Gen. Pharmac.Vol. 23, No. 5, pp. 827432, 1992 Printed in Great Britain. All rights reserved
0306-3623/92$5.00+ 0.00 Copyright © 1992PergamonPress Ltd
ABSENCE OF MITOCHONDRIAL fl-ADRENOCEPTORS IN GUINEA PIG MYOCARDIUM: EVIDENCE FOR TISSUE DISPARITY FRASER D. RUSSELL,PETER MOLENAARand ROGER J. SUMMERS* Department of Pharmacology, University of Melbourne, Parkville, 3052 Victoria, Australia [Fax 61(03) 347-1452] (Received 7 February 1992) Abatract--1. Binding sites in guinea pig myocardial tissue labelled by (-)-[t2SI]cyanopindolol (CYP) were investigated using differential centrifugation and autoradiographic techniques. Autoradiographs of myocardial sections (0.1/~m) indicated (-)-[125I]CYP binding to sarcolemmal membrane. A low density of binding sites was observed to mitochondria. 2. Binding studies were performed in subcellular fractions. The density of binding sites in the mitochondrial fraction (36.1 +9.4fmol/mg protein) was
0306-3623/92$5.00+ 0.00 Copyright © 1992PergamonPress Ltd
ABSENCE OF MITOCHONDRIAL fl-ADRENOCEPTORS IN GUINEA PIG MYOCARDIUM: EVIDENCE FOR TISSUE DISPARITY FRASER D. RUSSELL,PETER MOLENAARand ROGER J. SUMMERS* Department of Pharmacology, University of Melbourne, Parkville, 3052 Victoria, Australia [Fax 61(03) 347-1452] (Received 7 February 1992) Abatract--1. Binding sites in guinea pig myocardial tissue labelled by (-)-[t2SI]cyanopindolol (CYP) were investigated using differential centrifugation and autoradiographic techniques. Autoradiographs of myocardial sections (0.1/~m) indicated (-)-[125I]CYP binding to sarcolemmal membrane. A low density of binding sites was observed to mitochondria. 2. Binding studies were performed in subcellular fractions. The density of binding sites in the mitochondrial fraction (36.1 +9.4fmol/mg protein) was
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