
Abdelhafeez a
Department of Microbiology and Botany; Faculty of Science; Al-Zakazik University; AlZakazik, Egypt b
Click for updates
Department of Internal Medicine; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt c
Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Asyut, Egypt d
Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Cairo, Egypt e
Department of Pediatrics; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt
f
Department of Botany; Faculty of Science, Al-Zakazik University; Al-Zakazik, Egypt Published online: 19 Jun 2014.
To cite this article: Heba Elrashidy, Gamal El-Didamony, Ashraf Elbahrawy, Alaa Hashim, Ahmed Alashker, Mohamed Hanafy Morsy, Ahmed Elwassief, Amr Elmestikawy, Abdallah Mahmoud Abdallah, Abdel-Gawad Saeid Mohammad, Mohamed Mostafa, Nilly M George & Hafez Abdelhafeez (2014) Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination, Human Vaccines & Immunotherapeutics, 10:8, 2336-2341, DOI: 10.4161/ hv.29521 To link to this article: http://dx.doi.org/10.4161/hv.29521
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any
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Research Paper Research Paper
Human Vaccines & Immunotherapeutics 10:8, 2336–2341; August 2014; © 2014 Landes Bioscience
Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination 1 Department of Microbiology and Botany; Faculty of Science; Al-Zakazik University; Al-Zakazik, Egypt; 2Department of Internal Medicine; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt; 3Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Asyut, Egypt; 4Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Cairo, Egypt; 5Department of Pediatrics; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt; 6Department of Botany; Faculty of Science, Al-Zakazik University; Al-Zakazik, Egypt
Downloaded by [New York University] at 06:53 01 July 2015
Keywords: Children, Egypt, HBV, IDDM, occult HBV infection, vaccination Abbreviations: HB, hepatitis B; IDDM, insulin-dependent diabetes mellitus; anti-HBs, antibody to hepatitis B surface antigen; HBsAg, hepatitis B surface antigen; anti-HBc, antibody to hepatitis B core antigen; DM, diabetes mellitus; HbA1c, glycated hemoglobin; HBV, hepatitis B virus; OBI, occult hepatitis B infection
Background: The prevalence of occult hepatitis B (HB) infection (OBI) in HB-vaccinated diabetic children has not yet been tested. Here, we aimed to determine the prevalence of OBI among HB-vaccinated children and adolescents with insulin-dependent diabetes mellitus (IDDM). Results: Eighty-seven (51.2%) children had a titer for antibodies to HB surface antigen (anti-HBs) of 100 IU/L. Among those IDDM children with anti-HBs ≥ 10 IU/L, the mean duration of IDDM was 2 ± 0.66 y and the mean HbA1c was 6.89% ± 1.78%. Children with anti-HBs < 10 IU/L Eighty-seven children had an anti-HBs titer of 0.05). The healthy group included 16 (37.21%) males and 27 (62.79%) females, and the IDDM group included 23 (52.27%) males and 21 (47.73%) females. The mean anti-HBs titers were 1.93 ± 3.17 IU/L and 2.46 ± 2.44 IU/L among healthy and IDDM children, respectively (P = 0.38). Among the IDDM children with anti-HBs titer of
Human Vaccines & Immunotherapeutics Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/khvi20
Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination a
a
b
c
b
Heba Elrashidy , Gamal El-Didamony , Ashraf Elbahrawy , Alaa Hashim , Ahmed Alashker , d
b
b
Mohamed Hanafy Morsy , Ahmed Elwassief , Amr Elmestikawy , Abdallah Mahmoud b
b
e
f
Abdallah , Abdel-Gawad Saeid Mohammad , Mohamed Mostafa , Nilly M George & Hafez b
Abdelhafeez a
Department of Microbiology and Botany; Faculty of Science; Al-Zakazik University; AlZakazik, Egypt b
Click for updates
Department of Internal Medicine; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt c
Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Asyut, Egypt d
Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Cairo, Egypt e
Department of Pediatrics; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt
f
Department of Botany; Faculty of Science, Al-Zakazik University; Al-Zakazik, Egypt Published online: 19 Jun 2014.
To cite this article: Heba Elrashidy, Gamal El-Didamony, Ashraf Elbahrawy, Alaa Hashim, Ahmed Alashker, Mohamed Hanafy Morsy, Ahmed Elwassief, Amr Elmestikawy, Abdallah Mahmoud Abdallah, Abdel-Gawad Saeid Mohammad, Mohamed Mostafa, Nilly M George & Hafez Abdelhafeez (2014) Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination, Human Vaccines & Immunotherapeutics, 10:8, 2336-2341, DOI: 10.4161/ hv.29521 To link to this article: http://dx.doi.org/10.4161/hv.29521
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any
Downloaded by [New York University] at 06:53 01 July 2015
form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Research Paper Research Paper
Human Vaccines & Immunotherapeutics 10:8, 2336–2341; August 2014; © 2014 Landes Bioscience
Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination 1 Department of Microbiology and Botany; Faculty of Science; Al-Zakazik University; Al-Zakazik, Egypt; 2Department of Internal Medicine; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt; 3Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Asyut, Egypt; 4Department of Clinical Pathology; Al-Azhar School of Medicine, Al-Azhar University; Cairo, Egypt; 5Department of Pediatrics; Al-Azhar School of Medicine; Al-Azhar University; Cairo, Egypt; 6Department of Botany; Faculty of Science, Al-Zakazik University; Al-Zakazik, Egypt
Downloaded by [New York University] at 06:53 01 July 2015
Keywords: Children, Egypt, HBV, IDDM, occult HBV infection, vaccination Abbreviations: HB, hepatitis B; IDDM, insulin-dependent diabetes mellitus; anti-HBs, antibody to hepatitis B surface antigen; HBsAg, hepatitis B surface antigen; anti-HBc, antibody to hepatitis B core antigen; DM, diabetes mellitus; HbA1c, glycated hemoglobin; HBV, hepatitis B virus; OBI, occult hepatitis B infection
Background: The prevalence of occult hepatitis B (HB) infection (OBI) in HB-vaccinated diabetic children has not yet been tested. Here, we aimed to determine the prevalence of OBI among HB-vaccinated children and adolescents with insulin-dependent diabetes mellitus (IDDM). Results: Eighty-seven (51.2%) children had a titer for antibodies to HB surface antigen (anti-HBs) of 100 IU/L. Among those IDDM children with anti-HBs ≥ 10 IU/L, the mean duration of IDDM was 2 ± 0.66 y and the mean HbA1c was 6.89% ± 1.78%. Children with anti-HBs < 10 IU/L Eighty-seven children had an anti-HBs titer of 0.05). The healthy group included 16 (37.21%) males and 27 (62.79%) females, and the IDDM group included 23 (52.27%) males and 21 (47.73%) females. The mean anti-HBs titers were 1.93 ± 3.17 IU/L and 2.46 ± 2.44 IU/L among healthy and IDDM children, respectively (P = 0.38). Among the IDDM children with anti-HBs titer of
