Eschbach et al. Eur J Med Res (2015) 20:73 DOI 10.1186/s40001-015-0162-0
Open Access
RESEARCH
A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48 h D. Eschbach1* , T. Steinfeldt2, F. Hildebrand4, M. Frink1, K. Schöller3, M. Sassen2, T. Wiesmann2, F. Debus1, N. Vogt3, E. Uhl3, H. Wulf2, S. Ruchholtz1, H. C. Pape4 and K. Horst4
Abstract Background: An animal polytrauma model was developed, including trunk and extremity injuries combined with hemorrhagic shock and a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy. Methods: A standardized polytrauma including lung contusion, liver laceration and lower leg fracture was applied in 25 pigs. They underwent controlled haemorrhage either with a blood volume loss of 45 % and a median arterial pressure (MAP)
Open Access
RESEARCH
A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48 h D. Eschbach1* , T. Steinfeldt2, F. Hildebrand4, M. Frink1, K. Schöller3, M. Sassen2, T. Wiesmann2, F. Debus1, N. Vogt3, E. Uhl3, H. Wulf2, S. Ruchholtz1, H. C. Pape4 and K. Horst4
Abstract Background: An animal polytrauma model was developed, including trunk and extremity injuries combined with hemorrhagic shock and a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy. Methods: A standardized polytrauma including lung contusion, liver laceration and lower leg fracture was applied in 25 pigs. They underwent controlled haemorrhage either with a blood volume loss of 45 % and a median arterial pressure (MAP)
