115th Annual Meeting of the American Neurological Association October 14-17, 1990 Atlanta Hilton & Towers, Atlanta, GA

Program Monday, October 15

Saturday, October 13

9:OO The Society for Experimental Neuropathology -430 (SENP) will hold its Third Annual Meeting Scientific Sessions I, 11, and 111 Vienna Room, Third Floor

7:OO ANA Registration -5:OO Grand Ballroom Foyer, Second Floor

9:OO All-day poster presentation 1 and exhibits -5:3O (Authors present 1:OO-2:30) Grand Salon

430 Poster Session for the Society of Experimental -6:00 Neuropathology (SENP) DusseldorfiLisbon Rooms, Third Floor


8:3O PRESIDENTIAL SYMPOSIUM ON THE -1 1 :35 IMPACTS OF MOLECULAR GENETICS O N NEUROLOGY Chair: Joseph B. Martin, San Francisco, CA Grand Ballroom East

Sunday, October 14 Morning

9.90 The Society for Experimental Neuropathology’s -12:OO (SENP) Scientific Session IV, Guest Lecturer,

890 The Power of Molecular Genetics: An

and Peter Lampert Award RockdaleiForsythe Rooms, Second Floor

-9:OO Overview Joseph B. Martin, San Francisco, CA

8:15 The Movement Disorder Society (MDS) and the -12:OO Parkinson Study Group (PSG) present a symposium on “The Etiology, Pathogenesis and Prevention of Parkinson’s Disease” Grand Ballroom A, Second Floor

9:00 The Clinical Eye Movement Society (CEMS) -5:OO presents its Seventh Ocular Motor Symposium Fayettemewton Rooms, Second Floor

9:00 Bennett Lecture: The Application of Genetic -9:45 Linkage Analysis to Neurological Disease:

Neurofibromatosis Type I Ray White, Salt Lake City, iJT

9:45 The Role of Recessive Oncogenes in the Formation of Central Nervous System Tumors Robert Martma, Boston, M A


lO:3O Coffee break -1 0.30


1:3O The Parkinson Study Group (PSG) and The -5:OO Movement Disorder Society (MDS) present a symposium on “Hyperkinetic Movement Disorders” Grand Ballroom A, Second Floor

10:5O Prions: An Exploration of How -1 1 :35 Neurodegenerative Diseases Can be Both Genetic and Infectious Stanlcy B . Prtrsiner, San Francisco, C A 11 :35 First Executive Session of Membership -12:3O Grand Ballroom East

12:OO ANA Registration -8:00 Grand Ballroom Foyer, Second Floor

Afternoon Evening 6:00 Early Bird Cocktail Reception (cash bar) Grand Ballroom D, Atlanta Hilton & Towers


12:OO Visit posters and exhibits -2.30 (Authors present 1:OO-230)

Grand Salon-sandwich available

and beverage lunch

Program and Abstracts, American Neurological Association 203


P1. Defining a Cerebral Network That Subserves Picture Comprehension Using Positron Emission Tomographic Activation Techniques Murray Grossman, Martin Reivich, Wayne Alves, Donald Momion, Samir Misra, Abass Akzvi, and Joel Greenberg, Philadelphia, PA P2. A Prospective Study of Magnetic Resonance in P a r e n t e d Drug Users with Human Immunodeficiency Virus R. Mayeux, G. Dooneief; G . Todak, R. MalouA J . Bello, K. Marder, I. Mun, K. Bell, and Y . Stern, New York, NY P3. Interictal Depression in Patients with Medically Intractable Complex Partial Seizures: Electroencephalography and Cerebral Metabolic Correlates Jeffrey I. Victoroff; D . Frank Benson, Jerome Engel,Jr, Scott Grafton, and John C. Mazziotta, Los Angeles, C A P4. Coma and the Vegetative State Associated with Thalamic Injury after Cardiac Arrest Norman R. Relkin, Carol K. Petito, and Fred Plum, New York, N Y P5. Bilateral Impairment of Somesthetically Mediated Object Recognition in Man: Anatomical and Behavioral Correlates Richard J . Caselli, Rochester, M N P6. Spontaneous Reaching Patterns in Frontal Neglect: Spatial Versus Motor Deficit Ruthmaqi K. Deuel, St Louis, M O P7. Differences in Behavioral State-Specific Changes in Human Hippocampal Theta Activity As a Function of Seizure Focus J . L. Thomp.ton, K. J . Meador, D. W . Lwing, G. P. Lee, D . W. King, B. B. Gallagher, A. M.Murro, J. R. Smith, and H . F. Flanigin, Augusta, GA PS. Properties of Apraxia Test Items That Distinguish Early States of Dementia R . K. Deuel, D . F . Edward, and C. Baum. St Louis, MO

P9.Determination of Language Dominant Hemisphere with Rapid Transcranial Magnetic Stimulation Alvam Pascual-Leone,J . R. Gates, and Anil K. Dhuna, Minneapolis, M N 204 Annals of Neurology Vol 28 No 2 August 1990

POSTER PRESENTATION: CEREBROVASCULAR DISEASE P10. Blockade of Voltage-Gated Na+ Channels with Tetrodotoxin Protects Central White Matter Against Anoxic Injury Peter K. Stys, Bruce R. Ransom, and Stephen G. Waxman, New Haven, C T , and West Haven, CT P11. Risk of Tissue Plasminogen Activator Thrombolysis with Concurrent Aspirin Therapy Wayne M. Clark>Ken P. Madden, and Justin A . Zivin, San Diego, C A P12. Correction of Ischemic Brain Acidosis with a Novel Thromboxane Receptor Antagonist Combined with a Thromboxane Synthase Inhibitor L. C . Pettigrew,J . D. Hazle, and G. Gutierrez, Lexington, KY, and Houston, T X P13. Expression of Basic Fibroblast Growth Factor-binding Sites in Rat Ischemic Neurons Takeo Kato, Shinichi Nakano, Miyazaki Kyuya Kogure, Hajime Sasaki, Kazunori Koiwai, Tada.rhi Katagiri, and Hideo Sasaki, Yamagata,Japan, and Sendai. Japan P14. Is Family History of Stroke a Risk Factor for Stroke: The Framingham Study Philip A. Wolf; L. Adrienne Cupplrs, Carlos S. Kase, Dan Kiely, and Richard H. Myers, Boston, M A P15. Incomplete Antiplatelet Effects in Patients on Aspirin Compounds Robert H . Ackerman and K e q L. Newman, Boston, M A P16. Regional Cerebral Blood Flow As a Laboratory Marker in Systemic Lupus Erythematosus S. Goldstein, M . J . Kashner, W. M . Aloes, D. F. Morrison, G. 0. DeBolt, J . Cbawluk, B. E. Skolnick, B . Freunrllicb, and M . Reieich, Philadelphia, FA P17. Infarcts with a Cardiac Source of Embolism in the National Institute of Neurological Disorders and Stroke Stroke Data Bank: Features on Initial Computed Tomography Scan S. J . Kittner, C. M . Sharkness, T. R. Price, M . A. Sloan, J . M. Dambrosia, P. A. Wolf; J . P . Mohr, R. L. Sacco, D . B. Hiw, and S. Tuhrim, Baltimore and Bethesda, M D , Boston, M A , New York, N Y , and Chicago, IL P18. A Dose-Escalation Safety Study of Intravenous Tissue Plasminogen Activator in Patients Treated from 90 to 180 Minutes from Onset of Acute Ischemic Stroke E. Clarke Haley. Jr, David Levy, George Sheppard, Thomas Brott, John Marlw, and James Torner, Charlottesville, VA, New York, NI.: Winchester, VA, Cincinnati, OH, and Bethesda, M D

P19. A Comparative Study of Cerebrovascular Complications of Cocaine: Alkaloidal versus Cocaine Hydrochloride S. R. k i n e , N . Futrell, K.-L. Ho, J . C. M . Brust. D. Blake, C. H. Millikan, L. M. Brass, P. Fayad, L. R. Schultz, K. M . A . Welch, Detroit. MI, Neu: York, N Y , and New Haven, CT P20. Lipoprotein Metabolism and Restriction Fragment Length Polymorphisms for High-Density Lipoprotein in Strokes Frank M. Yatsu, Rita Alum, Kasturi Ranganna, Thomas DeGraba, and Juergen Kraus, Houston, T X , and Aachen, West Germany P2 1. Accuracy of Transcranial Doppler in the Vertebrobasilar Circulation C. J . Estol, L. D. DeWitt, B. Tettenborn, G. Kraemer, M . S. Pessin, and L. R. Capkzn, Boston, M A , and Maim, West Gemzany

P22. Ischemic Cerebrovascular Complications and Risk Factors in Idiopathic Hypertrophic Subaortic Stenosis James W. Russell,Jose Biller, Zina D. Hajduczok, Michael Jones, Richard E. Kerber, and Harold P. Adam, Jr. Iowa City, IA P23. Recurrent Thromboembolic and Stroke Risk in Patients with Neurological Events and Antiphospholipid Antibodies The Antiphospholipid Antibodies and Stroke Study Group, Detroit, M I P24. Hydroxyethyl Starch 20010.5 Reduces Infarct Volume in a Rat Model of Cerebral Ischemia A. D. Perez-Trepichio, S . C . Jones, J . K. Little, and A. J. Furlan, Cleveland, OH P25. Circadian Rhythmicity of Stroke Onset: Intracerebral and Subarachnoid Hemorrhage M . A. Sloan, T . K. Price, M . A. Foulkes. J . R. Marleer,J . P. Mohr. D. B. Hier, P. A . Wolf; and L. R. Capkzn, Baltimore and Bethesda. MD, New York, N Y j Chicago, IL, and Boston, M A P26. Hemorrhagic Transformation of Small Cerebral Infarcts in the Rat Nancy Futrell,J . H . Garcia, and Clark Millikan. Detroit, M I , and Birmingham, A L P27. Prediction of Outcome with Early Single Photon Emission Computed Tomography in Acute Cerebral Infarction Pierre B. Fayad, Paul B. Hoffer, and Lawrence M. Brass. New Hatien, CT

