PROGRAM

Fourteenth Annual Meeting of The American Society for Bone and Mineral Research Minneapolis Convention Center MINNEAPOLIS, MINNESOTA

SEPTEMBER 30-OCTOBER 4, 1992 WEDNESDAY, SEPTEMBER 30, 1992 2:OO P.M.4:OO P.M.

WORKSHOP A-Proto-oncogenes Room 101A-J

4:OO P.M.6 : O O P.M.

WORKSHOP B-Bone Hormone Responsive Elements and Co-receptors (See p ~ g e xvii) Room 101A-J

8:OO P.M.

WINEKHEESE WELCOME RECEPTION Ballroom A/B

8:OO P.M.1O:OO P.M.

in Bone ( S w pcige x v i i )

PLENARY POSTER SESSION (See Po5ler P r o g r d m , pdgrs S I(I-518) Ballroom A/B

THURSDAY, OCTOBER 1,1992 7:45 A.M.-

8:OO A.M.

OPENING ADDRESS Room 101 A-J M xk R. H w s s k r . Ph.D.

ORAL PROGRAM 8:OO A.M.8:45 A.M.

GERALD AURBACH MEMORIAL LECTURE Room 101 A-J PARATHYROID HORMONE A N D ITS RECEPTOR: EVOLUTIONARY LINKS A N D BIOLOlHYDKOXYVlTAMIN I) ;-HOUNI) VITAMIN I ) KECEPTOK COMPLEX W I T H THE OSTEO(‘AL(:IN KESI’ONSE EL€MENT AN11 N U CLEAK ACCESSOKY FACTOK. M . U ( ~ / l d c iA’. , 0 / ( 1 / 7 ~ 1 , /. I’iko, Kurdia C:hcmic-,il Co., Tokyo, Oscikwish Hospital of St. Louis, Washington University, St. Louis, MO OSTEOPOROSIS Room 103 A-F CHAIRPERSONS-Peggy Backup Richard Eastell

2:45 P.M.

80.

B O D Y SWAY A N D BONE MINERAL DENSITY AKE PREUICTOKS O F FKACTUKE PREVALENCE: THE DUBBO OSTEOPOROSIS EPIDEMIOLOLY STUDY. T . Nguycvi, P. Sambrook, P. Kelly, 5. Lord, 1. F r e u d , 1. Eisman, Garv'in Institute, St. Vincent's Hospital, Sydney, Australia

3 : O O P.M.

81.

PROPERTIES OF OSTEOPROGENITOR CELLS I N BONE MAKROW O F AGED A N D OVARIECTOMIZED RATS. S. Nishida, A. Ydniaguchi, H . T ~ k ~ i h hS, i , Yoshiki, 7. Sutla, Showa University, Tokyo and Niigata University, Niigiita, Jiipnn

3:15 P.M.

82.

THE LONG TERM EFFECTS OF ALENDRONATE ON HONE REMOUELINL I N THE SPINE OF OVARIECTOMIZED BABOONS. R. Nalcn'?, A. M,irk,itos, M . L.if;igt>, P. Masarachia, M. Gentile, G. Rodan, Merck Research Lh)mtories, Wcist Point, PA

3:3O P.M.

83.

RESPONSE OF HORMONE REPLACEMENT THEKAPY ON HONE MINERAL DENSITY ACCORDING T O SERUM LEVELS OF OSTEOCALCIN. /. H m , Y. Ahn, Y. Min, Cheil General Hospital, Seoul, Korea

3:45 P.M.

84.

THE EFFECT OF POSTMENOPAUSAL A N D LATER LIFE ESTKOGENS ON HONE MINERAL DENSITY I N ELDERLY WOMEN. D . Felson, Y . Zh'ing, M . H,inn,in, 1. Anderson, Boston University, Boston, M A

4:OO P.M.

85.

RESPONSE TO ESTROGEN REPLACEMENT THERAPY I N POSTMENOPAUSAL 0 s TEOPOROSIS IS DEPENDENT ON AGE A N D BODY MASS. K . A m i , i n i c ~ n t o - V i l / , i r ~ ~ ~ i l , 1. Avioli, R. Civitelli, The Jewish Hospital &itW,ishington University, St. Louis, MO

4:15 P.M.

86.

INADEQUATE MONOCYTE SECRETION OF IL-1 RECEPTOK ANTAGONIST IN POSTMENOPAUSAL OSTEOPOROSIS. R. P,~.ific-i,1. V,inniw, L. Kit&, K . S l d , R . Kimble, The Jewish Hospital of St. Louis, St. Louis, MO, ,ind Syncvgen, Incorporated, Boulder, C O

4:30 P.M.

87.

CANCELLOUS BONE STRUCTURE IN POSTMENOPAUSAL WOMEN: COMPAKISON A M O N G OSTEOPOROSIS O K PRIMARY HYPEKPAKATHYKOIDISM A N D NORMALS. M . Parisien, R . Mellish, M . Schnirzer, 1. Nicvci+, F . Cosni,in, K . Kclc-kw, D. Kimmel, S. Silverberg, E . Shanc, 1. Bilrziki,~n,K . l i n t l a y , ,!I f)cmpster, . Hclcn Hayes Hospital, West Haverstraw, NY, Columbia University NY, i i n d Crcighton University, Omaha, NE

5:OO P.M.6:30 P.M. 7:OO P.M.1O:OO P.M.

BUSINESS MEETING Room 101 A-J EVENING RECEPTION MINNEAPOLIS INSTITUTE O F ARTS Bu.res Llep'irt From The Convention Ccntcv at h:4.5 P.M.

411-

SATURDAY, OCTOBER 3, 1992

PLENARY SESSION IllA Room 101 A-J

8:30 A.M.1O:OO A.M.

METABOLIC BONE DISEASE A N D OSTEOPOROSIS CHAIRPERSONS-I. C. Gallagher Michael Whyte

8::lo A.M.

aa.

A MUTATION THAT UNCOUPLES RECEPTORS FROM ADENYLYL CYCLASE IN ALBRIGHT HEREDITARY OSTEODYSTROPHY. W . Schwindinger, M . Levine, Johns Hopkins School of Medicine, Baltimore, MD

8:45 A.M.

89.

A N ACTIVATING G,a MUTATION I S PRESENT I N FIBROUS DYSPLASIA OF BONE I N THE McCUNE-ALBRIGHT SYNDROME. A. Shenker, D. Sweet, A. Spiegel, L. Weinsrein, NIDDK, NIH, Bethesda, MD and Armed Forces Institute of Pathology, Washington, DC

9:OO A.M.

90.

PARAMYXOVIRAL TRANSCRIPTS ARE EXPRESSED I N FRESHLY ISOLATED MARROW CELLS A N D MARROW-DERIVED MULTINUCLEATED CELLS FROM PAGET'S PATIENTS BUT N O T FROM NORMALS. S. Reddy, N.Kuzhandaivelu, S. Takahashi, I). Hosking, F. Singer, C. Roodrnan, University of Texas Health Science Center and Audie Murphy VAMC, San Antonio, TX, Cedars-Sinai Medical Center, Los Angeles, CA, .ind City Hospital, Nottingharn, UK

9:15 A.M.

91.

OVARIECTOMY I N THE MOUSE UPREGULATES HEMATOPOIETIC PRECURSORS I N THE BONE MARROW A N D THEIR PROGENY I N THE PERIPHERAL BLOOD: A MEDIATING ROLE O F IL-6. R. lilka, C. Cirasole, C. Passer;, S. Cooper, C. Hmgoc, 1. A b r m s , H . Broxmeyer, S. Manoldgas, VAMC and Indiana University, Indianapolis, I N and the DNAX Research Institute, Palo Alto, CA

9:30 A.M.

92.

ANTISENSE BONE MORPHOGENETIC PROTEIN 3 CONSTRUCTIONS DECREASE NEW BONE FORMATION I N A PROSTATE CANCER MODEL. S. Harris, B . Boyc-e, 1. Feng, P. Mahy, M . Harris, C. Mundy, University ofTexas Health Sciencecenter, San Antonio. TX

9:45 A.M.

93.

THE EFFECTS OF PHYSICAL ACTIVITY, SEXUAL MATURATION, A N D WEIGHT GAIN ON BONE GROWTH I N CHILDREN. C. Slemendd, 5. Hui, 1. Miller, C./ohmton, / r . , Indiana University School of Medicine, Indianapolis, IN

1O:OO A.M.10:15 A.M. PLENARY SESSION I l l B Room 101 A-J

10:15 A.M.12:15 P.M.

OSTEOPOROSIS C H A IK PERSO NS-J . C . G d I Idghe r Michael Whyte 1 0 : 15 A.M.

94.

RELATIONSHIP BETWEEN BONE FORMATION RATE A N D OSTEOBLAST SURFACE I N AGING A N D OSTEOPOROSIS: EVIDENCE F O R IMPAIRED OSTEOBLAST KECRUITMENT I N PATHOGENESIS. A. Pdrlitt, M . Shih, D. Rdo, M. Kleerekoper, Henry Ford Hospital, Detroit, M I

4 1 2-

SATURDAY, OCTOBER 3,1992

10:30 A.M.

95.

PARATHYROID HORMONE IS MORE EFFECTIVE THAN ESTROGEN O R DIPHOSPHONATES FOR REVERSAL OF OSTEOPENIA IN OVARIECTOMIZED RATS. T . Wronski, C. Yen, H. Qi, L. Dann, University of Florida, Gainesville, FL

10:45 A.M.

96.

INFUSION OF IL-1 RECEPTOR ANTAGONIST PREVENTS BONE LOSS IN OVAKIECTOMIZED RATS. R. Kimble, /. Vannice, D. Bloedow, K . Thompson, R. P x i h i, The Jewish Hospital of St. Louis, St. Louis, MO, dnd Synergen Incorporated, Boulder, C O

1 1:00 A.M.

97.

LATERAL DUAL ENERGY X-RAY ABSORPTIOMETRY: A N IMPROVED METHOD T O ASSESS VERTEBRAL STRENGTH. 8.Myers, K. Bittenbender, S. Lobdugh, K. Hdrper, M . Drezner, Duke University Medical Center, Durham, NC

11:15 A.M.

98.

GEOMETRIC MEASUREMENTS FROM DUAL X-RAY ABSORPTIOMETRY SCANS PREDICT HIP FRACTURE. K. Faulkner, C. Cluer, L. PJlermO, D. Black, H . (;(want, S. Cummings, University of California, San Francisco, and Universities of Maryland, Minnesota, Pittsburgh, and the Kaiser Health Research Group, Portland, O R

11 :30 A.M.

99.

LONG-TERM TREATMENT WITH INTERMITTENT, CYCLICAL ETIDRONATE: EFFECT ON BONE MASS A N D FRACTURE RATE. 7. Storm, C;. Thamshorg, H . Sorensen, C. Kollerup, H . Cenant, 0. Sorensen, Sundhy Hospital, Copenhagen, Denmark, and University of California, San Francisco, CA

11:45 A.M.

100.

EFFECT OF INTRANASAL CALCITONIN ON BONE MASS A N D FRACTURE RATES IN ELDERLY WOMEN. A DOSE-RESPONSE STUDY. K. Overgdard, M. Hmscn, C. Christiansen, University of Copenhagen, Denmark

12:oo NOON

101.

GAINS MADE IN SPINAL BONE DENSITY IN RESPONSE T O FLUORIDE THERAPY FOR OSTEOPOROSIS ARE N O T MAINTAINED AFTER FLUORIDE THERAPY IS DISCONTINUED. 1. Talbot, M . f i s h e r , S. farley, 6 . Dure-Smith, E . Schulrr, C. Libanati, D. Baylink, Lorna Linda University and Pettis VAMC, Loma Linda, CA POSTER SESSION C (See Poster Program page5 S7 I-W17) Ballroom A/B

12:15 P.M.2 9 5 P.M.

SCIENTIFIC SESSION III-CONCURRENT SESSIONS: Peptide Calciotropic Hormones (Room 101 A-J), Bone, Cartilage and Matrix Proteins (Room 102 A-F) and Osteoporosis (Room 103A-F)

2:45 P.M.4:15 P.M.

PEPTIDE CALCIOTROPIC HORMONES Room 101 A-J CHAIRPERSONS-Richard Bringhurst Robert Nissenson 2:45 P.M.

102.

PTH/PTHrP RECEPTOR mRNA EXPRESSION AS ASSESSED BY NORTHERN BLOT A N D IN SlTU HYBRIDIZATION. P. Urena, K. Lee, D. Weaver, X. Kong, D. Brown, A. Bond, A. Abou-Samra, C. Segre, Massachu5etts General Hospital, Boston, M A

3:OO P.M.

103.

A NEGATIVE REGULATORY ELEMENT IN THE PTHrP GENE PROMOTER. R. Vdsavada, 1. Wysolmerski, W. Philbrick, A. Broadus, Yale University School of Medicine, N e w Haven, CT

4 1 3-

SATURDAY, OCTOBER 3, 1992

3 : l S P.M.

104.

TKANSFORMING G R O W T H FACTOK BETA INCREASES STABILITY O F PARATHYROID HORMONE RELATED PROTEIN MESSENGEK KNA. D. Z'ik'ilik, 1 ) . Diep, M . Hooks, K . Nissenson, C . Stwwler, V A M C .ind University of Californi.i, S,in Fr,incisco, CA

3 : 3 0 P.M.

10.5.

TKANSCRIPTION OF H U M A N PTH-RELATED PEPTIDE GENE IS ACTIVATED T H R O U G H A CAMP-DEPENDENTPATHWAY BY PROSTAGLANDIN E, IN HTLV-IINFECTED T CELLS. K. Ikeda, K . O k c ~ z , i k iD. , Inoue, T . M,~tsurnoto,University of Tokyo School of Medicine, Tokyo, Japan

3:45 P.M.

10b.

