Accepted Manuscript Title: A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma Author: Christopher Cao David Tian John Park James Allan Kristopher A. Pataky Tristan D. Yan PII: DOI: Reference:

S0169-5002(13)00540-0 http://dx.doi.org/doi:10.1016/j.lungcan.2013.11.026 LUNG 4497

To appear in:

Lung Cancer

Received date: Revised date: Accepted date:

10-9-2013 25-11-2013 28-11-2013

Please cite this article as: Cao C, Tian D, Park J, Allan J, Pataky KA, Yan TD, A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma, Lung Cancer (2013), http://dx.doi.org/10.1016/j.lungcan.2013.11.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Article type: Original article Title: A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma

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Authors: Christopher Cao1,2,3, David Tian1, John Park1, James Allan1, Kristopher A.

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Pataky1, Tristan D. Yan1,4

Affiliations: The Systematic Review Unit, Collaborative Research (CORE) Group,

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Sydney, Australia1; Department of Cardiothoracic Surgery, St George Hospital,

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Sydney, Australia2; The Baird Institute for Applied Heart and Lung Surgical Research, Sydney, Australia;3 Department of Cardiothoracic Surgery, Royal Prince

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Alfred Hospital, University of Sydney, Sydney, Australia4

Keywords: mesothelioma, meta-analysis, pneumonectomy, pleurectomy, systematic

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review Abstract word count: 250

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Main text word count: 2274

Corresponding Author: Christopher Cao, Collaborative Research (CORE) Group, Sydney, Australia; e-mail: [email protected]; Phone: +61291131111 Fax: +61291133393

Disclaimers: No potential conflicts of interest. Funding: None Acknowledgements: Sunil Gupta, Thomas Nienaber, David Chandrakumar for data editing; Nil funding sources decalred.

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ABSTRACT Background

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Malignant pleural mesothelioma (MPM) is an aggressive disease of the pleural lining with a dismal prognosis. Surgical treatments of MPM with a curative intent include

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extrapleural pneumonectomy and extended pleurectomy/decortication (P/D). This

and extended P/D for selected surgical candidates.

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Methods

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meta-analysis aimed to compare the perioperative and long-term outcomes of EPP

A systematic review of the literature was performed on five electronic databases to

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identify all relevant data on comparative outcomes of extended P/D and EPP in a multimodality setting. Endpoints included perioperative mortality and morbidity, as

Results

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well as long-term overall survival.

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Seven relevant studies with comparative data on EPP (n= 632) versus extended P/D (n=513) were identified from the current literature. Comparison of these two groups demonstrated significantly lower perioperative mortality (2.9% vs 6.8%, p=0.02) and morbidity (27.9% vs 62.0%, p

A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma.

Malignant pleural mesothelioma (MPM) is an aggressive disease of the pleural lining with a dismal prognosis. Surgical treatments of MPM with a curativ...
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