POSTER PRESENTATION: DEMENTIA AND AGING P30. Amyloid Plaque Size in Alzheimer’s Disease Is Strongly Correlated with Capillary Association Mitsuru Kawai, Patrick Cras, Sandra Siedkak, and George Pervy, Claekznd, OH P31. Titration Procedures Not Helpful in Clinical Trials of Physostigmine in Alzheimer’s Disease M. Sano, Y . Stern, L. Stricks, K. Murder, and R. Mayeux, New York, N Y P32. Amyloid of Neurofibrillary Tangles of Guamanian Amyotrophic Lateral Sclerosis Contains Low Molecular Weight Proteins D. C. Guiroy, M . Miyazaki, R. At. Garruto, R. Yamgibara, and D. C. Gajdusek, Bethesah, M D

P33. Driving Performance in Mild Senile Dementia of the Alzheimer Type Lindz A . Hunt, Dorothy Edwavds, John C. Morris, and Ada Mui, St Louis, MO

P34. Cognitive Factors Alone Predispose to Falls in Community-Dwelling Elderly Persons John C. Morris, Gavy Paige, Shirley Suhmzann, Chock Tsering, N a n q Van Fleet, Nan Roberts, Cynthia Arfkn. and Paula Davis, St Louis, MO, and Pittsburgh, PA P35. Blood Flow and Metabolism in Alzheimer’s Disease with Aphasia S. Goldstein, A. Akzvi, A. Saykin, R. Gar, W . Alves, J. CbawL.uk, B. Souder, and M . Reivich, Phikzdelphia, P A P36. Dystrophic Neurites in Alzheimer’s Disease May Accumulate Amyloid Precursor Protein Prior to Developing Cytoskeletal Abnormalities P. Cras, M . Kawai, S. Siedlak, P. Mulvihill, G . Perry, D. Lowery. R. A . Altman, and B. Greenberg, Cleveland, OH, and Kalamazoo, MI P37. 31PNuclear Magnetic Resonance Spectroscopy and Alzheimer’s Disease, Multiple Subcortical Infarct Dementia, and Mixed Alzheimer’s/Multi-InfarctDementia G . G. Brown, S. R. Levine, N . Futrell, J. W . Gdowski.J . B. Rich, J . M . Gorell, A. M . Q. Van& Linde. andK. M. A. Welch, Detroit, MI

P28. Transcranial Doppler in Acute Hemispheric Brain Infarction Michael Kushner, Elietta Zanette, Stefan0 Bastianello, G. Mancini, Maria Luisa Sacchetti, Antonio Carolei, and Luigi Bozzao, Philade&hia, PA, and Rome, ltaly

P38. Implication for Mercury in the Alteration of P-Tubulin Observed in Alzheimer’s Disease J . T . Sleein, D. J . Gunnetsen, E. Duhr, and B. E. Haley, Lexington, K Y

P29. Inosine Monophosphate Single Photon Emission Computed Tomographic Evaluation of Regional Ischemia in Patients with Transient Hemispheric Attacks Paul M . Katz, Janet A . Lan, Sherman L. Heller, Daniel M. Ro.renbaum, and Leonard M . Freeman, Bronx, N Y

P39. Mild Senile Dementia of the Alzheimer Type: Longitudinal and Cross-Sectional Assessment Leonard Berg, John C . Morris,J . Philip Millev, Eugene H . Rubin! Martha Stvrandt, Deborah S. Smith, and Lawrence A. Coben, St Louis, MO

Program and Abstracts, American Neurological Association 205

P40. Neuropsychological Validity of Dementia Rating Scale G. E. Smith, R. C. Petersen, E . Kokmm, E . Tangalos, R. J . Ivnik, L. T. Kurland, Rochester, M N

POSTER PRESENTATION: DEGENERATIVE DISEASE P41. Distribution and Number of Transferrin Receptors in Parkinson’s Disease and in MPTP-treated Mice Deborah C. Mash, Juan Sanchez-Ramos, and William J . Weivier, Miami, FL P42. Immunohistochemical Studies on Complexes I, 11,111, and IV of Mitochondria in Parkinson’s Disease Nobutaka Hattori, Shin-ichirou ikebc, Yoshikuni Mizuno, Tomoyoshi Kondo, Takeshi Sato, Masashi Tanaka, and Takayuki Ozawa, Tokyo and NagqYa, Japan P43. Glutamate Dehydrogenase Isoproteins Purified from Human Cerebellum Are Differentially Altered in Cerebellar Degenerative Disorders Andreas Plaitakis and P. Shashidharan. New York, NY P44. “Active” Relapsing and Progressive Multiple Sclerosis Patients Have Similar Magnetic Resonance Imaging Behavior: Implications for Clinical Trial Design J . H . Noseworthy, S. J . Karlik, S . Wiebe, M . Hopkins, M. K. Vandervoort, L. Hewitt, G. P. A. Rice, G. C. Ebers, and D . H . Lee, London, Ontario, Canada P45. Demonstration of a Linear Decline in Amyotrophic Lateral Sclerosis with a Clinical Scale Michael Grundman, H y m n Domenfed> W. Allen Hauser. and Joseph C. Masdeu, New York, N Y P46. Quantitative Natural History of Amyotrophic Lateral Sclerosis: Early Rapid Linear Loss of Tongue Isometric Muscle Strength in Prebulbar Amyotrophic Lateral Sclerosis Patients Roxanne DePaul, Benjamin Rix Brooks, Melissa Wang, and Mohammed Sanjak,, Madison, Wl P47. Computer Models of Amyotrophic Lateral Sclerosis: Effects of Position of Onset on Kinetics of Cell Loss Robert L. Sujit, Madzson, Wl P48. Preponderance of Rigidity, Positive Babinski Signs, and Clonus in Young Amyotrophic Lateral Sclerosis Patients with Recreational Drug or Metal Exposure Hishdm Hakim, Benjamin Rix Brooks, Robert Suf;t, Bradley Beinlich, Peter Eichman, and Henvy Peters, Madison, W i

206 Annals of Neurology Vol 28 No 2 August 1990

P49. Presumed Joseph Disease: Three New Kindreds and Response to Anti-Parkinson Drugs S. H . Subramony, R. D. Currier, J . F . Jackron, and G . M . Collins, Jackson, MS

POSTER PRESENTATION: HEADACHE AND PAIN P50. Treatment of Thalamic Pain Syndrome With Mexiletine Gazin Awerbuch, Bay City, MI P5 1. Exaggerated Cerebral Vasoconstriction As an Interictal Marker of Migraine James R. Mckughlin. Camilo R. Gomez, Sandra M . Gomez, Denise Taylor, and Simon Horenstein, St Louis, M O P52. Function and Morphology of the Trigeminal Root in Facial Pain Syndromes A. C . Ludolph. M . Riepe, G. Fahrendorf; R. Kromminga, and H . Miiller-Fahlbusch, Munster, West Germany P53. Dissociated Cranial Sympathetic Dysfunctions in Posttraumatic Headaches Ramesh K. Khurana, Baltimore, M D

POSTER PRESENTATION : MOVEMENT DISORDERS P54. The Anatomical and Disease Specificity of Complex I Deficiency in Parkinson’s Diseme A. H. V. Schapira, J . M . Cooper, V . M . Mann, D . Dexter, P. Jennw./. B. Clark, and C . D . Marsden, London, UK P55. Fetal Neural Implants for Advanced Parkinson’s Disease N . L. Rosenberg, C . R. Freed, R. E. Breeze. J. M . Bawett, T . Wells, S . T. Grafton, S. C . Huang, D . Eidelberg, and D . A.Rottenberg, Dentier, CO, Miami, FL, Southgate and Los Angeles, CA, and New York, N Y P56. Quantitative Electromyographic Analysis of Response to Botulinum Toxin Therapy for Spasmodic Torticollis Aron S. Buchman, Cynthia L. Comella, Mark J. Garratt, and Caroline M . Tanner, Chicago, I L P57. Botulinum Toxin Treatment of Tremors Joseph Jankovic and Kenneth Schartz, Houston, T X P58. The Time C ~ w s of e Spontaneous Recovery in 1-Methyl4Phenyl-1,2,3,GTetrahydropyridineInduced Parkinsonian Monkeys Roger Kurlan, Michael H . Kim, and Don M . Gash, Rochester, NY


P59. Rapidly Progressive Autosomal Dominant Parkinsonism and Dementia Zbigniew Wszolek, Ronald F . Pfeiffer, Robert L. Rodnitzky, Robert L. Schelper, Donald B. Calne, and Eric Ch. Wolters, Omaha, NE, Iowa City, IA, Vancouver, BC, Canada. and Amsterdam, The Netherlands

P69. A Comparative Study of the Electron Microscopic Finding in the Muscle Biopsy Specimens from Patients with Myopathies due to AZT and Human Immunodeficiency Virus G. Pezeshkpour and Marinos Dalakas, Washington, DC, and Bethesda, M D

P60. Autologous Adrenal Medullary Transplantation in Parkinson’s Disease: 18-Month Results C. W . Ohnow, W. Koller, and C . Goetz, Tampa, FL, Kansas City, XS, and Chicago, IL J?61.Movement-RelatedPotentials in Patients with 1-Methyl4Phenyl-1,2,3,GTetrahydropyridineInduced Parkinsonism and Early- and Late-Onset Parkinson’s Disease J . Singh, B. R. Bloem, R. T . Knight, W .Jagust, D. L. Woods, D. J . Beckley, J , Tetrud, and J . W. Lungston, San Jose and Martinez, C A

