Psychopharmacology DOI 10.1007/s00213-014-3568-4
ORIGINAL INVESTIGATION
11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors Zi-Wei Chen & Cunde Wang & Kathiresan Krishnan & Brad D. Manion & Randy Hastings & John Bracamontes & Amanda Taylor & Megan M. Eaton & Charles F. Zorumski & Joseph H. Steinbach & Gustav Akk & Steven Mennerick & Douglas F. Covey & Alex S. Evers
Received: 20 December 2013 / Accepted: 28 March 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Rationale While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A (GABAA) receptors, the binding sites that mediate these actions have not been definitively identified. Objectives This study was conducted to synthesize neurosteroid analogue photolabeling reagents that closely mimic the biological effects of endogenous neurosteroids and have photochemical properties that will facilitate their Electronic supplementary material The online version of this article (doi:10.1007/s00213-014-3568-4 ) contains supplementary material, which is available to authorized users. Z.
ORIGINAL INVESTIGATION
11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors Zi-Wei Chen & Cunde Wang & Kathiresan Krishnan & Brad D. Manion & Randy Hastings & John Bracamontes & Amanda Taylor & Megan M. Eaton & Charles F. Zorumski & Joseph H. Steinbach & Gustav Akk & Steven Mennerick & Douglas F. Covey & Alex S. Evers
Received: 20 December 2013 / Accepted: 28 March 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Rationale While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A (GABAA) receptors, the binding sites that mediate these actions have not been definitively identified. Objectives This study was conducted to synthesize neurosteroid analogue photolabeling reagents that closely mimic the biological effects of endogenous neurosteroids and have photochemical properties that will facilitate their Electronic supplementary material The online version of this article (doi:10.1007/s00213-014-3568-4 ) contains supplementary material, which is available to authorized users. Z.