CALCITONIN INDUCES A PROTEIN KINASE II-DEPENDENT A N D PROFOUND INHIBITION O F THE N a ' / H i EXCHANGEK TYPE 2 DURING S PHASE O F THE CELL CYCLE IN LLC-PK1 KIDNEY CELLS. M . C ' h ~ k r ~ i h o r l D. y , Ch,ifterjee, A. Rubeg'iM,i/e, C. SlCiynidn,R. &iron, Ydlcx University School of Medicine, N e w Haven, CT

4:OO P.M.

107.

A VITAMIN D ANALOGUE (EB-1089) PREVENTS THE DEVELOPMENT O F MALIGNANCY-ASSOCIATED HYPERCALCEMIA IN VIVO. M . H'iq, 11. Coltzman, R. Kremer, S. R,ibbani, M c G i l l University and Royal Victoria Hospitcil,Montreal, Can'idii BONE, CARTILAGE A N D MATRIX PROTEINS Room 102 A-F CHAIRPERSONSLynda Bonewald

M,is.ihiko S,ito 2:45 P.M.

108.

H U M A N OSTEOCLAST-LIKE CELLS ADHEKE T O SEVERAL EXTRACELLULAR M A TRIX PKOTEINS VIA THE RELEASE O F ENDOGENOUS MATRIX PROTEIN A N D THE KECKUITMENT O F M O R E T H A N ONE INTEGRIN RECEPTOR. M. Crano, 5.Colucc-i, 1'. Zigrino, C. Z m ~ b o n i nA. , T c t i , 1'. M,(1. Quinn, St. Louis University Medical Center, St. Louis, MO

*121.

EXPRESSION OF W N J GROWTH FACTORS IN BONE CELLS. N . Endo, S. Kutkdgc~, C. Rodan, A. Schmidt, Merck Kesearch Laboratories, West Point, PA

122.

POSITIVE A N D NEGATIVE GLUCOCORTICOID REGULATORY SEQUENCES O F THE OSTEOPONTIN GENE PROMOTEK. 5. HJradci, S. Kodan, L. Suva, f. Opas, X. Cuo, I). Denhardt, C. Rodan, Merck Research Lahor,itorics, West Point, PA, and Rutgers University, Piscataway, NJ

12%.

REGULATED EXPRESSION OF T W O HOMOLOGS O F THE DKOSOPHILA FRIZZLEII GENE IN UMR 106 CELLS. 5. C h m , M . Fowlkcs, M. Liu, , NE, ,in(/ A l l d i x Corporation, Toronto, C,in,itJ;i ESTROGEN KECEPTOK: ITS D N A ANI) inKNA AMf'l.IFI(:ATION IJY K K .

('.

Liu,

5. Chcn, K. Am~slrong,M . Zh,ing, Amcric.,in L'ikc VAM(:, Tt\c oni,i, WA, Univcnily ot W,ishington 'ind Children's Hospitril,ind Mcdic-,ilCcvitcv, So,tttlc, W A RACIAL DIFFERENCES IN EAKLY I'OSTMENOI'AUSAL I). Mvicv, 5 . W ' t / h i \ k i / i , K . L ' i p I / ) & , Mount Sin,ii York, N Y

t3ONE L( )SS. M .

Lirc

key,

S( hool of Mcdit inc, Nciw

EFFECT O F INTKANASAL CALCITONIN ON HONE MASS ANI) HONE TlJKNOV€K IN POSTMENOPAUSAL WOMEN. A DOSE-KESI'ONSE STUIIY. K . Ov(*rg,t'tr(/, M . Hd 1 1 . ~ 1 1 (, -.C / Ir i.\t i,in . w r ~U , nivvrs it y (If C c )penhagcln, L )tin rn,\ r k LOAD-RELATED OSTEOGENESIS, f'KOSTACYCLIN ANI) IC;F-II. S. K ' I ~ ~ ( / I / ~ ~ o / I , 5. M o / i m , 0. U'iylink, I . I ~ i n y o n Thc , Koy,il Vctc-rin.iry (:ollc~g:c,London, U K , ,in0 Lom.i Lind,i Univcrsity, f'ettis VAMC, Lom,i Lind,i, (:A A NEW VITAMIN 0 DEKIVATIVE, 2p-( ~ - H Y D K O X Y I ' K O I ' O X Y ) - ~ ~ X , ~ ' , ( O ~ - ~ ) , I ) (ED-71) RESTORES THE HONE MASS IN ESTAHLISHED OSTEOI'OKOSIS IN KATS. H. J s u r u k ~ m i , T . N ~ G I / I I LM. / ~ ~YIc, t ~ ~ ~ t uK r. ,N~tr(1\~tw,t, ~, I 1. ) / 1 1 1 i \ h i , K . .Si//i/A/, K. S,tto, M. N,tnjo, University of( )ccupition,il ,tnd Environmcwt,il t iwlth. Kit/ESTKO(;EN I I E F I CIENCY ON CORTICAL A N D CANCELLOUS BONE L O S S IN THE KAT. V . S/MYI, K. Rirchmm, K . Xu, K . Lint/s,ty, 11. l)cvnp.sl(ir, Hciltvi H,iyci\ Ho\pitcil, Wcist H'ivcvstraw, NY, ,ind Colunil)i,i University, N c w York, NY

-S23-

WEDNESDAY, SEPTEMBER 30, 1992

199.

PREDICTION OF HIP FRACTURE FROM MEASUREMENTS MADE ON PELVIC X-RAY RADIOGRAPHS. C. Cluer, 5. Cummings, 1. Li, K. Cluer, A. Pressman, S. Crampp, K . Faulkner, H . Cenant, University of California, San Francisco, and the Universities of Pittsburgh, Minnesota and Maryland, and the Kaiser Health Research Group, Portland, OR

200.

EFFECTS OF OVARIECTOMY A N D ESTROGEN ADMINISTRATION ON SERUM INSULIN-LIKE GROWTH FACTOR-I A N D ITS BINDING PROTEINS. D. Kalu, R. Birnbaum, 6 . Arjmandi, C. Liu, E . Salerno, University of Texas Health Science Center, San Antonio, TX, GRECC, VAMC, Tacoma, WA, and University of Washington, Seattle, W A

201.

MONITORING BONE RESORPTION I N EARLY POST-MENOPAUSAL WOMEN BY A N IMMUNOASSAY FOR CROSS-LINKED COLLAGEN PEPTIDES. D. Eyre, B. Certz, P. Shao, D. Hanson, 5. Harris, H . Cenant, C. Chestnut 111, University of Washington, Seattle, WA, Merck and Company, Rahway, NJ, and University of California, San Francisco, CA

202.

ETIDRONATE CYCLICAL THERAPY FOR TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS: 4 YEAR EXPERIENCE. C. Chestnut 111, H . Cenant, S. Harris, R. lackson, A. Licata, P. Miller, P. Ross, R. Wasnich, N . Watts, University of Washington, Seattle, University of California, San Francisco, Ohio State University, Cleveland Clinic, University of Colorado, Hawaii Osteoporosis Center and Emory University, Atlanta, GA

203.

VIGOROUS EXERCISE A N D BONE MINERAL DENSITY. E . Krall, B. DawsonHughes, USDA Human Nutrition Research Center at Tufts University, Boston, M A

204.

TALLER YOUNG WOMEN HAVE A N INCREASED RISK OF HIP FRACTUREESPECIALLY IF THEY SHRINK. A PROSPECTIVE STUDY. M. Nevitt, S. Cumrnings, 1. Tao, I . Cauley, D. Black, University of California, San Francisco, CA, and the Universities of Pittsburgh, Minnesota, Maryland, and the Kaiser Health Research Group, Portland, OR

205.

IDENTIFICATION OF P-ANDRENERGIC RECEPTOR KINASE A N D P-ARRESTIN-LIKE SPECIES I N R O S 17/2.8 CELLS BY PCR A N D REGULATION OF THEIR mRNA LEVELS BY DEXAMETHASONE. M . Blizioles, 1. Murtagh, K . Wiren, L. Alberque, Portland VAMC, Portland, OR, and Atlanta, VAMC, Atlanta, G A

206.

REGULATED EXPRESSION OF PARATHYROID HORMONE-RELATED PROTEIN A N D ITS RECEPTOR mRNA IN RAT AORTIC SMOOTH MUSCLE CELLS SUGGESTS A N AUTOCRINE VASOACTIVE ROLE. C. Pirola, H. Wang, S. Wu, K . Okano, H . ldppner, A. Abou-Samra, C. Segre, 1. Forrester, I . Fagin, 1.Clernens, Cedars Sinai Medical Center, Los Angeles, CA, and Massachusetts General Hospital, Boston, M A

207.

EVIDENCE FOR POTENT DESENSITIZATION OF RESPONSIVENESS T O PARATHYROID HORMONE-RELATED PEPTIDE IN KERATINOCYTE CELL LINES. S. Kaiser, R. Kremer, D. Coltzman, McGill University and Royal Victoria Hospital, Montreal, Canada

208.

THE EXPRESSION OF RECEPTORS FOR EPIDERMAL GROWTH FACTOR IS INCREASED BY PARATHYROID HORMONE IN UMR 106-01 CELLS. M. Drake, 1. Baldassare, C. McConkey, K . Martin, St. Louis University, St. Louis, MO

-524-

WEDNESDAY, SEPTEMBER 30, 1992

209.

PARATHYROID HORMONE STIMULATES THE NON-RECEPTOR SRC TYROSINE KINASE IN BONE CELLS. f . Izbicka, 7. Yoneda, M. Niewolna, C. Lowe, C. Mundy, University of Texas Health Science Center, San Antonio, TX

210.

PARATHYROID HORMONE A N D PHORBOL ESTER MODULATE EXPRESSION O F TYPE II TGF p RECEPTOR rnRNA IN OSTEOBLAST-LIKE CELLS. N . Malagd, F . Ichikawa, K. Miyazono, M. Noda, Tokyo Medical and Dental University, Tokyo, japan, and Ludwig Institute of Cancer Research, Uppsala, Sweden

211.

PTH REGULATES PHOSPHATE UPTAKE IN PTH RECEPTOR-TRANSFECTED LLCPKl CELLS INDEPENDENTLY OF CYCLIC AMP, PHOSPHOLIPASE-C OR CALCIUM. f . Sringhurst, A. Abou-Samra, H . luppner, C. Segre, Massachusetts General Hospital, Boston, M A

21 2.

CHARACTERIZATION OF SEQUENCES IN THE H U M A N PARATHYROID HOKMONE GENE THAT MEDIATE TRANSCRIPTIONAL REPRESSION IN RESPONSE T O 1,25 DIHYDROXYVITAMIN D , . M. Dernay, M. Kiernan, H . Kronenberg, Massachusetts General Hospital, Boston, M A

213.

DEPLETION OF INTRACELLULAR CA" STORES STIMULATES CAL' ENTRY INTO PARATHYROID CELLS. 0. Shoback, 7. Chen, S. Pratt, VAMC and University of California, San Francisco, CA

214.

ISOLATION A N D CHARACTERIZATION OF A GC-RICH PROMOTER O F THE H U M A N PARATHYROID HORMONE-RELATED PEPTIDE GENE. R. VdMVadd, 1. Wysolmerski, A. Broadus, W . Philbrick, Yale University School of Medicine, N e w Haven, CT

215.

THE CLONED H U M A N CALCITONIN RECEPTOR CAN COUPLE T O T W O ALTERNATIVE SECOND MESSENGER PATHWAYS WHEN EXPRESSED IN BHK CELLS. E . Moore, R. Kueslner, 0. Thompson, 1. Kuijper, 0. Thastrup, S. Mathewes, f . Grant, R. Elrod, S. Stroop, 6. Smith, P. Sheppard, F. Hagen, ZymoGenetics, Seattle, W A

216.

CHARACTERIZATION OF FUNCTIONAL RECEPTORS F O R CALCITONIN GENERELATED PEPTIDE IN MOUSE ALVEOLAR MACROPHAGES. C. Miyaura, /. wan, 7. Tamura, 7. Suda, Showa University, Tokyo, Japan

217.

BIOSYNTHESIS A N D PROCESSING OF ENDOGENOUS PARATHYROID HOKMONE RELATED PEPTIDE BY THE RAT LEYDIG CELL TUMOR, H-500. M . H d c / , 0. Coltzman, S. Rabbani, McGill University and Royal Victoria Hospital, Montreal, Canada

218.

ALTERED CAMP SIGNALLING IN EMBRYONIC STEM CELLS DIFFERENTIATING IN RESPONSE T O RETlNOlC ACID OR AGGREGATION. R. Clobus, .+ky,(:. McIutcikri, M. Holick, Boston University, Boston, MA, University of Alherta, Edmonton, AlIwrt,i, Canada, Haukeland Hospital, Bergen, Norway, University of the Witw,itc~rsr,intl, Bertsham, South Africa, and Hopital Dc Clinicas, Buenos Aires, Argentin,)

308.

THE EFFECT OF 1 , 2 5 DIHYDROXYCHOLECALCIFEKOl ON TlHlAL IlYSCH( INDROPLASIA IN BROILER CHICKENS. 1. Kcnnw, H. Thorp, C. W h , / c 4 ~ ~ ~Instituk 1t/, of Animal Physiology and Genetics Research, Roslin, Midlothi,in, Sc-otl,ind

309.

EFFECTS OF T W O NEW VITAMIN C) ANALO(;UES, K H I O M ) A N 0 EH 1089, ( I N HONE RESORPTION IN VITRO. 0. Ljunggrw, S. Ljung/i,i//, llnivchrsity Hospit'il, Uppsala, Sweden

3 10.

EFFECTS O F INSULIN-LIKE GROWTH FACTOK I THEKAPY ON BIOMAKKEKS F O K BONE METABOLISM IN OSTEOPOROSIS: A CASE K E N )KT. A. /Ohd/J.+\O/J, F . l i n t l l i , S.Liunghall, University Hospital, Uppsal,i, Sweden

,.

,

433-

THURSDAY, OCTOBER 1, 1992

311.

THE SYNTHESIS A N D CHARACTERIZATION OF la,24(R) A N D la,24(S) DIHYDROXYVITAMIN D,. R. Moriarty, L. Cuo, R. Penmasta, L. Zhao, Steroids, Ltd., Chicago, IL

31 2.