P62. Neuropsychological Functioning in Early Untreated Parkinson’s Disease K. Kieburtz, P. G. Como, M . McDermott, A. Rudolph, J . J . Growdon, M . Tennis, J . Brady, B. Kanigan, J . A. Saint-Cyr, C. Kierans, E. Landow, Y . Stern,J . Thelen, and the Parkinson Study Group, Rochester, N Y , Boston, MA, Ann Arbor, M I , Saskatoon and Toronto, Canada, Charlottesville, V A , Nezu York, N Y . and Chicago, I L

P70. Genetic Abnormalities of the Duchenne Dystrophy Locus and Mental Retardation Steven J . Huber, Arthur M . Burghes, Christopher J . Klein, Lindu Signore, Regina P. Gunsett, Morris Schaner, Wendy King, Jerry R. Mendell. and the CIDD Study Group, Columbus, OH P71. Experimental Autoimmune Neuropathy in the Rabbit with Immunoglobulin Deposits at Nodes of Ranvier, Following Immunization With GM1 or Gal(B1-3)GalNAc Florian P. Thomas, Werner Trojaborg, Csongor Nagy, Umberto Valhjos, Maria Santoro, Saud A . Sadiq, N o m n Lutov, and Arthur P. Hays, New York., NY P72. Eosinophilia Myalgia Syndrome: The Role of Muscle Biopsy in Detecting Vasculitis-Implications for Therapy Kathleen Gleason Beavis, Matyann Fitzmaurice, and Melinda L. Estes, Cleveland, OH

P63. Reaction Time During Delayed Response Tasks in Parkinson’s Disease Robert J . kbutta, Rosalyn B. M i h , Mark Hallett, and Jerome N . Sanes, Bethesda. MD, Washington, DC, and Providence, RI P a . Autonomic Involvement in Extrapyramidal or Cerebellar System Disorders Paola Sandroni,J . Eric Ahlskog, Robert D. Fealey, and Phillip A. Low, Rochester, MN P65. Transport and Metabolism of Levodopa in the Striatum of Parkinsonian Primates G u i l l m o M. Alexander,John R. Grotbusen, clnd Robefl J. Schwartzman, Philadlphia, PA. P66. Practical Benefits from Monitoring Plasma Levodopa in the Treatment of Advanced Parkinson’s Disease i2largq El. Mark, Denise M . MrHale, Patricia K . Sonsa/la, Dawn Vitigliano, and Jacob I . Sage, New Bvunswick, NJ

P73. Cerebral Spinal Fluid Enzyme-linked Immunosorbent Assay Poliovirus Antibodies in Postpolio Patients Bark Jubelt, Edgar F . Salazar-Grueso, Raymond P. Roos, and Neal R. Cashman, Syracuse, N Y , Chicago, IL, and Montreal, Quebec, Canada P74. Comparison of Treatments for Chronic Inflammatory Demyelinating Polyneuropathy Allan H. Ropper, Gorizalo Zuniga, and Eelco Wijdicks, Boston, MA, and Utrecht, The Netherlands P75. Mitochondrial DNA Deletion with Leigh Syndrome-like Encephalopathy, Renal Fanconi Syndrome, Multiple Endocrine Insufficiencies, and Elements of Kearns-Sayre Syndrome Masahiko Yamumoto, Edward B. Blau, Andrew G. Engel, and Paula R. Clemens, Rochester, M N , and Marshjeld. WI

P67. Spasmodic Dysphonia in Parkinson’s Disease Stewart A . Factor, Carlos Singer, and William J . Weiner. Albany, N Y , and Miami, F L

P76. Antibodies to Myelin-Associated Glycoprotein and Sulfatide in Predominantly Sensory Polyneuropathies A. Pestronk, F. Li, J . Grzyjn, E. Feldman, D. Cornblath,J. Trotter, and B. Winslow, St Louis, MO, Baltimore, MD, and Ann Arbor, MI

P68. Impaired Scaling of Long Latency Reflexes in the Lower Extremity of Parkinson Patients Dennis J. Beckley, Bastiaan R. Bloem, Michael P. Remler, James W . Tetrad, and J . William Langston, Martinez and San Jose, C A

P77. Regenerating and Newly Denervated Muscle Fibers Express a Specific N-CAM Molecule Recognized by Monoclonal Antibodies to NK Cells Isabel Ilka, Marta Leon-Monzon, and Marinos Dalakas, Bethesda, M D

Program and Abstracts, American Neurological Association 207

P78. Treatment of Chronic Inflammatory Demyelinating Polyneuropathy with Intravenous Immunoglobulin Dazid R. Cornblath, Vinay Chaudhhry, and John W. Griffin,Baltimore, M D P79. Detection of Early Autonomic Dysfunction in Patients with Familial Amyloidotic Polyneuropathy: Analysis by the Laser Doppler Method Yukio Ando, Shukuro Araki, Osamu Shimoh, and Tatsubiko Kano, Kumamoto, Japan P80. Withdrawn P81. Recombinant Human Autoantigen and Mouse L Cell Transfection Define the Epitope and HLA Class I1 Restriction of a Thymic T-cell Clone in Myasthenia Gravis Benjamin Ong, Nicholas Willcox, John Newsom-Davis, Daniel Altmnn, and John Trawsdale, Oxford and London, UK P82. Identification of Late-onset and Sporadic Cases of Familial Amyloidotic Polyneuropathy Type 1 by Detecting Variant Transthyretin Using Serum and DNA Diagnosis Shinichi Ikegawa, Tastufumi M urakami, Se& Nishiguchi, Shigehiro Yi, Yukio Andu, Akira Miyazaki, Susumu Watanabe. and Shukuro Araki, Kumamato, Japan P83. Long-Term Azathioprine in the Management of Refractory Myasthenia Gravis Boyd Uwyer and R. F. Mayer, Baltimore, M D P84. Activation of Muscle Afferents by Magnetic Stimulation of Muscle A. Sturr, Y. Zhu, G. Woodward, S.-H. Su, and P. Rossini, Irvine, CA, and Rome, ltab P85. Definition of B-Cell Epitopes in Recombinant a-Subunit Protein 1-210 of Human Nicotinic Acetylcholine Receptor M. Sam, D. J . McCormick, G. E. Griesmann, S. Talib, K . Leiby, T. B. Okarmu, and V. A. Lennon, Rochester, M N . and Menlo Park, C A P86. A Demyelination Index to Monitor the Course of Acute and Chronic Inflammatory Demyelinating Polyneuropathy Didier Cros, Gonzalo Zuniga, Jiunjun Fang, Allan El. Rupper, and Bhagwan Shahani. Boston, MA

P88. Antibody-mediated Demyelination of Dorsal Root Ganglion Cultures Is Dependent on Channel-forming Terminal Complement Complex, C5b-8 Suneeti S. Mane, and Carol Lee Koski, Baltimore, M D P89. Effect of Total Lymphoid Irradiation, with or without Steroids, on Lymphocyte Count and Prognosis in Chronic Progressive Multiple Sclerosis S. D. Cook, C. Devereux, R. Ttriiano, C. Robowski-Kochan, A . Sheffet, G. Zito, A. Jotkowitz, S. Band, and P. Dowling, East Orange, Newark, and Belhille, NJ

W. Human Glial Cells Infected with Human Immunodeficiency Virus Type 1 Produce Interleukin-6 Larry D. Altstiel, Kirk Spwber, and Lloyd Mayer, New York, N Y

P91. Pulmonary Involvement As a Mirror of Human T-Lymphotropic Virus Type I- Associated Myelopathy Shukuro Araki, Minebaru Sugimoto, and Eiichiro Uyamu, Kumamoto, Japan

W2. Gadolinium-Enhancing Lesions on Magnetic Resonance Imaging: Neuropathological Findings D. Katz, J . Taubenberger, C. Raine, D. McFarlin, and H . McFarland, Bethesda, M D P93. Contrasting Effects of Alpha, Beta, and Gamma Interferons on Suppressor Function in Multiple Sclerosis Avertuno Noronha, Angela Toscas, and Mark A . Jensen, Chicago, IL

P94. Antibodies to Acidic Glycolipids in Guillain-Barre Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy Amjad A. llyas, Francis A. Mithen, Zi-Wei Chen, Marinos Dalakas, and Stuart D. Cook, S t Louis, MO, Newark, NJ, and Betbesda, M D

P95. Bowelia btlrgdovfieri Infection in the Chronic Fatigue Syndrome P. K. Coyle and Lauren Krupp, Stony Brook, N Y P96.Search for Antibodies to Neutral Glycolipids in Guillain-Bard Syndrome Amjad A. llyas, Francis A. Mithen, Zi-Wei Chen, and Stuart D. Cook, Newark, NJ, and St Louis, M O P97. A Randomized Trial of Colchicine

POSTER PRESENTATION: NEUROIMMUNOLOGY P87. Evidence for Receptor-Mediated Attachment of Lymphocytes to Central Nervous System Endothelial Cells During Chronic Relapsing Experimental Allergic Encephalomyelitis Anne H. Cross. Barbaru Cannellu, and Cedric S. Raine, Bmn.x, N Y

208 Annals of' Neurology Vol 28 No 2 August 1990

Versus Placebo in Progressive Sclerosis J . E. Friedman, C. Plank, P. Cahill, P. Mehta, and J . B. Zabriskie, New York and Staten Island, N Y

