Cerebellum DOI 10.1007/s12311-014-0550-y
ORIGINAL PAPER
Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing Jitka Hüttlova & Zora Kikinis & Milos Kerkovsky & Sylvain Bouix & Mai-Anh Vu & Nikos Makris & Martha Shenton & Tomas Kasparek
# Springer Science+Business Media New York 2014
Abstract Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional
anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n=7), and those with normal performance, the SQnorm group (n=17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn
Jitka Hüttlova and Zora Kikinis, both authors, contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s12311-014-0550-y) contains supplementary material, which is available to authorized users. J. Hüttlova : T. Kasparek (*) Department of Psychiatry, Masaryk University and University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic e-mail: [email protected] J. Hüttlova : T. Kasparek Behavioral and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Zerotinovo nam. 9, 601 77 Brno, Czech Republic Z. Kikinis : S. Bouix : M.
ORIGINAL PAPER
Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing Jitka Hüttlova & Zora Kikinis & Milos Kerkovsky & Sylvain Bouix & Mai-Anh Vu & Nikos Makris & Martha Shenton & Tomas Kasparek
# Springer Science+Business Media New York 2014
Abstract Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional
anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQabn group (n=7), and those with normal performance, the SQnorm group (n=17). Schizophrenia patients of the SQnorm subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQabn subgroup did not differ from the controls. However, the SQabn subgroup showed impaired integrity of the left SCP, whereas the SQnorm subgroup did not. Abnormalities in the right CST in the SQnorm and in the left SCP in SQabn groups suggest that the patients with SQabn
Jitka Hüttlova and Zora Kikinis, both authors, contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s12311-014-0550-y) contains supplementary material, which is available to authorized users. J. Hüttlova : T. Kasparek (*) Department of Psychiatry, Masaryk University and University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic e-mail: [email protected] J. Hüttlova : T. Kasparek Behavioral and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Zerotinovo nam. 9, 601 77 Brno, Czech Republic Z. Kikinis : S. Bouix : M.
