J Gastrointest Canc DOI 10.1007/s12029-015-9719-y
CASE REPORT
A Report of Two Cases of Leptomeningeal Carcinomatosis Arising from Gallbladder Carcinoma Dinesh Chandra Doval 1,2 & Saud Azam 2 & Rupal Sinha 2 & Ullas Batra 1 & Anurag Mehta 3 & Avinash Rao 4
# Springer Science+Business Media New York 2015
Introduction Gallbladder carcinoma (GBC) is a rare disease around most parts of the world but is common in the northern part of India, Japan, and Chile [1]. It is a very aggressive tumor which is diagnosed in the advanced stages and has very poor prognosis. The most common site of metastasis at the time of first diagnosis is the liver [2]. Least common sites of metastasis are lung, cerebral, and osseous [3]. Leptomeningeal carcinomatosis (LMC) is among the most serious complications in cancer, and in GBC, it is rarely reported. We report two cases of GBC with LMC during the treatment without metastasis in the central nervous system (CNS).
Case Report 1 A 58-year-old normotensive, nondiabetic lady presented at our hospital in October 2011 with complaints of vomiting and pain in right upper quadrant of the abdomen of 4 months duration. She also had history of chronic constipation for 1–2 years. * Dinesh Chandra Doval [email protected] 1
Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Sector-5, Rohini, Delhi, India
2
Department of Research, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
3
Department of Laboratory Services, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
4
Department of Radiology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
Clinically, she had pallor, no icterus or pedal edema. Multiple firm mobile lymph nodes with the largest measuring 2 cm were felt in left supraclavicular region. Per abdomen examination revealed tenderness in right hypochondrium with no organomegaly. Her hematological parameters were within normal limits. Biochemical investigations showed mild derangement of alkaline phosphatase (AP, 266 U/L) and gamma-glutamyl transpeptidase (GGT, 208 U/L). Carbohydrate antigen 19–9 (CA 19–9) was within the normal limits (
CASE REPORT
A Report of Two Cases of Leptomeningeal Carcinomatosis Arising from Gallbladder Carcinoma Dinesh Chandra Doval 1,2 & Saud Azam 2 & Rupal Sinha 2 & Ullas Batra 1 & Anurag Mehta 3 & Avinash Rao 4
# Springer Science+Business Media New York 2015
Introduction Gallbladder carcinoma (GBC) is a rare disease around most parts of the world but is common in the northern part of India, Japan, and Chile [1]. It is a very aggressive tumor which is diagnosed in the advanced stages and has very poor prognosis. The most common site of metastasis at the time of first diagnosis is the liver [2]. Least common sites of metastasis are lung, cerebral, and osseous [3]. Leptomeningeal carcinomatosis (LMC) is among the most serious complications in cancer, and in GBC, it is rarely reported. We report two cases of GBC with LMC during the treatment without metastasis in the central nervous system (CNS).
Case Report 1 A 58-year-old normotensive, nondiabetic lady presented at our hospital in October 2011 with complaints of vomiting and pain in right upper quadrant of the abdomen of 4 months duration. She also had history of chronic constipation for 1–2 years. * Dinesh Chandra Doval [email protected] 1
Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Sector-5, Rohini, Delhi, India
2
Department of Research, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
3
Department of Laboratory Services, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
4
Department of Radiology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India
Clinically, she had pallor, no icterus or pedal edema. Multiple firm mobile lymph nodes with the largest measuring 2 cm were felt in left supraclavicular region. Per abdomen examination revealed tenderness in right hypochondrium with no organomegaly. Her hematological parameters were within normal limits. Biochemical investigations showed mild derangement of alkaline phosphatase (AP, 266 U/L) and gamma-glutamyl transpeptidase (GGT, 208 U/L). Carbohydrate antigen 19–9 (CA 19–9) was within the normal limits (