W8. Intrathecal Formation of IgM Immune Complexes in Multiple Sclerosis P. K. Coyle, Stony Brook, N Y

FYI. Enhanced Stimulation of Virgin T Cells (CD4+ CD45RA+) by Activated CD8' Cells in Multiple Sclerosis Mark S. Freedman and Jack P. Antel, Montreal, Quebec, Canada

P100. Changes in Lymphocyte Populations in Chronic Progressive Multiple Sclerosis Patients After Total Lymphoid Irradiation plus Low-Dose Steroids C. Rohowsky-Kochan, D. Eimun, C. Devereux, R. Troiano, S. Bansil, A. Jotkowicz, and S. D. Cook, Bellmille and Newark, NJ P101. Modification of Murine Experimental Allergic Encephalomyelitis with Cytokines M . Racke, S. Dhib-Jalbut, H. McFurland, and D. McFarlin, Bethesda, M D P102. Minimal Toxicity Associated with Monthly Pulses of Cyclophospharnide in the Treatment of Chronic Progressive Multiple Sclerosis: Preliminary Observations Andrew D. Goodmun, Daniel Giang, David H. Mattson, Jane Armer, and R. B. Schiffer, Rochester, N Y

P109. Neurological Manifestations of Esthesioneuroblastoma B. Mokri, M . J. Ebersold, C. R. Jack, and B. W . Scheithauer, Rochester, MN P110. Paraneoplastic Subacute Cerebellar Degeneration with a Circulating Antibody Against Neural and Extraneural Tissues H. Tomimoto,J . M . Brengman, and T . Yanagrharu, Rochester, MN P111. Cronassial As a Neuroprotective Agent Against Vincristine Neuropathy Lisa M. DeAngelis, Clare Gnecco, Raymond P. Warrell,Jr, and Lynne Taylor, N w York, N Y


P112. Treatment of Idiopathic Intracranial Hypertension with Digoxin James A. Goodwin, Chicago, IL

POSTER PRESENTATION: NEUROONCOLOGY P103. Expression and Biological Activities of Transforming Growth Factor-Alpha and Epidermal Growth Factor Receptor in Human Gliomas W. K. Alfred Yung, Janet Bruner, and Peter A. Steck, Houston. T X P104. Diagnosis of Gynecological Cancer Aided by Autoimmune Serological Tests in Patients with Subacute Cerebellar Degeneration D&d Hetzel, C. Robert Stanhope, Brian P. OWeill, and Vanda A. Lennon. Rochester, MN P105. A Model of Experimental Metastatic Brachial Plexopathy F. Vega, L. Davild, J . Y . Delattre, G. Said, J . V i h q ,J . C. Rosenwdd, H . itlagdelenut,and M . Poisson, Paris, France

P113. Saccades Evoked by Frontal Cortical Stimulation in a Human Mark J . Morrow, Robert W. Baloh, and William W. Sutherling, Los Angeles, C A P114. Saccadic Intrusions in Creutzfeldt-Jakob Disease Stephen C. Cannon, Boston, M A P115. Normal and Neuropathic Human Optic Nerves: Innervation of Vasa Nervorum Otto Appenzeller. Jill Lincoln, Pam Milner, and Clrfford Qualls, Albuquerque, N M , and London. UK


P106. Unregulated Expression and Somatic Rearrangement of Proto-Oncogene c-myc in Glioblastoma Satyakam Bhagwatz, Manya Dhar, and M . A. Q. Siddiqzi, Brooklyn, N Y

P116. Central Polyamines and Cardiovascular Control William T. T h a n and Hisashi Ohta, Iowa City. IA

P107. Immunophenotypic Abnormalities of Peripheral Blood Lymphocytes in Patients with Recurrent Malignant Astrocytomas Kurt A. Jaeckle and Marguerite V . Shaw, Salt Luke City, U T P108. PET-FDG and Proton Magnetic Resonance Spectroscopy in the Assessment of Cerebral Gliorna Metabolism Michael Fulham, Jefrey Alger>Albert0 Bizzi, Joseph Frank, Btyan DeSozza, Susan Inscoe, Jeanette Black, and Giovanni Di Chiro, Bethesda. M D

P117. Benzodiazepine Effects on Regional Cerebral Blood Flow Are Receptor Mediated E. Matthew, P. Andreason, R. Cohen, K. Pettigrew, P. Herscovitch, R. Carson, C . King, C.-E. Johan.ron, K. Burden, D. Pickar, and S. M . Paul, Bethesda, M D P118. Naxagolide Treatment of Parkinsonism Peter A. LeWitt, Richard C. Berchou, and Vicki Berchou, Detroit, M I

P119. Receptors for “Dopaminergic” and “Serotonergic” Drugs in Human Choroid Plexus Sally J . BoyJon and Cathy Adams, Denver, CO

Program and Abstracts, American Neurological Association 2W

P129. Myelopathy in Patients with the Acquired Immunodeficiency Syndrome Coinfected With Human T-Lymphotropic Virus Type I Barbara S. Koppel, Sara Williams>Michael Daras, David DePietro, Mark Kapkzn, Maria Coronesi, and Willium Hull, New York, N Y

P120. The p-Carboline Abecarnil: Anticonvulsant Action in Rodents and Baboon, Papio papio L. Turski, D. N.Stephens, L. H. Jensen, E. N . Petersen, B. S. Meldrum, S. Patel, J. Bondo Hansen, W. Loscher, H . H . Schneider, and R. Schmiechen, Berlin and Hannover, West Germany, Soeborg, Denmark, and London, UK

P130.Absence of Human T-Lymphotropic Virus Type I Gene Sequences in Peripheral Blood Mononuclear Cells and Autopsy Tissue of Multiple Sclerosis Patients Using Gene Amplification Naraporn Prayoonwiwat, Larry R. Pease, and Moses Rodriguez, Rochester, M N

P121. Electroencephalogram in Chronic Cocaine Addicts Alvaro Puscual-Leone and And K. Dhuna, Minneapolis, M N

P13 1. Central Nervous System Demyelination Following Peripheral Inoculation with Herpes Simplex Virus Type 1 Is Immune Mediated Lorne F. Kastrukoff and Allen Lug, Vancouver, Canada

POSTER PRESENTATION: REHABILITATION, REGENERATION, AND RECOVERY P122. Development of an Electroencephalogram-Based Brain-Computer Interface Jonathan R. Wolpaw. Dennis J. McFarkznd. Gregoiy W. Neat, and Catherme A. Forneris, Albany and Troy, N Y P123. The Data Glove for Precise Quantitative Measurement of Upper Motor Neuron Function in Amyotrophic Lateral Sclerosis A. D. Will, D. J. Warner. G . W. Peterson, E. J . Sale. and S. H. Price, Loma Linda, C A P124. Neurological Evaluation in Chronic Fatigue Syndrome Lauren B. Krupp, Lynne J. Lungenbach, Susan Fernquist, Wallace B. Mendelson, and David M . Masur, Stony Brook, N Y P125. Operant Conditioning of Human Spinal Stretch Reflexes Richard L. Segal and Steven L. Wolf; Atlanta, G A

P132. Longitudinal Intra-BBB IgG Synthesis Rate: Temporal and Clonal Stability of Intra-BBB IgG Synthesis Lasting up to Eighteen Years in Patients with Multiple Sclerosis P. deCastro, R. W . Baumhefner, K. Syndulko, and W. W. Tourtellotte,Los Angeles, C A


NERVOUS SYSTEM Chair: Richard W. Price, Minneapolis, MN Grand Ballroom East

2 3 0 Neural-Immune Interactions: An Overview

-3:OO Clghrd B. Saper, Chicago. IL 3:OO Relationship of HTLV-1 to Neurological

-3:30 Diseases Dale E , McFarlin, Bethesda, M D


3:30 Coffee Break

-4:OO P126. Central Nervous System Disease Determinants of Genetically Engineered Theiler’s Viruses Raymond P. Roos, Moses Rodrigzrez. Jianlin Fu, and Steven Stein, Chicago, IL, and Rochester. M N

4:OO The Genetics of Susceptibility to Multiple -4:3O Sclerosis

P127. Polymerase Chain Reaction of Cerebral Fluid in Human Immunodeticiency Virus Neurological Disease P. Schmid, A . Conrad, W. W . Tourtellotte, K . Syndulko, E. Singer, and P. Singer, Los Angeles, C A


P128. Evidence of Actively Replacing Epstein-Barr Virus in Patients with the Chronic Fatigue Syndrome Benjamin H. Nutelson, Ning Ye, and Yung-Chi Cheng, East Orange, NJ, and New Haven, CT

210 Annals of Neurology Vol 28 No 2 August 1990

Stepheiz L. Hauser, Boston, M A

4:3O Nervous-Immune System Interactions and Multiple Sclerosis Barry G. Arnason, Chicago, IL


6:15 Annual Banquet High Museum of Art


10:45 Development of an HSV-mediated Gene -I I :00 Transfer Latency Vector David J . Fink. Ann Arbor, M I

Tuesday, October 16 Morning

11:00 Recovery of Motor Function after Stroke -11:lS Studied with PET F . Chollet, London, England

7:OO ANA Registration -5:OO Grand Ballroom Foyer, Second Floor 9:OO All-day poster presentation I1 and exhibits -530 (Authors present 1:00-2:30) Grand Salon

11 :I 5 Topographical Organization of the -1 1:30 SensorylMotor Homunculus in Man:

Activation Studies with PET Cerebral Blood Flow Imaging Scott T . Grafton, Los Angeles. CA

8:30 PLENARY SCIENTIFIC SESSION -11:30 Grand Ballroom East

119 0 Second Executive Session of Membership -12:OO Grand Ballroom East


a:.?0 First Annual Presentation of the Derek -9.00 Denny-Brown Young Neurological Scholar Award Presented by Joseph B. Martin, President

