Bio-Medical Materials and Engineering 24 (2014) S1 DOI 10.3233/BME-140968 IOS Press
S1
Foreword This special issue of Bio-Medicals Materials and Engineering is devoted to a collection of selected papers which has been presented during the 8th International Meeting of “Lorraine Pole of Cartilage Engineering” which took place at the Faculty of Medicine in Vandœuvre-lès-Nancy (France), September 26–27, 2013. The meeting was organized by the Research Unit 7365 CNRS-Université de Lorraine “Molecular Engineering, Articular Pathophysiology”. It was supported by a grant from the Lorraine Region, Communauté Urbaine du Grand Nancy, and CNRS. This meeting gave the opportunity to scientists and students from several European countries to meet together and exchange ideas and projects on cartilage engineering. Three sessions have been presented. The first session “Proteoglycans, alteration of the extracellular matrix, tissue regeneration” put emphasis on the importance of this class of polysaccharidic macromolecular complexes that play a key role on the organization of the matrix, and which are early targets of cartilage deterioration. This session, under the auspice of the CNRS (Associated European Laboratory Nancy–Dundee, UK), was also devoted to diseases related to proteoglycan dysfunctions, particularly the Ehlers–Danlos syndrome. The second session “New insights into joint inflammation” updated new perspectives in the treatment of the inflammation of the joint. In that respect, the role of the micro RNAs, of several type of cells (mesenchymal stem cells, osteoclasts, T cells) or alarmins has been highlighted. The third session was related to osteoarticular ageing and on the important progressive changes both in composition and biological properties of cartilage. Impact of obesity, the decrease in mobility of patients, alteration of signaling pathways on cartilage homeostasis are important aspects to consider. A satellite meeting has been organized September 24–25, 2013 also in Vandœuvre-lès-Nancy, on the theme “Xenobiotics, Cartilage Engineering and Osteoarthritis” under the framework of the Laboratoire sans Mur Nancy–Wuhan (China). This fruitful collaboration supported by several grants (National Natural Science Foundation of China, Cai Yuanpei, Région Lorraine) was the unique occasion to invite six talented scientists from the School of Medicine of Wuhan to present their work on the impact of environment on the risk of osteoarthritis. This new area of research shows the importance of some environmental substances on the osteoarthritis incidence. The research developed in these two meetings fits within a concerted action of advances in scientific knowledge at the international level, which is favorable to the design of new treatments for osteoarthritis patients. J. Magdalou J.F. Stoltz P. Netter A. Pinzano
0959-2989/14/$27.50 © 2014 – IOS Press and the authors. All rights reserved
Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
S1
Foreword This special issue of Bio-Medicals Materials and Engineering is devoted to a collection of selected papers which has been presented during the 8th International Meeting of “Lorraine Pole of Cartilage Engineering” which took place at the Faculty of Medicine in Vandœuvre-lès-Nancy (France), September 26–27, 2013. The meeting was organized by the Research Unit 7365 CNRS-Université de Lorraine “Molecular Engineering, Articular Pathophysiology”. It was supported by a grant from the Lorraine Region, Communauté Urbaine du Grand Nancy, and CNRS. This meeting gave the opportunity to scientists and students from several European countries to meet together and exchange ideas and projects on cartilage engineering. Three sessions have been presented. The first session “Proteoglycans, alteration of the extracellular matrix, tissue regeneration” put emphasis on the importance of this class of polysaccharidic macromolecular complexes that play a key role on the organization of the matrix, and which are early targets of cartilage deterioration. This session, under the auspice of the CNRS (Associated European Laboratory Nancy–Dundee, UK), was also devoted to diseases related to proteoglycan dysfunctions, particularly the Ehlers–Danlos syndrome. The second session “New insights into joint inflammation” updated new perspectives in the treatment of the inflammation of the joint. In that respect, the role of the micro RNAs, of several type of cells (mesenchymal stem cells, osteoclasts, T cells) or alarmins has been highlighted. The third session was related to osteoarticular ageing and on the important progressive changes both in composition and biological properties of cartilage. Impact of obesity, the decrease in mobility of patients, alteration of signaling pathways on cartilage homeostasis are important aspects to consider. A satellite meeting has been organized September 24–25, 2013 also in Vandœuvre-lès-Nancy, on the theme “Xenobiotics, Cartilage Engineering and Osteoarthritis” under the framework of the Laboratoire sans Mur Nancy–Wuhan (China). This fruitful collaboration supported by several grants (National Natural Science Foundation of China, Cai Yuanpei, Région Lorraine) was the unique occasion to invite six talented scientists from the School of Medicine of Wuhan to present their work on the impact of environment on the risk of osteoarthritis. This new area of research shows the importance of some environmental substances on the osteoarthritis incidence. The research developed in these two meetings fits within a concerted action of advances in scientific knowledge at the international level, which is favorable to the design of new treatments for osteoarthritis patients. J. Magdalou J.F. Stoltz P. Netter A. Pinzano
0959-2989/14/$27.50 © 2014 – IOS Press and the authors. All rights reserved
Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
