IDCases 9 (2017) 104–105
Contents lists available at ScienceDirect
IDCases journal homepage: www.elsevier.com/locate/idcases
Case report
A case of suspected symptomatic Zika Neuroretinitis a,⁎
b
b
Avidesh Panday , Sherry Sandy , David King , Shivanand Ramdeen
MARK c
a
Department of Medicine, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago Department of Clinical Medical Sciences, University of the West Indies (St. Augustine), Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago c Department of Ophthalmology, Sangre Grande Hospital, Sangre Grande, Trinidad, WI, Trinidad and Tobago b
Introduction Neuroretinitis can be defined as a type of optic neuropathy whereby there is acute visual loss that is unilateral or bilateral occurring due to optic disc swelling and hard exudates arranged in a star-like pattern around the fovea [1]. This rare condition has been included in the spectra of optic neuritis which also includes retrobulbar neuritis and papillitis. The exact prevalence of neuroretinitis still remains to be elucidated based upon current literature. However much of the data identified Bartonella Henselae in Cat Scratch Disease as the most common etiology [2]. Other etiologies of neuroretinitis include infections, idiopathic and miscellaneous causes [2]. With the emergence of Zika virus and its associated neurological manifestations particularly within the Caribbean [3] it should not be surprising that there may be a direct link between neuroretinitis and Zika virus. Case report A twenty-year-old female presented with a two-month history of blurred vision as well as painful extraocular movements which progressed to the point that her daily activities were compromised. This was preceded by a viral illness consisting of fever, generalized skin rash, body and joint pain type symptoms about one month prior to the onset of symptoms. Her general examination was unremarkable and no rash was appreciated. Her neurological examination was unremarkable. Apart from a right relative afferent pupillary defect, her neuro-ophthalmological examination was unremarkable with preserved visual acuity and a normal Humphrey Visual Field. Her intra-ocular pressure was 10 mmHg on the right eye and 13 mmHg in the left eye (both within normal range). Anterior segment, chamber and vitreal assessment was normal and no media opacities detected. Fundoscopic camera revealed bilateral disc oedema with hard exudates arranged in a star like pattern at the macula (Fig. 1). Her baseline haematological test (complete blood count) as well as renal function, liver function and electrolytes inclusive of serum calcium were within normal limits. Testing for cytoplasmic-antineutrophil
⁎
cytoplasmic antibody (C-ANCA), perinuclear-antineutrophil cytoplasmic antibody (P-ANCA), anti-nuclear factor (ANF), antibody to double stranded Deoxyribonucleic Acid (Anti-dsDNA) as well as an extractable Nucleic Acid (ENA) panel was negative. Toxoplasma serology Immunoglobulin G (IgG) and Immunoglobulin M (IgM) were negative and Veneral Disease Research Laboratory (VDRL) testing for Treponema pallidum was non-reactive. A non-contrast MRI Brain was unremarkable. Her CT (computed tomography) Chest was within normal limits as were her serum ACE (angiotensin converting enzymes) levels. Discussion Neuroretinitis which is a form of optic neuropathy can be as a result of various infective and non-infective aetiologies [1]. Various causes of neuroretinitis include Bartonella Henselae [2] (most common) as well as other infections such as Toxoplasma Gondii and Treponema Pallidum, Human Immunodeficiency Virus, Idiopathic and miscellaneous causes such as Sarcoidosis. The pathogenesis of neuroretinitis is obscure but occurs due to an inflammatory response of the optic disc vasculature with fluid exudation into the peripapillary retina [4]. With leakage of fluid, the lipidrich portion penetrates into the outer plexiform layer and subsequent resolution leaves behind lipid exudates giving a macular star pattern [5]. Since the onset of the Zika epidemic in Trinidad and Tobago in February 2016, there have been 718 cases, 463 of which are confirmed cases noted in pregnancy. Thus far, for 2017, there have been confirmed births of babies with microcephaly. As of November 2016, there have been 33 suspected cases of GBS (Guillain-Barre Syndrome) for 2016, 5 of which were confirmed to be related to the Zika virus [6]. Given the history of preceding viral symptoms and the Zika epidemic in Trinidad, serology for Zika Immunoglobulin M (IgM) was done which was positive. Zika RNA testing was not available at the time. A review of the literature has revealed previous evidence of neuroretinitis in infants as well as a single case report of neuroretinitis in an immunocompromised patient with Zika [7], however in our opinion,
Corresponding author. E-mail address: [email protected] (A. Panday).