Afternoon 12:OO Visit posters and exhibits -2:3O (Authors present 1:OO-2:30) Grand Salon-sandwich and beverage lunch available

9.00 Molecular Genetics of Alzheimer-type -9:15 Amyloid Precursor Protein Processing in Neural and AD-Fibroblast-Neural Hybrid Cultures Roger N . Rosenberg, DallaJ, T X 9:IS Synaptic Loss and Plasticity in Association - 9 9 0 Cortex in Alzheimer’s Disease: An Ultrastructural Study Steven T . DeKosky, Pittsburgh, FA

POSTER PRESENTATION: BEHAVIORAL NEUROLOGY P133. Study of Patients with Apraxia of Gait by Magnetic Resonance Imaging and Positron Emission Tomography Fuji Yokoi, Hirosbi Sbibasaki, Atsuyuki Kamei, Ken Ikedu, Masaaki lio, and Toshihiko Hara, Tokyo-Japan

NEUROTRANSMITTERS, RECEPTORS, AND DISEASE Chair: Clifford B. Saper, Chicago, IL 9:30 Endogenous Benzodiazepines: Identification, -9:45 Characterization, and Their Role in Hepatic Encephalopathy -Jeffrey .. . D. Rothstein, Baltrmore, M D 9:45 Expression of Muscarinic Receptor Subtype -1O:OO mRNA and Protein in Rat and Human Brain:

Implications for Selective Cholinergic Treatment of Neurological Disease Allan b e y , Baltimore, M D 1o:oo Recombinant Human Acetylcholine Receptor -1O:15 Alpha-Subunit Potently Induces Experimental Autoimmune Myasthenia Gravis Van& A. Lemon, Rochester, MN 10:15 Stiff-man Syndrome-80: A Variant Associated -10:30 with Abnormal Visual Processing and a New Antineuronal Antibody Robert B. Darnell, New York, N Y

GENERAL NEUROSCIENCE Chair: Roger J. Porter, Bethesda, MD 10.30 Neuronotrophic Factor Rescue of Toxic -10:45 Neuropathy

Stuart C. Apfl, Bronx, N Y

P134. Idiopathic Recurring Coma: A Case with Possible Involvement of the GABA-ergic System P . Montagna, P. Cortelli, P. Tinuper, P. Avoni, A . Lugaresi, P. Schoch, E P. Bonetti, A . Morreale, R. Gallassi, E. Sforza, R. Roui, and E. Lugaresi, Bologna, Italy, and Basel, Switzerland P135. Leuko-araiosis, Cerebral Atrophy, and Blood Flow in Elderly Patients with Dementia John S. Meyer, Jun kkwamura, Makoto Ichijo, Masahiro Kobari, and Yasuo Terayama, Houston, T X P136. The Relation of Visuospatial Difficulties in Parkinson’s Disease to Executive Dysfunction Y . Stem, V. Hinton, L. Stricks, A. Herman, M . Sano, and L. J. Cote, New York, N Y P137. Prosopagnosia: A Bihemispheric Disorder D. F. Benron, M . Beckon, E. C. Amos, T. M. Ettlin, and G. Pin&, Los Angeks, CA, Basel, Switzerland, and Bakersjeld, C A

Program and Abstracts, American Neurological Association 211

P138. Posterior Cortical Atrophy: Neuropsychological and Neuroradiological Correlates Steven Z. Rapcsak, Cynthia Ochipa, Margaret G. Roeltgen, and David P. Roeltgen, Philadelphia, PA

P149. The Value of Duplex and Continuous Wave Doppler Ultrasonography in the Evaluation of Extracranial Vertebral Artery: A Prospective Comparison with Angiography P. K. Yip) R. Y . Yuan, H . M , Liu, B. S. Hwang, and R. C. Chen, Taipei, Taiwan

P139. Functional Dissociations in Hemispatial Neglect: Brainprints and Quantitative Lesion Localization Mark Jude Tramo, Maria A. Guglielmo,Patriiia Reuter-Lorenz, and Michael S. Gazzaniga, Hanover, N H

P150. Relationship Between Carotid Plaque Neovascularization and Common Risk Factors for Stroke Jerome B. Wade, Camilo R. Gomez, Richard T . Kubiniec, and Carlos Bedrossian, St Louis, M O

P140. Anxiety and Depression As Neuropsychiatric Symptoms of Systemic Lupus Erythematosus Mary Lou O’Neill, Daniel Giang, Peter G. Como, and Randolph B. Schiffw, Rochester, N Y

PI5 1. Sensitivity of Magnetic Resonance Imaging in Patients with. Acute Stroke Mark J . Alberts, Mike Faulstich, and Linda Gray, Durham, NC

P141. A Case of Transient Global Amnesia Recorded on a Telephone Answering Machine Steven Lewis, Chicago. IL

P152. Cerebral Ischemia in Young Adults Peter Berlit, Mannheim, West Germany

P142. Foreign Accent Syndrome Following a Left Internal Capsule Infarct: A Case Study Dean S. Tippett and Kelly Yeakle, Baltimore, M D

P153. Strokes from Other Causes Masquerading as Migraine-Stroke Ashfaq Shuaib, Suskatoon, Saskatchewan, Canada P154. Occlusion of the Internal Auditory Artery Clark Millikan and Nancy Futrell, Detroit, M I


P155. ICH-PERT A Microcomputer-based Expert System for Decision Support in Spontaneous Intracerebral Hemorrhage K/aus Spitzer. Loris Christante, Andreas Thie, and Klaus Kunze, Hamburg, West Gemzany

P143. Antiphospholipid Antibodies and Transient Neurological Deficits in Young People: A Case-Controlled Study Gretchen E. Tietjen, Steven R. Levine, Eileen Brown, and K. M . A. Welch, Detroit. MI

P156. Experimental Cerebral Venous Thrombosis Laurie E. Knepper, John J . Moossy, and John Moossy, Pittsburgh, PA

P144. Computer Modeling in Human Intracranial Aneurysms: Physiological, Neuroradiological, and Neuropathological Correlations Patricio F. Reyes, Carlos F . Gonzalez, Young 1. Cho, and Hector Ortega, Philadelphia, PA

P157. Left Ventricular Hypertrophy and Risk of Intracerebral Hemorrhage Gary H . Friday, John Phillip Colmenares, Milton Alter, Sue-Min Lai, and Patricia Renee Bmwn, Philadelphia, PA

P145. A Twin Study of Stroke Lawrence M. Brass, Kathleen R. Merikangar, and C . Dennis Robinette, New Haven, CT, and Washington, DC P146. Race and Gender lnfluence on Cerebral Atherosclerosis in Patients with Transient Ischemic Attack Rajeev Deveshwar, Steven R. Levine, Nabih M . Ramadan, Eileen Brown, and K. M. A . Welch, Detroit, MI P147. Qualitative Versus Quantitative Interpretation of Positron Emission Tomography in Acute Stroke D. Gzesh, S. Goldstein, W. A h , D. Jamiuon, M. Kushner, J . Chawluk, A . Akavi, and M . Reivirh, Philadelphia, PA P148. The Natural History of Nontraumatic Parenchymal Brain Hemorrhage Leon A. Wezsberg, New Orleans, LA

212 Annals of Neurology Vol 28 No 2 August 1990

POSTER PRESENTATION: DEMENTIA AND AGING P158. Patterns of Memory Decline in Parkinson’s Disease: A Distinct Neuropsychological Profile Bonnie E. LezJin,Scott Reisman, Mariu M. Llubre. Juan Sanchez-Ramos. WilliamJ . Weiner, and Carlos Singer, Miami, FL

P159. Magnetic Resonance Imaging of the Human Corpus Callosum: Sex Differences and Normal Aging P. M. Doraiswamy, M. M . Husain, G. S. Figiel> S. A . Shah, W. M . McDonald, 0. B. Boyko, E. H. Ellinwood, Jr, and K. R. R. Kvisbnan, Durham, and Chapel Hill, NC, and St Louis, MO

P160. Analysis of Chromosome 21 Linkage in Familial Alzheimer’s Disease S. Sorbi, M. Mortilkz, B. Nacmias, S. Piacentini, L. Amaducci, P. H . St. George-Hyslop, and G. Marcon, Florence and Udine, Italy. and Boston, M A Pl61. Neuronal Vulnerability in Aged Rats After Chronic Brain Hypoperfusion J . C. de la Torre,J . Saundws, T . Fortin, and M . Richard, Ottawa, Ontario, Can& P162. Clinical and Magnetic Resonance Imaging Findings in Patients with Alzheimer’s Disease: A CERAD Study C. Clark, L. Gray, K. Welsh, N . Earle, A. Heyman, J . Hughes, and P. Davis, Philadelphia, PA, Durham, NC, Seattle, W A , and Atlanta, G A P163. Alzheimer’s Disease: Asymmetries in Cortical and Cerebellar Regional Cerebral Blood Flow L. Bracco, A . Pupi, M . T . R. De Cristgaro, M. Falcini, C. Giorgi, G . Dal Pozzo, and L. Amaducci, Florence, Italy P164. Detection of Abnormal Memory Decline in Mild Cases of Alzheimer’s Disease Using CERAD Neuropsychological Measures Kathleen A. Welsh, Nelson Butters, James Hughes, Richard Mobs, and Albert Heyman, Durham, NC, San Diego. CA, Seattle, W A , and New York, N Y P165. The Effects of High-Dose Thiamine in Dementia of Alzheimer’s Type K. J . Meador, D. W. Loring, M . H. Rivner, E. E. Moore, 0. L. Abney, M . E. Allen, H . J. Posas, and E. Y. Zamrini, Augusta, GA Pl66. Causes of Dizziness in the Elderly Lawy E. Davis, Albuquerque, NM P167. Convex Third Ventricle-A Sign for Memory Impairment Artiss L. Powell, New Brunfwick, NJ