METABOLISM OF 1a,24(R)-DIHYDROXYVITAMlN D, INTO CALCITROIC ACID IN RAT KIDNEY THROUGH T W O DIFFERENT METABOLIC PATHWAYS. C. Reddy, S. Ishizuka, K. Wankadiya, K. Jserng, 6. Yeung, P. Vouros, Women and Infants Hospital, Brown University, Providence, RI, Teijin Institute for Biomedical Research, Tokyo, Japan, VAMC, Case Western Reserve University, Cleveland, OH, and Northeastern University, Boston, M A

313.

1a,25 DIHYDROXYVITAMIN D,-26,23-LACTONE PRODUCTION I N NORMAL H U M A N OSTEOBLASTS IN CULTURE UNDER PHYSIOLOGICAL CONDITIONS. C. Reddy, 5. Ishizuka, K. Wankadiya, L. Zou, E. Schwartz, Women and Infants Hospital, Brown University, Providence, RI, and Teijin Institute for Biomedical Research, Tokyo, Japan

31 4.

SYNTHESIS OF 25-HYDROXYVITAMIN D, ANALOGS WITH A CAROTENOID LIKE A-RING. N . Lee, C. Reddy,/. Clark, P. Williard, Brown University, Women and Infants Hospital and Roger Williams General Hospital, Providence, RI

31 5.

NOVEL EVIDENCE FOR THE REDUCTION OF THE DOUBLE B O N D IN A22-l ,25DIHYDROXYVITAMIN D K . Wankadiya, M. Uskokovic, 1. Clark, K. Tserng, C. Reddy, Women and Infants Hospital, Providence, RI, Hoffmann-LaRoche, Inc., Nutley, NJ, Roger Williams Medical Center, Providence, RI, and VAMC, Cleveland, OH

316.

CHARACTERIZATION OF VITAMIN D METABOLITES BY STATIC A N D DYNAMIC FAST A T O M BOMBARDMENT TANDEM MASS SPECTROMETRY. B. Yeung, C. Reddy, P. Vouros, Northeastern University, Boston, MA, Women and Infants Hospital, Brown University School of Medicine, Providence, RI

31 7.

METABOLISM OF 1,25-DIHYDROXYVITAMIN D, BY RWLEU4 CML CELLS A N D BIOLOGICAL ACTIVITY OF ITS NATURAL METABOLITES A N D RELATED ANALOGS. 1. Clark, M. Uskokovic, R. Horst, C.P. Reddy, A. Santos, K. Wankadiya, C. Reddy, Roger Williams Hospital, Providence, RI, Hoffmann LaRoche, Inc., Nutley, NJ, USDA, Ames, IA, and Women and Infants Hospital, Providence, RI

318.

H U M A N B LYMPHOCYTES FAIL T O METABOLIZE 1,25-DIHYDROXYVITAMIN D, BUT RESPOND T O THE HORMONE IN THE PRESENCE OF INTERLEUKIN-4. 1. Morgan, C. Reddy, K . Wankadiya, M . Uskokovic, 5. Sharma, Roger Williams Cancer Center, Women and Infants Hospital, Brown University, Providence, RI, and Hoffmann LaRoche, Inc., Nutley, NJ

319.

METABOLISM OF 1,25-DIHYDROXYVlTAMIN D, BY H U M A N PLACENTA IN VITRO. L. Rubin, K. Wankadiya, C. McCovern, 6. Yeung, P. Vouros, C. Reddy, Brown University School of Medicine and Women and Infants Hospital, Providence, RI, and Northeastern University, Boston, M A

320.

THE DEPENDENCE OF PTH’S ACTION ON THE RENAL 1-HYDROXYLASE ON INSULIN-LIKE GROWTH FACTOR-1. E. Spencer, 6. Halloran, California Pacific and VAMC, San Francisco, CA

,.

434-

THURSDAY, OCTOBER 1, 1992

321.

22-OXA-CALCITRIOL, A NONCALCEMIC ANALOG OF CALCITRIOL, SUPPRESSES CELL PROLIFERATION AS WELL AS PRODUCTION A N D SECRETION OF PTHRELATED PEPTIDE BY HTLV-I-INFECTED TCELLS. D. Inoue, K. Ikeda, T . Matsurnoto, University of Tokyo School of Medicine, Tokyo, Japan

322.

DIFFERENCES I N INTERACTION BETWEEN TGFP A N D 1,25(OH),D, IN VDR A N D OSTEOCALCIN GENE EXPRESSION. A. Staal, H . Pols, C. Buurrnan, T. Vink, C. van den Bernd, 1. Birkenhager, 1. van Leeuwen, Erasrnus University Medical School, Rotterdam, The Netherlands

323.

24,25-DIHYDROXYVITAMIN D., ADDED T O 1a-HYDROXYVITAMIN D I AUGMENTS CORTICAL BONE MASS IN PREDIALYSIS RENAL BONE DISEASE. D. Birkenhager-Frenkel, H. Pols, A. Nigg, E . Clermonts, A. de jong, 1. Birkenhager, Erasrnus University, Rotterdam, The Netherlands

324.

LOW BONE MASS I N ADULTS WITH PREVIOUS HYPOTHALAMIC-PITUITARY TUMORS A N D L O W GROWTH HORMONE RESPONSES T O GROWTH HORMONE RELEASING-HORMONE A N D SERUM IGF-I LEVELS. R. Bing-You, C. Rosen, M . Denis, Maine Medical Center, Portland, ME

325.

SURVIVAL FOLLOWING VERTEBRAL FRACTURES: A POPULATION-BASED STUDY. C. Cooper, E. Atkinson, S. lacobsen, W . O’Fallon, 8 . Riggs, L. Melton, 111, Mayo Clinic, Rochester, MN

326.

DENSITOMETRIC EVIDENCE FOR LEAD-INDUCED OSTEOPENIA IN THE RAT. H . Cruber, T. Sanchez, F. Khalil-Manesh, H . Conick, Cedars-Sinai Medical Center and UCLA, Los Angeles, CA, and Norland Corporation, Fort Atkinson, WI

327.

CHANGING FUNCTIONAL DISABILITY IN OSTEOPOROTIC PATIENTS DURING A N AEROBIC EXERCISE PROGRAM. A. Hodsman, E . Helmes, D. Lazowski, Lawson Research Institute, London, Ontario, Canada

328.

NORMAL BODY MASS DOES N O T PROTECT AGAINST OSTEOPOROSIS-RELATED WRIST FRACTURES. 1. Bernstein, 1. Crisso, F . Kaplan, University of Pennsylvania, Philadelphia, PA

329.

SEASONAL CHANGES IN BONE MASS A N D BIOCHEMICAL MARKERS OF BONE TURNOVER IN RURAL ELDERLY WOMEN. C. Rosen, 5. Hunter, T. Morrison, H . Zhao, T. Chen, M. Holick, St. Joseph Hospital, Bangor, ME, and Boston City Hospital, Boston, M A

330.

THE IMPACT OF SPINAL FRACTURES ON GENERAL WELL-BEING IN ELDERLY WOMEN. C. Rosen, P. Linnell, S. Herrnansen, M. Robbins, M . Elias, B . Love, M. McClung, L. Lester, 1. Overdoff, 1. Stock, St. Joseph Hospital, Bangor, ME, Providence Medical Center, Portland, OR, and Medical Center of Central Massachusetts, Worcester, M A

331.

BIOCHEMICAL PATTERNS OF BONE A N D MINERAL METABOLISM IN AMENORRHEIC ATHLETES. 5 . Drinkwater, C. Chesnut, 111, Pacific Medical Center and University of Washington Medical Center, Seattle, W A

332.

ALL IN THE FAMILY? OSTEOPOROSIS FAMILY HISTORY A N D BONE DENSITY IN MEN. 5. Soroko, E. Barreft-Connor, D. Kritz-Silverstein, 5. Edelstein, University of California, La Jolla, CA

435-

THURSDAY, OCTOBER 1, 1992

333.

TRABECULAR REGENERATION I N BONE DEFECTS. 1. Aaron, 7. Skerry, University of Leeds and Bristol, UK

334.

BONE MINERAL STATUS OF WOMEN WITH MARFAN SYNDROME. L. Kohlmeier, R. Marc-us, Stanford University and VAMC, Palo Alto, CA

335.

CHARACTERIZATION OF A N IMMUNOASSAY FOR DETECTION OF BONE ISOENZYME O F ALKALINE PHOSPHATASE I N SERUM. Z. Avnur, 5. Pedersen, Syva Company, Palo Alto, CA

33h .

THE EFFECT OF BODY SIZE ON BONE MINERAL DENSITY IN FEMALE. S. Okamoto, K . Kushida, K . Yamazaki, T . Inoue, Harnarnatsu University School of Medicine, Hamarnatsu, Japan

337.

AREAL VERSUS VOLUMETRIC BONE MINERAL DENSITY OF THE FEMORAL NECK I N CHILDREN. D. Drinkwdter, D. Bailey, R. Faulkner, H . McKay, R. McCulloch, A. Wilkinson, C. Houston, University of Saskatchewan, Saskatoon, Canada

338.

THE RELATIONSHIP OF BONE MINERAL DENSITY OF THE LUMBAR SPINE (USING THREE DIFFERENT PROJECTION PROTOCOLS) T O PROXIMAL FEMUR BONE MINERAL DENSITY IN 74 ASYMPTOMATIC PREMENOPAUSAL WOMEN. H . McKay, D. Bailey, 0. Drinkwater, A. Wilkinson, University of Saskatchewan, Saskatoon, Canada

339.

CHANGES I N HEALTH RELATED QUALITY OF LIFE DURING OSTEOPOROSIS TREATMENT. 5. Silverman, M . Creenwald, D. Brandli, The Osteoporosis Medical Center, Wadsworth VAMC and UCLA School of Medicine, Los Angeles, CA

-340.

DIURNAL RHYTHM OF H U M A N SERUM BONE RESORBING ACTIVITY. P. Lakatos, A. Blumsohn, R. Eastell, 6 . Morris, H . Shinoda, P. Stern, Northwestern University, Chicago, IL, University of Sheffield, Sheffield, UK, and Tohoku University, Sendai, Idpan

341.

SHORT A N D LONGER-TERM PRECISION OF BROADBAND ULTRASOUND ATTENUATION MEASUREMENTS OF THE 0s CALCIS. L. Salamone, D. Zantos, f . Makrauer, 6 . Dawson-Hughes, USDA Human Nutrition Research Center o n Aging at Tufts University, Boston, M A

342.

URINE PYRlDlNOLlNE IS RELATED T O SERUM OSTEOCALCIN IN NORMAL MEN A N D WOMEN: AGE A N D SEX CONTRASTS. 1. Tobin, 5. Sherman, C. Plato, C. Cundberg, L. Nielsen, V . Kung, S.Seyedin, NIA, Baltimore, MD, Yale University, New Haven, CT, and Metra Biosysterns, Palo Alto, CA

343.

USE O F '"Ca A N D "Ca T O TEST ABSORPTION A N D SKELETAL KINETICS. V. Mafkovic-, 1. Linder, f . Hubacher, L. Hsieh, 1. Ilich, K . Foland, The Ohio State University, Columbus, OH

344.

QUANTITATION O F SKELETAL ALKALINE PHOSPHATASE ACTIVITY IN H U M A N SERUM: COMPARISON O F METHODS USING HEAT INACTIVATION A N D WHEAT GERM AGGLUTININ PRECIPITATION. 5. Hall, 1. Wergedal, C. Libanati, 1. farley, Loma Linda University and Pettis VAMC, Lorna Linda, CA

-S36-

THURSDAY, OCTOBER 1, 1992

345.

INCREASED IGF-IIA N D TGF-P IN H U M A N CALVARIAL BONE: POTENTIAL MECHANISM FOR INCREASED GRAFT SURVIVAL A N D DECREASED OSTEOPOROSIS. R. Finkelman, R. Hardesty, A. Eason, D. Rakijian, Y. Tutundzhyan, D. Baylink, Pettis VAMC and Lorna Linda University, Lorna Linda, CA

346.

COMPARISON OF QUANTITATIVE CT DENSITOMETRY USING LIQUID VERSUS SOLID PHANTOMS. 1. Healey, P. Williams-Russo, T. Szatrowski, R. Schneider, 5. Paget, K . Ales, P. Schwdrzberg, Cornell Musculoskeletal Arthritis Center, New York, NY

347.

EVALUATION O F FEMORAL NECK MEASUREMENTS BY DUAL ENERGY X-RAY ABSORPTIOMETRY. I. Molczyk, 1. Callagher, 1. Verter, Creighton University, Omaha, NE

348.

COMPARISON OF BONE MINERAL DENSITIES IN FEMALE LONG-DISTANCE RUNNERS VS. SWIMMERS. P. Buckenmeyer, K . Rourke, F. Thomas, R. Weinstock, A. Moses, Syracuse University and SUNY Health Science Center, Syracuse, N Y

349.

SALMON CALCITONIN MINIPUMP INFUSION IN BONE PAIN FROM BONE METASTASES. D. Agnusdei, M. Azria, C. Angelini, A. Camporeale, S. (hnnelli, C. Cenndrr, University of Siena, Italy, and Sandoz Ltd., Milan, Italy and Basel, Switzerland

350.

RADIOGRAPHIC ABSORPTIOMETRY: CORRELATIONS WITH OTHER BONE MASS MEASURING TECHNIQUES. C. Chesnut, S. Ott, University of Washington, Seattle, W A

351.

THE NURSE COORDINATOR’S ROLE IN THE PLANNING A N D INITIATION OF CLINICAL DRUG TRIALS FOR OSTEOPOROSIS RESEARCH. 1. DeBrock, M. Pitzd, M. Rogers, University of Washington, Seattle, W A

352.

BONE DENSITY MEASUREMENTS FOR HORMONE REPLACEMENT THERAPY. K. h i , M . Renc-ken, B. Drinkwater, C. Chestnut, University of Washington, Seattle, W A

353.