http://dx.doi.org/10.1016/j.idcr.2017.06.010 Received 20 June 2017; Received in revised form 27 June 2017; Accepted 27 June 2017 2214-2509/ © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
IDCases 9 (2017) 104–105
A. Panday et al.
[2] Kaliaperumal S, Neuroretinitis Narayan S. Update on a visual emergency and role of technology in its diagnosis. J. Biomed. Sci. Eng. 2013;6:15–9. [3] Pan American Health Organization Zika – Epidemiological Update. 12 January 2017. http://www.paho.org/hq/index.php?option=com_docman & task=doc_ view & Itemid=270 & gid=37671 & lang=en (Accessed Feb 13, 2017) [4] Fatteh N, Feldman BH, Vaphiades MS, Shah VA. Am. Acad. Ophthalmol. 2014; 2014 http://eyewiki.aao.org/Neuroretinitis#Pathophysiology (Accessed 15 February 2017). [5] Walsh FB, Hoyt WF. Neuroretinitis. Clinical Neuro-Ophthalmology. 3rd edition Baltimore, Md (MD): Williams & Wilkins Co; 1982. p. 234–5. [6] Statistics available from Office of Chief Medical Officer of Health, Ministry of Health, Trinidad and Tobago. [7] Henry CR, Al-Attar Luma, Cruz-Chacón Alexis M, Davis Janet L. Chorioretinal lesions presumed secondary to zika virus infection in an immunocompromised adult. JAMA Opthamol. 2017;135:386–9.
Fig. 1. Fundus photograph revealing bilateral disc edema as well as macular star pattern indicative of Neuroretinitis.
this represents the first suspected case of symptomatic Zika mediated neuroretinitis in an immunocompetent adult patient. References [1] Maitland CG, Miller NR. Neuroretinitis. Arch Ophthalmol. 1998;102:1146–50.
105
Contents lists available at ScienceDirect
IDCases journal homepage: www.elsevier.com/locate/idcases
Case report
A case of suspected symptomatic Zika Neuroretinitis a,⁎
b
b
Avidesh Panday , Sherry Sandy , David King , Shivanand Ramdeen
MARK c
a
Department of Medicine, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago Department of Clinical Medical Sciences, University of the West Indies (St. Augustine), Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago c Department of Ophthalmology, Sangre Grande Hospital, Sangre Grande, Trinidad, WI, Trinidad and Tobago b
Introduction Neuroretinitis can be defined as a type of optic neuropathy whereby there is acute visual loss that is unilateral or bilateral occurring due to optic disc swelling and hard exudates arranged in a star-like pattern around the fovea [1]. This rare condition has been included in the spectra of optic neuritis which also includes retrobulbar neuritis and papillitis. The exact prevalence of neuroretinitis still remains to be elucidated based upon current literature. However much of the data identified Bartonella Henselae in Cat Scratch Disease as the most common etiology [2]. Other etiologies of neuroretinitis include infections, idiopathic and miscellaneous causes [2]. With the emergence of Zika virus and its associated neurological manifestations particularly within the Caribbean [3] it should not be surprising that there may be a direct link between neuroretinitis and Zika virus. Case report A twenty-year-old female presented with a two-month history of blurred vision as well as painful extraocular movements which progressed to the point that her daily activities were compromised. This was preceded by a viral illness consisting of fever, generalized skin rash, body and joint pain type symptoms about one month prior to the onset of symptoms. Her general examination was unremarkable and no rash was appreciated. Her neurological examination was unremarkable. Apart from a right relative afferent pupillary defect, her neuro-ophthalmological examination was unremarkable with preserved visual acuity and a normal Humphrey Visual Field. Her intra-ocular pressure was 10 mmHg on the right eye and 13 mmHg in the left eye (both within normal range). Anterior segment, chamber and vitreal assessment was normal and no media opacities detected. Fundoscopic camera revealed bilateral disc oedema with hard exudates arranged in a star like pattern at the macula (Fig. 1). Her baseline haematological test (complete blood count) as well as renal function, liver function and electrolytes inclusive of serum calcium were within normal limits. Testing for cytoplasmic-antineutrophil