P171. Focal Diagnosis in Partial Epilepsy Using Cerebral Blood Flow Single Photon Emission Computed Tomography Olaf B. Paulson and Allan R. Andersen, Copenhagen, Denmark P172. Positron Emission Tomography and Single Photon Emission Tomography in Epilepsy: Comparison of Cerebral Blood Flow and Glucose Metabolism William H. Theodore, Rahman Jahkari, Deborah Leidermun, John MrBumey, and DouglaJ Van Nostrand, Bethesda, MD, and Washington, DC P173. Unexpected Effects of Routine Hyperventilation on pCOr and pOz in Normal Subjects: Implications for Electroencephalography Interpretation Jane M. Achenbach-Ng. Keith H. Chiappa, and Nicokas Mavroudakis, Boston, M A P174. Double-blind Crossover Bioequivalency Study of Brand-name Versus Generic Carbamazepine in Partial Seizure Patients K. S. O h ,J . K. Penly, L. D. Smzth, J. C. Dean, and T . R. Riela, Winston-Salem,NC P175. The Relationship of Epileptogenic Zone Resection, Lesion Resection, and Outcome in Twenty-seven Patients with Neocortical Epilepsy Paul C. Van Ness, h a m A . Awad, Hans 0. Liidws, and Joseph F . Hahn, Cleveland, OH P176. Seizures Provoked by Cocaine Use Cynthia L. Harden, Raul E. Montejo, Alan J . Tuchman, and Michael Daras, New York, N Y P177. Induction of Seizures and Activation of Epileptic Foci with Rapid Transcranial Magnetic Stimulation Anil K. Dhuna, J . R. Gates, and Alvaro Puscud-Leone, Minneapolis, M N

P168. Perceived Personality Change in Patients Evaluated for Memory Disorders I . C. Siegler; K. A . Wehh, D. V . Dawson, N . L. Earl, E. B. Kaplan, and C. M. Clark, Durham, NC

P169. CERAD Protocol for Assessment of Family History of Alzheimer’s Disease J . Silverman, L. Farrw, J. Morris, M . Pwicak-Vance, G. Fillenbaum, and A. Heyman, Bronx, N Y , Boston, MA, St Louis, MO, and Durham, NC

P178. Idiopathic Generalized Epilepsy of Adolescence Linked to Chromosome 6 M . Dumer, D. Janz, D. A. Greenberg, A. V . Delgado-Escueta>and T. Sander, New York. N Y , Los Angeles, CA. and Berlin, West Germany P179. Clinical Significance and Etiological Correlation of Periodic Lateralized Epileptiform Discharges J . S. Khara, A. R. Towne, R. Jaitly, and R. J . DeLorenzo, Richmond, V A


P180. Nonconvulsive Status Epilepticus in Adults at the Mayo Clinic from 1975 to 1988 Donn D. Dexter and Barbara Westmoreland, Rochester, M N

P170. Maturational Increase in Brain Creatine Kinase Activity and Decrease in Hypoxia-induced Seizures David Holtzman, Francis Jensen, Martin Oflutt, and Leo Neuringer, Boston and Cambridge, M A

P181. Acute and Convalescent Magnetic Resonance Imaging in Puerperal Seizures WilliamJ. Triggs, L. James Willmore, Joel W. Yeakley, Todd J . JunuI, und Bruce A. Levy, Houston, T X

Program and Abstracts, American Neurological Association

2 13

POSTER PRESENTATION: MOVEMENT DISORDERS P182. Comparison of Levodopa Doses with Cerebrospinal Fluid Homovanillic Acid Concentrations and Clinical Scores in Patients with Parkinson’s Disease E. R. Siemers, E. C. Daly, R. V . Reddyi and M. R. Farlw, Indianapolis, IN P183. Effects of Levodopa on Regional Brain Serotonin Metabolism in Rats with Unilateral Destruction of Dopamine Pathways H. Kerasidis, P. J , Karstaedt,J. H . Pincu.r, R. Meloni, and K. Gale, Washington, DC P184. Correlation Between Cerebrospinal Fluid Pharmacokinetics of Levodopa and Motor Performance in Parkinson’s Disease C. W. Olanow,J . Cedzrbaum, and Lisa Gauger, Tampa, FL, and White Plains, N Y P185. CQA 206-291: Six Months’ Experience in Parkinson’s Disease Ronald F . Pfe;fferand Ruth Hofmn. Omaha, NE P186. Simultaneous Four-Channel Electromyography As an Adjunct to Selective Denervation in the Treatment of Spasmodic Torticollis Louis S. Russo, Jr, and Carlos Arce, Jacksonville, FL P187. Parkinson’s Disease and Smoking Among Seventh-Day Adventists Z . Davanipour and A. D . Will, Loma Linda, CA P188. Dystonic Movements Associated with Cocaine Use Danielle Rebischung, Michael Daras, and Alan J . Tuchman, New York, NY P189. The Unified Parkinson’s Disease Rating Scale: A Factor Analytic Study C. L. Liss, D. F. Bush, and R. S. Epstein, West Point, PA P190. A One-year Program for Sequential, Individualized Patient Education in Parkinson’s Disease Bruce Quinn, James F. Fries, and Abraham Liebeberman, Cambridge. M A , Stanford, CA, and Phoenix, A Z P191. Evaluation of Early Brain Changes in Corticobasal Ganglionic Degeneration Ronald E. Wilson, Stanlqy R. Burns, Robert M . Kessler, Kathleen Shannon, and William 0. Whetsell,Jr, Nashville, TN P192. Effects of Trauma and Motor Vehicle Accidents on the Progression of Parkinson’s Disease Christopher G. Goetz and Glenn T . Stebbins, Chicago, IL

214 Annals of Neurology Vol 28 No 2 August 1990

P193. Affected-pair Linkage Analysis of Parkinson’s Disease W .Johnson, M. Davidson, H. Yoshidome, A. Lustenberger, L. Golbe, W. Koller, E. Stenroos, and R. Duvoisin, New York, N Y , New Brunswick, NJ, and Kansas City, KS P194. A Brief Screening Questionnaire for Parkinsonism Caroline M .Tanner, David W. Gillqy, and Chrirtopher G . Goetz. Chicago, IL P195. Different Categories of Postural Dyscontrol in Patients with Multiple Sclerosis Robert M. Herndon, Carol A . Pratt, and Fay B. Horak, Portland, OR P196. Putaminal Lesion and Asymmetrical Cerebral Glucose Metabolism in a Case of Spasmodic Torticollis Paul J. Bedurd, Jean-Pierre Bouchard, Antoine M . Hakim. Lucas Yamamoto, and Albert Gjedu’e, Quibec and Montrial, Canada P197. Focal Dystonia in Dyke-Davidoff-Masson Syndrome Baka V. Manyam, SpringfieLdj IL

POSTER PRESENTATION: NEUROMUSCULAR DISEASE P198. Intrafamilial Heterogeneity of Motor Neuron Diseases J . Appelbaum, R. P. Roos, E. F. Salazar-Grueso, T . Siddique, S. T . lannaccane, R. Glantz, and A. Buchman, Chicago, IL, Durham, NC, and Cincinnati, OH P199. The “Amyotrophic Lateral Sclerosis Form” of Chronic Inflammatory Demyelinating Polyneuropathy Shin J . Oh, Birmingham, A L P200. Spine Stabilization in Duchenne Muscular Dystrophy: Effect on Pulmonary Function Shree Pandya, R. T . Moxley, R. C. Griggs, and K. V. Jackman, Rochester, N Y P201. Multipoint Linkage Analysis of Chromosome 2 1 Restriction Fragment Length Polymorphism Markers to Familial Amyotrophic Lateral Sclerosis T. Siddique, M. A. Pericak-Vance, R. P. Roos, P. Watkins, W - Y . Hung, A . Jefsers, T . DeShields, B. R. Brooks, J. Bebout, F . Noore, R. Tandan, G. Nicholson, D. Williams,J . Antel, T. L. Munsat, A . P. Walker, R. J . Bartlett, and A . D. Roses, Durham, N C , Chicago, IL. Gaithwsburg, MD, Madison, WI, Sydney, Australia, Burlington, V T , Concord, Australia, Rochester, MD, Montreal, Canada, and Boston, M A P202. Routine Quantitative Testing of Thermal Specific and Thermal Pain Sensations Renato Verdugo and Jose L. Ochoa, Portland, OR

P203. Peripheral Neuropathy Associated with Eosinophilia-Myalgia Syndrome T. D. Heiman-Patterson, S. J . Bird, G.J . Parry. J. Varga, M . E. Shy, N . W. Culligan. L. Edelsohn, G. T . Tatarian, M . P. Htyes, C. A. Garcia, and A. J. Tahmoush, Philade&hia, PA, and Baltimore, M D P204. Nicotinic Receptor Regulation of Directly and Indirectly Activated Eccrine Sweat Glands Tonette L. Opfer-Gehrking and Phillip A. Low, Rochester, M N

P2 14. Congenital Muscular Dystrophy Associated with Choreiform Movements: Report of Two Cases Neal Hemzanwicz, Brad Beinlich, and Robert Suft, Ann Arbor, MI, and Madison, WI P2 15. Inflammatory Neuropathy in Diabetes Dona1 A. Costigan, David A . Krendel, Linton C . Hopkins, and Jeff Crittenden, Atlanta, G A P216. The Site of Minimum Threshold for Activation of Lower Extremity Muscles Using a Magnetic Coil Stimulus Tangential to the Scalp in the Midline Richard A. L. Macdonell, Keith H. Chiappa, Didier Cros, BruceJ. Day, Barbara E. Shapiro, and Bhagwan T . Shahani, Boston, M A