EXTRANEOUS FACTORS AFFECTING VALIDITY OF BONE MINERAL DENSITY MEASUREMENTS OF THE LUMBAR SPINE. M . Rencken, K. Lai, C. Chesnut, University of Washington, Seattle, W A

354.

BONE MASS IN EARLY POSTMENOPAUSAL WOMEN. 1. Smith, C . Dalsky, K. Shoukri, D. Kennedy, M . Trahiotis, University of Connecticut Health Center, Farmington, CT

3 55 .

BONE MASS IN ACTIVE A N D SEDENTARY OLDER MEN. G. Ddlsky, K. Shoukri, D. Kennedy, A. Zetterlund, University of Connecticut Health Center, Farrnington, CT

356.

THE ROTTERDAM ELDERLY STUDY: A N INTERIM ANALYSIS O F BONE MASS MEASUREMENTS IN MEN A N D WOMEN. H . Burger, P. van DJ&, I). A/gra, A. Hofman, 1. Birkenhdger, H . Schutte, H . Pols, Erasrnus University Medical School, Rotterdam. The Netherlands

357.

STRUCTURAL ANALYSIS OF BONE FRAGILITY AT THE HIP USING DEXA. C. Turner, P. Markwdrdt, Indiana University, Indianapolis, IN, and Lunar Corporation, Madison. WI

437-

THURSDAY, OCTOBER 1, 1992

358.

BONE L O S S AND FRACTURES OCCUR WITHIN SIX MONTHS AFTER HEART TRANSPLANTATION. M . del C. Rivas, S. Silverberg, T . Kim, 1. Bilezikian, E . Shane, College of Physici,ins and Surgeons, Columbia University, New York, N Y

359.

THE EFFECT OF THlAZlDE DIURETICS ON OSTEOCALCIN IN AGED INDIVIDUALS. \ f . Perry, 111, 1. lenscn, F . Kaiber, M . Horowitr, St. Louis University School of Medicine, St. Louis, MO

360.

BONE MINERAL DENSITY ABOVE A MULTI-SEGMENTAL LUMBAR SPINAL FUSION. (;, Ihgdmffy, T . Floyd, D. Ohnnieiss, R. Cuyer, S. Criffith, Texas Back Institute Kesmrch Found.ition, Plano, TX OSTEOPOROSIS IN YOUNG ADULTS WITH CYSTIC FIBROSIS. L. Bachrach, (1. l o u l i l , K . Marcus, Stanford University, Stanford and VAMC, Palo Alto, CA ()UANTIFICATION OF BONE LOSS FOLLOWING TOTAL HIP ARTHROPLASTY USING DUAL ENERGY X-RAY DENSITOMETRY. L. lenis, C . Steinberg, L. Osier, U . lLirctn, University of Massachusetts Medicdl Center, Worcester, M A

3 63 .

BONE DENSITOMETRY O F THE H A N D SKELETON: EVALUATION OF THE ACCUKACY AND PRECISION IN VITRO AND IN VIVO. S. Coemaere, 1. Kaufman, P. Stcigcr, P. Van dc Winkel, P. Covens, E. Veys, Ghent University Hospital, Ghent, Vrije Universiteit, Brussels, Belgium, and Hologic, Inc., Waltham, M A

NEED F O R STANDARDIZATION O F BONE MINERAL DENSITY MEASUREMENTS BY DXA IN THE PROXIMAL FEMUR. 1. Kalinowski, M. Sindki, W. Dunn, H . Wahner, M'iyo Clinic, Rochester, M N TKANSIENT ANALYSIS O F CANCELLOUS BONE REMODELING ACTIVATION AFTEK ESTROGEN WITHDRAWAL BY COMPUTER SIMULATION. P. Weinhold, 1. (;i/hert,1. Woodard, Mississippi State University, MS, and University of Florida THE CALCIUM INFORMATION CENTER: A COMPONENT O F THE CLINICAL NUTRITION RESEARCH UNIT O F THE NEW YORK HOSPITAL-CORNELL UNIVERSITY MEDICAL CENTER. B. Levine, L. Skluth, M . Wigren, R. Rivlin, R. Bockman, 1. Lane, The New York Hospital, Cornell Medical Center, Hospital for Special Surgery .ind Memorial Sloan-Kcttering Cmcer Center, NY

307.

A MODEL F O R FLUORIDE UPTAKE BY BONE. C. Turner, C. Soivin, P . Meunier, Indima School of Medicine, Indianapolis, IN, and Faculte A. Carrel, Lyon, France

368.

REPRODUCIBILITY O F UNCORKECTED VELOCITY OF SOUND DOES NOT INDICATE TKUE PRECISION. , WI

381.

INTER-OBSEKVER RELIABILITY O F SPINE A N D HIP BONE MINERAL ANALYSES HY DUAL-ENERGY RADIOGRAPHY. L. Alekt.4, 1'. k h / i n g , 1. ( . / ~ s ( ~ yK,. Woik~,~u, M . Sl,iughrer, K . Sfillman, University of Illinois, UrImn;i, IL

3112.

KEPRODUCIBILITY O F TOTAL A N D REGIONAL BODY COMIY>SITION MEASUKEMENTS BY DUAL-ENERGY RADIOGRAPHY. 1. C/,i\cy, l'. Fchlirig, 1. A h k 4 , R. Roilem, M . Sbughter, K . S t i l l m m , University o f Illinois, Url)m,i, IL

38.3.

EVIDENCE THAT INCREASED BONE FORMATION LEADS T O CALCIUM DEFICIENCY A N D PERIPHERAL BONE LOSS IN FLUORIDE TREATED PATIENTS: COKKECTION WITH 1 ,25 VITAMIN 0 . 11. Dure-SIiIith, S.f < i r / ( ' y , S. Li/ikh,irt, I ) . / 3 ' i y / / / i k , Loni,i L i d , ] University and Pettis VAMC, L.om'i Linda, CA

3 84.

A METHOD F O R COMPARING FRACTURE PREDICTOKS. S. f f u i , (.. .';hi/iJ(3nt/d, C. /ohn.\ton, / r . , Indiana University School of M d i c i n c , Iridi,incipolis, IN

439-

THURSDAY, OCTOBER 1, 1992

385.

LOADING-DEPENDENT VARIATIONS I N REGIONAL BONE DENSITY A N D LEAN BODY MASS. R. Whalen, 1. Tamanaha, 5. Arnaud, NASNAmes Research Center, Moffett Field, CA

386.

EVALUATION OF SERUM PHOSPHOCALCIC PARAMETERS I N THE NORMAL ELDERLY. R. luvin, P. Pillon, C. Bochu-Pillon, M. Denis, X . Phelip, Hopital A. Michallon, Grenoble, France

387.

A SUGGESTED METHOD FOR LOWER LIMB A N D SPINE VOLUMETRIC BONE MINERAL DENSITY ESTIMATION FROM WHOLE BODY DENSITOMETRIC DATA. A. Mondragon, 1. Tamayo, M. Aguilar, Universidad Nacional Autonoma de Mexico, Mexico

388.

USE OF THE REGRESSION DISCONTINUITY DESIGN I N A CLINICAL TRIAL OF CALCIUM EFFICACY. M. Barger-Lux, R. Heaney, K . Davies, Creighton University, Omaha, NE

389.

VERTEBRAL FRACTURE PROFILE FOR A N ELDERLY FEMALE COHORT. K . Davies, R. Recker, 5. Hinders, Creighton University, Omaha, NE

390.

ULTRASOUND MEASUREMENT OF BONE QUALITY OF A STRATIFIED SAMPLE OF A RURAL POPULATION. M . Stegman, R. Heaney, R. Recker, 1. Leist, D. TraversGustfason, Creighton University, Omaha, NE

391.

THE REPRODUCIBILITY OF BONE DENSITY ANALYSES USING DUAL X-RAY ABSORPTIOMETRY. C. €/-Hajj Fuleihan, 1. Angel/, N . Porrino, 5. Chung, M. LeBoff, Brigham and Women’s Hospital and Harvard Medical School, Boston, M A

392.

PRECISION OF DlGlTlZATlON MEASUREMENT OF VERTEBRAL HEIGHTS ON LATERAL SPINE RADIOGRAPHY. 1. Li, C. Wu, A. Friedlander, A. Wang, H . Cenant, University of California, San Francisco, CA

393.

MORPHOMETRIC CRITERIA FOR FRACTURE DEFINITION: MULTIPLE COMPARISONS WITH VERTEBRAL BONE DENSITOMETRY. C. Wu,]. Li, H . Cenant, University of California, San Francisco, CA

394.

UPGRADING DUAL ENERGY X-RAY ABSORPTIOMETRY SCANNERS: DO NEW MODELS PROVIDE EQUIVALENT RESULTS? K . Harper, B. Lobaugh, 5. King, M. Drezner, Duke University Medical Center, Durham, N C

395.

BLACK-WHITE DIFFERENCES OF COLLEGE-AGE WOMEN IN RADIAL BONE MASS A N D ANTHROPOMETRY: DIETARY A N D LIFESTYLE VARIABLES. 1. Anderson, F. Tylavsky, V . Adeleke, L. Wu, R. Talmage, 1. Taft, University of North Carolina, Chapel Hill, NC

396.

A NOVEL A N D IMPROVED METHOD FOR CALIBRATING DUAL ENERGY X-RAY DENSITOMETERS. 1. Finkelstein, B. Mitlak, D . Slovik, R. Neer, Massachusetts General Hospital, Boston, M A

397.

BONE MINERAL DENSITY OF LUMBAR VERTEBRAL BODY DETERMINED IN SUPINE A N D LATERAL DECUBITUS. A STUDY OF PRECISION A N D SENSITIVITY. D . Slosman, R. Rizzoli, A. Donath, 1. Bonjour, University Hospital, Geneva, Switzerland

-S40-

THURSDAY, OCTOBER 1, 1992

398.

GENETIC DETERMINANTS, AGE- A N D SITE-SPECIFICITY O F ASSOCIATIONS BETWEEN FAT MASS, FAT-FREE MASS A N D BONE DENSITY. C. Tsahmandris, 1. Hopper, E. Seeman, Austin Hospital and University of Melbourne, Australia

399.

COMPARISON OF ACUTE BIOCHEMICAL VARIATIONS INDUCED BY INGESTION OF DIFFERENT CALCIUM SALTS IN HEALTHY VOLUNTEERS. 1. Reginsfer, D. Denis, V. BJrtsc-h, R. Deroisy, f . frdnchimont, University of Liege, Belgium, and Georgetown University Medical Center, Washington, D C

400.

BONE MINERAL DENSITY MEASURED BY DUAL PHOTON ABSORPTIOMETRY A N D DUAL ENERGY X-RAY ABSORPTIOMETRY. A PROBLEM O F ACCURACY. 5. Rorenberg, A. feretz, 1. Praef, /. Vandromme, H. Ham, Free Universities of Brussels, Hopital Saint-Pierre, Brussels, Belgium

401.

A PILOT STUDY OF THE EFFECT O F A N EXERCISE PROGRAM, UTILIZING A WEIGHTED VEST, ON BONE MINERAL DENSITY. C. GrwndJle, S. Hirsch, T. Hahn, UCLA School of Medicine, Los Angeles, CA

402.

BONE VIABILITY IS LOST WITH AGING IN THE FEMORAL HEAD BUT N O T THE LUMBAR VERTEBRA. THE LOSS OF VIABILITY DOES N O T APPEAR T O AFFECT BONE COMPRESSIVE STRENGTH. C. Dunsfan, N. Somers, U. Milthorpe, R. Evans, Concord Hospital, Sydney, Australia

403.

NASAL SALMON CALCITONIN IN THE PREVENTION O F COKTICOSTEROIDINDUCED OSTEOPOROSIS. 1. Addchi, M. Steele, M . Gordon, W . Bensen, M. Hell, F . Bianchi, A. Cividino, G . Craig, R. Sebd/t, W. Sturtridge, L . Them&s, R. Roberts, M. Gent, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada

404.

VOLTAREN INHIBITS BONE RESORPTION IN POSTMENOPAUSAL A N D N O T PREMENOPAUSAL WOMEN: EVIDENCE THAT PROSTAGLANDINS MEDIATE POSTMENOPAUSAL BONE LOSS. N. S d l , D. tyre, K . Easlell, A. Colwell, R. Russell, 1. Shary, Medical University of South Carolina and VAMC, Chdrleston, SC, University of Washington, Seattle, WA, and University of Sheffirld Medical School, Sheffield, UK

405.

GLUCOCORTICOID-INDUCED OSTEOPOROSIS IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS. H. T d k ~ h a s h i ,H. Kurnagai, M. Kirnura, A. Hishidii, E. Sugiydma, A. Omura, K . Ydmazaki, K. Kushidd, Hamamatsu University School of Medicine, Hamamatsu , la pan

406.

CORRELATES OF BONE MINERAL DENSITY IN THE POSTMENOPAUSAL ESTROGENIPROGESTIN INTERVENTION TRIALS. R. Marcus, C. Grecnddr, B. Wells, Bowman-Gray School of Medicine, Winston Saltvn, N C

407.

CALCIUM AHSORPTION A N D ENDOGENOUS SECRETION DURING BED REST. A. LeBhnc, V . Srhneider, E . Spector, H. Evms, R. Rowc, B,iylor College of Mcdicinc and johnson Space Center, NASA, Houston, TX

408.

REGIONAL LEAN MASS A N D MUSCLE STRENGTH PKEDICT HIP DENSITY IN PREMENOPAUSAL WOMEN. C. Snow-Harter, T. Robinson, 1. $haw, A. Shellcy, M. Wegner, Oregon State University, Corvallis, O R

4 4 1-

THURSDAY, OCTOBER 1,1992

409.

TOTAL BODY BONE TURNOVER A N D BONE MASS CHANGES DURING 2 YEARS OF CALCIUM SUPPLEMENTATION A N D HORMONE REPLACEMENT. C. Webber, 1. Blake, L. Chambers, McMaster University Medical Centre, Hamilton, Ontario, Canada

410.

