Title

1056

Detection of FGFR3 mutations from urine sediment DNA to predict the risk of intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma Eur Urol Suppl 2015;14/2;e1056          

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Seisen T.1 , Rouprêt M. 1 , Cancel-Tassin G.2 , Léon P. 1 , Compérat E. 3 , Drouin S. 1 , Phé V. 1 , Renard-Penna R.4 , Mozer P. 1 , Cussenot O.1 1 Hopital

Pitié - Salpêtrière, Dept. of Urology, Paris, France, 2 Hopital Pitié - Salpêtrière, Dept. of Cancer Research, Paris, France, 3 Hopital

Pitié - Salpêtrière, Dept. of Pathology, Paris, France, 4 Hopital Pitié - Salpêtrière, Dept. of Radiology, Paris, France INTRODUCTION & OBJECTIVES: To assess the role of FGFR3 mutations, detected from urine sediment DNA, in intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). MATERIAL & METHODS: Freshly voided urine samples were obtained from 46 patients before undergoing RNU to treat UTUC. DNA was extracted from urine sediments to perform allele-specific PCR assays for the detection of R248C, S249C, G372C and Y375C mutations. Kaplan Meier method and log-rank test have been used to analyse IVR-free survival according to FGFR-3 status. Univariate and multivariate Cox regression analyses have been conducted to determine predictors of IVR. RESULTS: Overall, FGFR3 mutations occurred in 21 (46%) patients. The mutation in codon 249 was the most frequent (13/61%), followed by Y375C (4/19%), R248C (2/10%) and G372C (2/10%). Patients with FGFR3 mutations were more likely to develop ureteral (57% vs 40%; p=0.04) superficial (81% vs 52%; p=0.04), low-grade (67% vs 8%; p

A neurophysiological profile in Parkinson's disease with mild cognitive impairment and dementia in China.

Mild cognitive impairment (MCI) and dementia (D) are frequent features of Parkinson's disease (PD) but widely disparate criteria have been used. Our u...
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