P205. Lambert-Eaton Myasthenic Syndrome with External Ophthalmoplegia Paul E. Barkhaus and Marian Rubenfild, Minneapolis, M N P206. Characterization of Motor Neuron Antigens That Are Targets for Anti-Gal(B1-3)GalNAc Antibodies A. Lugaresi, F. P. Thomas, S. A . Sadiq, K. W. Lee, C. Kilidzreas, N.Latov, N . Miyatani, and R. K. Y u , N w York, N Y , and Richmond, V A P207. Dystrophin Analysis in Congenital Muscular Dystrophy J . R. Mendell, S. T . Iannaccone, K. L. B u m , K. H . Fischbeck, K. W . Rammohan, D. Cowert, D. E. Bulman, K. Bove. I. W .Jacobs,J . Michaels. G. Miller, and A. H . M . Burghes. Columbus and Cincinnati, OH, and Philadelphia, P A

P2 17. The VPL Data Glove as a Tool for Hand Rehabilitation and Communication D. .J. Warner, A. D. Will, G. W. Peterson, S. H. Price, and E. J . Sale, Loma Linda, C A P218. Vasomotor Changes Induced in the Hands by Median Nerve Stimulation Peter Siao. Didier Cros,Jianjun Fan, and Bhdgwan Shahani, Boston, MA P219. Fatty Acid Composition in Human Erythrocyte Ghosts, Sarcolemma, and Sarcoplasrnic Reticulum in Muscular Diseases Dale L. Birkle, Jack E. Rigg, John A. Lucci, Elizabeth A . Johnson, and Albert J . Azzaro, Margantown, WV

P208. Idiopathic Granulomatous Polyneuropathy: A Restricted Form of Satcoidosis? David A. Krendel and Donal A. Costigan, Atlanta, G A P209. Hereditary Pressure-Sensitive Neuropathy: Demonstration of “Tomacula” in Motor Nerve Fibers Ken-ichiro Oda, Hiroshi Shibasaki and Chiyoko Endo, Kodaira. Tokyo. Japan

P2 10. Idiopathic Postural Tachycardia Syndrome Ronald Schondorf and Phillip A. Law, Rochester, M N

POSTER PRESENTATION: NEUROSCIENCE P220. Neurochemical Characterization of Excitotoxin Lesions in Cerebral Cortex M. Flint Beal. Kenton J , Swartz, Stephen F. Finn, Michael F. Mazurek, and Neil W. Kawall, Boston, M A , and Hamilton, Ontario, Canada P22 1. Development of the Dorsal Root Afferent Projection to Motor Pools in Rat and Human Spinal Cord C . Tsering, N. Gorukanti, and W. D. Snider, St Louis, MO

P2 11. Juvenile Myasthenia Gravis in an Urban Clinic Population Abid Ali and Roger W. Kuka, Brooklyn, NY

P222. What Can Hypogravity and Hypergravity Tell Us About Central Nervous System Compensation? Shirley G. Diamond and Charles H . Markham, Los Angeles, C A

P212. Susceptibility to Experimental Autoimmune Myasthenia Gravis Passively Transferred with Monoclonal Anti-acetylcholine Receptor Antibody Is Dependent on Recipient Weight Bonita L. DuPont and David P. Richman, Chicago, IL P2 13. Association of Physical Exertion with Amyotrophic Lateral Sclerosis in a Pilot Study Daniel Strickland, Robert M . Raelofs, Linda Go.ldmun, and Gad D o l l s Minneapolh, MN

P223. The Effects of Chronic L-deprenyl Treatment on Striatal Dopamine Levels in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydroxypyridinelesioned Mice Hiroyuki Nakashima, Kazuho Harada, Di Tang, Jaw Y . L m , Menek Goldstein, and Ariel Y. Deutch, N w York, N Y , and N w Haven, CT

Program and Abstracts, American Neurological Association 2 15

P224. Postischemic Brain Alkalosis, Duration of Ischemia, and the Role of Mg2+ Michael Chopp, Ana M . Q. Van& Linde, Hua Chen, and K. M . A. Welch, Detroit, MI

P235. Serial Magnetic Resonance Imaging Scans in Multiple Sclerosis Lawrence W. Myers, George W. Ellison, and John R. Bentson, Los Angeles, C A

P225. Odorant Evoked Potentials in Rats W .James Evans and Arnold S t a q Iwine, C A

P236. Evaluation of Chlorambucil in Multiple Sclerosis L. W. Myers. G. W. Ellison, M . R. Mickey, B . D. Leake. M. R. Nuwer, J. W. Packuood, W. W. Tourtellotte, R. W . Baumhdner, K. Syndulko, C. D. Lerner, and S. L. Craig. Los Angeles, C A

P226. Neuronal Surface Sets in the Mammalian Brain P. D . Kushner, D. T . Stephenson, S. Wright, and E. Garrett, San Francisco, C A P227. Sex-Dependent Side Difference in Middle Cerebral Artery Flow Velocity on Transcranial Doppler Domenico Inzitari. Andrea Ginanneschi, and Marinella Marinoni, Florence, Itah P228. Silent Period Evoked by Transcortical Magnetic Stimulation in Tonically Active Forearm Muscles Bruce Day, Didier Cros,Jianjun Fang, and Bhagwan Shahani, Boston, M A

POSTER PRESENTATION: NEUROIMMUNOLOGY P229. Lymphokine Production by Activated Lymphocytes in Multiple Sclerosis Shalini B a n d , Raymond Troiano. Stuart D. Cook, and Christine Rohouisky-Kochan, Newark, NJ P230. Familial Aggregation of Autoimmune Disease in Multiplex Multiple Sclerosis Kindreds Teresa Doolittle, Richard Myers, Timothy McDemott, and Stephen Hazlsw, Boston, M A P231. Restriction of Spontaneous Plasma Cell VH Gene Family Expression in MRL Mice: Association with High Anticardiolipin Antibody Levels and Disease Expression Robin L. Brey, Jack L. Komisar, Ronald R. Crawley, and Judy M . Teale, San Antonio, T X P232. Serial Gadolinium-enhanced Magnetic Resonance Imaging Scanning in Patients with Early Relapsing Remitting Multiple Sclerosis Jonathan 0. Hawis, Joseph Frank, NichokasJ . Patmnas, Dale E. McFarlzn, and Henry McFarland, Bethesda, M D

P237. Retinoic Acid Suppresses Immune-Mediated Astroglial Proliferation In Vitro 0.Jacopo, F. Sarlo, M . Vergelli, E. Castigli, L. Massacesi, and L. Amadzmi, Florence, Italy P238. Increased Suppressor-Inducer T Cells in Multiple Sclerosis After High-dose Immunoglobulin G Treatment Richard B. Tenser,Judith A . Aberg, and Paula J . Romano, Hershey, PA P239. Difficulties Quantifying Change in Patients with Multiple Sclerosis George W. Ellison, Lawrence W . Myers, Barbara D. bake, Margaret V . Frane, and M . Ray Mickey, Los Angeles, C A P240. The Association of Cervical Spondylosis and Multiple Sclerosis Robert S. Burgerman, Daniele Rigamonti, Paul Fishnzun, and Kenneth P. Johnson, Baltimore, M D POSTER PRESENTATION: PEDIATRIC NEUROLOGY P241. Fatal Cardiomyopathy, Neuropathy, and Mitochondrial Long-chain 3-HydroxyacylCoA Dehydrogenase Deficiency C. Dionisi Vici, B. Garavaglia, A. B. Burlina, E. Bertirii, G. Sabetta, M . Rimoldi and S. DiDonato, Rome, Milan, and Padua, Italy P242. Quality of Obsessive-Compulsive Symptoms in Tourette’s Syndrome Peter G . Como and Roger Kurlan, Rochester, N Y P243. Evoked Potentials in Type C Niemann-Pick Disease M . Balish, C . ArgofJ; A. Pikus, S. Sato, R. Grtual, K . Yu, P. Pentchev, R. Brady. and N.Barton, Bethesda, M D

P233. Antiphospholipid Autoantibodies in a Sample of Neuroleptic-treated Chronic Schizophrenics W . Steven Metzer, Rosa T . Canoso, and Joseph E . 0. Newton, Little Rock, A R , and Brockton, M A

P244. Neuropathological Study of Septo-optic Dysplasia with Dysfunction of the Hypothalamic-Pituitary Axis C. L. Coulter, R. W. Leech, G. B. Schaefer, B. W. Scheithauw, and R. A. Brumback, Oklahoma City, OK, and Rochester, M N

P234. An Immunochemical Comparison of Human Myelin Basic Protein and Its Modified, Nonbasic Form, C8 John N.Whitaker, Paula K. Hemzan, Mario A. Moscarello, and A. Denise Wood, Birmingham. A L , Toronto, Ontario. Canadz

P245. Neurological Outcome in Treated Patients with Hyperphenylalaninemia-A Clinical, Neurophysiological, and Magnetic Resonance Imaging Study A. C. Lardolph, K . Ullrich, U.Sick, G. Fahrendod and S. Nedjut, Munster, West Germany

