HHS Public Access Author manuscript Author Manuscript
Ann Thorac Surg. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: Ann Thorac Surg. 2016 October ; 102(4): 1059–1066. doi:10.1016/j.athoracsur.2016.06.069.
A Multicenter Study of Volumetric Computed Tomography for Staging Malignant Pleural Mesothelioma Valerie W. Rusch, MD1, Ritu Gill, MD2, Alan Mitchell, MS3, David Naidich, MD4, David C. Rice, MD5, Harvey I. Pass, MD6, Hedy Kindler, MD7, Marc De Perrot, MD8, Joseph Friedberg, MD9,10, and on behalf of the Malignant Mesothelioma Volumetric CT Study Group* 1Memorial
2Brigham 3Cancer 4New 5MD
Sloan Kettering Cancer Center, Department of Surgery, New York, NY
and Women’s Hospital, Department of Radiology, Boston, MA
Research and Biostatistics, Seattle, WA
York University School of Medicine, Department of Radiology, New York, NY
Anderson Cancer Center, Department of Surgery, Houston, TX
York University School of Medicine and Comprehensive Cancer Center, Department of Surgery, New York, NY 7The
University of Chicago, Department of Medicine, Chicago, IL
General Hospital and Princess Margaret Hospital, Department of Surgery, Toronto,
of Pennsylvania, Department of Surgery, Philadelphia, PA
Abstract Background—Standard imaging modalities are inaccurate in staging malignant pleural mesothelioma (MPM). Single institution studies suggest that volumetric computed tomography (VolCT) is more accurate but labor intensive. We established a multicenter network to test interobserver variability, accuracy (relative to pathologic stage) and prognostic significance of semi-automated VolCT. Methods—Six institutions electronically submitted clinical and pathologic data to an established multicenter database on patients with MPM who had surgery. Institutional radiologists reviewed
Address correspondence to: Valerie W. Rusch, MD, Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave. New York, NY, 10065, [email protected]
*Group Information: A complete list of the members of the Malignant Mesothelioma Volumetric CT Study Group appears at the end of this article. 10Current address: Division of Thoracic Surgery, University of Maryland, Baltimore, MD Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Presented at the Fifty-second Annual Meeting of The Society of Thoracic Surgeons, Phoenix, AZ, Jan 23–27, 2016. Set conflict box: Dr Rice discloses a financial relationship with the Olympus Corporation. Query author on spelling of Dr Hedi L Kindler’s first name – Hedi or Hedy.
Rusch et al.
preoperative CT scans for quality then submitted via electronic network (AG mednet) to biostatistical center (BC). Two reference radiologists, blinded to clinical data, performed semiautomated tumor volume calculations using commercially available software (Vitrea Enterprise 6.0), then submitted readings to BC. Study endpoints included: feasibility of network; interobserver variability for VolCT; correlation of tumor volume to pTN stages, and overall survival (OS). Results—Of 164 cases, 129 were analyzable and read by reference radiologists. Most tumors were