⁎
cytoplasmic antibody (C-ANCA), perinuclear-antineutrophil cytoplasmic antibody (P-ANCA), anti-nuclear factor (ANF), antibody to double stranded Deoxyribonucleic Acid (Anti-dsDNA) as well as an extractable Nucleic Acid (ENA) panel was negative. Toxoplasma serology Immunoglobulin G (IgG) and Immunoglobulin M (IgM) were negative and Veneral Disease Research Laboratory (VDRL) testing for Treponema pallidum was non-reactive. A non-contrast MRI Brain was unremarkable. Her CT (computed tomography) Chest was within normal limits as were her serum ACE (angiotensin converting enzymes) levels. Discussion Neuroretinitis which is a form of optic neuropathy can be as a result of various infective and non-infective aetiologies [1]. Various causes of neuroretinitis include Bartonella Henselae [2] (most common) as well as other infections such as Toxoplasma Gondii and Treponema Pallidum, Human Immunodeficiency Virus, Idiopathic and miscellaneous causes such as Sarcoidosis. The pathogenesis of neuroretinitis is obscure but occurs due to an inflammatory response of the optic disc vasculature with fluid exudation into the peripapillary retina [4]. With leakage of fluid, the lipidrich portion penetrates into the outer plexiform layer and subsequent resolution leaves behind lipid exudates giving a macular star pattern [5]. Since the onset of the Zika epidemic in Trinidad and Tobago in February 2016, there have been 718 cases, 463 of which are confirmed cases noted in pregnancy. Thus far, for 2017, there have been confirmed births of babies with microcephaly. As of November 2016, there have been 33 suspected cases of GBS (Guillain-Barre Syndrome) for 2016, 5 of which were confirmed to be related to the Zika virus [6]. Given the history of preceding viral symptoms and the Zika epidemic in Trinidad, serology for Zika Immunoglobulin M (IgM) was done which was positive. Zika RNA testing was not available at the time. A review of the literature has revealed previous evidence of neuroretinitis in infants as well as a single case report of neuroretinitis in an immunocompromised patient with Zika [7], however in our opinion,
Corresponding author. E-mail address: [email protected] (A. Panday).
http://dx.doi.org/10.1016/j.idcr.2017.06.010 Received 20 June 2017; Received in revised form 27 June 2017; Accepted 27 June 2017 2214-2509/ © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
IDCases 9 (2017) 104–105
A. Panday et al.
[2] Kaliaperumal S, Neuroretinitis Narayan S. Update on a visual emergency and role of technology in its diagnosis. J. Biomed. Sci. Eng. 2013;6:15–9. [3] Pan American Health Organization Zika – Epidemiological Update. 12 January 2017. http://www.paho.org/hq/index.php?option=com_docman & task=doc_ view & Itemid=270 & gid=37671 & lang=en (Accessed Feb 13, 2017) [4] Fatteh N, Feldman BH, Vaphiades MS, Shah VA. Am. Acad. Ophthalmol. 2014; 2014 http://eyewiki.aao.org/Neuroretinitis#Pathophysiology (Accessed 15 February 2017). [5] Walsh FB, Hoyt WF. Neuroretinitis. Clinical Neuro-Ophthalmology. 3rd edition Baltimore, Md (MD): Williams & Wilkins Co; 1982. p. 234–5. [6] Statistics available from Office of Chief Medical Officer of Health, Ministry of Health, Trinidad and Tobago. [7] Henry CR, Al-Attar Luma, Cruz-Chacón Alexis M, Davis Janet L. Chorioretinal lesions presumed secondary to zika virus infection in an immunocompromised adult. JAMA Opthamol. 2017;135:386–9.
Fig. 1. Fundus photograph revealing bilateral disc edema as well as macular star pattern indicative of Neuroretinitis.
this represents the first suspected case of symptomatic Zika mediated neuroretinitis in an immunocompetent adult patient. References [1] Maitland CG, Miller NR. Neuroretinitis. Arch Ophthalmol. 1998;102:1146–50.
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