216 Annals of Neurology Vol 28 No 2 August 19913

POSTER PRESENTATION: NEUROVIROLOGY P246. Limb-Girdle Syndrome and Autonomic Failure Associated with Human T Lymphotrophic Virus Type 1 Infection Steven Herskovitz, Steven A. Sparr, and Michael D. Laimre, Bronx, N Y , and Atlanta, G A P247. Drug-Alcohol Abuse History but Not Depression Is Associated with Neuropsychological Deficits in Human Immunodeficiency Virus Neurological Disease K. Syndulko, E. J , Singer, B. Faby-Cbandon, P. Singer, E. Tuzco, and W . W . Tourtellotte, Los Angeles, C A P248. Herpes Simplex Encephalitis: Early Magnetic Resonance Imaging Findings in the Face of Normal Electroencephalogram Alvaro Pascual-Leone, Anil Dbuna, and Frederick Langendorf;Minneapolzs, M N P249. Safety and Efficacy of Retrovir (Zidovudine: AZT) in Human T Lymphotrophic Virus Type I-Related Tropical Spastic Paraparesis: Preliminary Data W . A. Vogt, R. Lazar, R. W . Kula, T . Harasbima. S.Bhagavati. and 8.J . Pozese, Brooklpn and Spracuse, N Y P250. Altered Cerebrospinal Fluid Levels of Cortisol and Biogenic Amines in Acquired Immunodeficiency Syndrome Dementia Complex Versus Asymptomatic Seropositives: Partial Correction with Zidovudine Therapy E. Singer,J . Wilktns, K. Syndulko, P. Sznger, B. Fahy-Chandon. D. Sedota, J . GafieU, R. Mztsuyasu. E. Tuico, and W . W. Tourtellotte, Los Angeles. C A

POSTER PRESENTATION: TRAUMA/INJURY P251. High Altitude Cerebral Edema: A Clinical Imaging Correlation Philip R. Yamell, Joseph Heit, Kenneth Reynard, and Peter Hackett, Denver, CO, and Anchorage, AK P252. Dysfunctional Changes in Lumbosacral Spinal Motoneurons Caudal to Traumatic Cervical Cord Injuries Michael Rubin, Mindy Aisen, and William F . Brown, New York, N Y . and London. Ontario

P254. Dideoxycytidine Neuropathy: An Animal Model in the Rabbit J . Arezzo, C. Brosnan, M. Litwak, H. Schaumburg, T . Anderson. and A. Davidovicb, Bronx, N Y , and Nutley, NJ P255. Azathioprine Therapy and Cancer Risk in Multiple Sclerosis: A Prospective Long-term Study Maria Pia Amato, Gianfranco Siracusa, Laura Fratiglioni, and Luigi Amaducci,Florence, Italy P256. Neurological Complications of Gaucher's Disease R. P. Grewal, S. H . Doppelt, W . Cohen, R. 0. Brady. and N . W . Barton, Betbesda, MD, Boston, MA, and Los Angeles, C A P257. Effect of Nifedipine on Cerebral Blood Flow Using Transcranial Doppler Ultrasonography Nabih M . Ramadan, Kelly S. Lewis. Valarie A. Silvas, Susan P. Steigemalt, and Susan C. Fagan, Detroii, M I P258. X-Linked Proteolipid Protein Deficiency in the Female Rat Arnulf H. Koeppen, Charles K. Csiza, Ann M . Willey, and Mogens Rpnne, Albany. N Y , and Odense, Denmark P259. A Comparative, Controlled Study of '33Xenon Inhalation Cerebral Blood Flow in Late Onset Migraine Accompaniments Vertebrobasilar Transient Ischemic Attacks Nabib M. Ramadan, Steven R. Levine, Lonnie R. Scbultz, and K. M. A. Welcb, Detroit, MI P260. Spinal Epidural Abscess E. S. Nussbaum, D. Rigamonti. and H . Standiford, Baltimore, M D P261. Persisting Electroencephalographic Abnormalities after Lithium Neurotoxicity Agustin Legido and Milton Alter, Philadelphia, PA P262. Pain-Related Somatosensory Evoked Potentials in Syringomyelia Ryusuke Kakigi, Hirosbi Scbibasaki, Ysuo Kuroda, Rygji Nesbige, and Kazuo Tabucbi, Saga, Japan, and Kodaira, Tokyo,Japan P263. Neurological Complications Following Liver Transplantation Daniel P. Stein, Richard J . Ledemn, David P . Vogt, and William D. Carey, Cleveland, OH P264. Sympathetic Skin Response in Multiple Sclerosis Jose A. Gutrecbt. and Guillernio Suarez, Burlington, M A


POSTER PRESENTATION: OTHER P253. Reactivity of Lambert-Eaton Autoantibodies with Voltage-gated Calcium Channel Complex of Human Cerebral Cortex Vanda A . Lennon, Roche.rter, MN

Sir William Osler, American Neurological Association Member James F . Toole, Sarah-Patsy Knight, and Linda Wilkerson, Winston-Salem,NC, and Minneapolis, MN

Program and Abstracts, American Neurological Association 217

American Neurological Association Archives Sarah-Patsy Knigbt, James F. Toole, and Lawrence C . McHenry, Jr,t Winston-Salem, NC

2:30 CURRENT ISSUES I N NEUROLOGY Chair: Anne B. Young, Ann Arbor, MI Grand Ballroom East


2:3O Etiology of Parkinson’s Disease -3:OO J . William Langton, San Jose, C A 3:OO Experimental Therapeutics of Parkinson’s -3:30 Disease Ira Shoulson, Rochester. N Y

3.30 Coffee break -4:OO 4:OO T h e Future of Neurological Practice in the -5:OO Era of High Technology Co-Chain: Norrnan H . Bass. Pittsburgh, PA. Robert J . Joynt, Rochester, N Y

Punel: NelJon G. Richards, Ricbmond, V A , Ste-uen P. Ringel. Denver, CO Evening

6:15 President’s Reception -8:30 Carter Presidential Center Wednesday, October 17 Morning 7:OO ANA Registration Grand Ballroom Foyer, Second Floor



Abstracts PLENARY SESSION Molecular Genetics of Alzheimer-type Amyloid Precursor Protein Processing in Neural and Alzheimer’s Disease-Fibroblast-Neural Hybrid Cultures Roger N. Rosenberg and Fred Baskin, Dallas, T X Extracellular amyloidic deposits of an A4 peptide, seen early in specific areas of Alzheimer’s disease (AD) brain, are presumably derived from abnormal degradation products of the transmembrane protein, APP. The 115 kd APP product normally released into CSF or cell culture media is not amyloidogenic as it does not contain thc entire A4 peptide region. We have used clonal neuronal and AD-fibroblastneural hybrid cultures to examine the induction of APP mRNAs and the effect of prior membrane or structural protein damage on the release of abnormal A4-containing APP products. We have shown that interleukin-IA, 7 s NGF, and phorbol esters increase APP 7511770 mRNAs in PC-12 cultures. Western immunochemical analyses with several APP peptide-specific antisera indicate the decreased release of the normal 115 kd APP and the increased release of abnormal A4 containing 60 and 42 kd APP products from cultures grown with 0.003% SDS and other membrane-damaging agents. Growth with microtubule or microfilament disruptive agents reduces the release of the 115 kd APP product, but does not cause the release of A4-containing peptides. Preliminary microsequencing of the A4-containing immunoprecipitated 60 kd product reveals an N-terminus corresponding to amino acids 380-384 of APP. These data provide the first evidence for the extracellular release of a soluble potentially amyloidogenic form of APP and support the importance of prior neuronal membrane damage to amyloidogenesis in AD.

Chair: Alan K. Percy, Houston, TX 8:30 Inherited Neurodegeneration in the -9.2 0 Nematode C. elegans Martin Chalfie, New Yo&, NY

Synaptic Loss and Plasticity in Association Cortex in Alzheimer’s Disease: A n Ultrastructural Study Steven T . DeKosky and Stephen W. Schefi Pittsburgh, PA. and Lexington. KY

9:lO Plasticity of Neuronal Organization During -9:50 CNS Development Dennis O’Leaq, St Louis, MO

A more precise definition of the neuropathological and neurochemical changes in Alzheimer’s disease (AD) has been achieved in the last decade. Synaptic connections have been less well studied, owing to the difficulty of obtaining appropriate tissue samples that allow accurate ultrastructural assessment of cortical morphology. We quantitatively assessed synapse number and synapse size in lamina I11 and V of human frontal (area 9 ) and middle and superior temporal (areas 21 and 22) cortex obtained at autopsy from patients with A D and age-matched control subjects. Significant decreases in synapse number per unit volume were found in all three areas. Mean synaptic apposition length was increased in AD and correlated significantly with degree of synapse loss. This appeared to be a compensatory response, rather than a selective loss of small synapses. In lamina V of area 9, the total amount of synaptic contact area per unit volume of cortex did not decline, despite a 27% loss of synapses. In lamina I11 of area 7, total synaptic contact area was significantly reduced only lls,despite a 42% loss of synapses. In area 22, lamina 111 had a 3196 decline in synapse number and a significant 8% decline in synaptic contact area; lamina V had a 27% loss of synapses but no change in total synaptic

9.30 Coffee Break -1O:lO

1O:lO The Pathophysiology of N e u r o n d Death i n -1 O:50 Development and Disease Steven M . Rothman, St Louis, MO 1050 Soriano Lecture: Trophic Factors i n Cell -11:30 Death i n Aging and Disease Donald L. Price. Baltimore, M D

Afternoon 1:OO The American Society for Neurological


Investigation (ASNI) will present an Annual Symposium on “Frontiers of Neurotoxicology” Grand Ballroom East



Annals of Neurology

Vol 28 N o 2

August 1990

115th annual meeting of the American Neurological Association. October 14-17, 1990, Atlanta, GA. Abstracts.

115th Annual Meeting of the American Neurological Association October 14-17, 1990 Atlanta Hilton & Towers, Atlanta, GA Program Monday, October 15 Sa...
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