PRECISION OF DENSITOMETRY A N D SEQUENTIAL CHANGES IN BONE MASS IN YOUNG WOMEN. M . Luz Villa, B. Lewis, D. Cuido, L. Nelson, Stanford University, and VAMC, Palo Alto, CA

411.

AXIAL SKELETAL BONE DENSITY IN MEXICAN AMERICAN A N D NON-HISPANIC WHITE WOMEN. R. Bauer, S . Haffner, University of Texas Health Science Center and Audie Murphy VAMC, San Antonio, TX

41 2 .

SURVEY OF TREATMENT OF OSTEOPOROSIS IN MEDICAL PRACTITIONERS 1990. A. Licata, The Cleveland Clinic Foundation, Cleveland, OH

41 3.

COMPARISON BETWEEN THE RADIOGRAPHIC VERTEBRAL TRABECULAR PATTERN WITH VERTEBRAL FRACTURE PREVALENCE A N D VERTEBRAL BONE MINERAL DENSITY. C. Schnitzler, D. Pitchford, E. Willis, K. Gear, University of the Witwatersrand, Johannesburg, South Africa

414.

EFFECTS OF DIMETHYL PAMIDRONATE TREATMENT ON BIOCHEMICAL MARKERS OF BONE TURNOVER IN POSTMENOPAUSAL OSTEOPOROSIS. /. Zanchetta, C. Bogado, lnstituto de lnvestigaciones Metabolicas, Buenos Aires, Argentina

41 5 .

LONG TERM EFFECT OF NASAL CALCITONIN ON VERTEBRAL A N D FEMORAL BONE MASS IN EARLY MENOPAUSE: RESULTS OF A CONTROLLED PROSPECTIVE 3-YEAR STUDY. C. Ribot, f . Jremollieres, 1. Pouilles, P. Riffaud, C H U Purpan, Toulouse, and Sandoz Company, France

41 6.

VARIATIONS I N GASTROINTESTINAL CALCIUM ABSORPTION: RESPONSIBLE F O R HETEROGENEITY OF BONE REMODELING A N D RATES OF BONE LOSS IN FEMALE TYPE I OSTEOPOROSIS? M. Tellez, E . Mawer, A. Diaz, M. Arlot, R. Hesp, / . R . Green, P. Meunier, 1. Reeve, MRC Clinical Research Centre, Harrow, Department of Medicine, Manchester, UK, and INSERM U.234, Lyon, France

41 7.

MICROSTRUCTURAL CHARACTERISTICS A N D REMODELING OF BONE IN THE NECK OF FEMUR AT THE TIME OF FRACTURE. 1. Zanelli, 1. Bradbeer, S. Moyes, 1. Wand, 1. Roux, 1.R. Green, M. Arlot, P. Meunier, 1. Reeve, Clinical Research Centre, Harrow, UK, and INSERM U.234, Lyon, France

41 8.

SALMON CALCITONIN NASAL SPRAY A N D BONE TURNOVER: A DOSE-FINDING STUDY I N NORMAL PERIMENOPAUSAL WOMEN. 5. Connelli, A. Camporeale, D. Agnusdei, C. Angelini, D. Vassellatti, C. Cennari, University of Siena and Sandoz, Milan, Italy

41 9.

EFFECTS OF BONE TURNOVER A N D BONE MASS OF H U M A N RECOMBINANT GROWTH HORMONE A N D SALMON CALCITONIN IN POSTMENOPAUSAL OSTEOPOROSIS. C. Cennari, 5. Connelli, C. Cepollaro, M. Montomoli, A. Camporeale, D. Agnusdei, f . Zacchei, M. Campagna, University of Siena, Italy

420.

TOTAL BODY BONE MINERAL IN NORMAL A N D OSTEOPOROTIC WOMEN. A. Ohmura, K. Kushida, K. Yamazaki, S. Okamoto, M. Taniguchi, H. Katsuno, J. Inoue, Harnarnatsu University School of Medicine, Harnarnatsu, Japan -542-

THURSDAY, OCTOBER 1, 1992

421.

BONE HISTOMORPHOMETRY AFTER LONG-TERM TREATMENT WITH CYCLICAL PHOSPHORUS A N D ETIDRONATE. P. Miller, W . Huffer, 1. Zhu, D. Mclntyre, M . Yanover, M. Anger, M. Harrison, D. Cillurn, University of Colorado Health Sciences Center, Denver, C O

422.

DEPENDENCE OF BONE QUALITY, MINERAL DENSITY A N D FLUORIDE C O N TENT ON THE MODE OF FLUORIDE ADMINISTRATION. P. Antich, C. Boivin, P. Meunier, /. Gonzales, l. Anderson, 1. Prior, 1. Zerwekh, C. Pak, University of Texas Southwestern Medical Center, Dallas, TX

423.

THlAZlDES A N D SEASONAL BONE CHANGE IN HEALTHY POSTMENOPAUSAL WOMEN. 6. Dawson-Hughes, S. Harris, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, M A

424.

CHARGED BEADS A N D BONE REPAIR. B. Burns, R. Lozano, D. Simmons, M. Krukowski, M. Robson, University of Texas Medical Branch, Galveston, TX, and Washington University, St. Louis, MO

425.

CELL-CELL INTERACTION BETWEEN OSTEOBLASTS A N D BONE MARROW STROM A L CELLS. Y. Sakagarni, S. Nakai, H . Kobayashi, M . Funasako, M. Ohata, Wakayama Medical College, Wakayama, japan

426.

EFFICIENCY OF RESORPTION A N D THE NUMBER OF NUCLEI O F OSTEOCLASTS. S. /ones, K. Piper, A. Boyde, University College, London, UK

427.

CHARACTERIZATION OF ION CURRENTS IN A N OSTEOSARCOMA OSTEOBLAST-LIKE CELL LINE. 1. Loza, 5. Sirnasko, R. Dziak, SUNY, Buffalo, NY

428.

NEUROGENIC PEPTIDES ENHANCE BONE FORMATION IN VITRO. C. Shih, T . Wang, 1. Shyu, H . Chao, National Defense Medical Center, Taipei, Republic of China

429.

EFFECT OF ESTRADIOL ON PROLIFERATION OF H U M A N OSTEOSARCOMA CELLS IS MODULATED BY CULTURE CONDITIONS. A. €&ween, H. Kloosterboer, Organon International, Oss, The Netherlands

430.

IDENTIFICATION A N D ANALYSIS O F THE LY-6 DIFFERENTIATION ANTIGEN ON MURINE OSTEOBLASTS. M. Horowitz, A. Fields, H-Y Qian, D. DeMeo, E . Trepman, Yale University School of Medicine, N e w Haven, CT

431.

DISPARITY BETWEEN IN V l V O A N D IN VITRO EFFECTS O F GALLIUM NITRATE ON BONE FORMATION PARAMETERS. L. /enis, C. Waud, D. Baran, 1. Lian, C. Stein, University of Massachusetts Medical Center, Worcester, M A

432.

INTERLEUKIN-4 AS A MODULATOR OF OSTEOBLAST FUNCTION. I. RiJncho, M. Zarrabeitia, 1. Amado, 1. Olrnos, 1. Gonzales-Macias, Hospital M. Valdecill,i, University Cantabria, Santander, Spain

433.

GENE EXPRESSION IN 'IMMORTALIZED' H U M A N MARROW STROMAL STEM CELL-LINES. M. Nuttall, K. Hart, P. Callirnore, B. Ashton, D. lohnstone, University of Birmingham, RJ&AH Orthopaedic Hospital, Oswestry, Shropshire, and I.C.I. Pharmaceuticals, Cheshire, UK

643-

THURSDAY, OCTOBER 1, 1992

434.

REGULATION OF a 1 (I) COLLAGEN A N D BIGLYCAN rnRNA BY HORMONES A N D GROWTH FACTORS I N NORMAL A N D IMMORTALIZED OSTEOBLASTS. D. Thicdmutl, A. Porret, W. Hofstetter, H . Cuenther, H . Fleisch, University Hospital, Laus,inne m d University of Berne, Switzerland

435.

MECHANISM OF GROWTH HORMONE ACTIONS ON SAOS2 OSTEOBLAST-LIKE CELLS. M . Zheng, 5. Wysoc-ki, M . Beilharz, 1. Papadimitriou, D. Wood, University of Western Australia, Nedlands, Western Australia

4 .3 0 .

CHARACTEKIZATION OF THE EFFECTS OF THE PHORBAL ESTER TPA ON H U M A N OSTEOSARCOMA CELLS. 7. Ringborn-Anderson, M. Sandberg, K . Akerman, Abo Akaderni University and University of Turku, Turku, Finland

4.37.

ISOLATION METHOD O F OSTEOIDOSTEOCYTES. 1.Matsuo, Y. Hakeda, H. Kamiokd, K . Nemoto, K . Okano, K . Nanba, M. Ohta, M . Kumegawa, Hikone Research Laboratories, Maruho Co., Ltd., Hikone and Meikai University School of Dentistry, Sakado, Japan

4.38.

ISOLATION OF c D N A ENCODING SPECIFIC PROTEIN I N BONE FORMING CELL. M . Ohta, K . Tezuka, 1. Matsuo, H. Kamioka, Y. Haketa, K . Tanaka, K . Suzuki, M . Kurneg'iwd, Meikai University School of Dentistry, Sakado, Saitarna and CibaGeigy (Japan)Ltd., Takarazuka, Hyogo, Japan

439.

OSTEOBLAST-LIKE CELLS SECRETE GRANULOCYTE-MACROPHAGE A N D MACKOPHALE COLONY-STIMULATING FACTOR I N RESPONSE T O LIPOPOLYSACCHARIDE. K . Andi, N . Kurihara, 1. Tatsumi, K . Ikeda, Meikai University Faculty of Dentistry, Saitarna, Japan

440.

LEUKEMIA INHIBITORY FACTOR MODULATES ACTION OF 125,-DIHYDROXYVITAMIN D, ON OSTEOBLASTS BY DOWN-REGULATION OF VITAMIN D RECEPTORS. K . Tandkd, Y. Hakeda, K . Higashino, K . Ishizuka, M. Kumegawa, Meikai University School of Dentistry, Sakado, Saitarna and Teijin Institute for Bio-Medical Kescwch, Hino, Tokyo, Japan

441.

KAPlD OSTEOBLAST DIFFERENTIATION IN PRIMARY CULTURES OF RAT BONE MARROW STROMAL CELLS. 1. Kazhdan, 1. Sullivan, P. Leboy, University of Pennsylvania, Phi ladel p h ia, PA

442.

TUMOR NECROSIS FACTORC -I DECREASES OSTEOBLAST 1,25(OH),D, RECEPTORS BY A POST-TKANSCRIPTIONAL MECHANISM. N . Mayur, S. Lewis, M. Nanes, Emory University School of Medicine and VAMC, Atlanta, G A

443.

INHIBITION O F MINERALIZATION BY TRANSFORMING GROWTH FACTORBETA IS ACCOMPANIED BY INCREASED LACTATE PRODUCTION IN COLLAGEN GEL CULTURES O F NEONATAL RAT OSTEOBLASTS. D. TaIley-Ronsholdt, E . Lajiness, M,irquette University School of Dentistry, Milwaukee, W I

444.

OSTEOGENESIS A N D BONE REPAIR I N EXPERIMENTAL OSTEOPOROSIS A N D AGING. M . Fulldnd-lornet, S. Dong, V . Kalen, R. Strates, University of Florida and VAMC, G'iinesvillc, FL

445.

PHOSPHOLIPASE C INHIBITOR U-73122 BLOCKS ENDOTHELIN A N D PARATHYROID HORMONE-INDUCED CALCIUM TRANSIENTS IN UMR-106 CELLS. A. 7 ~ t r d i ,5.LW, P. Stern, Northwestern University, Chicago, IL 444-

THURSDAY, OCTOBER 1, 1992

446.

INDUCTION OF C-FOS mRNA LEVELS BY TRANSFORMING GROWTH FACTOR-PI IN NORMAL H U M A N OSTEOBLAST-LIKE CELLS. M . Subramaniam, M. Oursler, K. Rasmussen, 6. Riggs, T. Spelsberg, Mayo Foundation, Rochester, MN

447.

EVIDENCE FOR PROGESTIN RECEPTORS IN THE H U M A N TE85 OSTEOBLASTIC CELL LINE. 1. Cunnet, F . Persico, I. €vans, 15. Cryan, K . Demarest, The R.W. Johnson Pharmaceutical Research Institute, Raritan, Nl

448.

ROLE OF PROSTAGLANDIN E2 ON BONE CELL PROLIFERATION IN RESPONSE T O A CAPACITIVELY COUPLED ELECTRIC FIELD. 0. lorich, 1. Corsetti, C. Brighron, University of Pennsylvania, Philadelphia, PA

449.

THE A M O U N T OF SKELETAL ALKALINE PHOSPHATASE IN H U M A N OSTEOBLAST-LINE CELLS IS DIRECTLY DETERMINED BY PHOSPHATE A N D THE RATE OF RELEASE OF THE ENZYME IS INVERSELY DETERMINED BY CALCIUM. 1. Farley, S. Hall, M. Tanner, 1. Wergedal, Lorna Linda University and Pettis VAMC, Lorna Linda, CA

450.

BONE CELL PROLIFERATION A N D EXTREMELY L O W AMPLITUDE EMFs. R. Filzsimmons, 1. Ryaby, F. Magee, 0. Baylink, Pettis VAMC, Loma Linda, CA, and Orthologic Corp., Phoenix, A 2

451.

LACK OF PARATHYROID HORMONE RESPONSE IN RAT MANDIBULAR BONE CELLS. C. Yeh, T . Hymer, M . Katz, University of Texas Health Science Center and GRECC, VAMC, San Antonio, TX

452.

H U M A N OSTEOGENIC PROTEIN-1 INDUCES CHONDROBLASTIC DIFFERENTIATION OF OSTEOPROGENITOR CELLS DERIVED F R O M NEWBORN RAT CALVARIA. 1. Asahina, T. Sampath, 1. Nishimura, P. Hauschka, Children's Hospital and Harvard School of Dental Medicine, Boston and Creative BioMolecules, Hopkinton, M A

453.

