Announcement
Am J Physiol Renal Physiol 308: F794, 2015; doi:10.1152/ajprenal.00062.2015.
2015 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section THE AMERICAN PHYSIOLOGICAL Society (APS) Renal Section has selected Thomas R. Kleyman, MD (Fig. 1) as the recipient of the 2015 Carl Gottschalk Distinguished Lectureship. Dr. Kleyman is the Sheldon Adler Professor of Medicine and Chief of the Renal-Electrolyte Division at the University of Pittsburgh. He is also a Professor of Cell Biology, and a Professor of Pharmacology and Chemical Biology at the University of Pittsburgh, and is the Director of the Pittsburgh Center for Kidney Research. Dr. Kleyman received his undergraduate degree from Syracuse University, and his medical degree from Washington University in St. Louis. He trained in Internal Medicine and Nephrology at Columbia-Presbyterian Medical Center in New York. Following postdoctoral training in transport physiology and membrane biochemistry under Dr. Qais Al-Awqati at Columbia University, he joined the University of Pennsylvania faculty. He moved to the University of Pittsburgh School of Medicine in 2000. Over the past 30 years, Dr. Kleyman’s research has been supported by grants from the National Institutes of Health (NIH), Depart- Dr. Thomas Kleyman ment of Veterans Affairs, and the American Heart Association. He is the principal investigator of NIH R01, T32, and T35 grants, and the O’Brien Kidney Research Core Center. His current research focuses primarily on epithelial Na⫹ channels (ENaCs). Dr. Kleyman’s early work centered on the development and use of derivatives of the diuretic amiloride as Na⫹ channel probes. His recent work has been directed at elucidating mechanisms by which external factors, such as proteases, laminar shear stress, and ions (including Na⫹), regulate ENaC gating. Dr. Kleyman collaborated with Dr. Rebecca Hughey to demonstrate that the ␣- and ␥-subunits of ENaC are cleaved by specific proteases at defined sites within their extracellular domains, activating the channel by releasing small inhibitory fragments. His group recently identified critical residues within an extracellular acidic pocket in an ENaC subunit that form a key regulatory Na⫹ binding site. In collaboration with Dr. Lisa Satlin, Dr. Kleyman has been studying the regulation of large-conductance, Ca2⫹-activated K⫹ (BK) channels by laminar shear stress and other factors. Dr. Kleyman served as an associate editor and as the editor-in-chief of the American Journal of Physiology-Renal Physiology. He is currently the deputy editor-in-chief of Physiological Reports, a new open access journal jointly sponsored by APS and The Physiological Society. He has served on the editorial boards of the Journal of Biological Chemistry, the Journal of Clinical Investigation, the American Journal of Physiology-Renal Physiology, and the American Journal of Physiology-Cell Physiology. He has also served on numerous national peer review groups, including the CMBK study section of the NIH. Dr. Kleyman is a member of the American Society for Clinical Investigation and the Association of American Physicians. Dr. Kleyman continues to make important contributions in the areas of renal and transport physiology, and to APS. The Renal Section is honored to have him present the 2015 Carl Gottschalk Distinguished Lecture.
F794
1931-857X/15 Copyright © 2015 the American Physiological Society
http://www.ajprenal.org
Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Am J Physiol Renal Physiol 308: F794, 2015; doi:10.1152/ajprenal.00062.2015.
2015 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section THE AMERICAN PHYSIOLOGICAL Society (APS) Renal Section has selected Thomas R. Kleyman, MD (Fig. 1) as the recipient of the 2015 Carl Gottschalk Distinguished Lectureship. Dr. Kleyman is the Sheldon Adler Professor of Medicine and Chief of the Renal-Electrolyte Division at the University of Pittsburgh. He is also a Professor of Cell Biology, and a Professor of Pharmacology and Chemical Biology at the University of Pittsburgh, and is the Director of the Pittsburgh Center for Kidney Research. Dr. Kleyman received his undergraduate degree from Syracuse University, and his medical degree from Washington University in St. Louis. He trained in Internal Medicine and Nephrology at Columbia-Presbyterian Medical Center in New York. Following postdoctoral training in transport physiology and membrane biochemistry under Dr. Qais Al-Awqati at Columbia University, he joined the University of Pennsylvania faculty. He moved to the University of Pittsburgh School of Medicine in 2000. Over the past 30 years, Dr. Kleyman’s research has been supported by grants from the National Institutes of Health (NIH), Depart- Dr. Thomas Kleyman ment of Veterans Affairs, and the American Heart Association. He is the principal investigator of NIH R01, T32, and T35 grants, and the O’Brien Kidney Research Core Center. His current research focuses primarily on epithelial Na⫹ channels (ENaCs). Dr. Kleyman’s early work centered on the development and use of derivatives of the diuretic amiloride as Na⫹ channel probes. His recent work has been directed at elucidating mechanisms by which external factors, such as proteases, laminar shear stress, and ions (including Na⫹), regulate ENaC gating. Dr. Kleyman collaborated with Dr. Rebecca Hughey to demonstrate that the ␣- and ␥-subunits of ENaC are cleaved by specific proteases at defined sites within their extracellular domains, activating the channel by releasing small inhibitory fragments. His group recently identified critical residues within an extracellular acidic pocket in an ENaC subunit that form a key regulatory Na⫹ binding site. In collaboration with Dr. Lisa Satlin, Dr. Kleyman has been studying the regulation of large-conductance, Ca2⫹-activated K⫹ (BK) channels by laminar shear stress and other factors. Dr. Kleyman served as an associate editor and as the editor-in-chief of the American Journal of Physiology-Renal Physiology. He is currently the deputy editor-in-chief of Physiological Reports, a new open access journal jointly sponsored by APS and The Physiological Society. He has served on the editorial boards of the Journal of Biological Chemistry, the Journal of Clinical Investigation, the American Journal of Physiology-Renal Physiology, and the American Journal of Physiology-Cell Physiology. He has also served on numerous national peer review groups, including the CMBK study section of the NIH. Dr. Kleyman is a member of the American Society for Clinical Investigation and the Association of American Physicians. Dr. Kleyman continues to make important contributions in the areas of renal and transport physiology, and to APS. The Renal Section is honored to have him present the 2015 Carl Gottschalk Distinguished Lecture.
F794
1931-857X/15 Copyright © 2015 the American Physiological Society
http://www.ajprenal.org
Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
