ONCOLOGY LETTERS 8: 1470-1476, 2014
1470
Aberrant expression of NEK2 and its clinical significance in non‑small cell lung cancer XINWEN ZHONG1, XIAOJIAO GUAN2,3, WENKE LIU1 and LIN ZHANG1 1
Department of Thoracic Surgery, The First Clinical College; 2Department of Pathology, The Second Clinical College; 3 Department of Pathology, Basic Science College, China Medical University, Shenyang, Liaoning, P.R. China Received October 5, 2013; Accepted March 27, 2014 DOI: 10.3892/ol.2014.2396
Abstract. The purpose of the present study was to identify a potential biomarker that is more effective than those already available for the prognosis of non‑small cell lung cancer (NSCLC) patients. The expression of never in mitosis gene A (NIMA)‑related kinase 2 (NEK2), minichromosome maintenance complex component 7 (Mcm7) and Ki67 was evaluated in 270 NSCLC tissues using immunohistochemical and immunofluorescence techniques. Associations between protein expression and clinicopathological characters were assessed, and the impact on overall survival was analyzed. High levels of NEK2, Mcm7 and Ki67 expression were detected in 25.9, 35.2 and 24.4% of the NSCLC tissues. Overexpression of NEK2 was detected more frequently in cases with high T and N stages (P
1470
Aberrant expression of NEK2 and its clinical significance in non‑small cell lung cancer XINWEN ZHONG1, XIAOJIAO GUAN2,3, WENKE LIU1 and LIN ZHANG1 1
Department of Thoracic Surgery, The First Clinical College; 2Department of Pathology, The Second Clinical College; 3 Department of Pathology, Basic Science College, China Medical University, Shenyang, Liaoning, P.R. China Received October 5, 2013; Accepted March 27, 2014 DOI: 10.3892/ol.2014.2396
Abstract. The purpose of the present study was to identify a potential biomarker that is more effective than those already available for the prognosis of non‑small cell lung cancer (NSCLC) patients. The expression of never in mitosis gene A (NIMA)‑related kinase 2 (NEK2), minichromosome maintenance complex component 7 (Mcm7) and Ki67 was evaluated in 270 NSCLC tissues using immunohistochemical and immunofluorescence techniques. Associations between protein expression and clinicopathological characters were assessed, and the impact on overall survival was analyzed. High levels of NEK2, Mcm7 and Ki67 expression were detected in 25.9, 35.2 and 24.4% of the NSCLC tissues. Overexpression of NEK2 was detected more frequently in cases with high T and N stages (P