OSTEOBLASTIC-RELATED GENE EXPRESSION BUT N O T DIFFERENTIATION IS SERUM DEPENDENT IN MC3T3-El OSTEOBLASTS. D. Yohay, L. Quarles, Duke University Medical Center, Durham, N C

454.

COMPARISON OF EFFECTS OF PULSED ELECTROMAGNETIC FIELDS O N PARATHYROID HORMONE RECEPTORS A N D BETA-ADRENERGIC RECEPTORS IN BONE CELLS. R. Luben, A. Morgan, A. Carlson, University of California, Riverside, CA

455.

AGE-DEPENDENT VARIATION IN 1,25-DIHYDROXYVlTAMIN D, REGULATION OF PROLIFERATION A N D ALKALINE PHOSPHATASE ACTIVITY A N D rnRNA IN RAT OSTEOGENIC CELL LINES. S. Murray, C. Clackin, €. Murray, Sepulveda VAMC and University of California, Los Angeles, CA

456.

PARATHYROID HORMONE STIMULATES CALPAIN 1/11 ACTIVITIES IN OSTEOBLASTIC CELL LINES. K . Tram, S. Murr,!y, D. Lee, t. Murray, Sepulveda VAMC and University of California, Los Angeles, CA

457.

ALTERNATIVE FORMS OF MOUSE TWIST, A BONE ASSOCIATED HELIX-LOOPHELIX REGULATORY MOLECULE. C. Clackin, €. Murray, S. Murray, VAMC, Sepulveda, and UCLA, Los Angeles, CA

THURSDAY, OCTOBER 1, 1992

458.

EFFECT OF AGE ON OSTEOGENESIS STIMULATED BY NEGATIVELY CHARGED RESINS I N KATS. M . Krukowski, D. Simmons, P. Osdoby, T . Winkelrnann, B. Eppky, Washington University, St. Louis, MO, UTMB, Galveston, TX, and Indiana University, Indianapolis, I N

45'1.

CALCITONIN GENE-RELATED PEPTIDE A N D PARATHYROID HORMONE ACUTELY BLOCK "Ca' ' UPTAKE I N OSTEOBLASTIC CELLS BY DIFFERENT MECHANISMS. T . Kawase, C. Howad, B. Roos, D. Burns, GRECC, VAMC and University of Miami School of Medicine, Miami, FL

460.

CONNEXIN 43 AS A POTENTIAL MEDIATOR O F PTH REGULATION O F CELL-TOCELL COMMUNICATION I N RAT OSTEOBLASTS. P. Schiller, P. Mehta, B. Roos, L. How,ird, GRECC, VAMC and University of Miami School of Medicine, Miami, FL

4hl.

NEUKOPEPTIDES MODULATE GENE EXPRESSION I N BONE METABOLISM. VAMC and University of Miami School of Medicine, Miami, FL

M.Bentlix, P. Sc-hiller, G.Howard, H. Roos, GRECC,

4hZ.

THE COMBINED ACTION OF RETINOIC ACID A N D INSULIN-LIKE GROWTH FACTOR (IGF1) ON THE PHENOTYPE O F BONE CELLS IS MODULATED BY THE EXTRA-CELLULAK MATRIX. H . Cuenthcr, H . Fleisc-li, University of Berne, Berne, Sw itrer IJ nd

463.

INTEKLEUKIN-1 A N D TRANSFORMING GROWTH FACTOR-BETA DOWN REGULATE PDGF-AA BINDING SITES ON H U M A N OSTEOBLASTIC CELLS. D. Craves, M . C h c i I l ~ i Y. , K m g , Y. Yeh, Boston University School of Graduate Dentistry, Boston, M A

464.

DO THlAZlDE DIURETICS ACT DIRECTLY ON OSTEOBLAST? D. Lajeunesse, R . Morcm~,Maisonneuve-Rosemont Hospital Research Center and University ot Montreal, Montreal , Canada

46s.

EXPRESSION O F ADHESION RECEPTORS BY RAT OSTEOBLAST-LIKE CELLS IN CULTURE. R. M'ijeska, T . Einhorn, Mount Sinai School of Medicine, N e w York, NY

4hO.

1,25(OH),L1, RECEPTOR LEVELS I N OSTEOCYTE DERIVED NORMAL H U M A N BONE CELLS. A. Bdttmann, N . Hartmann, B . Schroder, C . Seibold, A. Schulz, Justus-LiebigUniversity, Giessen, Germany

467.

ASSAY F O R OSTEOBLAST ADHESION MEDIATED BY RGD. K . Tan, C. Koncsics, Smith Kline Beecham Pharmaceuticals, King of Prussia, PA

468.

ENHANCEMENT O F MINERALIZATION I N H U M A N OSTEOBLAST-LIKE CELLS BY VITAMIN K,. Y. Koshihar,~,K . Hoshi, M . Shiraki, Tokyo Metropolitan Institute of Gerontology ,ind Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

4hY.

THE EFFECT O F (;LUCOCORTICOID ON THE SYNTHESIS OF SMALL PROTEOGLYCANS (BIGLYCAN A N D DECORIN) I N H U M A N BONE CELLS A N D BONE MARROW STROMAL CELLS. S. Kimoto, S. Cheng, L. Avioli, The Jewish Hospital of St. Louis at Washington University Medical Center, St. Louis, MO

-S46-

THURSDAY, OCTOBER 1, 1992

470.

CYTOKINE INDUCTION OF IL-6 CAN BE REGULATED BY ESTKOGEN IN H U M A N OSTEOBLASTS BUT NOT IN BONE MARROWSTROMAL CELLS. 1. Kiias, 1. K C W W ~ , R. P a d i c i , 1. Avioli, The Jewish Hospital at Washington University Medical Ccntcv, St. Louis, MO and Syntex Research, Palo Alto, CA

471.

DIFFERENTIAL EFFECTS OF GLUCOCORTICOIDS ON IGF I A N D ITS BINDIN(; PROTEINS IN H U M A N BONE MARROW STROMAL CELLS A N D H U M A N OSTEOBLASTS. S. Cheng, 5. Zhang, A. Fau5t0, 1. Avioli, The Jewish Hospital at Washington Univenity Medical Center, St. Louis, MO

472.

REGULATION OF MESSENGER RNA IN OSTEOBLAST-LIKE CELLS BY PARATHYROID HORMONE, CYCLIC AMP, A N D INSULIN-LIKE C;KOWTH FACTOK I. R. Drivdahl, C . Ric-hardson, VAMC, Tacoma, W A

473.

THE REGULATION OF COL1 A1 GENE EXPRESSION IN TKANSGENIC MOUSE CALVARIAE A N D OSTEOBLASTIC CELL LINE R O S 17/2.8. A. H c d ~ l o v ,I). I’avlin, Z. Bogthnovic, C. Woody, S. Clark, U . Kream, 0. Rowe, A. Lic hfler, University of Connecticut Health Center, Fdrrnington, CT and The Univwsity of Connecticut, Storrs, CT

474.

DETECTION OF AP-2 BINDING ACTIVITY IN A N UPSTREAM REGION O F THE KAT a I ( I ) COLLAGEN PROMOTER. M. Kronenlierg, A. lichtler, University of Connecticut Health Center, Farmington, CT

475.

1.2.5 DIHYDROXYVITAMIN D, MODULATES THE EFFECT O F H U M A N OSTEOGENIC PROTEIN-1 ON OSTEOBLASTS IN CULTURE. 1. Mc1/i‘ika/, T. S ~ m p i r h , C r e ~ t i v eBioMolecules, Hopkinton, M A

476.

DEXAMETHASONE A N D RETINOIC ACID ENHANCE EXPRESSION O F BETALLYCAN (TYPE Ill TGF-BETA RECEPTOR) GENE IN OSTEOBLAST-LIKE CELLS. H . Nakayama, F. Ichikawa, 1. Antlrcs, 1. M J S S J ~ UMC. >No&, , Medical Kcscwc-h Institute, Tokyo Medical and Dental University, Tokyo, lapin, and Memorial Sloan Kettering Cancer Center, N e w York, N Y

477.

EXPRESSION OF THE OSTEOBLAST DIFFERENTIATION MAKKEK H57 IS REGULATED BY DEXAMETHASONE IN VITKO. U . Linske, M. Alkirison, In\titutc of Pathology, GSF-Munich, Germany

478.

ATTACHMENT A N D GKOWTH O F CULTUKED H U M A N OSTEOBLASTS IN THE PRESENCE OF PROSTHETIC MATERIALS. 1. (;uo, W . Rmnic., University of M,initoh, Winnipeg, Canada

47’).

EFFECTS OF SECRETORY PRODUCTS O F BKEAST CANCER CELLS ON OSTE( 1BLASTS. M. lacroix, A!. Collrtfc,1. Uocly, Inst. I. Bordct, Univ. Lihre de Bruxcllvs, Bclgi urn

4w.

A N ANTISENSE OLIGODEOXYNUCLEOTIDE COMPLEMENTAKY T( 1 C-FOS PKOT( 1ONCOGE NE KNA PAKTIALLY I NHIB ITS KAT A N D H U M A N OSTE( >BLASTIC CELLS PROLIFERATION. M . M a hwatc, A. /ul/rcnnc,M . M o u k h ~ i rI’., MCirw,Hol)it,il LJ r iho i\ iere, Paris , F rancc

481.

THROMBOSPONDIN INDUCES THE PKOLIFEKATION O F RAT CALVAKIA OSTEOBLASTIC CELLS. M. Hort, P. Clcbz,irdin, I’. Marie., t i o p i t a l Larihoisierc, P,iri\ mtl Hopital E. Herriot, Lyon, France

447-

THURSDAY, OCTOBER 1,1992

482.

EXPRESSION OF P,-PURINOCEPTORS BY HUMAN AND RAT OSTEOBLASTS: POSSIBLE ROLE FOR ECTO-NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHATASE I N MODULATION OF PURINERGIC RESPONSES IN BONE. B. Oyajobi, R. Russell, A. Caswell, University of Sheffield Medical School, Sheffield and University of Leeds, Leeds, UK

483.

VITAMIN K, MODULATES PROLIFERATION A N D FUNCTION OF OSTEOBLASTIC CELLS IN VITRO. Y. Akedo, T. Hosoi, Y . Mizuno, A. Ikegami, 5. Inoue, T. Nakamura, Y. Ouch;, H . Orimo, Faculty of Medicine, University of Tokyo, Japan

484.

THE NEW AMINO-TERMINUS OF THE THROMBIN-CLEAVED THROMBIN RECEPTOR REGULATES CYTOSOLIC FREE CALCIUM A N D INTRACELLULAR p H IN H U M A N OSTEOBLAST-LIKE SaOS-2 CELLS. R. Ofori-Darko, 1. Maraganore, A. Tashjian, Ir., Harvard Medical School, Harvard School of Public Health, Boston and Biogen, Inc., Cambridge, M A

485.

REGULATION OF SKELETAL INSULIN LINE GROWTH FACTOR I A N D II SYNTHESIS BY LOCAL GROWTH FACTORS. E . Canalis, M. Centrella, B. Cabbitas, 5. Rydziel, T. McCarthy, St. Francis Hospital and Medical Center, Hartford, CT, and University of Connecticut School of Medicine, Farrnington, CT

486.

DIFFERENCES IN THE CELLULAR RESPONSE OF THE ENDOSTEUM T O FASTING A N D CALCIUM DEFICIENCY. K. Wright, P. McMillan, Lorna Linda University, Lorna Linda, CA

487.

TRANSFORMING GROWTH FACTOR BETA SUPPRESSES CHICK OSTEOBLAST FUNCTION. K. Kaysinger, W. Ramp, Carolinas Medical Center, Charlotte, N C

488.

PLASMIN ACTIVATABLE GROWTH FACTORS DIFFERENTIALLY REGULATE SECRETION OF PLASMIN SYSTEM COMPONENTS BY OSTEOSARCOMA CELLS. P. Campbell, 7. Yanosick, 1. Novack, Allegheny-Singer Research Institute, Pittsburgh, PA

489.

OPPOSING INFLUENCE OF WY-47,766 ON ADENYLATE CYCLASE A N D PHOSPHOlNOSlTlDE SIGNALLING IN ROS 17/2.8 CELLS. 5. Rohde, F . Bex, 1. Bilezikian, College of Physicians & Surgeons, N e w York, NY, and Wyeth-Ayerst Research, Princeton, NJ

490.

EXTRACELLULAR MATRIX SYNTHESIZED BY CLONAL OSTEOGENIC CELLS IS OSTEOINDUCTIVE, IN VITRO. M. Kirk, A. Kahn, University of California, San Francisco, CA

491.

ALTERED EXPRESSION OF THE IGF-II/MANNOSE-6-P RECEPTOR IN TRANSFORMED OSTEOBLASTS MAY BE DUE T O INAPPROPRIATE rnRNA LEVELS. 1. Puzas, 5. Song, R. Rosier, 5. Reynolds, M. Ishibe, University of Rochester, Rochester, NY

492.

IMMORTALIZATION OF A N OSTEOBLASTIC CELL CLONED FROM PIG BONE MARROW. N . Morrison, D. Durnam, 0. Thastrup, T. Whitmore, E. Moore, Zyrnogenetics, Seattle, W A

493.

HISTOMORPHOMETRY OF THE TIBIA OF GROWING RATS TREATED W I T H SODIUM ZEOLITE A. C. Firling, C. Evans, C. Wakley, R. Turner, University of Minnesota, Duluth and Mayo Graduate School of Medicine, Rochester, MN

448-

THURSDAY, OCTOBER 1, 1992

494.

ELECTRIC FIELDS MODULATE BONE CELL FUNCTION IN A DENSITY-DEPENDENT MANNER. K. Mc-Lcod, H. Dondhue, P. Levin, M. Font~ine,C. Rubin, SUNY, Stony Brook, N Y

495.

AGE-INDUCED DESENSITIZATION T O PARATHYROID HORMONE IN CISTEOBLASTS: A DEFECT IN ADENYLATE CYCLASE IS N O T INVOLVED. H. Donahuc., L. t'orres, C. Dee, C. Rubin, SUNY, Stony Brook, N Y

496.

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 ENHANCES INSULINLIKE GROWTH FACTOR BINDING A N D MITOGENESIS IN OSTEOBLAST-LIKE CELLS. D. Andress, S. Loop, VAMC, Seattle and Tdcoma and University of Washington, Se'ittle, W A

497.

BASIC FIBROBLAST GROWTH FACTOR INCREASES INSULIN-LIKE . / 3 r a ~ ( h , M. Bruns, D . Bruns, 1. Ferguson I/, D. Burton, I. Deitos, University of California ,ind VAMC, San Diego, CA, and University of Virginia, Ch,irlottesville, VA

574.

A H U M A N CHROMOGRANIN-A FUSION PROMOTER IS EXPRESSED IN CALCIT( 1NIN-POSITIVE NEUROENDOCRINE CELLS. E . Nolan, I . Hc4nidn, L. Dciros, Univcvsity of California and VAMC, San Diego, CA, m d NCVNIH, Bethesda, MD

-s55-

FRIDAY, OCTOBER 2, 1992

575.

FURTHER STUDIES ON THE EFFECT OF CHROMOCRANIN A-PEPTIDES ON THE SECRETION OF CALClTONlN GENE PRODUCTS. E. Martin, C. Chalberg, K. Smith, 5. Tu, I. Deftos, University of California and VAMC, San Diego, CA

576.

REGULATION OF BOVINE PARATHYROID CELL G, mRNA BY EXTRACELLULAR CALCIUM CONCENTRATIONS. F. Sun, M. levine, L. fitzpatrick, Mayo Clinic and Foundation, Rochester, MN, and JohnsHopkins University, Baltimore, MD

577.

COMPARATIVE ANALYSIS BETWEEN ADENOMA, HYPERPLASTIC A N D NORMAL PARATHYROID TISSUE. I. fitzpatrick, M. Herrera, C. Grant, 1. van Heerden, Mayo Clinic and Foundation, Rochester, MN

578.

PARATHYROID HORMONE-RELATED PROTEIN CONCENTRATIONS IN RAT MILK: RELATIONSHIPS WITH THE INTENSITY OF SUCKLING, FOOD INTAKE A N D PROLACTIN. M. Yamamoto, L . Duong, M. Caulfield, Merck Research Laboratories, West Point, PA

579.

INHIBIT10 N OF UTERINE CONTRACTION BY PARATHY ROID HORMONE RELATED-PEPTIDE IS DEPENDENT ON NITRIC OXIDE FORMATION. R. Shew, 1. Yee, University of Oklahoma Health Sciences Center, Oklahoma City, OK, and Creighton University, Omaha, NE

580.

PARATHYROID HORMONE DYNAMICS I N BLACK SUBJECTS. C. €/-Hajj Fuleihan, C. Cundberg, R. Cleason, N. Porrino, E. Brown, Brigham and Women’s Hospital, Boston, M A , and Yale University School of Medicine, N e w Haven, CT

581.

LEVELS OF PTHrP IN HYPERCALCEMIA OF MALIGNANCY ARE N O T LOWERED BY TREATMENT WITH THE BISPHOSPHONATE B M 21.0955. E . Blind, F . Raue, 7. Meinel, C. Wuster, R. Ziegler, University of Heidelberg, Heidelberg, Germany

582.

REGULATION OF SODIUM/CALCIUM EXCHANGE IN OSTEOBLASTS BY PARATHYROID HORMONE. C. Short, D. Bushinsky, N. Krieger, University of Rochester School of Medicine, Rochester, NY

583.

CALCITONIN MODULATION OF OSTEOCLAST ANTIGEN EXPRESSION A N D CYTOSOLIC CALCIUM IN AVIAN MARROW-DERIVED MONONUCLEAR A N D GIANT CELLS. R. Calvin, T . Nelson, P. Osdoby, R. Civitelli, Washington University and The Jewish Hospital, St. Louis, MO

584.

ABSTRACT WITHDRAWN

585.

ANDROGENS INHIBIT PARATHYROID-RELATED PEPTIDE GENE EXPRESSION IN THE HYPERCALCEMIC RAT LEYDIG TUMOR CELLS. B. Liu, D. Coltzman, 5. Rabbani, McGill University and Royal Victoria Hospital, Montreal, Canada

586.

ISOLATION A N D CHARACTERIZATION OF GENOMIC CLONES ENCODING HUM A N CHROMOGRANIN A. A. Mouland, 5. Bevan, G. Hendy, McGill University and Royal Victoria Hospital, Montreal, Canada

587.

PROTO-ONCOGENE EXPRESSION A N D CELL CYCLE ANALYSIS I N PROLIFERATING BOVINE PARATHYROID CELLS. I . Sohi, A. Mouland, C. Hendy, McGill University and Royal Victoria Hospital, Montreal, Canada

456-

FRIDAY, OCTOBER 2, 1992

588.

ANALYSIS OF THE MECHANISMS INVOLVED IN THE UNIQUE INTERACTION OF CALCITONIN WITH ITS RECEPTOR. 5. Coldring, M . Flannery, C. Manning, A. Gorn, Harvard Medical School, N e w England Deaconess Hospital and Massachusetts General Hospital, Boston, M A

589.

ESTROGEN REGULATION OF PTHrP GENE EXPRESSION I N THE RAT NERVOUS SYSTEM IS TISSUE-SPECIFIC. W . Crasser, D. Petersen, S. Srnoc-k, M. Thiede, Pfizer Central Research, Groton, CT

590.

COEXPRESSION OF PTHrP A N D PTH/PTHrP RECEPTOR mRNA IN VASCULATURE SUPPORTS A LOCAL MECHANISM OF ACTION IN CARDIOVASCULAR TISSUES. M. Thiede, D. Petersen, W . Crasser, H . ldppner, A. Abou-Snrnra, C. Segre, Pfizer Central Research, Groton, CT, and Massachusetts General Hospital, Boston, M A

591.

OCTREOTIDE, A SOMATOSTATIN ANALOG, SIMULTANEOUSLY DlMlNlSHEU BONE RESORPTION A N D ENHANCED FORMATION, IN A PATIENT WITH SEVERE PAGET'S DISEASE. C. Pdrnieri, H . Sacks, D. Nutting, University of Tennessee, Memphis, T N

592.

ACTIVATION OF THE IGF-IIKATION-INDEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BY ACID PHOSPHATASES STIMULATES A RAPID NET INFLUX OF CA' ' IN BALBK 3T3 FIBROBLASTS. M. Zuscik, M . Ishibe, R. Rosier, J. Cunter, K. Cunter, 1. Puzas, University of Rochester, Rochester, NY

593.

COMPARISON OF SIMILAR MODELS O F PARATHYROID HORMONE A N D PARATHYROID HORMONE-RELATED PROTEIN EXCESS I N NUDE MICE. J. Guise, 1. Chirgwin, B. Boyce, C. Favarato, C . Mundy, University of Texas Health Science Center, San Antonio, TX

594.

INTERLEUKIN-6 A N D LEUKEMIA INHIBITORY FACTOR ARE IMMEDIATE-EARLY GENES INDUCED BY CAMP I N RESPONSE T O PARATHYROID HOKMONE. E . Greenfield, 5. Cornik, Case Western Reserve University, Cleveland, OH

595.

THE RATIO OF C-iPTH/I-iPTH I N SERUM A N D ITS SET-POINT VARY IN RELATION WITH BOTH THE MAGNITUDE A N D THE DIRECTION O F CA" CHANGES. 1. Brossard, L. Rousseau, P. D'Arnour, Hopital Saint-Luc and Universite de Montreal, Montreal, Canada

596.

MODULATION OF CANINE CIRCULATING PARATHYROID HOKMONE I M M U NOHETEROGENEITY BY IONIZED CALCIUM CONCENTRATION. M. Cloulier, H . Zhang, 1. Rousseau, P. D'Amour, Hopital Saint-Luc and Universite de Montreal, Montreal, Canada

597.

COMPARISON OF FLUORIDE A N D VANADATE EFFECTS ON PROLIFERATION O F H U M A N OSTEOBLAST-LIKE CELLS IN VITRO. T. Fakkeldij, C. Darnen, 5. Duursma, 8.Scheven, University Hospital, Utrecht, The Netherlands.

598.

CALCIUM MODULATES THE EXPRESSION OF CYCLIN D 1 IN A PARATHYROID CELL LINE. 5. Bianchi, S. Fabian;, A. Arnold, M. Brand;, University of Florence, Florence, Italy, and Massachusetts General Hospital, Boston, M A

457-

FRIDAY, OCTOBER 2,1992

599.

EVIDENCE THAT HYDROGEN PEROXIDE IS THE OSTEOBLAST-OSTEOCLAST COUPLING FACTOR FOR VITAMIN D-,-INDUCED STIMULATION OF BONE RESORPTION. M . Zaidi, B. Banerji, C. Bax, A. Alam, V. Shankar, 6. Moonga, M. Pazianas, 5.Abott, T. Sahinoglu, N. Nazhat, C. Stevens, D. Blake, 6 . Bax, St. George's Hospital Medical School and London Hospital Medical School, London, UK

600.

PARATHYROID HORMONE EXHIBITS DUAL ACTIONS ON THE STRETCH-ACTIVATED CATION CHANNEL OF THE OSTEOBLAST. R. Duncan, K. Hruska, The Jewish Hospital of St. Louis, St. Louis, MO

601.

STIMULATION OF PARATHYROID HORMONE-RELATED PROTEIN PRODUCTION BY TRANSFORMING GROWTH FACTOR-P, IN A SQUAMOUS CARCIN O M A CELL LINE. 1. Merryman, 7. Rosol, 1. DeWille, 5. Farmer, 1. Werkmeister, C. Capen, The Ohio State University, Columbus, OH

602.

PARATHYROID HORMONE-RELATED PROTEIN PRODUCTION BY NORMAL HUM A N KERATINOCYTES I N VlTRO IS ASSOCIATED WITH A LESS DIFFERENTIATED PHENOTYPE. 1. Werkmeister, T. Rosol, 1. Merryman, C. Capen, The Ohio State University, Columbus, OH

60

DESIGN A N D EVALUATION OF NOVEL CALClTONlN LIGANDS T O STUDY THE CONTACT POINTS BETWEEN CALClTONlN A N D ITS CLONED RECEPTOR. M . Chorev, M. Caulfield, C. Leu, 1. Levy, M. Flannery, 5. Coldring, M. Rosenblatt, Beth Israel Hospital and Harvard Medical School, Boston, Hebrew University, Jerusalem, Israel, Merck Research Labs, West Point, PA, and Massachusetts General Hospital, Boston, M A

604.

PARATHYROID HORMONE, CALCITONIN, A N D OSTEOCALCIN LEVELS A M O N G JAPANESE-POPULATION BASED STUDY. S. Fujiwara, M. Shiraki, R. Sposto, K. Kodarna, H. Sasaki, Y. Hosoda, K. Shimaoka, Radiation Effects Research Foundation, Hiroshima and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

605.

BONE DISC BIOASSAY FOR CALCIOTROPIC AGENTS. W. Bergstrom, SUNY Health Science Center, Syracuse, N Y

606.

ACTIVATION OF THE PHOSPHOLIPASE D PATHWAY BY PTH (1-841, PTH (1-34) A N D PTH FRAGMENT (3-34) IN A H U M A N OSTEOSARCOMA CELL LINE, OHS-4. B. Fournier, /. Ferralli, D. Rohner, 1. Pfeilschifter, Ciba-Geigy Ltd., Basel and Biocenter University of Basel, Switzerland

607.

DlLTlAZEM STIMULATES PARATHYROID HORMONE SECRETION IN V l V O WHEREAS FELODIPINE DOES NOT. 1. Casez, L. Villiger, R. Takkinen, Ph. laeger, University of Berne, Switzerland.

608.

REGULATION OF PARATHYROID HORMONE-RELATED PEPTIDE EXPRESSION IN N O R M A N H U M A N MAMMARY EPITHELIAL CELLS. M. Sebag, /. Henderson, V. Papavasiliou, D. Coltzman, R. Kremer, McGill University and Royal Victoria Hospita I, Montrea I, Canada

609.

LOW DOSES OF 1,25(OH),D., DRAMATICALLY INHIBIT THE IN V l V O DEVELOPMENT OF THE WALKER CARCINOMA IN RATS. M. Cohen-Solal, Z. Bouizar, M. Denne, A. Craulet, 1. Cueris, A. lullienne, M . de Vernejoul, Hopital Lairboisiere, Paris, France

458-

FRIDAY, OCTOBER 2, 1992

61 0.

LATE-ONSET NEONATAL HYPOCALCEMIA A N D HYPOPARATHYROIDISM IN T W O INFANTS OF MOTHERS WITH HYPERPARATHYROIDISM. 1. Bennett, B. Thomas, University of Arkansas, Little Rock, AR

611.

DEVELOPMENT OF ANIMAL MODELS OF HYPERPARATHYROIDISM A N D H U MORAL HYPERCALCEMIA OF MALIGNANCY USING SOMATIC CELL GENE TRANSFER. M. Melton, 1. Wilson, University of Michigan, Ann Arbor, M I

61 2.

GUANYLIN: A NOVEL PEPTIDE HORMONE THAT REGULATES KIDNEY GUANYLATE CYCLASE BY A PARACRINE MECHANISM. L. Forte, W. Krause, R. Freeman, 1. Kato, R. Wiegand, K . Fok, M. Currie, Missouri University, Columbia, MO, and Monsanto Corporate Research, St. Louis, MO

61 3.

PROTEIN TYROSINE PHOSPHORYLATION I N A N OPOSSUM KIDNEY CELL CLONE. 1. Cole, A. Thurston, University of Missouri, Columbia, MO

61 4.

LOCALIZATION OF PTHrP A N D PTH/PTHrP RECEPTOR mRNAs I N THE RAT CENTRAL NERVOUS SYSTEM BY IN SlTU HYBRIDIZATION. K . Lee, D. Weaver, A. Bond, C . Segre, Massachusetts General Hospital, Boston, M A

61 5.

CHARACTERIZATION OF THE c D N A ENCODING THE H U M A N PTH/PTHrP RECEPTOR. €. Schipani, H. Karga, A. Karaplis, P. Hellman, L. Xie, ). Potts, If., H . Kronenberg, A. Abou-Samra, C. Segre, H. luppner, Massachusetts General Hospital, Boston, M A

61 6.

BONE EXTRACELLULAR MATRIX INCREASES PARATHYROID HORMONE-RELATED PROTEIN PRODUCTION BY CULTURED LUNG SQUAMOUS CELL CARCIN O M A . R. Rizzoli, 1. Bonjour, University Hospital, Geneva, Switzerland

61 7.

EFFECT OF PTH A N D PTHrP ON PROLIFERATION, KILLING, A N D MEMBRANE MARKER EXPRESSION OF ANTIGEN SPECIFIC CD4' T CELL CLONES. C. Lowik, 1. Oudshoorn, 1. Dieleman, F. Koning, University Hospital, Leiden, The Netherlands

61 8.

TRIIODOTHYRONINE INCREASES INSULIN-LIKE GROWTH FACTOR mRNA LEVELS IN THE CLONAL OSTEOBLASTIC CELL LINE MC3T3-El. F. Varga, M. Rurnpler, K . Klaushofer, Ludwig Boltzmann Institute for Osteology and Hanusch Hospital, Vienna, Austria

61 9.

DOSE A N D TIME EFFECTS OF PROPRANOLOL ON BONE MECHANICS, MINERALIZATION A N D COLLAGEN IN VIVO. 6. Minkowitz, M . Yarnauchi, C. Mechanic, S. Varano, C. Lerner, A. Boskey, Maimonides Medical Center, Brooklyn, NY, University of North Carolina Dental Research, Chapel Hill, NC, and Hospital for Special Surgery, New York, N Y

620.

PLASMA IGF-I, CALCITONIN A N D VERTEBRAL B M D IN HYPERPROLACTINEMIC WOMEN. 0 . Torring, E . Bucht, B. Isberg, A. Hulting, H . Sjoberg, Karolinska Hospital, Stockholm and Huddinge Hospital, Huddinge, Sweden

621.

DIFFERENTIAL EFFECTS OF TRANSFORMING GROWTH FACTORS p 1 A N D p2, BONE MORPHOGENETIC PROTEIN-2 A N D OSTEOGENIC PROTEIN-1 ON C H O N DRO-OSTEOGENESIS IN CULTURED FETAL MOUSE LONG BONES. S. Dieudonne, S. Coei, C. Semeins, 1. Klein Nulend, E. Burger, ACTA-Free University, Amsterdam, The Netherlands

459-

FRIDAY, OCTOBER 2, 1992

622.

CHARACTERISTICS OF CALCIUM TRANSPORT IN THE LUMINAL A N D THE BASOLATERAL VESICLES FROM RAT KIDNEY CORTEX OF HYPERCALCEMIC RATS BEARING THE WALKER CARCINOSARCOMA 256. f . deMiguel, P . Esbrit, Fundacion Jimenez Diaz, Madrid, Spain

623.

HORMONE REPLACEMENT THERAPY DECREASES PlJLSATlLE PTH SECRETION IN EARLY POSTMENOPAUSAL WOMEN. H. Hdrms, 0 . Neubauer, P . Wustermann, R. Horn, C. Kayser, A. V.Z. Muhlen, R. Hesch, Medizinische Hochschule, Hannover, Germany

h24.

THE TUMOR-PROMOTING LACTONE, THAPSIGARGIN, INHIBITS BONE RESORPTION A N D STIMULATES PROSTAGLANDIN E, FORMATION IN CULTURED MOUSE CALVARIA. M. Ransjo, U . Lerner, University of Umea, Sweden

h25.

FAMILIAL ISOLATED PRIMARY HYPERPARATHYROIDISM. M. Kassem, C. Xu,

5. Brdsk, E . Eriksen, L. Mosekilde, 7. Kruse, University of Aarhus, Denmark 626.

EXERCISE ENHANCED TlBlAL CORTICAL BONE MASS BY STIMULATED PERIOSTEAL BONE FORMATION A N D SUPRESSED ENDOSTEAL BONE RESORPTION IN FEMALE ADULT AGED RATS. M. Chen, 1. Yeh, 1. Aloia, 1. Tierney, WinthropUniversity Hospital, Mineola, NY, and SUNY, Stony Brook, NY

h27.

H U M A N CHROMOSOMAL LOCALIZATION OF A BONE MORPHOGENETIC PROTEIN SUBFAMILY: BMP5, BMP6, A N D BMP7. C. Hahn, R. Cohen, /. Wozney, C. Levitz, M. Zasloff, F . Kaplan, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, PA, and Genetics Institute, Cambridge, M A

628.

EVIDENCE THAT BISPHOSPHONATE-MEDIATED INHIBITION OF MINERALIZATION PROMOTES BONE-MATRIX PRODUCTION IN VITRO. H . Tenenbaum, B. Sukhu, M . Torontali, M. Dowhaniuk, P. Birek, Mount Sinai Hospital, Toronto, Canada

629.

EFFECTS OF PHYTOCHEMICAL, GARLIC, ON CALCIUM A N D ZINC STATUS OF ADULT MALE A N D FEMALE SPRAGUE-DAWLEY RATS. S. Kaup, S. Ahn, 1. Rader, Food and Drug Administration, Washington, D C

h30.

EFFECTS OF PHYTOCHEMICAL, GARLIC, ON CALCIUM A N D ZINC STATUS I N WEANLING MALE A N D FEMALE SPRAGUE-DAWLEY RATS. S. Kaup, S. Hight, 1. R d e r , Food and Drug Administration, Washington, D C

h31.

STIMULATION O F PROTEIN KINASE C ACTIVITY I N CHONDROCYTE CULTURES BY VITAMIN D, METABOLITES IS DEPENDENT UPON CELL MATURATION. V . Sylvia, L. Schuman, Z. Schwartz, R. Comez, B. Boyan, University of Texas Health Science Center, San Antonio, TX, and Hebrew University, Jerusalem, Israel

632.

ADENOSINE TRIPHOSPHATE PROMOTES MINERAL DEPOSITION IN DIFFERENTIATING CHICK LIMB-BUD MESENCHYMAL CELL CULTURES. A. Boskey, D. Stiner, R. Mendelsohn, S. Doty, The Hospital for Special Surgery, N e w York, NY

h33.

SERUM PROPEPTIDE OF PROOSTEOCALCIN, INTACT OSTEOCALCIN A N D N-FRAGMENT O F OSTEOCALCIN: A SPECIFIC MARKER OF BONE FORMATION A N D RESORPTION. 5. Kanzaki, T. Moriwake, M . h u e , H. Tanaka, T . Kubo, K . Hosada, T . YJmaji, Y. Seino, Okayama University Medical School, Okayama and Teijin Ltd., Tokyo, Japan -S60-

FRIDAY, OCTOBER 2,1992

634.

THE ABILITY OF RECOMBINANT H U M A N BONE MORPHOGENETIC PROTEIN T O HEAL SEGMENTAL BONE DEFECTS-A COMPARISON OF PHYSIOLOGIC CARRIERS TO AUTOLOGOUS BONE GRAFT. 6 . Cole, A. Yasko, M. Browne, E. lomin, S. Waller, V . Rosen, 1. Lane, The Hospital for Special Surgery, New York, NY, and Genetics Institute, Cambridge, M A

635.

RECOGNITION OF BSPll A N D OSTEOPONTIN RGD-CONTAINING PEPTIDES REGULATES [Caz']i I N H U M A N OSTEOCLAST-LIKE CELLS. REGULATION BY PHORBOL ESTERS. R. Paniccia, M . Crano, P. Cehron Robey, A. Zambonin Zallone, A. leti, University of Bari, Italy and NIDR/NIH, Bethesda, MD

636.

ASSESSMENT OF BONE HISTOMORPHOMETRY IN CHILDREN A N D ADOLESCENTS: GROWTH A N D BIOCHEMICAL CORRELATIONS. M. Norman, A. Taylor, 1. Bowen, R. Travers, F. Glorieux, Alfred I. duPont Institute, Wilmington, DE, Jefferson Medical College, Philadelphia, PA, Shriner's Hospital and McGill University, Montreal, Canada

637.

STIMULATION OF MINERAL DEGRADATION, BUT N O T COLLAGEN DEGRADATION BY LIPOPOLYSACCHARIDE IN NEWBORN RAT CALVARIA. 1. Kim, 6 . Han, Glaxo Inc. Research Institute, Research Triangle Park, NC

638.

EVIDENCE THAT FLUORIDE A N D PHENYTOIN ACT IN CONCERTTO STIMULATE BONE FORMATION A N D BONE VOLUME I N ADULT RATS. 1.Ohta, 1. Wergedal, D. Baylink, K . Lau, Loma Linda University and Pettis VAMC, Loma Linda, CA, and Sapporo Medical College, Japan

639.

STIMULATED PHOSPHATE TRANSPORT I N BONE-RESORBING CHICKEN OSTEOCLASTS. A. Fujimora, A. Miyauchi, M. Fukase, 1.Tsukamoto, 1.Fujita, K. Chihara, Kobe University School of Medicine, Kobe, Japan and National Sanatorium, Hyogo Chuo, Hyogo, Japan

640.

STATUS OF EPIPHYSEAL GROWTH PLATE IN THE SKELETON OF THE GUINEA PIG. A HISTOLOGICAL A N D RADIOGRAPHIC STUDY. A. Pataki, M. Glatt, CibaGeigy Ltd., Basle, Switzerland

641.

OSTEOCALCIN ON OSTEOCLAST FORMATION A N D BONE RESORPTION. N. Kurihara, K. Hosada, M. Kumegawa, K. Ikeda, Meikai University, Saitama and Teijin Institute for Biomedical Research, Tokyo, Japan

642.

EFFECT OF rhBMP-2 ON CHONDROBLASTIC DIFFERENTIATION IN VITRO. A. Yamaguchi, T. Katagiri, C. ]in, 1.Ikeda, I. Wozney, V . Rosen, 1.Suda, 5. Yoshiki, Showa University School of Dentistry, Tokyo, Japan, and Genetics Institute, Inc., Cambridge, M A

643.

TOOTH ENAMEL INTEGRITY DURING CONSUMPTION OF ACIDIC FOODSTUFFS. M. Andon, R. Kanerva, C. Schuster, K. Smith, The Procter & Gamble Company, Cincinnati, OH

644.

DOES HYALURONATE PLAY A ROLE IN BONE FORMATION? 1. Dickson, P. Roughley, Brunel University, Uxbridge, UK, and Shriner's Hospital, Montreal, Canada

645.

CALCITONIN EFFECTS ON RABBIT ARTICULAR CARTILAGE EXPLANTS. 5 . Baca, R. Altman, D. Dean, GRECC, VAMC and University of Miami, Miami, FL

FRIDAY, OCTOBER 2, 1992

REGULATION O F OSTEOCALCIN mRNA LEVELS BY 1,25(OH), VITAMIN D, I N BONE A N D INTESTINE. 1. Fleet, 1. Hock, USDA HNRCA and School of Dental Medicine, Tufts University and VA OPC, Boston, M A DIFFERENTIAL EFFECTS OF GROWTH FACTORS I N REGULATION O F CLEAVAGE O F AMINO-TERMINUS A N D CARBOXYL-TERMINUS EXTENSION PEPTIDES O F TYPE I PKOCOLLAGEN. 1. Peterson, M . Anderson, S. Bonde, 7. Spelsberg, 6 . Riggs, M,iyo Clinic and Foundation, Rochester, MN 048.

A N IMMUNOASSAY FOR THE C-TERMINAL PROPEPTIDE 50.

DETERMINATION O F TOTAL URINARY HYDROXYPROLINE I N RATS, DOGS, A N D MICE USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH PRECOLUMN DERIVITIZATION. L. Minor, A. Farber, K. Dernarest, The R.W. Johnson Pharnixeutical Research Institute, Raritan, NJ

6.51.

EVIDENCE F O R A PROGRESSIVE DECLINE OF IGF-I I N H U M A N BONE I N BOTH MALES A N D FEMALES AS A FUNCTION OF AGE. V . Nicolas, A. Prewett, P. Betlicd, A. E w m , D. Bdylink, R . Finkelman, Pettis VAMC and Lorna Linda University, Lorna Linda, CA, and Osteotech, Inc., Shrewsbury, NJ

652.

DEVELOPMENT O F SYNTHETIC IMPLANT MATERIALS T O PROMOTE BONE REPAIR I N THE RAT TlBlAL DEFECT MODEL. P. Behrens, €. Dodson, S. Mohan, 1. Wergtdil, R. Finke/nJan, T . Ohta, 1. Hassenpflug, D. Baylink, VAMC and Loma Linda University, Lorna Linda, CA, and University of Kiel, Germany

6s 3 .

LOCALIZATION OF IMMUNOREACTIVE BASIC FIBROBLAST GROWTH FACTOR LIKE ACTIVITY I N THE AVIAN EPIPHYSEAL GROWTH PLATE. W. Twal, R. V ~ ~ i l a t o ~ Younken, C. Lay, R. Leach, The Pennsylvania State University, University Park, PA

654.

VALIDATION O F DUAL ENERGY X-RAY ABSORPTIOMETRY AS A QUANTITATIVE MEASURE O F BODY COMPOSITION I N SMALL SUBJECTS. K . Wedekind, P. T o l l , I). R i c h d s o n , W. Burkholder, Mark Morris Associates, Topeka, I58.

A NOVEL APPROACH F O K THE DEVELOPMENT (IF A KADIOIMMUNOASSAY F O R CANINE OSTEOCALCIN. .S. WJflg, K. &fllJrc3l, /.